Bone marrow fat is inversely related to cortical bone in young and old subjects

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 3, 2011, Pages 782-786

  Wren, Tishya A L ^a   Chung, Sandra A ^a   Dorey, Frederick J ^a   Bluml, Stefan ^a   Adams, Gregor B ^b   Gilsanz, Vicente ^a  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANTHROPOMETRY; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; BONE MARROW; CORTICAL BONE; DIAPHYSIS; FAT CONTENT; FEMALE; FEMUR; FEMUR SHAFT; HUMAN; HUMAN EXPERIMENT; LONG BONE; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OSSIFICATION; OUTCOME ASSESSMENT; PRIORITY JOURNAL;

ABSORPTIOMETRY, PHOTON; ADIPOSE TISSUE; ADIPOSITY; ADOLESCENT; ADULT; AGED; AGING; ANTHROPOMETRY; BODY HEIGHT; BODY MASS INDEX; BODY WEIGHT; BONE MARROW; DIAPHYSES; FEMALE; FEMUR; HUMANS; LINEAR MODELS; LIPID METABOLISM; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 79952294308     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-1922     Document Type: Article

References (22)

1. Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB 2005 TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309:1074-1078 (Pubitemid 41134465)
2. Nakashima K, de Crombrugghe B 2003 Transcriptional mechanisms in osteoblast differentiation and bone formation. Trends Genet 19:458-466 (Pubitemid 36930029)
3. Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GW, Beddington RS, Mundlos S, Olsen BR, Selby PB, Owen MJ 1997 Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89:765-771 (Pubitemid 27516179)
4. Lecka-Czernik B 2006 PPARs and bone metabolism. PPAR Res 2006:18089
5. Maurin AC, Chavassieux PM, Frappart L, Delmas PD, Serre CM, Meunier PJ 2000 Influence of mature adipocytes on osteoblast proliferation in human primary cocultures. Bone 26:485-489 (Pubitemid 30204469)
6. Burkhardt R, Kettner G, Böhm W, Schmidmeier M, Schlag R, Frisch B, Mallmann B, Eisenmenger W, Gilg T 1987 Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study. Bone 8:157-164 (Pubitemid 17111858)
7. Meunier P, Aaron J, Edouard C, Vignon G 1971 Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. Aquantitative study of 84 iliac bone biopsies. Clin Orthop Relat Res 80:147-154
8. Verma S, Rajaratnam JH, Denton J, Hoyland JA, Byers RJ 2002 Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol 55:693-698 (Pubitemid 34970093)
9. Yeung DK, Griffith JF, Antonio GE, Lee FK, Woo J, Leung PC 2005 Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: a proton MR spectroscopy study. J Magn Reson Imaging 22:279-285 (Pubitemid 41045443)
10. Griffith JF, Yeung DK, Antonio GE, Lee FK, Hong AW, Wong SY, Lau EM, Leung PC 2005 Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: dynamic contrast-enhanced MR imaging and MR spectroscopy. Radiology 236:945-951 (Pubitemid 41170858)
11. Shen W, Chen J, Punyanitya M, Shapses S, Heshka S, Heymsfield SB 2007 MRI-measured bone marrow adipose tissue is inversely related to DXA-measured bone mineral in Caucasian women. Osteoporos Int 18:641-647 (Pubitemid 46525539)
12. Wehrli FW, Hopkins JA, Hwang SN, Song HK, Snyder PJ, Haddad JG 2000 Cross-sectional study of osteopenia with quantitative MR imaging and bone densitometry. Radiology 217:527-538
13. Di Iorgi N, Mo AO, Grimm K, Wren TA, Dorey F, Gilsanz V 2010 Bone acquisition in healthy young females is reciprocally related to marrow adiposity. J Clin Endocrinol Metab 95:2977-2982
14. Di Iorgi N, Rosol M, Mittelman SD, Gilsanz V 2008 Reciprocal relation between marrow adiposity and the amount of bone in the axial and appendicular skeleton of young adults. J Clin Endocrinol Metab 93:2281-2286
15. Bredella MA, Fazeli PK, Miller KK, Misra M, Torriani M, Thomas BJ, Ghomi RH, Rosen CJ, Klibanski A 2009 Increased bone marrow fat in anorexia nervosa. J Clin Endocrinol Metab 94:2129-2136
16. Gurevitch O, Slavin S, Feldman AG 2007 Conversion of red bone marrow into yellow - cause and mechanisms. Med Hypotheses 69:531-536 (Pubitemid 47043277)
17. Duque G 2008 Bone and fat connection in aging bone. Curr Opin Rheumatol 20:429-434
18. Chamberlain G, Fox J, Ashton B, Middleton J 2007 Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25:2739-2749 (Pubitemid 350127858)
19. Hartsock RJ, Smith EB, Petty CS 1965 Normal variations with aging of the amount of hematopoietic tissue in bone marrow from the anterior iliac crest. A study made from 177 cases of sudden death examined by necropsy. Am J Clin Pathol 43:326-331
20. Vost A 1963 Osteoporosis: a necropsy study of vertebrae and iliac crests. Am J Pathol 43:143-151
21. Bredella MA 2010 Perspective: the bone-fat connection. Skeletal Radiol 39:729-731
22. Rosen CJ, Bouxsein ML 2006 Mechanisms of disease: is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol 2:35-43