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Volumn 16, Issue 7, 2014, Pages

Hypercortisolism in obesity-associated hypertension

Author keywords

Adiposity; Aldosterone; Cortisol; Cortisol associated hypertension; Cortisone; Dexamethasone; Dysmetabolic syndrome; Elevated blood pressure; Exogenous Cushing's syndrome; Glucocorticoid excess; Glucocorticoid induced hypertension; Glucocorticoids; Hydrocortisone; Hypercortisolism; Insulin resistance; Mineralocorticoid activation; Obesity hypertension; Pseudo Cushing's syndrome; Subclinical Cushing's syndrome; Visceral fat excess

Indexed keywords

CELL ADHESION MOLECULE; CORTICOTROPIN; DEXAMETHASONE; ENDOTHELIN; EPITHELIAL SODIUM CHANNEL; GLUCOCORTICOID RECEPTOR; HOMOCYSTEINE; HYDROCORTISONE; MINERALOCORTICOID; MINERALOCORTICOID RECEPTOR; OSTEOPROTEGERIN; VASCULOTROPIN; ANTIHYPERTENSIVE AGENT; GLUCOCORTICOID;

EID: 84902329631     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-014-0443-y     Document Type: Article
Times cited : (15)

References (60)
  • 1
    • 84880016480 scopus 로고    scopus 로고
    • Prevalence of physical activity and obesity in US counties, 2001-2011: A road map for action
    • doi:10.1186/1478-7954-11-7
    • Dwyer-Lindgren L, Freedman G, Engell RE, Fleming TD, Lim SS, Murray CJ, et al. Prevalence of physical activity and obesity in US counties, 2001-2011: a road map for action. Popul Health Metrics. 2013;11(1):7. doi:10.1186/1478-7954- 11-7.
    • (2013) Popul Health Metrics , vol.11 , Issue.1 , pp. 7
    • Dwyer-Lindgren, L.1    Freedman, G.2    Engell, R.E.3    Fleming, T.D.4    Lim, S.S.5    Murray, C.J.6
  • 2
    • 74549140993 scopus 로고    scopus 로고
    • Prevalence and trends in obesity among US adults, 1999-2008
    • doi:10.1001/jama. 2009.2014
    • Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA: J Am Med Assoc. 2010;303(3):235 - 41. doi:10.1001/jama. 2009.2014.
    • (2010) JAMA: J Am Med Assoc , vol.303 , Issue.3 , pp. 235-241
    • Flegal, K.M.1    Carroll, M.D.2    Ogden, C.L.3    Curtin, L.R.4
  • 3
    • 55849103124 scopus 로고    scopus 로고
    • Epidemiology of obesity in the Western Hemisphere
    • doi:10.1210/jc.2008-1356
    • Ford ES, Mokdad AH. Epidemiology of obesity in the Western Hemisphere. J Clin Endocrinol Metab. 2008;93(11 Suppl 1):S1-8. doi:10.1210/jc.2008-1356.
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.11 SUPPL. 1
    • Ford, E.S.1    Mokdad, A.H.2
  • 5
    • 84870555466 scopus 로고    scopus 로고
    • Obesity-associated hypertension
    • Koch CA, Chrousos GP, editors. New York: Humana Press; A comprehensive discussion of the entity of obesityassociated hypertension, including its recognition, underlying pathophysiology, contributory factors and clinical associations, as well as an exhaustive discussion of the therapeutic options and how they fare in this condition as compared to typical essential hypertension
    • .• Uwaifo GI. Obesity-associated hypertension. In: Koch CA, Chrousos GP, editors. Endocrine hypertension; Underlying mechansims and therapy. New York: Humana Press; 2013. p. 251 - 88. A comprehensive discussion of the entity of obesityassociated hypertension, including its recognition, underlying pathophysiology, contributory factors and clinical associations, as well as an exhaustive discussion of the therapeutic options and how they fare in this condition as compared to typical essential hypertension.
    • (2013) Endocrine Hypertension; Underlying Mechansims and Therapy , pp. 251-288
    • Uwaifo, G.I.1
  • 6
    • 36549001222 scopus 로고    scopus 로고
    • Glucocorticoids and cardiovascular disease
    • doi:10. 1530/EJE-07-0455
    • Walker BR. Glucocorticoids and cardiovascular disease. Eur J Endocrinol/Eur Fed Endocr Soc. 2007;157(5):545 -59. doi:10. 1530/EJE-07-0455.
    • (2007) Eur J Endocrinol/Eur Fed Endocr Soc , vol.157 , Issue.5 , pp. 545-559
    • Walker, B.R.1
  • 8
    • 4444351617 scopus 로고    scopus 로고
    • Obesity related hypertension as a metabolic disorder
    • Oparil S, Weber MA, editors. Philadelphia: WB Saunders Company
    • Landsberg L. Obesity related hypertension as a metabolic disorder. In: Oparil S, Weber MA, editors. Hypertension; A companion to Brenner and Rector 's the Kidney. Philadelphia: WB Saunders Company; 2000. p. 118-24.
    • (2000) Hypertension; a Companion to Brenner and Rector 'S the Kidney , pp. 118-124
    • Landsberg, L.1
  • 9
    • 0006523401 scopus 로고    scopus 로고
    • Obesity-Hypertension; Effetcs on cardiovascular and renal systems; The therapeutic approach
    • Oparil S, Weber MA, editors. Philadelphia: WB Saunders Company
    • Reisin E, Hutchison HG. Obesity-Hypertension; Effetcs on cardiovascular and renal systems; The therapeutic approach. In: Oparil S, Weber MA, editors. Hypertension; acompanion to Brenner and Rector 's the kidney. Philadelphia: WB Saunders Company; 2000. p. 206-11.
    • (2000) Hypertension; Acompanion to Brenner and Rector 's the Kidney , pp. 206-211
    • Reisin, E.1    Hutchison, H.G.2
  • 11
    • 0035904776 scopus 로고    scopus 로고
    • Assessment of frequency of progression to hypertension in nonhypertensive participants in the Framingham Heart Study: A cohort study
    • doi:10.1016/S0140- 6736(01)06710-1
    • Vasan RS, Larson MG, Leip EP, Kannel WB, Levy D. Assessment of frequency of progression to hypertension in nonhypertensive participants in the Framingham Heart Study: a cohort study. Lancet. 2001;358(9294):1682-6. doi:10.1016/S0140- 6736(01)06710-1.
    • (2001) Lancet , vol.358 , Issue.9294 , pp. 1682-1686
    • Vasan, R.S.1    Larson, M.G.2    Leip, E.P.3    Kannel, W.B.4    Levy, D.5
  • 12
    • 77249132356 scopus 로고    scopus 로고
    • Endocrinology of obesity
    • doi:10.1016/j.cvsm.2009. 10.004
    • Kil DY, Swanson KS. Endocrinology of obesity. Vet Clin N Am Small Anim Pract. 2010;40(2):205-19. doi:10.1016/j.cvsm.2009. 10.004.
    • (2010) Vet Clin N Am Small Anim Pract , vol.40 , Issue.2 , pp. 205-219
    • Kil, D.Y.1    Swanson, K.S.2
  • 13
    • 84876267697 scopus 로고    scopus 로고
    • Cortisol, obesity, and the metabolic syndrome: A cross-sectional study of obese subjects and review of the literature
    • doi:10.1002/oby.20083. An important clinical study that details the problems with interpreting findings from HPA-axis investigation in obese subjects without overt Cushing's syndrome and reviews the conflicting literature on the findings in this regard. Also highlights the important distinction between findings regarding systemic cortisol dynamics as opposed to local tissue dynamics
    • .• Abraham SB, Rubino D, Sinaii N, Ramsey S, Nieman LK. Cortisol, obesity, and the metabolic syndrome: a cross-sectional study of obese subjects and review of the literature. Obesity. 2013;21(1):E105 -17. doi:10.1002/oby. 20083. An important clinical study that details the problems with interpreting findings from HPA-axis investigation in obese subjects without overt Cushing's syndrome and reviews the conflicting literature on the findings in this regard. Also highlights the important distinction between findings regarding systemic cortisol dynamics as opposed to local tissue dynamics.
    • (2013) Obesity , vol.21 , Issue.1
    • Abraham, S.B.1    Rubino, D.2    Sinaii, N.3    Ramsey, S.4    Nieman, L.K.5
  • 14
    • 10044223172 scopus 로고    scopus 로고
    • Glucocorticoid excess and hypertension
    • Baid S, Nieman LK. Glucocorticoid excess and hypertension. Curr Hypertens Rep. 2004;6(6):493-9. (Pubitemid 39600106)
    • (2004) Current Hypertension Reports , vol.6 , Issue.6 , pp. 493-499
    • Baid, S.1    Nieman, L.K.2
  • 15
    • 72449133267 scopus 로고    scopus 로고
    • Obesity and corticosteroids: 11Beta-hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease
    • doi:10.1016/j.mce.2009.09.024 A comprehensive discussion of the role and place of 11 beta HSD-type 1 in the normal physiology of cortisol metabolism, its role and place in obesity, hypercortisolemic states and a detailed discussion of relevant animal models, relevnace to clinical therapeutics and potential future directions in innovation and research
    • .• Morton NM. Obesity and corticosteroids: 11beta-hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease. Mol Cell Endocrinol. 2010;316(2):154-64. doi:10.1016/j.mce.2009.09.024. A comprehensive discussion of the role and place of 11 beta HSD-type 1 in the normal physiology of cortisol metabolism, its role and place in obesity, hypercortisolemic states and a detailed discussion of relevant animal models, relevnace to clinical therapeutics and potential future directions in innovation and research.
    • (2010) Mol Cell Endocrinol , vol.316 , Issue.2 , pp. 154-164
    • Morton, N.M.1
  • 16
    • 84864774826 scopus 로고    scopus 로고
    • Subclinical Cushing's syndrome
    • doi:10.1016/j.beem.2012.02.001. A topical discussion of the controversial topic of subclinical Cushing's syndrome including its prevalence, clinical presentation, diagnostic evaluation protocols with the controversies therein, as well as discussion of its association with increased cardiovascular risk, associated comorbidites including hypertension and the current available management strategies
    • • De Leo M, Cozzolino A, Colao A, Pivonello R. Subclinical Cushing's syndrome. Best Pract Res Clin Endocrinol Metab. 2012;26(4):497-505. doi:10.1016/j.beem.2012.02.001. A topical discussion of the controversial topic of subclinical Cushing's syndrome including its prevalence, clinical presentation, diagnostic evaluation protocols with the controversies therein, as well as discussion of its association with increased cardiovascular risk, associated comorbidites including hypertension and the current available management strategies.
    • (2012) Best Pract Res Clin Endocrinol Metab , vol.26 , Issue.4 , pp. 497-505
    • De Leo, M.1    Cozzolino, A.2    Colao, A.3    Pivonello, R.4
  • 18
    • 79955740942 scopus 로고    scopus 로고
    • Cushing's syndrome: All variants, detection, and treatment
    • doi:10.1016/j.ecl.2011.01.006 A thorough review of the various etiolic considerations in the differential diagnosis of Cushing 's syndrome and other hypercortisolemic states, their association with hypertension, and a discussion of the available therapeutic options
    • .• Sharma ST, Nieman LK. Cushing's syndrome: all variants, detection, and treatment. Endocrinology and metabolism clinics of North America. 2011;40(2):379-91, viii-ix. doi:10.1016/j.ecl.2011.01.006. A thorough review of the various etiolic considerations in the differential diagnosis of Cushing 's syndrome and other hypercortisolemic states, their association with hypertension, and a discussion of the available therapeutic options.
    • (2011) Endocrinology and Metabolism Clinics of North America , vol.40 , Issue.2
    • Sharma, S.T.1    Nieman, L.K.2
  • 21
    • 0026668030 scopus 로고
    • Glucocorticoid-dependent hypertension
    • Mantero F, Boscaro M. Glucocorticoid-dependent hypertension. J Steroid Biochem Mol Biol. 1992;43(5):409-13.
    • (1992) J Steroid Biochem Mol Biol , vol.43 , Issue.5 , pp. 409-413
    • Mantero, F.1    Boscaro, M.2
  • 22
    • 79955726640 scopus 로고    scopus 로고
    • How do glucocorticoids cause hypertension: Role of nitric oxide deficiency, oxidative stress, and eicosanoids
    • doi:10.1016/j.ecl.2011.01.010 A comprehensive discussion of the basic and animal model-based data that detail the role of glucocorticoids in influencing vascular tone, compliance and endothelial reactivity, as well as the relevance of this to the development of glucocorticoid-induced hypertension in both animal models and human patients
    • .• Ong SL, Whitworth JA. How do glucocorticoids cause hypertension: role of nitric oxide deficiency, oxidative stress, and eicosanoids. Endocrinology and metabolism clinics of North America. 2011;40(2):393-407, ix. doi:10.1016/j.ecl.2011.01.010. A comprehensive discussion of the basic and animal model-based data that detail the role of glucocorticoids in influencing vascular tone, compliance and endothelial reactivity, as well as the relevance of this to the development of glucocorticoid-induced hypertension in both animal models and human patients.
    • (2011) Endocrinology and Metabolism Clinics of North America , vol.40 , Issue.2
    • Ong, S.L.1    Whitworth, J.A.2
  • 23
    • 80053898763 scopus 로고    scopus 로고
    • Impaired endothelium mediated vascular reactivity in endogenous Cushing's syndrome
    • Chandran DS, Jaryal AK, Jyotsna VP, Deepak KK. Impaired endothelium mediated vascular reactivity in endogenous Cushing's syndrome. Endocr J. 2011;58(9):789-99.
    • (2011) Endocr J , vol.58 , Issue.9 , pp. 789-799
    • Chandran, D.S.1    Jaryal, A.K.2    Jyotsna, V.P.3    Deepak, K.K.4
  • 25
    • 3042781466 scopus 로고    scopus 로고
    • Glucocorticoids and vascular reactivity
    • DOI 10.2174/1570161043476483
    • Yang S, Zhang L. Glucocorticoids and vascular reactivity. Curr Vasc Pharmacol. 2004;2(1):1-12. (Pubitemid 38855010)
    • (2004) Current Vascular Pharmacology , vol.2 , Issue.1 , pp. 1-12
    • Yang, S.1    Zhang, L.2
  • 27
    • 84893793046 scopus 로고    scopus 로고
    • Effects of salt status and blockade of mineralocorticoid receptors on aldosterone-induced cardiac injury
    • doi:10.1038/hr. 2013.124
    • Hattori T, Murase T, Sugiura Y, Nagasawa K, Takahashi K, Ohtake M, et al. Effects of salt status and blockade of mineralocorticoid receptors on aldosterone-induced cardiac injury. Hypertens Res: Off J Jpn Soc Hypertens. 2014;37(2):125-33. doi:10.1038/hr. 2013.124.
    • (2014) Hypertens Res: Off J Jpn Soc Hypertens , vol.37 , Issue.2 , pp. 125-133
    • Hattori, T.1    Murase, T.2    Sugiura, Y.3    Nagasawa, K.4    Takahashi, K.5    Ohtake, M.6
  • 31
    • 84855172950 scopus 로고    scopus 로고
    • Role of mineralocorticoid action in the brain in salt-sensitive hypertension
    • doi:10.1111/j.1440- 1681.2011.05538.x
    • Oki K, Gomez-Sanchez EP, Gomez-Sanchez CE. Role of mineralocorticoid action in the brain in salt-sensitive hypertension. Clin Exp Pharmacol Physiol. 2012;39(1):90-5. doi:10.1111/j.1440- 1681.2011.05538.x.
    • (2012) Clin Exp Pharmacol Physiol , vol.39 , Issue.1 , pp. 90-95
    • Oki, K.1    Gomez-Sanchez, E.P.2    Gomez-Sanchez, C.E.3
  • 33
    • 0031697764 scopus 로고    scopus 로고
    • The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states
    • doi:10.1210/ edrv.19.5.0346
    • Newell-Price J, Trainer P, Besser M, Grossman A. The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states. Endocr Rev. 1998;19(5):647-72. doi:10.1210/ edrv.19.5.0346.
    • (1998) Endocr Rev , vol.19 , Issue.5 , pp. 647-672
    • Newell-Price, J.1    Trainer, P.2    Besser, M.3    Grossman, A.4
  • 34
    • 19944407441 scopus 로고    scopus 로고
    • Obesity and cortisol status
    • DOI 10.1055/s-2005-861374
    • Salehi M, Ferenczi A, Zumoff B. Obesity and cortisol status. Horm Metab Res Horm Stoffwechselforschung Horm Metabol. 2005;37(4):193-7. doi:10.1055/s-2005-861374. (Pubitemid 40756337)
    • (2005) Hormone and Metabolic Research , vol.37 , Issue.4 , pp. 193-197
    • Salehi, M.1    Ferenczi, A.2    Zumoff, B.3
  • 35
    • 68549139946 scopus 로고    scopus 로고
    • Clinical review: The pathogenetic role of cortisol in the metabolic syndrome: A hypothesis
    • doi:10.1210/jc.2009-0370
    • Anagnostis P, Athyros VG, Tziomalos K, Karagiannis A, Mikhailidis DP. Clinical review: the pathogenetic role of cortisol in the metabolic syndrome: a hypothesis. J Clin Endocrinol Metab. 2009;94(8):2692 - 701. doi:10.1210/jc.2009- 0370.
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.8 , pp. 2692-2701
    • Anagnostis, P.1    Athyros, V.G.2    Tziomalos, K.3    Karagiannis, A.4    Mikhailidis, D.P.5
  • 36
    • 0141975309 scopus 로고    scopus 로고
    • State-specific prevalence of selected chronic disease-related characteristics-Behavioral Risk Factor Surveillance System, 2001
    • Ahluwalia IB, Mack KA, Murphy W, Mokdad AH, Bales VS. State-specific prevalence of selected chronic disease-related characteristics-Behavioral Risk Factor Surveillance System, 2001. Morbid Mortal Wkly Rep Surveill Summ. 2003;52(8):1-80.
    • (2003) Morbid Mortal Wkly Rep Surveill Summ , vol.52 , Issue.8 , pp. 1-80
    • Ahluwalia, I.B.1    Mack, K.A.2    Murphy, W.3    Mokdad, A.H.4    Bales, V.S.5
  • 37
    • 0030936556 scopus 로고    scopus 로고
    • Does central obesity reflect 'Cushing's disease of the omentum '?
    • Bujalska IJ, Kumar S, Stewart PM. Does central obesity reflect "Cushing's disease of the omentum"? Lancet. 1997;349(9060):1210-3. doi:10.1016/S0140-6736(96)11222-8. (Pubitemid 27190044)
    • (1997) Lancet , vol.349 , Issue.9060 , pp. 1210-1213
    • Bujalska, I.J.1    Kumar, S.2    M, S.P.3
  • 38
    • 84864829915 scopus 로고    scopus 로고
    • The hypothalamic-pituitary-adrenal axis and sex hormones in chronic stress and obesity: Pathophysiological and clinical aspects
    • doi:10.1111/j.1749-6632.2012.06569.x
    • Pasquali R. The hypothalamic-pituitary-adrenal axis and sex hormones in chronic stress and obesity: pathophysiological and clinical aspects. Ann N YAcad Sci. 2012;1264:20-35. doi:10.1111/j.1749-6632.2012.06569.x.
    • (2012) Ann N YAcad Sci , vol.1264 , pp. 20-35
    • Pasquali, R.1
  • 39
    • 0027185253 scopus 로고
    • The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution
    • doi:10.1210/jcem.77.2.8393881
    • Pasquali R, Cantobelli S, Casimirri F, Capelli M, Bortoluzzi L, Flamia R, et al. The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab. 1993;77(2):341 - 6. doi:10.1210/jcem.77.2.8393881.
    • (1993) J Clin Endocrinol Metab , vol.77 , Issue.2 , pp. 341-346
    • Pasquali, R.1    Cantobelli, S.2    Casimirri, F.3    Capelli, M.4    Bortoluzzi, L.5    Flamia, R.6
  • 40
    • 77957735956 scopus 로고    scopus 로고
    • Resistant hypertension, secondary hypertension, and hypertensive crises: Diagnostic evaluation and treatment
    • doi:10.1016/j.ccl.2010.07.002
    • Acelajado MC, Calhoun DA. Resistant hypertension, secondary hypertension, and hypertensive crises: diagnostic evaluation and treatment. Cardiol Clin. 2010;28(4):639-54. doi:10.1016/j.ccl.2010.07.002.
    • (2010) Cardiol Clin , vol.28 , Issue.4 , pp. 639-654
    • Acelajado, M.C.1    Calhoun, D.A.2
  • 41
    • 2942589264 scopus 로고    scopus 로고
    • Portal and peripheral cortisol levels in obese humans
    • DOI 10.1007/s00125-004-1389-4
    • Aldhahi W, Mun E, Goldfine AB. Portal and peripheral cortisol levels in obese humans. Diabetologia. 2004;47(5):833-6. doi:10.1007/s00125-004-1389-4. (Pubitemid 38756995)
    • (2004) Diabetologia , vol.47 , Issue.5 , pp. 833-836
    • Aldhahi, W.1    Mun, E.2    Goldfine, A.B.3
  • 42
    • 63249083541 scopus 로고    scopus 로고
    • Cortisol release from adipose tissue by 11 betahydroxysteroid dehydrogenase type 1 in humans
    • doi:10.2337/db08-0969
    • Stimson RH, Andersson J, Andrew R, Redhead DN, Karpe F, Hayes PC, et al. Cortisol release from adipose tissue by 11 betahydroxysteroid dehydrogenase type 1 in humans. Diabetes. 2009;58(1):46-53. doi:10.2337/db08-0969.
    • (2009) Diabetes , vol.58 , Issue.1 , pp. 46-53
    • Stimson, R.H.1    Andersson, J.2    Andrew, R.3    Redhead, D.N.4    Karpe, F.5    Hayes, P.C.6
  • 43
    • 84877873639 scopus 로고    scopus 로고
    • Is there visceral adipose tissue (VAT) intracellular hypercortisolism in human obesity?
    • doi:10.1055/s-0033-1337986
    • Alfonso B, Araki T, Zumoff B. Is there visceral adipose tissue (VAT) intracellular hypercortisolism in human obesity? Horm Metab Res Horm Stoffwechselforschung Horm Metab. 2013;45(5):329-31. doi:10.1055/s-0033-1337986.
    • (2013) Horm Metab Res Horm Stoffwechselforschung Horm Metab , vol.45 , Issue.5 , pp. 329-331
    • Alfonso, B.1    Araki, T.2    Zumoff, B.3
  • 44
    • 84873972678 scopus 로고    scopus 로고
    • High-end normal adrenocorticotropic hormone and cortisol levels are associated with specific cardiovascular risk factors in pediatric obesity: A cross-sectional study
    • doi:10.1186/1741-7015-11-44
    • Prodam F, Ricotti R, Agarla V, Parlamento S, Genoni G, Balossini C, et al. High-end normal adrenocorticotropic hormone and cortisol levels are associated with specific cardiovascular risk factors in pediatric obesity: a cross-sectional study. BMC Med. 2013;11:44. doi:10.1186/1741-7015-11-44.
    • (2013) BMC Med , vol.11 , pp. 44
    • Prodam, F.1    Ricotti, R.2    Agarla, V.3    Parlamento, S.4    Genoni, G.5    Balossini, C.6
  • 45
  • 47
    • 84902331845 scopus 로고    scopus 로고
    • Hypertension in patients with Cushing's syndrome
    • Koch CA, Chrousos GP, editors. New York: Humana press; A comprehensive review of the etiopathogenesis of hypertension in Cushing's syndrome, the treatment options, and its relevance to hypertension in obesity in general
    • .• Kantorovich V, Koch CA, Chrousos GP. Hypertension in patients with Cushing's syndrome. In: Koch CA, Chrousos GP, editors. Endocrine hypertension; Underlying mechansims and therapy. New York: Humana press; 2013. p. 51-68. A comprehensive review of the etiopathogenesis of hypertension in Cushing's syndrome, the treatment options, and its relevance to hypertension in obesity in general.
    • (2013) Endocrine Hypertension; Underlying Mechansims and Therapy , pp. 51-68
    • Kantorovich, V.1    Koch, C.A.2    Chrousos, G.P.3
  • 48
    • 0023743171 scopus 로고
    • Mineralocorticoid action: Target tissue specificity is enzyme, not receptor, mediated
    • Funder JW, Pearce PT, Smith R, Smith AI. Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science. 1988;242(4878):583-5. (Pubitemid 18263202)
    • (1988) Science , vol.242 , Issue.4878 , pp. 583-585
    • Funder, J.W.1    Pearce, P.T.2    Smith, R.3    Smith, A.I.4
  • 49
    • 21244485815 scopus 로고    scopus 로고
    • Mineralocorticoid receptors: Distribution and activation
    • DOI 10.1007/s10741-005-2344-2
    • Funder JW. Mineralocorticoid receptors: distribution and activation. Heart Fail Rev. 2005;10(1):15-22. doi:10.1007/s10741-005-2344-2. (Pubitemid 40895312)
    • (2005) Heart Failure Reviews , vol.10 , Issue.1 , pp. 15-22
    • Funder, J.W.1
  • 52
    • 0030049329 scopus 로고    scopus 로고
    • Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11beta-hydroxysteroid dehydrogenase type 2 gene
    • DOI 10.1016/S0140-6736(96)90211-1
    • Stewart PM, Krozowski ZS, Gupta A, Milford DV, Howie AJ, Sheppard MC, et al. Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11 beta-hydroxysteroid dehydrogenase type 2 gene. Lancet. 1996;347(8994):88-91. (Pubitemid 26017854)
    • (1996) Lancet , vol.347 , Issue.8994 , pp. 88-91
    • Stewart, P.M.1    Krozowski, Z.S.2    Gupta, A.3    Milford, D.V.4    Howie, A.J.5    Sheppard, M.C.6    Whorwood, C.B.7
  • 53
    • 0034747418 scopus 로고    scopus 로고
    • 11beta-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess
    • White PC. 11beta-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess. Am J Med Sci. 2001;322(6):308-15. (Pubitemid 33139184)
    • (2001) American Journal of the Medical Sciences , vol.322 , Issue.6 , pp. 308-315
    • White, P.C.1
  • 54
    • 0030480758 scopus 로고    scopus 로고
    • Human hypertension caused by mutations in the 11beta-hydroxysteroid dehydrogenase gene: A molecular analysis of apparent mineralocorticoid excess
    • Whorwood CB, Stewart PM. Human hypertension caused by mutations in the 11 beta-hydroxysteroid dehydrogenase gene: a molecular analysis of apparent mineralocorticoid excess. J Hypertens Suppl: Off J Int Soc Hypertens. 1996;14(5):S19-24. (Pubitemid 27051074)
    • (1996) Journal of Hypertension, Supplement , vol.14 , Issue.5
    • Whorwood, C.B.1    Stewart, P.M.2
  • 55
    • 3142621133 scopus 로고    scopus 로고
    • Glucocorticoid-mediated mineralocorticoid receptor activation and hypertension
    • DOI 10.1097/01.mnh.0000133976.32559.b0
    • Frey FJ, Odermatt A, Frey BM. Glucocorticoid-mediated mineralocorticoid receptor activation and hypertension. Curr Opin Nephrol Hypertens. 2004;13(4):451-8. (Pubitemid 38901625)
    • (2004) Current Opinion in Nephrology and Hypertension , vol.13 , Issue.4 , pp. 451-458
    • Frey, F.J.1    Odermatt, A.2    Frey, B.M.3
  • 56
    • 0026008755 scopus 로고
    • The cortisol-cortisone shuttle and hypertension
    • Stewart PM, Edwards CR. The cortisol-cortisone shuttle and hypertension. J Steroid Biochem Mol Biol. 1991;40(4-6):501-9.
    • (1991) J Steroid Biochem Mol Biol , vol.40 , Issue.4-6 , pp. 501-509
    • Stewart, P.M.1    Edwards, C.R.2
  • 58
    • 33845233614 scopus 로고    scopus 로고
    • Subclinical Cushing's disease with amelioration of metabolic comorbidities after removal of pituitary tumor
    • DOI 10.2169/internalmedicine.45.1809
    • Minami I, Tateno T, Yoshimoto T, Doi M, Izumiyama H, Akashi T, et al. Subclinical Cushings disease with amelioration of metabolic comorbidities after removal of pituitary tumor. Intern Med. 2006;45(21):1231-5. (Pubitemid 44848859)
    • (2006) Internal Medicine , vol.45 , Issue.21 , pp. 1231-1235
    • Minami, I.1    Tateno, T.2    Yoshimoto, T.3    Doi, M.4    Izumiyama, H.5    Akashi, T.6    Hirata, Y.7
  • 59
    • 0027144405 scopus 로고
    • Response of hypertension to conventional antihypertensive treatment and/or steroidogenesis inhibitors in Cushing's syndrome
    • Fallo F, Paoletta A, Tona F, Boscaro M, Sonino N. Response of hypertension to conventional antihypertensive treatment and/or steroidogenesis inhibitors in Cushing's syndrome. J Intern Med. 1993;234(6):595-8. (Pubitemid 24010362)
    • (1993) Journal of Internal Medicine , vol.234 , Issue.6 , pp. 595-598
    • Fallo, F.1    Paoletta, A.2    Tona, F.3    Boscaro, M.4    Sonino, N.5


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