Age-related left ventricular remodeling and associated risk for cardiovascular outcomes the multi-ethnic study of atherosclerosis

Circulation: Cardiovascular Imaging

Volumn 2, Issue 3, 2009, Pages 191-198

  Cheng, Susan ^a,c,d   Fernandes, Veron̂ica R S ^a   Bluemke, David A ^a,b   McClelland, Robyn L ^e,f   Kronmal, Richard A ^e,f   Lima, João A C ^a,b,g  

^a Division of Cardiology   (United States)

^b Department of Radiology ^*  (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d Division of Cardiovascular Medicine   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f UNIVERSITY OF WASHINGTON   (United States)

^g JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Aging; MRI; Myocardium; Remodeling

Indexed keywords

ADULT; AGED; AGING; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; DIASTOLIC DYSFUNCTION; FEMALE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE MASS; HEART STROKE VOLUME; HEART VENTRICLE REMODELING; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SYSTOLIC DYSFUNCTION;

AGE DISTRIBUTION; AGE FACTORS; AGED; AGING; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASES; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MYOCARDIAL CONTRACTION; PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT; RISK FACTORS; STROKE VOLUME; UNITED STATES; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 76049100055     PISSN: 19419651     EISSN: 19420080     Source Type: Journal    
DOI: 10.1161/CIRCIMAGING.108.819938     Document Type: Article

References (50)

1. Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises, I: aging arteries: a "set up" for vascular disease. Circulation. 2003;107:139-146. (Pubitemid 36070946)
2. Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises, II: the aging heart in health: links to heart disease. Circulation. 2003;107:346-354. (Pubitemid 36135235)
3. Lakatta EG. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises, III: cellular and molecular clues to heart and arterial aging. Circulation. 2003;107:490-497.
4. Dannenberg AL, Levy D, Garrison RJ. Impact of age on echocardiographic left ventricular mass in a healthy population (the Framingham Study). Am J Cardiol. 1989;64:1066-1068.
5. Lindroos M, Kupari M, Heikkila J, Tilvis R. Echocardiographic evidence of left ventricular hypertrophy in a general aged population. Am J Cardiol. 1994;74:385-390.
6. Ganau A, Saba PS, Roman MJ, de Simone G, Realdi G, Devereux RB. Ageing induces left ventricular concentric remodelling in normotensive subjects. J Hypertens. 1995;13:1818-1822.
7. Gardin JM, Siscovick D, Anton-Culver H, Lynch JC, Smith VE, Klopfenstein HS, Bommer WJ, Fried L, O'Leary D, Manolio TA. Sex, age, and disease affect echocardiographic left ventricular mass and systolic function in the free-living elderly: the Cardiovascular Health Study. Circulation. 1995;91:1739-1748.
8. Olivetti G, Giordano G, Corradi D, Melissari M, Lagrasta C, Gambert SR, Anversa P. Gender differences and aging: effects on the human heart. J Am Coll Cardiol. 1995;26:1068-1079.
9. Hees PS, Fleg JL, Lakatta EG, Shapiro EP. Left ventricular remodeling with age in normal men versus women: novel insights using threedimensional magnetic resonance imaging. Am J Cardiol. 2002;90: 1231-1236.
10. Salmasi AM, Alimo A, Jepson E, Dancy M. Age-associated changes in left ventricular diastolic function are related to increasing left ventricular mass. Am J Hypertens. 2003;16:473-477.
11. Claessens TE, Rietzschel ER, De Buyzere ML, De Bacquer D, De Backer G, Gillebert TC, Verdonck PR, Segers P. Noninvasive assessment of left ventricular and myocardial contractility in middle-aged men and women: disparate evolution above the age of 50? Am J Physiol Heart Circ Physiol. 2007;292:H856-H865.
12. Gerstenblith G, Frederiksen J, Yin FC, Fortuin NJ, Lakatta EG, Weisfeldt ML. Echocardiographic assessment of a normal adult aging population. Circulation. 1977;56:273-278.
13. Merino A, Alegria E, Castello R, Martinez-Caro D. Influence of age on left ventricular contractility. Am J Cardiol. 1988;62:1103-1108.
14. Pearson AC, Gudipati CV, Labovitz AJ. Effects of aging on left ventricular structure and function. Am Heart J. 1991;121:871-875.
15. Sandstede J, Lipke C, Beer M, Hofmann S, Pabst T, Kenn W, Neubauer S, Hahn D. Age-and gender-specific differences in left and right ventricular cardiac function and mass determined by cine magnetic resonance imaging. Eur Radiol. 2000;10:438-442. (Pubitemid 30145755)
16. Nikitin NP, Loh PH, de Silva R, Witte KK, Lukaschuk EI, Parker A, Farnsworth TA, Alamgir FM, Clark AL, Cleland JG. Left ventricular morphology, global and longitudinal function in normal older individuals: a cardiac magnetic resonance study. Int J Cardiol. 2006;108:76-83.
17. Natori S, Lai S, Finn JP, Gomes AS, Hundley WG, Jerosch-Herold M, Pearson G, Sinha S, Arai A, Lima JA, Bluemke DA. Cardiovascular function in Multi-Ethnic Study of Atherosclerosis: normal values by age, sex, and ethnicity. AJR Am J Roentgenol. 2006;186:S357-S365.
18. Slotwiner DJ, Devereux RB, Schwartz JE, Pickering TG, de Simone G, Ganau A, Saba PS, Roman MJ. Relation of age to left ventricular function in clinically normal adults. Am J Cardiol. 1998;82:621-626.
19. Olivetti G, Melissari M, Capasso JM, Anversa P. Cardiomyopathy of the aging human heart: myocyte loss and reactive cellular hypertrophy. Circ Res. 1991;68:1560-1568.
20. Capasso JM, Fitzpatrick D, Anversa P. Cellular mechanisms of ventricular failure: myocyte kinetics and geometry with age. Am J Physiol. 1992;262:H1770-H1781.
21. Raizada V, Pathak D, Nakouzi A, Malhotra A. Prevention of age-related V1 myosin isozyme decrement in the adult rat heart. J Mol Cell Cardiol. 1994;26:293-296.
22. Roth DA, White CD, Podolin DA, Mazzeo RS. Alterations in myocardial signal transduction due to aging and chronic dynamic exercise. J Appl Physiol. 1998;84:177-184.
23. Lindsey ML, Goshorn DK, Squires CE, Escobar GP, Hendrick JW, Mingoia JT, Sweterlitsch SE, Spinale FG. Age-dependent changes in myocardial matrix metalloproteinase/tissue inhibitor of metalloproteinase profiles and fibroblast function. Cardiovasc Res. 2005;66:410-419.
24. Fleg JL, O'Connor F, Gerstenblith G, Becker LC, Clulow J, Schulman SP, Lakatta EG. Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J Appl Physiol. 1995;78: 890-900.
25. Mantero A, Gentile F, Gualtierotti C, Azzollini M, Barbier P, Beretta L, Casazza F, Corno R, Giagnoni E, Lippolis A. Left ventricular diastolic parameters in 288 normal subjects from 20 to 80 years old. Eur Heart J. 1995;16:94-105.
26. Fioranelli M, Piccoli M, Mileto GM, Risa MP, Sgreccia F, Azzolini AP, Puglisi A. Modifications in cardiovascular functional parameters with aging. Minerva Cardioangiol. 2001;49:169-178.
27. Salmasi AM, Dore C. Variation of aortic blood velocity with age at rest and during exercise in normal subjects. Clin Auton Res. 1995;5:19-23.
28. Alfakih K, Plein S, Thiele H, Jones T, Ridgway JP, Sivananthan MU. Normal human left and right ventricular dimensions for MRI as assessed by turbo gradient echo and steady-state free precession imaging sequences. J Magn Reson Imaging. 2003;17:323-329.
29. Hudsmith LE, Petersen SE, Francis JM, Robson MD, Neubauer S. Normal human left and right ventricular and left atrial dimensions using steady state free precession magnetic resonance imaging. J Cardiovasc Magn Reson. 2005;7:775-782.
30. Bild DE, Bluemke DA, Burke GL, Detrano R, Diez Roux AV, Folsom AR, Greenland P, Jacob DR Jr, Kronmal R, Liu K, Nelson JC, O'Leary D, Saad MF, Shea S, Szklo M, Tracy RP. Multi-ethnic study of atherosclerosis: objectives and design. Am J Epidemiol. 2002;156:871-881.
31. Edvardsen T, Detrano R, Rosen BD, Carr JJ, Liu K, Lai S, Shea S, Pan L, Bluemke DA, Lima JA. Coronary artery atherosclerosis is related to reduced regional left ventricular function in individuals without history of clinical cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2006;26:206-211.
32. Lakoski SG, Greenland P, Wong ND, Schreiner PJ, Herrington DM, Kronmal RA, Liu K, Blumenthal RS. Coronary artery calcium scores and risk for cardiovascular events in women classified as "low risk" based on Framingham risk score: the Multi-Ethnic Study of Atherosclerosis (MESA). Arch Intern Med. 2007;167:2437-2442.
33. Levy D. Left ventricular hypertrophy: epidemiological insights from the Framingham Heart Study. Drugs. 1988;35(Suppl 5):1-5.
34. Redfield MM, Jacobsen SJ, Borlaug BA, Rodeheffer RJ, Kass DA. Ageand gender-related ventricular-vascular stiffening: a community-based study. Circulation. 2005;112:2254-2262.
35. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, Solomon SD, Spencer KT, Sutton MS, Stewart WJ. Recommendations for chamber quantification: a report from the Am Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440-1463.
36. Alfakih K, Bloomer T, Bainbridge S, Bainbridge G, Ridgway J, Williams G, Sivananthan M. A comparison of left ventricular mass between twodimensional echocardiography, using fundamental and tissue harmonic imaging, and cardiac MRI in patients with hypertension. Eur J Radiol. 2004;52:103-109.
37. Anversa P, Hiler B, Ricci R, Guideri G, Olivetti G. Myocyte cell loss and myocyte hypertrophy in the aging rat heart. J Am Coll Cardiol. 1986;8: 1441-1448.
38. Anversa P, Palackal T, Sonnenblick EH, Olivetti G, Meggs LG, Capasso JM. Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart. Circ Res. 1990;67:871-885.
39. Kass DA. Age-related changes in ventricular-arterial coupling: pathophysiologic implications. Heart Fail Rev. 2002;7:51-62.
40. Chen CH, Nakayama M, Nevo E, Fetics BJ, Maughan WL, Kass DA. Coupled systolic-ventricular and vascular stiffening with age: implications for pressure regulation and cardiac reserve in the elderly. J Am Coll Cardiol. 1998;32:1221-1227.
41. Port S, Cobb FR, Coleman RE, Jones RH. Effect of age on the response of the left ventricular ejection fraction to exercise. N Engl J Med. 1980; 303:1133-1137.
42. Rodeheffer RJ, Gerstenblith G, Becker LC, Fleg JL, Weisfeldt ML, Lakatta EG. Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilatation and increased stroke volume compensate for a diminished heart rate. Circulation. 1984;69:203-213.
43. Nussbacher A, Gerstenblith G, O'Connor FC, Becker LC, Kass DA, Schulman SP, Fleg JL, Lakatta EG. Hemodynamic effects of unloading the old heart. Am J Physiol. 1999;277:H1863-H1871.
44. Bellenger NG, Burgess MI, Ray SG, Lahiri A, Coats AJ, Cleland JG, Pennell DJ. Comparison of left ventricular ejection fraction and volumes in heart failure by echocardiography, radionuclide ventriculography and cardiovascular magnetic resonance; are they interchangeable? Eur Heart J. 2000;21:1387-1396.
45. MacGowan GA, Shapiro EP, Azhari H, Siu CO, Hees PS, Hutchins GM, Weiss JL, Rademakers FE. Noninvasive measurement of shortening in the fiber and cross-fiber directions in the normal human left ventricle and in idiopathic dilated cardiomyopathy. Circulation. 1997;96:535-541.
46. de Simone G, Ganau A, Roman MJ, Devereux RB. Relation of left ventricular longitudinal and circumferential shortening to ejection fraction in the presence or in the absence of mild hypertension. J Hypertens. 1997;15:1011-1017.
47. Rosen BD, Edvardsen T, Lai S, Castillo E, Pan L, Jerosch-Herold M, Sinha S, Kronmal R, Arnett D, Crouse Jr. III, Heckbert SR, Bluemke DA, Lima JA. Left ventricular concentric remodeling is associated with decreased global and regional systolic function: the Multi-Ethnic Study of Atherosclerosis. Circulation. 2005;112:984-991.
48. Fernandes VR, Polak JF, Cheng S, Rosen BD, Carvalho B, Nasir K, McClelland R, Hundley G, Pearson G, O'Leary DH, Bluemke DA, Lima JA. Arterial stiffness is associated with regional ventricular systolic and diastolic dysfunction: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2008;28:194-201.
49. Bluemke DA, Kronmal RA, Lima JA, Olson J, Burke GL, Folsom AR Incident congestive heart failure in the MESA study: relationship to left ventricular mass. Circulation. 2005;112(Suppl II):II-800.
50. de Simone G, Devereux RB, Koren MJ, Mensah GA, Casale PN, Laragh JH. Midwall left ventricular mechanics: an independent predictor of cardiovascular risk in arterial hypertension. Circulation. 1996;93:259-265. (Pubitemid 26031483)