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Volumn 192, Issue 12, 2014, Pages 5789-5801

Targeting antigens through blood dendritic cell antigen 2 on plasmacytoid dendritic cells promotes immunologic tolerance

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BLOOD DENDRITIC CELL ANTIGEN 2; CELL ANTIGEN; INTERLEUKIN 12; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

EID: 84902205646     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1303259     Document Type: Article
Times cited : (25)

References (66)
  • 1
    • 84893401886 scopus 로고    scopus 로고
    • Controlling immune responses by targeting antigens to dendritic cell subsets and B cells
    • Chappell, C. P., N. V. Giltiay, C. Dresch, and E. A. Clark. 2014. Controlling immune responses by targeting antigens to dendritic cell subsets and B cells. Int. Immunol. 26:3-11.
    • (2014) Int. Immunol. , vol.26 , pp. 3-11
    • Chappell, C.P.1    Giltiay, N.V.2    Dresch, C.3    Clark, E.A.4
  • 2
    • 65449134871 scopus 로고    scopus 로고
    • Enhancing immune responses by targeting antigen to DC
    • Caminschi, I., M. H. Lahoud, and K. Shortman. 2009. Enhancing immune responses by targeting antigen to DC. Eur. J. Immunol. 39:931-938.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 931-938
    • Caminschi, I.1    Lahoud, M.H.2    Shortman, K.3
  • 3
    • 84879228653 scopus 로고    scopus 로고
    • Targeting dendritic cells: Why bother?
    • Kreutz, M., P. J. Tacken, and C. G. Figdor. 2013. Targeting dendritic cells: why bother? Blood 121:2836-2844.
    • (2013) Blood , vol.121 , pp. 2836-2844
    • Kreutz, M.1    Tacken, P.J.2    Figdor, C.G.3
  • 5
    • 84884812281 scopus 로고    scopus 로고
    • The physiological role of DCSIGN: A tale of mice and men
    • Garcia-Vallejo, J. J., and Y. Van Kooyk. 2013. The physiological role of DCSIGN: a tale of mice and men. Trends Immunol. 34:482-486.
    • (2013) Trends Immunol. , vol.34 , pp. 482-486
    • Garcia-Vallejo, J.J.1    Van Kooyk, Y.2
  • 6
    • 33744996268 scopus 로고    scopus 로고
    • C-type lectin-like receptors on myeloid cells
    • Pyz, E., A. S. Marshall, S. Gordon, and G. D. Brown. 2006. C-type lectin-like receptors on myeloid cells. Ann. Med. 38:242-251.
    • (2006) Ann. Med. , vol.38 , pp. 242-251
    • Pyz, E.1    Marshall, A.S.2    Gordon, S.3    Brown, G.D.4
  • 8
    • 33747245072 scopus 로고    scopus 로고
    • C-type lectins on dendritic cells and their interaction with pathogen-derived and endogenous glycoconjugates
    • Gijzen, K., A. Cambi, R. Torensma, and C. G. Figdor. 2006. C-type lectins on dendritic cells and their interaction with pathogen-derived and endogenous glycoconjugates. Curr. Protein Pept. Sci. 7:283-294.
    • (2006) Curr. Protein Pept. Sci. , vol.7 , pp. 283-294
    • Gijzen, K.1    Cambi, A.2    Torensma, R.3    Figdor, C.G.4
  • 9
    • 34247627809 scopus 로고    scopus 로고
    • Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation
    • Burgdorf, S., A. Kautz, V. Böhnert, P. A. Knolle, and C. Kurts. 2007. Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science 316:612-616.
    • (2007) Science , vol.316 , pp. 612-616
    • Burgdorf, S.1    Kautz, A.2    Böhnert, V.3    Knolle, P.A.4    Kurts, C.5
  • 11
    • 84859405717 scopus 로고    scopus 로고
    • Signaling by myeloid C-type lectin receptors in immunity and homeostasis
    • Sancho, D., and C. Reis E Sousa. 2012. Signaling by myeloid C-type lectin receptors in immunity and homeostasis. Annu. Rev. Immunol. 30:491-529.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 491-529
    • Sancho, D.1    Reis E Sousa, C.2
  • 12
    • 79953102822 scopus 로고    scopus 로고
    • Syk-coupled C-type lectins in immunity
    • Kerrigan, A. M., and G. D. Brown. 2011. Syk-coupled C-type lectins in immunity. Trends Immunol. 32:151-156.
    • (2011) Trends Immunol. , vol.32 , pp. 151-156
    • Kerrigan, A.M.1    Brown, G.D.2
  • 13
    • 33644755502 scopus 로고    scopus 로고
    • Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors
    • Zhang, J., A. Raper, N. Sugita, R. Hingorani, M. Salio, M. J. Palmowski, V. Cerundolo, and P. R. Crocker. 2006. Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors. Blood 107:3600-3608.
    • (2006) Blood , vol.107 , pp. 3600-3608
    • Zhang, J.1    Raper, A.2    Sugita, N.3    Hingorani, R.4    Salio, M.5    Palmowski, M.J.6    Cerundolo, V.7    Crocker, P.R.8
  • 14
    • 0035887505 scopus 로고    scopus 로고
    • + cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells
    • + cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J. Exp. Med. 194:1171-1178
    • (2001) J. Exp. Med. , vol.194 , pp. 1171-1178
    • Nakano, H.1    Yanagita, M.2    Gunn, M.D.3
  • 15
    • 33747803946 scopus 로고    scopus 로고
    • Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation
    • Blasius, A. L., E. Giurisato, M. Cella, R. D. Schreiber, A. S. Shaw, and M. Colonna. 2006. Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation. J. Immunol. 177:3260-3265.
    • (2006) J. Immunol. , vol.177 , pp. 3260-3265
    • Blasius, A.L.1    Giurisato, E.2    Cella, M.3    Schreiber, R.D.4    Shaw, A.S.5    Colonna, M.6
  • 16
    • 33644772437 scopus 로고    scopus 로고
    • Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12
    • Blasius, A. L., M. Cella, J. Maldonado, T. Takai, and M. Colonna. 2006. Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12. Blood 107:2474-2476.
    • (2006) Blood , vol.107 , pp. 2474-2476
    • Blasius, A.L.1    Cella, M.2    Maldonado, J.3    Takai, T.4    Colonna, M.5
  • 18
    • 0034679566 scopus 로고    scopus 로고
    • Natural interferon a/b-producing cells link innate and adaptive immunity
    • Kadowaki, N., S. Antonenko, J. Y. Lau, and Y. J. Liu. 2000. Natural interferon a/b-producing cells link innate and adaptive immunity. J. Exp. Med. 192:219-226.
    • (2000) J. Exp. Med. , vol.192 , pp. 219-226
    • Kadowaki, N.1    Antonenko, S.2    Lau, J.Y.3    Liu, Y.J.4
  • 19
  • 20
    • 0037128177 scopus 로고    scopus 로고
    • Virus-induced interferon a production by a dendritic cell subset in the absence of feedback signaling in vivo
    • Barchet, W., M. Cella, B. Odermatt, C. Asselin-Paturel, M. Colonna, and U. Kalinke. 2002. Virus-induced interferon a production by a dendritic cell subset in the absence of feedback signaling in vivo. J. Exp. Med. 195:507-516.
    • (2002) J. Exp. Med. , vol.195 , pp. 507-516
    • Barchet, W.1    Cella, M.2    Odermatt, B.3    Asselin-Paturel, C.4    Colonna, M.5    Kalinke, U.6
  • 21
    • 51349099789 scopus 로고    scopus 로고
    • Antigen-presentation properties of plasmacytoid dendritic cells
    • Villadangos, J. A., and L. Young. 2008. Antigen-presentation properties of plasmacytoid dendritic cells. Immunity 29:352-361.
    • (2008) Immunity , vol.29 , pp. 352-361
    • Villadangos, J.A.1    Young, L.2
  • 22
    • 0037388926 scopus 로고    scopus 로고
    • Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells
    • Krug, A., R. Veeraswamy, A. Pekosz, O. Kanagawa, E. R. Unanue, M. Colonna, and M. Cella. 2003. Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells. J. Exp. Med. 197:899-906.
    • (2003) J. Exp. Med. , vol.197 , pp. 899-906
    • Krug, A.1    Veeraswamy, R.2    Pekosz, A.3    Kanagawa, O.4    Unanue, E.R.5    Colonna, M.6    Cella, M.7
  • 23
    • 77952774795 scopus 로고    scopus 로고
    • Human plasmacytoid dendritic cells phagocytose, process, and present exogenous particulate antigen
    • Tel, J., A. J. Lambeck, L. J. Cruz, P. J. Tacken, I. J. De Vries, and C. G. Figdor. 2010. Human plasmacytoid dendritic cells phagocytose, process, and present exogenous particulate antigen. J. Immunol. 184:4276-4283.
    • (2010) J. Immunol. , vol.184 , pp. 4276-4283
    • Tel, J.1    Lambeck, A.J.2    Cruz, L.J.3    Tacken, P.J.4    De Vries, I.J.5    Figdor, C.G.6
  • 25
    • 1242276205 scopus 로고    scopus 로고
    • CpG-matured murine plasmacytoid dendritic cells are capable of in vivo priming of functional CD8 T cell responses to endogenous but not exogenous antigens
    • Salio, M., M. J. Palmowski, A. Atzberger, I. F. Hermans, and V. Cerundolo. 2004. CpG-matured murine plasmacytoid dendritic cells are capable of in vivo priming of functional CD8 T cell responses to endogenous but not exogenous antigens. J. Exp. Med. 199:567-579.
    • (2004) J. Exp. Med. , vol.199 , pp. 567-579
    • Salio, M.1    Palmowski, M.J.2    Atzberger, A.3    Hermans, I.F.4    Cerundolo, V.5
  • 27
    • 84873721737 scopus 로고    scopus 로고
    • Antigen delivery to plasmacytoid dendritic cells: Induction of tolerance and immunity
    • Loschko, J., and A. Krug. 2012. Antigen delivery to plasmacytoid dendritic cells: induction of tolerance and immunity. Crit. Rev. Immunol. 32:489-501.
    • (2012) Crit. Rev. Immunol. , vol.32 , pp. 489-501
    • Loschko, J.1    Krug, A.2
  • 28
    • 33846438598 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand
    • Ito, T., M. Yang, Y. H. Wang, R. Lande, J. Gregorio, O. A. Perng, X. F. Qin, Y. J. Liu, and M. Gilliet. 2007. Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand. J. Exp. Med. 204:105-115.
    • (2007) J. Exp. Med. , vol.204 , pp. 105-115
    • Ito, T.1    Yang, M.2    Wang, Y.H.3    Lande, R.4    Gregorio, J.5    Perng, O.A.6    Qin, X.F.7    Liu, Y.J.8    Gilliet, M.9
  • 30
    • 0037237628 scopus 로고    scopus 로고
    • Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: Dependency on antigen dose and differential Toll-like receptor ligation
    • Boonstra, A., C. Asselin-Paturel, M. Gilliet, C. Crain, G. Trinchieri, Y. J. Liu, and A. O'Garra. 2003. Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential Toll-like receptor ligation. J. Exp. Med. 197:101-109.
    • (2003) J. Exp. Med. , vol.197 , pp. 101-109
    • Boonstra, A.1    Asselin-Paturel, C.2    Gilliet, M.3    Crain, C.4    Trinchieri, G.5    Liu, Y.J.6    O'Garra, A.7
  • 32
    • 77349088003 scopus 로고    scopus 로고
    • Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance
    • Swiecki, M., and M. Colonna. 2010. Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol. Rev. 234:142-162.
    • (2010) Immunol. Rev. , vol.234 , pp. 142-162
    • Swiecki, M.1    Colonna, M.2
  • 33
    • 0034547923 scopus 로고    scopus 로고
    • BDCA-2, BDCA-3, and BDCA-4: Three markers for distinct subsets of dendritic cells in human peripheral blood
    • Dzionek, A., A. Fuchs, P. Schmidt, S. Cremer, M. Zysk, S. Miltenyi, D. W. Buck, and J. Schmitz. 2000. BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J. Immunol. 165:6037-6046.
    • (2000) J. Immunol. , vol.165 , pp. 6037-6046
    • Dzionek, A.1    Fuchs, A.2    Schmidt, P.3    Cremer, S.4    Zysk, M.5    Miltenyi, S.6    Buck, D.W.7    Schmitz, J.8
  • 34
    • 50549088692 scopus 로고    scopus 로고
    • Functional dichotomy of plasmacytoid dendritic cells: Antigen-specific activation of T cells versus production of type I interferon
    • Jaehn, P. S., K. S. Zaenker, J. Schmitz, and A. Dzionek. 2008. Functional dichotomy of plasmacytoid dendritic cells: antigen-specific activation of T cells versus production of type I interferon. Eur. J. Immunol. 38:1822-1832.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 1822-1832
    • Jaehn, P.S.1    Zaenker, K.S.2    Schmitz, J.3    Dzionek, A.4
  • 35
    • 0035905321 scopus 로고    scopus 로고
    • BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon α/β induction
    • Dzionek, A., Y. Sohma, J. Nagafune, M. Cella, M. Colonna, F. Facchetti, G. Günther, I. Johnston, A. Lanzavecchia, T. Nagasaka, et al. 2001. BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon α/β induction. J. Exp. Med. 194:1823-1834.
    • (2001) J. Exp. Med. , vol.194 , pp. 1823-1834
    • Dzionek, A.1    Sohma, Y.2    Nagafune, J.3    Cella, M.4    Colonna, M.5    Facchetti, F.6    Günther, G.7    Johnston, I.8    Lanzavecchia, A.9    Nagasaka, T.10
  • 36
    • 35649000957 scopus 로고    scopus 로고
    • BDCA2/FcεRI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells
    • Cao, W., L. Zhang, D. B. Rosen, L. Bover, G. Watanabe, M. Bao, L. L. Lanier, and Y. J. Liu. 2007. BDCA2/FcεRI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells. PLoS Biol. 5:e248.
    • (2007) PLoS Biol. , vol.5
    • Cao, W.1    Zhang, L.2    Rosen, D.B.3    Bover, L.4    Watanabe, G.5    Bao, M.6    Lanier, L.L.7    Liu, Y.J.8
  • 37
    • 0001103142 scopus 로고
    • Purification and coupling of fluorescent proteins for use in flow cytometry
    • 4th Ed. D. M. Weir, L. A. Herzenberg, C. Blackwell, and L. A. Herzenberg, eds. Blackwell Scientific Publications, Boston
    • Hardy, R. R. 1986. Purification and coupling of fluorescent proteins for use in flow cytometry. In Handbook of Experimental Immunology, 4th Ed. D. M. Weir, L. A. Herzenberg, C. Blackwell, and L. A. Herzenberg, eds. Blackwell Scientific Publications, Boston, p-31-1-31-12.
    • (1986) Handbook of Experimental Immunology , pp. 311-3112
    • Hardy, R.R.1
  • 39
    • 84868337977 scopus 로고    scopus 로고
    • Extrafollicular B cell activation by marginal zone dendritic cells drives T celldependent antibody responses
    • Chappell, C. P., K. E. Draves, N. V. Giltiay, and E. A. Clark. 2012. Extrafollicular B cell activation by marginal zone dendritic cells drives T celldependent antibody responses. J. Exp. Med. 209:1825-1840.
    • (2012) J. Exp. Med. , vol.209 , pp. 1825-1840
    • Chappell, C.P.1    Draves, K.E.2    Giltiay, N.V.3    Clark, E.A.4
  • 40
    • 0037407691 scopus 로고    scopus 로고
    • Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells
    • Kerkmann, M., S. Rothenfusser, V. Hornung, A. Towarowski, M. Wagner, A. Sarris, T. Giese, S. Endres, and G. Hartmann. 2003. Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells. J. Immunol. 170:4465-4474.
    • (2003) J. Immunol. , vol.170 , pp. 4465-4474
    • Kerkmann, M.1    Rothenfusser, S.2    Hornung, V.3    Towarowski, A.4    Wagner, M.5    Sarris, A.6    Giese, T.7    Endres, S.8    Hartmann, G.9
  • 41
    • 77956178739 scopus 로고    scopus 로고
    • BDCA-2 signaling inhibits TLR-9-agonist-induced plasmacytoid dendritic cell activation and antigen presentation
    • Jáhn, P. S., K. S. Zánker, J. Schmitz, and A. Dzionek. 2010. BDCA-2 signaling inhibits TLR-9-agonist-induced plasmacytoid dendritic cell activation and antigen presentation. Cell. Immunol. 265:15-22.
    • (2010) Cell. Immunol. , vol.265 , pp. 15-22
    • Jáhn, P.S.1    Zánker, K.S.2    Schmitz, J.3    Dzionek, A.4
  • 42
    • 33746864909 scopus 로고    scopus 로고
    • + T cell responses through in vivo targeting of antigen to dendritic cell-associated C-type lectin-1
    • + T cell responses through in vivo targeting of antigen to dendritic cell-associated C-type lectin-1. J. Immunol. 177:2276-2284.
    • (2006) J. Immunol. , vol.177 , pp. 2276-2284
    • Carter, R.W.1    Thompson, C.2    Reid, D.M.3    Wong, S.Y.4    Tough, D.F.5
  • 43
    • 79960544931 scopus 로고    scopus 로고
    • Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype
    • Lahoud, M. H., F. Ahmet, S. Kitsoulis, S. S. Wan, D. Vremec, C. N. Lee, B. Phipson, W. Shi, G. K. Smyth, A. M. Lew, et al. 2011. Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype. J. Immunol. 187:842-850.
    • (2011) J. Immunol. , vol.187 , pp. 842-850
    • Lahoud, M.H.1    Ahmet, F.2    Kitsoulis, S.3    Wan, S.S.4    Vremec, D.5    Lee, C.N.6    Phipson, B.7    Shi, W.8    Smyth, G.K.9    Lew, A.M.10
  • 46
    • 83755173163 scopus 로고    scopus 로고
    • Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity
    • Loschko, J., S. Heink, D. Hackl, D. Dudziak, W. Reindl, T. Korn, and A. B. Krug. 2011. Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity. J. Immunol. 187:6346-6356.
    • (2011) J. Immunol. , vol.187 , pp. 6346-6356
    • Loschko, J.1    Heink, S.2    Hackl, D.3    Dudziak, D.4    Reindl, W.5    Korn, T.6    Krug, A.B.7
  • 49
    • 34548751712 scopus 로고    scopus 로고
    • De novo production of antigen-specific suppressor cells in vivo
    • Kretschmer, K., T. S. Heng, and H. Von Boehmer. 2006. De novo production of antigen-specific suppressor cells in vivo. Nat. Protoc. 1:653-661.
    • (2006) Nat. Protoc. , vol.1 , pp. 653-661
    • Kretschmer, K.1    Heng, T.S.2    Von Boehmer, H.3
  • 52
    • 54549096767 scopus 로고    scopus 로고
    • CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease
    • Hadeiba, H., T. Sato, A. Habtezion, C. Oderup, J. Pan, and E. C. Butcher. 2008. CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nat. Immunol. 9:1253-1260.
    • (2008) Nat. Immunol. , vol.9 , pp. 1253-1260
    • Hadeiba, H.1    Sato, T.2    Habtezion, A.3    Oderup, C.4    Pan, J.5    Butcher, E.C.6
  • 56
    • 54049151564 scopus 로고    scopus 로고
    • The indoleamine 2, 3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation
    • Chen, W., X. Liang, A. J. Peterson, D. H. Munn, and B. R. Blazar. 2008. The indoleamine 2, 3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation. J. Immunol. 181:5396-5404.
    • (2008) J. Immunol. , vol.181 , pp. 5396-5404
    • Chen, W.1    Liang, X.2    Peterson, A.J.3    Munn, D.H.4    Blazar, B.R.5
  • 58
    • 84887494213 scopus 로고    scopus 로고
    • Targeting uptake receptors on human plasmacytoid dendritic cells triggers antigen cross-presentation and robust type I IFN secretion
    • Tel, J., S. P. Sittig, R. A. Blom, L. J. Cruz, G. Schreibelt, C. G. Figdor, and I. J. De Vries. 2013. Targeting uptake receptors on human plasmacytoid dendritic cells triggers antigen cross-presentation and robust type I IFN secretion. J. Immunol. 191:5005-5012.
    • (2013) J. Immunol. , vol.191 , pp. 5005-5012
    • Tel, J.1    Sittig, S.P.2    Blom, R.A.3    Cruz, L.J.4    Schreibelt, G.5    Figdor, C.G.6    De Vries, I.J.7
  • 60
    • 43249130188 scopus 로고    scopus 로고
    • Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-a production
    • Meyer-Wentrup, F., D. Benitez-Ribas, P. J. Tacken, C. J. Punt, C. G. Figdor, I. J. De Vries, and G. J. Adema. 2008. Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-a production. Blood 111:4245-4253.
    • (2008) Blood , vol.111 , pp. 4245-4253
    • Meyer-Wentrup, F.1    Benitez-Ribas, D.2    Tacken, P.J.3    Punt, C.J.4    Figdor, C.G.5    De Vries, I.J.6    Adema, G.J.7
  • 66
    • 84887621720 scopus 로고    scopus 로고
    • Targeting of memory T cells with alefacept in newonset type 1 diabetes (T1DAL study):12 month results of a randomised, double-blind, placebo-controlled phase 2 trial
    • T1DAL Study Team
    • Rigby, M. R., L. A. Dimeglio, M. S. Rendell, E. I. Felner, J. M. Dostou, S. E. Gitelman, C. M. Patel, K. J. Griffin, E. Tsalikian, P. A. Gottlieb, et al; T1DAL Study Team. 2013. Targeting of memory T cells with alefacept in newonset type 1 diabetes (T1DAL study):12 month results of a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Diabetes Endocrinol. 1:284-294
    • (2013) Lancet Diabetes Endocrinol. , vol.1 , pp. 284-294
    • Rigby, M.R.1    Dimeglio, L.A.2    Rendell, M.S.3    Felner, E.I.4    Dostou, J.M.5    Gitelman, S.E.6    Patel, C.M.7    Griffin, K.J.8    Tsalikian, E.9    Gottlieb, P.A.10


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