Is there visceral adipose tissue (VAT) intracellular hypercortisolism in human obesity?

Hormone and Metabolic Research

Volumn 45, Issue 5, 2013, Pages 329-331

  Alfonso, B ^a   Araki, T ^a   Zumoff, B ^a  

^a BETH ISRAEL MEDICAL CENTER   (United States)

Author keywords

11 hydroxysteroid dehydrogenase; intracellular cortisol production; obesity

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; CORTISONE; HYDROCORTISONE;

DIABETES MELLITUS; DISEASE ASSOCIATION; HUMAN; HYPERCORTISOLISM; INTRAABDOMINAL FAT; METABOLISM; OBESITY; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; REVIEW; SPLANCHNIC BLOOD FLOW; VISCERAL ADIPOSE TISSUE INTRACELLULAR HYPERCORTISOLISM;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; CUSHING SYNDROME; ENZYME INHIBITORS; HUMANS; HYDROCORTISONE; INTRA-ABDOMINAL FAT; INTRACELLULAR SPACE; OBESITY;

EID: 84877873639     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0033-1337986     Document Type: Review

References (13)

1. Salehi M., Ferenczi A., Zumoff B. Obesity and cortisol status. Horm Metabol Res: 2005; 37 193 197 (Pubitemid 40756337)
2. Bujalska I. J., Kumar S., Stewart P. M. Does central obesity reflect "Cushing's syndrome of the omentumo"? Lancet: 1997; 349 1210 1213 (Pubitemid 27190044)
3. Paulmyer-Lacroix O., Boullu S., Oliver C., Alessi M-C, Grino M. Expression of the mRNA coding for 11beta-hydroxysteroid dehydrogenase type I in adipose tissue from obese patients: an in situ hybridization study. J Clin Endocrinol Metab: 2002; 87 2701 2705 (Pubitemid 34655333)
4. Tomlinson J. W., Sinha B., Bujalska M., Hewison M., Stewart P. M. Expression of 11beta-hydroxysteroid dehydrogenase type I in adipose tissue is not increased in human obesity. J Clin Endocrinol Metab: 2002; 87 5630 5635 (Pubitemid 36034370)
5. Mariniello B., Ronconi V., Rilli S., Bernante P., Boscarso M., Mantero F., Giacchetti G. Adipose tissue 11beta-hydroxysteroid dehydrogenase type I expression in obesity and Cushing's syndrome. Eur J Endocrinol: 2006; 155 435 441 (Pubitemid 44463950)
6. Desbriere R., Vuaroqueaux V., Avhard V., Boullu-Ciocca S., Labuhn M., Dutout A., Grino M. 11Beta-hydroxysteroid dehydrogenase type I mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients. Obesity: 2006; 14 794 798 (Pubitemid 46219720)
7. Walker B. R., Andrew R. Tissue production of cortisol by 11beta-hydroxysteroid dehydrogenase type I and metabolic disease. Ann NY Acad Sci: 2006; 1083 165 184 (Pubitemid 44955472)
8. Aldhahi W., Mun E., Goldfine A. B. Portal and peripheral cortisol levels in obese humans. Diabetologia: 2004; 47 833 836 (Pubitemid 38756995)
9. Basu R., Singh R. J., Basu A., Chittilapilly E. G., Johnson M. C., Toffolo G., Cobelli C., Rizza R. A. Obesity and type 2 diabetes do not alter splanchnic cortisol production in humans. J Clin Endocrinol Metab: 2005; 90 3929 3926
10. Andrew R., Westerbacka J., Wahren J., Yki-Jarvinen H., Walker B. The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans. Diabetes: 2005; 54 1364 1370 (Pubitemid 40586665)
11. Stimson R. H., Andersson J., Andrew R., Redhead D. N., Karpe F., Hayes P. C., Olsson T., Walker B. W. Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type I in humans. Diabetes: 2009; 58 46 53
12. Tomlinson J. W., Walker E. A., Bujalska I. J., Draper N., Lavery G. G., Cooper M. S., Hewison M., Stewart P. M. 11beta-hydroxysteroid dehydrogenase type I: a tissue-specific regulator of glucocorticoid response. Endocrine Rev: 2004; 25 831 866 (Pubitemid 39366049)
13. Rosenstock J., Banarer S., Fonseca V. A., Inzucchi S. E., Sun W., Yao W., Hollis G., Flores R., Levy R., Williams W. V., Seckl J. R., Huiber R. The 11beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type-2 diabetes inadequately controlled by metformin. Diabetes Care: 2010; 33 1516 1522