Teriparatide increases bone formation and bone mineral density in adult women with anorexia nervosa

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 4, 2014, Pages 1322-1329

  Fazeli, Pouneh K ^a,c   Wang, Irene S ^a   Miller, Karen K ^a,c   Herzog, David B ^c   Misra, Madhusmita ^a,c   Lee, Hang ^a,c   Finkelstein, Joel S ^a,c   Bouxsein, Mary L ^b,c   Klibanski, Anne ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANOREXIA NERVOSA; BIOLOGICAL MARKERS; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MIDDLE AGED; OSTEOGENESIS; PROTEINS; TERIPARATIDE;

EID: 84898460378     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-4105     Document Type: Article

References (36)

1. Keski-Rahkonen A, Hoek HW, Susser ES, et al. Epidemiology and course of anorexia nervosa in the community. Am J Psychiatry. 2007;164:1259-1265.
2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) . 4th ed. Washington, DC: American Psychiatric Association; 1994.
3. Grinspoon S, Thomas E, Pitts S, et al. Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa. Ann Intern Med. 2000;133:790-794.
4. Miller KK, Grinspoon SK, Ciampa J, Hier J, Herzog D, Klibanski A. Medical findings in outpatients with anorexia nervosa. Arch Intern Med. 2005;165:561-566.
5. Rigotti NA, Neer RM, Skates SJ, Herzog DB, Nussbaum SR. The clinical course of osteoporosis in anorexia nervosa. A longitudinal study of cortical bone mass. JAMA .1991;265:1133-1138.
6. Trickey H. Eating disorders exact toll on adults, too. CNN website. http://www-cgi.cnn.com/2006/HEALTH/diet.fitness/03/24/hb.adult. eating.disorders/index.html. 2006. Accessed October 15,2013.
7. Lowe B, Zipfel S, Buchholz C, Dupont Y, Reas DL, Herzog W. Long-term outcome of anorexia nervosa in a prospective 21-year follow-up study. Psychol Med. 2001;31:881-890.
8. Scholtz S, Hill LS, Lacey H. Eating disorders in older women: does late onset anorexia nervosa exist? Int J Eat Disord. 2010;43:393-397.
9. Kellett J, Trimble M, Thorley A. Anorexia nervosa after the menopause. Br J Psychiatry. 1976;128:555-558.
10. Boast N, Coker E, Wakeling A. Anorexia nervosa of late onset. Br J Psychiatry. 1992;160:257-260.
11. Beck D, Casper R, Andersen A. Truly late onset of eating disorders: a study of 11 cases averaging 60 years of age at presentation. Int J Eat Disord. 1996;20:389-395.
12. Klibanski A, Biller BM, Schoenfeld DA, Herzog DB, Saxe VC. The effects of estrogen administration on trabecular bone loss in young women with anorexia nervosa. J Clin Endocrinol Metab. 1995;80: 898-904.
13. Grinspoon S, Thomas L, Miller K, Herzog D, Klibanski A. Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa. J Clin Endocrinol Metab. 2002;87:2883-2891.
14. Miller KK, Meenaghan E, Lawson EA, et al. Effects of risedronate and low-dose transdermal testosterone on bone mineral density in women with anorexia nervosa: a randomized, placebo-controlled study. J Clin Endocrinol Metab . 2011;96:2081-2088.
15. Gordon CM, Grace E, Emans SJ, et al. Effects of oral dehydroepi- androsterone on bone density in young women with anorexia ner-vosa: a randomized trial. J Clin Endocrinol Metab. 2002;87:4935-4941.
16. Bloch M, Ish-Shalom S, Greenman Y, Klein E, Latzer Y. Dehydro-epiandrosterone treatment effects on weight, bone density, bone metabolism and mood in women suffering from anorexia nervosa-a pilot study. Psychiatry Res. 2012;200:544-549.
17. Divasta AD, Feldman HA, Giancaterino C, Rosen CJ, Leboff MS, Gordon CM. The effect of gonadal and adrenal steroid therapy on skeletal health in adolescents and young women with anorexia ner-vosa. Metabolism. 2012;61:1010-1020.
18. Grinspoon S, Baum H, Lee K, Anderson E, Herzog D, Klibanski A. Effects of short-term recombinant human insulin-like growth factor I administration on bone turnover in osteopenic women with anorexia nervosa. J Clin Endocrinol Metab. 1996;81:3864-3870.
19. Stefanis N, Mackintosh C, Abraha HD, Treasure J, Moniz C. Dissociation of bone turnover in anorexia nervosa. Ann Clin Biochem. 1998;35(Pt6):709-716.
20. Soyka LA, Grinspoon S, Levitsky LL, Herzog DB, Klibanski A. The effects of anorexia nervosa on bone metabolism in female adolescents. JClin Endocrinol Metab. 1999;84:4489-4496.
21. PfeilschifterJ, Laukhuf F, Muller-Beckmann B, Blum WF, Pfister T, Ziegler R. Parathyroid hormone increases the concentration of insulin-like growth factor-I and transforming growth factor beta 1 in rat bone. J Clin Invest. 1995;96:767-774.
22. Watson P, Lazowski D, Han V, Frailer L, Steer B, Hodsman A. Parathyroid hormone restores bone mass and enhances osteoblast insulin-like growth factor I gene expression in ovariectomized rats. Bone. 1995;16:357-365.
23. Counts DR, Gwirtsman H, Carlsson LM, Lesem M, Cutler GB Jr. The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins. J Clin Endocrinol Metab. 1992;75:762-767.
24. Fazeli PK, Lawson EA, Prabhakaran R, et al. Effects of recombinant human growth hormone in anorexia nervosa: a randomized, placebo-controlled study. J Clin Endocrinol Metab. 2010;95:4889-4897.
25. Metropolitan Life Insurance Company. Metropolitan height and weight tables. Metropolitan Stat Bull. 1983;64:2-9.
26. Barthe N, BraillonP, DucassouD, Basse-Cathalinat B. Comparison of two Hologic DXA systems (QDR 1000 and QDR 4500/A). Br J Radiol. 1997;70:728-739.
27. Miller KK, Lee EE, Lawson EA, et al. Determinants of skeletal loss and recovery in anorexia nervosa. J Clin Endocrinol Metab. 2006; 91:2931-2937.
28. Lucas AR, Melton LJ 3rd, Crowson CS, O'Fallon WM. Long-term fracture risk among women with anorexia nervosa: a population-based cohort study. Mayo Clin Proc. 1999;74:972-977.
29. Misra M, Katzman D, Miller KK, et al. Physiologic estrogen replacement increases bone density in adolescent girls with anorexia nervosa. J Bone Miner Res. 2011;26:2430-2438.
30. McCarthy TL, Centrella M, Canalis E. Parathyroid hormone enhances the transcript and polypeptide levels of insulin-like growth factor I in osteoblast-enriched cultures from fetal rat bone. Endocrinology. 1989;124:1247-1253.
31. Yakar S, Bouxsein ML, Canalis E, et al. The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. The Journal of Endocrinology. 2006;189:289-299.
32. Drake MT, Srinivasan B, Modder UI, et al. Effects of parathyroid hormone treatment on circulating sclerostin levels in postmeno-pausal women. J Clin Endocrinol Metab. 2010;95:5056-5062.
33. Polyzos SA, Anastasilakis AD, Bratengeier C, Woloszczuk W, Pa-patheodorou A, Terpos E. Serum sclerostin levels positively correlate with lumbar spinal bone mineral density in postmenopausal women-the six-month effect of risedronate and teriparatide. Os-teoporos Int. 2012;23:1171-1176.
34. Gatti D, Viapiana O, Idolazzi L, Fracassi E, Rossini M, Adami S. The waning of teriparatide effect on bone formation markers in post-menopausal osteoporosis is associated with increasing serum levels of DKK1. J Clin Endocrinol Metab. 2011;96:1555-1559.
35. Faje AT, Fazeli PK, Katzman DK, et al. Sclerostin levels and bone turnover markers in adolescents with anorexia nervosa and healthy adolescent girls. Bone. 2012;51:474-479.
36. Shibli-Rahhal A, McCormick L. Teriparatide treatment of osteoporosis in a patient with anorexia nervosa. Eat Weight Disord. 2013;18:229-231.