Anorexia nervosa and bone metabolism

Bone

Volumn 66, Issue , 2014, Pages 39-45

  Fazeli, Pouneh K ^a   Klibanski, Anne ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Anorexia nervosa; Bone mineral density

Indexed keywords

ADIPONECTIN; BISPHOSPHONIC ACID DERIVATIVE; CONTRACEPTIVE AGENT; ESTRADIOL; ESTROGEN; FIBROBLAST GROWTH FACTOR 21; GHRELIN; GROWTH HORMONE; HYDROCORTISONE; INSULIN; LEPTIN; OXYTOCIN; PARATHYROID HORMONE[1-34]; PEPTIDE YY; PRASTERONE; SCLEROSTIN; SIRTUIN 1; SOMATOMEDIN; TESTOSTERONE;

ANOREXIA NERVOSA; BONE DENSITY; BONE DISEASE; BONE MASS; BONE METABOLISM; CALORIC INTAKE; COMORBIDITY; DISEASE ASSOCIATION; HIGH RISK PATIENT; HORMONAL THERAPY; HORMONE RESISTANCE; HUMAN; HYPOTHALAMIC AMENORRHEA; LOW BONE MINERAL DENSITY; OSTEOLYSIS; REVIEW; RISK ASSESSMENT; RISK REDUCTION; BONE; METABOLISM; ORGAN SIZE; PATHOLOGY; RISK FACTOR;

ANOREXIA NERVOSA; BONE AND BONES; BONE DENSITY; HUMANS; ORGAN SIZE; RISK FACTORS;

EID: 84902325815     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2014.05.014     Document Type: Review

References (117)

1. American Psychiatric Association Diagnostic and statistical manual of mental disorders (DSM-IV) 1994, [Washington, DC]. 4th ed.
2. Lucas A.R., Beard C.M., O'Fallon W.M., Kurland L.T. 50-year trends in the incidence of anorexia nervosa in Rochester, Minn.: a population-based study. Am J Psychiatry 1991, 148:917-922.
3. Lucas A.R., Crowson C.S., O'Fallon W.M., Melton L.J. The ups and downs of anorexia nervosa. Int J Eat Disord 1999, 26:397-405.
4. Keski-Rahkonen A., Hoek H.W., Susser E.S., Linna M.S., Sihvola E., Raevuori A., et al. Epidemiology and course of anorexia nervosa in the community. Am J Psychiatry 2007, 164:1259-1265.
5. Lowe B., Zipfel S., Buchholz C., Dupont Y., Reas D.L., Herzog W. Long-term outcome of anorexia nervosa in a prospective 21-year follow-up study. Psychol Med 2001, 31:881-890.
6. Trickey H. Eating disorders exact toll on adults, too http://www.cnn.com.
7. Muise A.M., Stein D.G., Arbess G. Eating disorders in adolescent boys: a review of the adolescent and young adult literature. J Adolesc Health 2003, 33:427-435.
8. Miller K.K., Grinspoon S.K., Ciampa J., Hier J., Herzog D., Klibanski A. Medical findings in outpatients with anorexia nervosa. Arch Intern Med 2005, 165:561-566.
9. Grinspoon S., Thomas E., Pitts S., Gross E., Mickley D., Miller K., et al. Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa. Ann Intern Med 2000, 133:790-794.
10. Rigotti N.A., Neer R.M., Skates S.J., Herzog D.B., Nussbaum S.R. The clinical course of osteoporosis in anorexia nervosa. A longitudinal study of cortical bone mass. JAMA 1991, 265:1133-1138.
11. Lucas A.R., Melton L.J., Crowson C.S., O'Fallon W.M. Long-term fracture risk among women with anorexia nervosa: a population-based cohort study. Mayo Clin Proc 1999, 74:972-977.
12. Stefanis N., Mackintosh C., Abraha H.D., Treasure J., Moniz C. Dissociation of bone turnover in anorexia nervosa. Ann Clin Biochem 1998, 35(Pt 6):709-716.
13. Miller K.K., Lee E.E., Lawson E.A., Misra M., Minihan J., Grinspoon S.K., et al. Determinants of skeletal loss and recovery in anorexia nervosa. J Clin Endocrinol Metab 2006, 91:2931-2937.
14. Misra M., Tsai P., Anderson E.J., Hubbard J.L., Gallagher K., Soyka L.A., et al. Nutrient intake in community-dwelling adolescent girls with anorexia nervosa and in healthy adolescents. Am J Clin Nutr 2006, 84:698-706.
15. Haagensen A.L., Feldman H.A., Ringelheim J., Gordon C.M. Low prevalence of vitamin D deficiency among adolescents with anorexia nervosa. Osteoporos Int 2008, 19:289-294.
16. Wiegelmann W., Solbach H.G. Effects of LH-RH on plasma levels of LH and FSH in anorexia nervosa. Horm Metab Res 1972, 4:404.
17. Mecklenburg R.S., Loriaux D.L., Thompson R.H., Andersen A.E., Lipsett M.B. Hypothalamic dysfunction in patients with anorexia nervosa. Medicine (Baltimore) 1974, 53:147-159.
18. Travaglini P., Beck-Peccoz P., Ferrari C., Ambrosi B., Paracchi A., Severgnini A., et al. Some aspects of hypothalamic-pituitary function in patients with anorexia nervosa. Acta Endocrinol (Copenh) 1976, 81:252-262.
19. Nillius S.J., Fries H., Wide L. Successful induction of follicular maturation and ovulation by prolonged treatment with LH-releasing hormone in women with anorexia nervosa. Am J Obstet Gynecol 1975, 122:921-928.
20. Boyar R.M., Katz J., Finkelstein J.W., Kapen S., Weiner H., Weitzman E.D., et al. Anorexia nervosa. Immaturity of the 24-hour luteinizing hormone secretory pattern. N Engl J Med 1974, 291:861-865.
21. Riis B.J., Rodbro P., Christiansen C. The role of serum concentrations of sex steroids and bone turnover in the development and occurrence of postmenopausal osteoporosis. Calcif Tissue Int 1986, 38:318-322.
22. Biller B.M., Saxe V., Herzog D.B., Rosenthal D.I., Holzman S., Klibanski A. Mechanisms of osteoporosis in adult and adolescent women with anorexia nervosa. J Clin Endocrinol Metab 1989, 68:548-554.
23. Klibanski A., Biller B.M., Schoenfeld D.A., Herzog D.B., Saxe V.C. The effects of estrogen administration on trabecular bone loss in young women with anorexia nervosa. J Clin Endocrinol Metab 1995, 80:898-904.
24. Grinspoon S., Thomas L., Miller K., Herzog D., Klibanski A. Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa. J Clin Endocrinol Metab 2002, 87:2883-2891.
25. Misra M., Katzman D., Miller K.K., Mendes N., Snelgrove D., Russell M., et al. Physiologic estrogen replacement increases bone density in adolescent girls with anorexia nervosa. J Bone Miner Res 2011, 26:2430-2438.
26. Soyka L.A., Grinspoon S., Levitsky L.L., Herzog D.B., Klibanski A. The effects of anorexia nervosa on bone metabolism in female adolescents. J Clin Endocrinol Metab 1999, 84:4489-4496.
27. van Binsbergen C.J., Coelingh Bennink H.J., Odink J., Haspels A.A., Koppeschaar H.P. A comparative and longitudinal study on endocrine changes related to ovarian function in patients with anorexia nervosa. J Clin Endocrinol Metab 1990, 71:705-711.
28. Miller K.K., Lawson E.A., Mathur V., Wexler T.L., Meenaghan E., Misra M., et al. Androgens in women with anorexia nervosa and normal-weight women with hypothalamic amenorrhea. J Clin Endocrinol Metab 2007, 92:1334-1339.
29. Miller K.K., Meenaghan E., Lawson E.A., Misra M., Gleysteen S., Schoenfeld D., et al. Effects of risedronate and low-dose transdermal testosterone on bone mineral density in women with anorexia nervosa: a randomized, placebo-controlled study. J Clin Endocrinol Metab 2011, 96:2081-2088.
30. Grinspoon S., Gulick T., Askari H., Landt M., Lee K., Anderson E., et al. Serum leptin levels in women with anorexia nervosa. J Clin Endocrinol Metab 1996, 81:3861-3863.
31. Misra M., Miller K.K., Kuo K., Griffin K., Stewart V., Hunter E., et al. Secretory dynamics of leptin in adolescent girls with anorexia nervosa and healthy adolescents. Am J Physiol Endocrinol Metab 2005, 289:E373-E381.
32. Miller K.K., Grinspoon S., Gleysteen S., Grieco K.A., Ciampa J., Breu J., et al. Preservation of neuroendocrine control of reproductive function despite severe undernutrition. J Clin Endocrinol Metab 2004, 89:4434-4438.
33. Legroux-Gerot I., Vignau J., Biver E., Pigny P., Collier F., Marchandise X., et al. Anorexia nervosa, osteoporosis and circulating leptin: the missing link. Osteoporos Int 2010, 21:1715-1722.
34. Lawson E.A., Miller K.K., Bredella M.A., Phan C., Misra M., Meenaghan E., et al. Hormone predictors of abnormal bone microarchitecture in women with anorexia nervosa. Bone 2010, 46:458-463.
35. Welt C.K., Chan J.L., Bullen J., Murphy R., Smith P., DePaoli A.M., et al. Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med 2004, 351:987-997.
36. Garfinkel P.E., Brown G.M., Stancer H.C., Moldofsky H. Hypothalamic-pituitary function in anorexia nervosa. Arch Gen Psychiatry 1975, 32:739-744.
37. Scacchi M., Pincelli A.I., Caumo A., Tomasi P., Delitala G., Baldi G., et al. Spontaneous nocturnal growth hormone secretion in anorexia nervosa. J Clin Endocrinol Metab 1997, 82:3225-3229.
38. Stoving R.K., Veldhuis J.D., Flyvbjerg A., Vinten J., Hangaard J., Koldkjaer O.G., et al. Jointly amplified basal and pulsatile growth hormone (GH) secretion and increased process irregularity in women with anorexia nervosa: indirect evidence for disruption of feedback regulation within the GH-insulin-like growth factor I axis. J Clin Endocrinol Metab 1999, 84:2056-2063.
39. Misra M., Miller K.K., Bjornson J., Hackman A., Aggarwal A., Chung J., et al. Alterations in growth hormone secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism. J Clin Endocrinol Metab 2003, 88:5615-5623.
40. Grinspoon S.K., Baum H.B., Peterson S., Klibanski A. Effects of rhIGF-I administration on bone turnover during short-term fasting. J Clin Invest 1995, 96:900-906.
41. Counts D.R., Gwirtsman H., Carlsson L.M., Lesem M., Cutler G.B. The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins. J Clin Endocrinol Metab 1992, 75:762-767.
42. Hotta M., Fukuda I., Sato K., Hizuka N., Shibasaki T., Takano K. The relationship between bone turnover and body weight, serum insulin-like growth factor (IGF) I, and serum IGF-binding protein levels in patients with anorexia nervosa. J Clin Endocrinol Metab 2000, 85:200-206.
43. Gianotti L., Pincelli A.I., Scacchi M., Rolla M., Bellitti D., Arvat E., et al. Effects of recombinant human insulin-like growth factor I administration on spontaneous and growth hormone (GH)-releasing hormone-stimulated GH secretion in anorexia nervosa. J Clin Endocrinol Metab 2000, 85:2805-2809.
44. Otto B., Cuntz U., Fruehauf E., Wawarta R., Folwaczny C., Riepl R.L., et al. Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur J Endocrinol 2001, 145:669-673.
45. Misra M., Miller K.K., Herzog D.B., Ramaswamy K., Aggarwal A., Almazan C., et al. Growth hormone and ghrelin responses to an oral glucose load in adolescent girls with anorexia nervosa and controls. J Clin Endocrinol Metab 2004, 89:1605-1612.
46. Misra M., Miller K.K., Kuo K., Griffin K., Stewart V., Hunter E., et al. Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents. Am J Physiol Endocrinol Metab 2005, 289:E347-E356.
47. Zhao T.J., Liang G., Li R.L., Xie X., Sleeman M.W., Murphy A.J., et al. Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc Natl Acad Sci U S A 2010, 107:7467-7472.
48. Gahete M.D., Cordoba-Chacon J., Luque R.M., Kineman R.D. The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female mice. Endocrinology 2013, 154:263-269.
49. Nakasaki M., Yoshioka K., Miyamoto Y., Sasaki T., Yoshikawa H., Itoh K. IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts. Bone 2008, 43:869-879.
50. Canalis E. Effect of insulin-like growth factor I on DNA and protein synthesis in cultured rat calvaria. J Clin Invest 1980, 66:709-719.
51. Grinspoon S., Miller K., Coyle C., Krempin J., Armstrong C., Pitts S., et al. Severity of osteopenia in estrogen-deficient women with anorexia nervosa and hypothalamic amenorrhea. J Clin Endocrinol Metab 1999, 84:2049-2055.
52. Grinspoon S., Baum H., Lee K., Anderson E., Herzog D., Klibanski A. Effects of short-term recombinant human insulin-like growth factor I administration on bone turnover in osteopenic women with anorexia nervosa. J Clin Endocrinol Metab 1996, 81:3864-3870.
53. Misra M., McGrane J., Miller K.K., Goldstein M.A., Ebrahimi S., Weigel T., et al. Effects of rhIGF-1 administration on surrogate markers of bone turnover in adolescents with anorexia nervosa. Bone 2009, 45:493-498.
54. Nishimura T., Nakatake Y., Konishi M., Itoh N. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim Biophys Acta 2000, 1492:203-206.
55. Zhang X., Yeung D.C., Karpisek M., Stejskal D., Zhou Z.G., Liu F., et al. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes 2008, 57:1246-1253.
56. Kharitonenkov A., Shiyanova T.L., Koester A., Ford A.M., Micanovic R., Galbreath E.J., et al. FGF-21 as a novel metabolic regulator. J Clin Invest 2005, 115:1627-1635.
57. Inagaki T., Dutchak P., Zhao G., Ding X., Gautron L., Parameswara V., et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 2007, 5:415-425.
58. Inagaki T., Lin V.Y., Goetz R., Mohammadi M., Mangelsdorf D.J., Kliewer S.A. Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell Metab 2008, 8:77-83.
59. Fazeli P.K., Misra M., Goldstein M., Miller K.K., Klibanski A. Fibroblast growth factor-21 may mediate growth hormone resistance in anorexia nervosa. J Clin Endocrinol Metab 2010, 95:369-374.
60. Wei W., Dutchak P.A., Wang X., Ding X., Wang X., Bookout A.L., et al. Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma. Proc Natl Acad Sci U S A 2012, 109:3143-3148.
61. Bredella M.A., Fazeli P.K., Miller K.K., Misra M., Torriani M., Thomas B.J., et al. Increased bone marrow fat in anorexia nervosa. J Clin Endocrinol Metab 2009, 94:2129-2136.
62. Gillum M.P., Erion D.M., Shulman G.I. Sirtuin-1 regulation of mammalian metabolism. Trends Mol Med 2010, 17:8-13.
63. Yamamoto M., Iguchi G., Fukuoka H., Suda K., Bando H., Takahashi M., et al. SIRT1 regulates adaptive response of the growth hormone-insulin-like growth factor-I axis under fasting conditions in liver. Proc Natl Acad Sci U S A 2013, 110:14948-14953.
64. Fukushima N., Hanada R., Teranishi H., Fukue Y., Tachibana T., Ishikawa H., et al. Ghrelin directly regulates bone formation. J Bone Miner Res 2005, 20:790-798.
65. Misra M., Miller K.K., Stewart V., Hunter E., Kuo K., Herzog D.B., et al. Ghrelin and bone metabolism in adolescent girls with anorexia nervosa and healthy adolescents. J Clin Endocrinol Metab 2005, 90:5082-5087.
66. Misra M., Prabhakaran R., Miller K.K., Goldstein M.A., Mickley D., Clauss L., et al. Prognostic indicators of changes in bone density measures in adolescent girls with anorexia nervosa-II. J Clin Endocrinol Metab 2008, 93:1292-1297.
67. Leung K.C., Doyle N., Ballesteros M., Waters M.J., Ho K.K. Insulin regulation of human hepatic growth hormone receptors: divergent effects on biosynthesis and surface translocation. J Clin Endocrinol Metab 2000, 85:4712-4720.
68. Baxter R.C., Turtle J.R. Regulation of hepatic growth hormone receptors by insulin. Biochem Biophys Res Commun 1978, 84:350-357.
69. Zumoff B., Walsh B.T., Katz J.L., Levin J., Rosenfeld R.S., Kream J., et al. Subnormal plasma dehydroisoandrosterone to cortisol ratio in anorexia nervosa: a second hormonal parameter of ontogenic regression. J Clin Endocrinol Metab 1983, 56:668-672.
70. Gordon C.M., Goodman E., Emans S.J., Grace E., Becker K.A., Rosen C.J., et al. Physiologic regulators of bone turnover in young women with anorexia nervosa. J Pediatr 2002, 141:64-70.
71. Gordon C.M., Grace E., Emans S.J., Feldman H.A., Goodman E., Becker K.A., et al. Effects of oral dehydroepiandrosterone on bone density in young women with anorexia nervosa: a randomized trial. J Clin Endocrinol Metab 2002, 87:4935-4941.
72. Divasta A.D., Feldman H.A., Giancaterino C., Rosen C.J., Leboff M.S., Gordon C.M. The effect of gonadal and adrenal steroid therapy on skeletal health in adolescents and young women with anorexia nervosa. Metabolism 2012, 61:1010-1020.
73. Boyar R.M., Hellman L.D., Roffwarg H., Katz J., Zumoff B., O'Connor J., et al. Cortisol secretion and metabolism in anorexia nervosa. N Engl J Med 1977, 296:190-193.
74. Misra M., Miller K.K., Almazan C., Ramaswamy K., Lapcharoensap W., Worley M., et al. Alterations in cortisol secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism. J Clin Endocrinol Metab 2004, 89:4972-4980.
75. Lawson E.A., Donoho D., Miller K.K., Misra M., Meenaghan E., Lydecker J., et al. Hypercortisolemia is associated with severity of bone loss and depression in hypothalamic amenorrhea and anorexia nervosa. J Clin Endocrinol Metab 2009, 94:4710-4716.
76. Misra M., Klibanski A. The neuroendocrine basis of anorexia nervosa and its impact on bone metabolism. Neuroendocrinology 2011, 93:65-73.
77. Canalis E. Clinical review 83: mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis. J Clin Endocrinol Metab 1996, 81:3441-3447.
78. Rauch A., Seitz S., Baschant U., Schilling A.F., Illing A., Stride B., et al. Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab 2010, 11:517-531.
79. McCarthy T.L., Centrella M., Canalis E. Cortisol inhibits the synthesis of insulin-like growth factor-I in skeletal cells. Endocrinology 1990, 126:1569-1575.
80. Padmanabhan V., Keech C., Convey E.M. Cortisol inhibits and adrenocorticotropin has no effect on luteinizing hormone-releasing hormone-induced release of luteinizing hormone from bovine pituitary cells in vitro. Endocrinology 1983, 112:1782-1787.
81. Urena P., Iida-Klein A., Kong X.F., Juppner H., Kronenberg H.M., Abou-Samra A.B., et al. Regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid by glucocorticoids and PTH in ROS 17/2.8 and OK cells. Endocrinology 1994, 134:451-456.
82. Moshang T., Parks J.S., Baker L., Vaidya V., Utiger R.D., Bongiovanni A.M., et al. Low serum triiodothyronine in patients with anorexia nervosa. J Clin Endocrinol Metab 1975, 40:470-473.
83. Miyai K., Yamamoto T., Azukizawa M., Ishibashi K., Kumahara Y. Serum thyroid hormones and thyrotropin in anorexia nervosa. J Clin Endocrinol Metab 1975, 40:334-338.
84. Croxson M.S., Ibbertson H.K. Low serum triiodothyronine (T3) and hypothyroidism in anorexia nervosa. J Clin Endocrinol Metab 1977, 44:167-174.
85. Leslie R.D., Isaacs A.J., Gomez J., Raggatt P.R., Bayliss R. Hypothalamo-pituitary-thyroid function in anorexia nervosa: influence of weight gain. Br Med J 1978, 2:526-528.
86. Casper R.C., Frohman L.A. Delayed TSH release in anorexia nervosa following injection of thyrotropin-releasing hormone (TRH). Psychoneuroendocrinology 1982, 7:59-68.
87. Moore R., Mills I.H. Serum T3 and T4 levels in patients with anorexia nervosa showing transient hyperthyroidism during weight gain. Clin Endocrinol (Oxf) 1979, 10:443-449.
88. Onur S., Haas V., Bosy-Westphal A., Hauer M., Paul T., Nutzinger D., et al. L-tri-iodothyronine is a major determinant of resting energy expenditure in underweight patients with anorexia nervosa and during weight gain. Eur J Endocrinol 2005, 152:179-184.
89. Fraser S.A., Anderson J.B., Smith D.A., Wilson G.M. Osteoporosis and fractures following thyrotoxicosis. Lancet 1971, 1:981-983.
90. Abu E.O., Bord S., Horner A., Chatterjee V.K., Compston J.E. The expression of thyroid hormone receptors in human bone. Bone 1997, 21:137-142.
91. Kindblom J.M., Gevers E.F., Skrtic S.M., Lindberg M.K., Gothe S., Tornell J., et al. Increased adipogenesis in bone marrow but decreased bone mineral density in mice devoid of thyroid hormone receptors. Bone 2005, 36:607-616.
92. Miell J.P., Taylor A.M., Zini M., Maheshwari H.G., Ross R.J., Valcavi R. Effects of hypothyroidism and hyperthyroidism on insulin-like growth factors (IGFs) and growth hormone- and IGF-binding proteins. J Clin Endocrinol Metab 1993, 76:950-955.
93. Misra M., Miller K.K., Tsai P., Gallagher K., Lin A., Lee N., et al. Elevated peptide YY levels in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab 2006, 91:1027-1033.
94. Utz A.L., Lawson E.A., Misra M., Mickley D., Gleysteen S., Herzog D.B., et al. Peptide YY (PYY) levels and bone mineral density (BMD) in women with anorexia nervosa. Bone 2008, 43:135-139.
95. Baldock P.A., Sainsbury A., Couzens M., Enriquez R.F., Thomas G.P., Gardiner E.M., et al. Hypothalamic Y2 receptors regulate bone formation. J Clin Invest 2002, 109:915-921.
96. Misra M., Miller K.K., Cord J., Prabhakaran R., Herzog D.B., Goldstein M., et al. Relationships between serum adipokines, insulin levels, and bone density in girls with anorexia nervosa. J Clin Endocrinol Metab 2007, 92:2046-2052.
97. Tagami T., Satoh N., Usui T., Yamada K., Shimatsu A., Kuzuya H. Adiponectin in anorexia nervosa and bulimia nervosa. J Clin Endocrinol Metab 2004, 89:1833-1837.
98. Housova J., Anderlova K., Krizova J., Haluzikova D., Kremen J., Kumstyrova T., et al. Serum adiponectin and resistin concentrations in patients with restrictive and binge/purge form of anorexia nervosa and bulimia nervosa. J Clin Endocrinol Metab 2005, 90:1366-1370.
99. Amitani H., Asakawa A., Ogiso K., Nakahara T., Ushikai M., Haruta I., et al. The role of adiponectin multimers in anorexia nervosa. Nutrition 2013, 29:203-206.
100. Ealey K.N., Kaludjerovic J., Archer M.C., Ward W.E. Adiponectin is a negative regulator of bone mineral and bone strength in growing mice. Exp Biol Med (Maywood) 2008, 233:1546-1553.
101. Arletti R., Benelli A., Bertolini A. Influence of oxytocin on feeding behavior in the rat. Peptides 1989, 10:89-93.
102. Bjorkstrand E., Uvnas-Moberg K. Central oxytocin increases food intake and daily weight gain in rats. Physiol Behav 1996, 59:947-952.
103. Colaianni G., Tamma R., Di Benedetto A., Yuen T., Sun L., Zaidi M., et al. The oxytocin-bone axis. J Neuroendocrinol 2014, 26:53-57.
104. Tamma R., Colaianni G., Zhu L.L., DiBenedetto A., Greco G., Montemurro G., et al. Oxytocin is an anabolic bone hormone. Proc Natl Acad Sci U S A 2009, 106:7149-7154.
105. Elabd C., Basillais A., Beaupied H., Breuil V., Wagner N., Scheideler M., et al. Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis. Stem Cells 2008, 26:2399-2407.
106. Lawson E.A., Donoho D.A., Blum J.I., Meenaghan E.M., Misra M., Herzog D.B., et al. Decreased nocturnal oxytocin levels in anorexia nervosa are associated with low bone mineral density and fat mass. J Clin Psychiatry 2011, 72:1546-1551.
107. Li X., Warmington K.S., Niu Q.T., Asuncion F.J., Barrero M., Grisanti M., et al. Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats. J Bone Miner Res 2010, 25:2647-2656.
108. McClung M.R., Grauer A., Boonen S., Bolognese M.A., Brown J.P., Diez-Perez A., et al. Romosozumab in postmenopausal women with low bone mineral density. N Engl J Med 2014, 370:412-420.
109. Maimoun L., Guillaume S., Lefebvre P., Philibert P., Bertet H., Picot M.C., et al. Role of sclerostin and dickkopf-1 in the dramatic alteration in bone mass acquisition in adolescents and young women with recent anorexia nervosa. J Clin Endocrinol Metab 2014, jc20132565.
110. Faje A.T., Fazeli P.K., Katzman D.K., Miller K.K., Breggia A., Rosen C.J., et al. Sclerostin levels and bone turnover markers in adolescents with anorexia nervosa and healthy adolescent girls. Bone 2012, 51:474-479.
111. Fazeli P.K., Wang I.S., Miller K.K., Herzog D.B., Misra M., Lee H., et al. Teriparatide increases bone formation and bone mineral density in adult women with anorexia nervosa. J Clin Endocrinol Metab 2014, jc20134105.
112. Schellinger D., Lin C.S., Hatipoglu H.G., Fertikh D. Potential value of vertebral proton MR spectroscopy in determining bone weakness. AJNR Am J Neuroradiol 2001, 22:1620-1627.
113. Shen W., Chen J., Punyanitya M., Shapses S., Heshka S., Heymsfield S.B. MRI-measured bone marrow adipose tissue is inversely related to DXA-measured bone mineral in Caucasian women. Osteoporos Int 2007, 18:641-647.
114. Shen W., Scherzer R., Gantz M., Chen J., Punyanitya M., Lewis C.E., et al. Relationship between MRI-measured bone marrow adipose tissue and hip and spine bone mineral density in African-American and Caucasian participants: the CARDIA study. J Clin Endocrinol Metab 2012, 97:1337-1346.
115. Di Iorgi N., Rosol M., Mittelman S.D., Gilsanz V. Reciprocal relation between marrow adiposity and the amount of bone in the axial and appendicular skeleton of young adults. J Clin Endocrinol Metab 2008, 93:2281-2286.
116. Wren T.A., Chung S.A., Dorey F.J., Bluml S., Adams G.B., Gilsanz V. Bone marrow fat is inversely related to cortical bone in young and old subjects. J Clin Endocrinol Metab 2011, 96:782-786.
117. Huang J.S., Mulkern R.V., Grinspoon S. Reduced intravertebral bone marrow fat in HIV-infected men. AIDS 2002, 16:1265-1269.