Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum

Free Radical Biology and Medicine

Volumn 73, Issue , 2014, Pages 229-238

  Sousa, André F ^a   Gomes Alves, Ana G ^a   Benítez, Diego ^b   Comini, Marcelo A ^b   Flohé, Leopold ^c,g   Jaeger, Timo ^d   Passos, Joana ^a   Stuhlmann, Friedrich ^e   Tomás, Ana M ^a,f   Castro, Helena ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b INSTITUT PASTEUR DE MONTEVIDEO   (Uruguay)

^c UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^e Schirm GmbH   (Germany)

^f UNIVERSITY OF PORTO   (Portugal)

^g UNIVERSITY OF PADOVA   (Italy)

Author keywords

Free radicals; Glutathionylspermidine; Leishmania; Target validation; Trypanosoma; Trypanothione

Indexed keywords

GLUTATHIONYLSPERMIDINE SYNTHETASE; PROTOZOAL PROTEIN; SPERMIDINE; TRYPANOTHIONE; TRYPANOTHIONE SYNTHETASE; UNCLASSIFIED DRUG; AMIDE SYNTHASE; ANTIPROTOZOAL AGENT; GLUTATHIONE; GLUTATHIONYLSPERMIDINE;

ALLELE; AMASTIGOTE; ANIMAL EXPERIMENT; ARTICLE; DNA SEQUENCE; GENE DELETION; HETEROLOGOUS EXPRESSION; KINETOPLASTIDA; LEISHMANIA INFANTUM; LIFE CYCLE STAGE; MOLECULAR MEDICINE; MOUSE; NONHUMAN; PARASITE LOAD; PRIORITY JOURNAL; PROMASTIGOTE; PROTOZOAL GENETICS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMISTRY; ENZYMOLOGY; GENE INACTIVATION; GENETICS; LEISHMANIASIS, VISCERAL; MALE;

AMIDE SYNTHASES; ANIMALS; ANTIPROTOZOAL AGENTS; GENE KNOCKOUT TECHNIQUES; GLUTATHIONE; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; MALE; MICE; MICE, INBRED BALB C; SPERMIDINE;

EID: 84902284220     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.05.007     Document Type: Article

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