Role of AMACR (α-methylacyl-CoA racemase) and MFE-1 (peroxisomal multifunctional enzyme-1) in bile acid synthesis in mice

Biochemical Journal

Volumn 461, Issue 1, 2014, Pages 125-135

  Autio, Kaija J ^a   Schmitz, Werner ^b   Nair, Remya R ^a   Selkäl̈a, Eija M ^a   Sormunen, Raija T ^a   Miinalainen, Ilkka J ^a   Crick, Peter J ^c   Wang, Yuqin ^c   Griffiths, William J ^c   Reddy, Janardan K ^d   Baes, Myriam ^e   Hiltunen, J Kalervo ^a  

^a UNIVERSITY OF OULU   (Finland)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c SWANSEA UNIVERSITY   (United Kingdom)

^d NORTHWESTERN UNIVERSITY   (United States)

^e UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Bile acid; Peroxisomal multifunctional enzyme 1 (MFE 1); Peroxisome; methylacyl CoA racemase (AMACR)

Indexed keywords

2 METHYLACYL COENZYME A RACEMASE; ACYL COENZYME A OXIDASE; ACYL COENZYME A OXIDASE 2; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILE ACID; BILE ACID CONJUGATE; CHENODEOXYCHOLIC ACID; CHOLENOIC ACID; CHOLIC ACID; CYTOCHROME P450; CYTOCHROME P450 3A11; CYTOCHROME P450 46A1; DIHYDROXYCOPROSTANOIC ACID; DIHYDROXYCOPROSTENOIC ACID; MURICHOLENOIC ACID; MURICHOLIC ACID; OXIDOREDUCTASE; PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 1; PEROXISOMAL MULTIFUNCTIONAL PROTEIN 2; PROSTANOIC ACID DERIVATIVE; QUATERNARY AMMONIUM DERIVATIVE; TAURINE; TETRAHYDROXYCOPROSTENOIC ACID; TRIHYDROXYCOPROSTANOIC ACID; TRIHYDROXYCOPROSTENOIC ACID; UNCLASSIFIED DRUG; VARANIC ACID;

24 HYDROXYLATION; AGING; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOPSY; BILE ACID BLOOD LEVEL; BILE ACID SYNTHESIS; BILE DUCT CARCINOMA; CELL HYPERPLASIA; CHOLANGITIS; CONTROLLED STUDY; CROSS BREEDING; DNA MODIFICATION; ENZYME ACTIVITY; EXON; FATTY ACID OXIDATION; FEMALE; GENE EXPRESSION; GENOTYPE; HEPATOCHOLANGIOCARCINOMA; HEPATOMEGALY; HETEROZYGOTE; HISTOPATHOLOGY; HYDROXYLATION; HYPOTHESIS; KNOCKOUT MOUSE; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LITTER SIZE; LIVER CELL; LIVER CELL CARCINOMA; LIVER TUMOR; MALE; MASS SPECTROMETRY; MICROSCOPY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RECTUM PROLAPSE; RNA ISOLATION; SIGNAL TRANSDUCTION; SMOOTH ENDOPLASMIC RETICULUM; UPREGULATION; WILD TYPE;

ANIMALS; BILE ACIDS AND SALTS; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, ANIMAL; MULTIENZYME COMPLEXES; RACEMASES AND EPIMERASES; SIGNAL TRANSDUCTION;

EID: 84902338484     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130915     Document Type: Article

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