Expression of human solute carrier family transporters in skin: Possible contributor to drug-induced skin disorders

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Fujiwara, Ryoichi ^a   Takenaka, Saya ^a   Hashimoto, Mitsuhiro ^a   Narawa, Tomoya ^a   Itoh, Tomoo ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; GLUCURONIC ACID; IBUPROFEN; IBUPROFEN ACYL GLUCURONIDE; PROTEIN S 100; S100A7A PROTEIN, HUMAN;

ANALOGS AND DERIVATIVES; CELL LINE; CELL SURVIVAL; HUMAN; KERATINOCYTE; LIVER; METABOLISM; PHYSIOLOGY; SKIN; SKIN DISEASE; SMALL INTESTINE; TRANSPORT AT THE CELLULAR LEVEL;

BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL LINE; CELL SURVIVAL; GLUCURONATES; HUMANS; IBUPROFEN; INTESTINE, SMALL; KERATINOCYTES; LIVER; MEMBRANE TRANSPORT PROTEINS; S100 PROTEINS; SKIN; SKIN DISEASES;

EID: 84902320063     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05251     Document Type: Article

References (36)

1. Dean, M., Hamon, Y. & Chimini, G. The human ATP-binding cassette (ABC) transporter superfamily. J. Lipid Res. 42, 1007-17 (2001). (Pubitemid 32645780)
2. Saier, M. H., Yen, M. R., Noto, K., Tamang, D. G. & Elkan, C. The Transporter Classification Database: recent advances. Nucleic Acids Res. 37, (Database issue), D274-278; doi: 10. 1093/nar/gkn862 (2009).
3. Kim, R. B. Organic anion-transporting polypeptide (OATP) transporter family and drug disposition. Eur. J. Clin. Invest. 2, 1-5 (2003).
4. Ho, R. H. & Kim, R. B. Transporters and drug therapy: implications for drug disposition and disease. Clin. Pharmacol. Ther. 78, 260-277 (2005). (Pubitemid 41254111)
5. Seithel, A., Karlsson, J., Hilgendorf, C., Björquist, A. & Ungell, A. L. Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells. Eur. J. Pharm. Sci. 28, 291-299 (2006). (Pubitemid 44218740)
6. Hilgendorf, C. et al. Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines. Drug Metab. Dispos. 35, 1333-1340 (2007). (Pubitemid 47121774)
7. Terada, T. & Inui, K. Gene expression and regulation of drug transporters in the intestine and kidney. Biochem. Pharmacol. 73, 440-449 (2007). (Pubitemid 44958370)
8. Fritsch, P. O. & Sidoroff, A. Drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis. Am. J. Clin. Dermatol. 1, 349-360 (2000).
9. Tsankov, N., Angelova, I. & Kazandjieva, J. Drug-induced psoriasis. Recognition and management. Am. J. Clin. Dermatol. 1, 159-165 (2000).
10. Kaplan, A. P. Drug-induced skin disease. J. Allergy Clin. Immunol. 74, 573-579 (1984). (Pubitemid 15200691)
11. Shiohara, T., Inaoka, M. & Kano, Y. Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses. Allergol. Int. 55, 1-8 (2006).
12. Saiag, P., Caumes, E., Chosidow, O., Revuz, J. & Roujeau, J. C. Drug-induced toxic epidermal necrolysis (Lyell syndrome) in patients infected with the human immunodeficiency virus. J. Am. Acad. Dermatol. 26, 567-574 (1992).
13. Harber, L. C. & Baer, R. L. Pathogenic mechanisms of drug-induced photosensitivity. J. Invest. Dermatol. 58, 327-342 (1972).
14. Takenaka, S., Itoh, T. & Fujiwara, R. Expression pattern of human ATP-binding cassette transporters in skin. Pharma. Res. Per. 1, e00005; DOI: 10. 1002/prp2. 2 (2013).
15. Sirotnak, F. M. & Tolner, B. Carrier-mediated membrane transport of folates in mammalian cells. Annu. Rev. Nutr. 19, 91-122 (1999). (Pubitemid 29380598)
16. Qiu, A. et al. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell. 127, 917-928 (2006). (Pubitemid 44792250)
17. Sakaguchi, K. et al. Glucuronidation of carboxylic acid containing compounds by UDP-glucuronosyltransferase isoforms. Arch. Biochem. Biophys. 424, 219-225 (2004). (Pubitemid 38401955)
18. Sternlieb, P. & Robinson, R. M. Stevens-Johnson syndrome plus toxic hepatitis due to ibuprofen. N Y State J Med. 78, 1239-1243 (1978). (Pubitemid 8395512)
19. Ho, R. H. et al. Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology. 130, 1793-1806 (2006).
20. Schoop, V. M., Mirancea, N. & Fusenig, N. E. Epidermal organization and differentiation of HaCaT keratinocytes in organotypic coculture with human dermal fibroblasts. J. Invest. Dermatol. 112, 343-353 (1999). (Pubitemid 29125112)
21. Yuasa, H., Inoue, K. & Hayashi, Y. Molecular and functional characteristics of proton-coupled folate transporter. J. Pharm. Sci. 98, 1608-1616 (2009).
22. Watson, P. H., Leygue, E. R. &Murphy, L. C. Psoriasin (S100A7). Int. J. Biochem. Cell. Biol. 30, 567-571 (1998). (Pubitemid 28302734)
23. Martinsson, H., Yhr, M. &Enerbäck, C. Expression patterns of S100A7 (psoriasin) and S100A9 (calgranulin-B) in keratinocyte differentiation. Exp. Dermatol. 14, 161-168 (2005). (Pubitemid 40394198)
24. Milavec-Puretić, V., Mance, M., Ceović, R. & Lipozenc?ić, J. Drug induced psoriasis. Acta. Dermatovenerol. Croat. 19, 39-42 (2011).
25. Cuthbert, R. J., Craig, J. I. & Ludlam, C. A. Stevens-Johnson syndrome associated with methotrexate treatment for non-Hodgkin's lymphoma. Ulster. Med. J. 62, 95-97 (1993). (Pubitemid 23177061)
26. Gayford, J. J. & Redpath, T. H. The side-effects of carbamazepine. Proc. R. Soc. Med. 62, 615-616 (1969).
27. Sun, J. J., Xie, L. & Liu, X. D. Transport of carbamazepine and drug interactions at blood-brain barrier. Acta. Pharmacol. Sin. 27, 249-253 (2006). (Pubitemid 43171166)
28. El-Sheikh, A. A., Masereeuw, R. & Russel, F. G. Mechanisms of renal anionic drug transport. Eur. J. Pharmacol. 585, 245-255 (2008).
29. Funk, C. The role of hepatic transporters in drug elimination. Expert Opin. Drug Metab. Toxicol. 4, 363-379 (2008). (Pubitemid 351728512)
30. Maeda, A. et al. Evaluation of the interaction between nonsteroidal antiinflammatory drugs and methotrexate using human organic anion transporter 3- transfected cells. Eur. J. Pharmacol. 596, 166-172 (2008).
31. van de Steeg, E. et al. Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1). Drug Metab. Dispos. 37, 277-281 (2009).
32. Hosomi, H. et al. An in vitro drug-induced hepatotoxicity screening system using CYP3A4-expressing and gamma-glutamylcysteine synthetase knockdown cells. Toxicol. In Vitro. 24, 1032-1038 (2010).
33. Iwamura, A., Fukami, T., Hosomi, H., Nakajima, M. & Yokoi, T. CYP2C9- mediated metabolic activation of losartan detected by a highly sensitive cell-based screening assay. Drug Metab. Dispos. 39, 838-846 (2011).
34. Koga, T., Fujiwara, R., Nakajima, M. & Yokoi, T. Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP- glucuronosyltransferase and human hepatocytes. Drug Metab. Dispos. 39, 54-60 (2011).
35. Sumida, K. et al. Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia. Mol. Pharmacol. 84, 679-686 (2013).
36. Hegyi, Z. et al. Vitamin D analog calcipotriol suppresses the Th17 cytokineinduced proinflammatory S100 "alarmins" psoriasin (S100A7) and koebnerisin (S100A15) in psoriasis. J. Invest. Dermatol. 132, 1416-1424 (2012).