Human plasmacytoid dendritic cells phagocytose, process, and present exogenous particulate antigen

Journal of Immunology

Volumn 184, Issue 8, 2010, Pages 4276-4283

  Tel, Jurjen ^a   Lambeck, Annechien J A ^a   Cruz, Luis J ^a   Tacken, Paul J ^a   De Vries, I Jolanda M ^a   Figdor, Carl G ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; B7 ANTIGEN; CD86 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; INTERLEUKIN 3; INTERLEUKIN 6; LIGAND; POLYGLACTIN; RESIQUIMOD; TETANUS TOXOID; BOVINE SERUM ALBUMIN; EPITOPE; GLYCOLIC ACID DERIVATIVE; POLY (LACTIC CO GLYCOLIC ACID); POLY (LACTIC-CO-GLYCOLIC ACID); TOLL LIKE RECEPTOR;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTATION; ARTICLE; CELL ACTIVATION; CELL POLARITY; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; INNATE IMMUNITY; LYMPHOCYTE PROLIFERATION; PARTICLE SIZE; PHAGOCYTOSIS; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; ANIMAL; BIOSYNTHESIS; CATTLE; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DENDRITIC CELL; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MEMBRANE MICROPARTICLE; METABOLISM; MICROCAPSULE;

ANIMALS; ANTIGEN PRESENTATION; CAPSULES; CATTLE; CELL DIFFERENTIATION; CELL-DERIVED MICROPARTICLES; CELLS, CULTURED; DENDRITIC CELLS; EPITOPES, T-LYMPHOCYTE; GLYCOLATES; HUMANS; INTERFERON-ALPHA; LIGANDS; LYMPHOCYTE ACTIVATION; PHAGOCYTOSIS; SERUM ALBUMIN, BOVINE; TETANUS TOXOID; TOLL-LIKE RECEPTORS;

EID: 77952774795     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0903286     Document Type: Article

References (51)

1. Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9: 271-296.
2. Villadangos, J. A., and L. Young. 2008. Antigen-presentation properties of plasmacytoid dendritic cells. Immunity 29: 352-361.
3. Piccioli, D., C. Sammicheli, S. Tavarini, S. Nuti, E. Frigimelica, A. G. Manetti, A. Nuccitelli, S. Aprea, S. Valentini, E. Borgogni, et al. 2009. Human plasmacytoid dendritic cells are unresponsive to bacterial stimulation and require a novel type of cooperation with myeloid dendritic cells for maturation. Blood 113: 4232-4239.
4. Schettini, J., and P. Mukherjee. 2008. Physiological role of plasmacytoid dendritic cells and their potential use in cancer immunity. Clin. Dev. Immunol. 2008: 106321.
5. Faith, A., E. Peek, J. McDonald, Z. Urry, D. F. Richards, C. Tan, G. Santis, and C. Hawrylowicz. 2007. Plasmacytoid dendritic cells from human lung cancer draining lymph nodes induce Tc1 responses. Am. J. Respir. Cell Mol. Biol. 36: 360-367.
6. Sinigaglia, F., D. D'Ambrosio, and L. Rogge. 1999. Type I interferons and the Th1/Th2 paradigm. Dev. Comp. Immunol. 23: 657-663.
7. Wenner, C. A., M. L. Güler, S. E. Macatonia, A. O'Garra, and K. M. Murphy. 1996. Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development. J. Immunol. 156: 1442-1447. (Pubitemid 26065854)
8. Parcina, M., C. Wendt, F. Goetz, R. Zawatzky, U. Zähringer, K. Heeg, and I. Bekeredjian-Ding. 2008. Staphylococcus aureus-induced plasmacytoid dendritic cell activation is based on an IgG-mediated memory response. J. Immunol. 181: 3823-3833.
9. Veckman, V., and I. Julkunen. 2008. Streptococcus pyogenes activates human plasmacytoid and myeloid dendritic cells. J. Leukoc. Biol. 83: 296-304.
10. Lou, Y., C. Liu, G. J. Kim, Y. J. Liu, P. Hwu, and G. Wang. 2007. Plasmacytoid dendritic cells synergize with myeloid dendritic cells in the induction of antigen-specific antitumor immune responses. J. Immunol. 178: 1534-1541. (Pubitemid 46154624)
11. Matsui, T., J. E. Connolly, M. Michnevitz, D. Chaussabel, C. I. Yu, C. Glaser, S. Tindle, M. Pypaert, H. Freitas, B. Piqueras, et al. 2009. CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions. J. Immunol. 182: 6815-6823.
12. Kim, R., M. Emi, K. Tanabe, and K. Arihiro. 2007. Potential functional role of plasmacytoid dendritic cells in cancer immunity. Immunology 121: 149-157. (Pubitemid 46663098)
13. Ito, T., M. Inaba, K. Inaba, J. Toki, S. Sogo, T. Iguchi, Y. Adachi, K. Yamaguchi, R. Amakawa, J. Valladeau, et al. 1999. A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells. J. Immunol. 163: 1409-1419. (Pubitemid 29352761)
14. Robinson, S. P., S. Patterson, N. English, D. Davies, S. C. Knight, and C. D. Reid. 1999. Human peripheral blood contains two distinct lineages of dendritic cells. Eur. J. Immunol. 29: 2769-2778.
15. Benitez-Ribas, D., G. J. Adema, G. Winkels, I. S. Klasen, C. J. Punt, C. G. Figdor, and I. J. de Vries. 2006. Plasmacytoid dendritic cells of melanoma patients present exogenous proteins to CD4+ T cells after Fc gamma RII-mediated uptake. J. Exp. Med. 203: 1629-1635.
16. Hoeffel, G., A. C. Ripoche, D. Matheoud, M. Nascimbeni, N. Escriou, P. Lebon, F. Heshmati, J. G. Guillet, M. Gannagé, S. Caillat-Zucman, et al. 2007. Antigen crosspresentation by human plasmacytoid dendritic cells. Immunity 27: 481-492. (Pubitemid 47418679)
17. Stent, G., J. C. Reece, D. C. Baylis, K. Ivinson, G. Paukovics, M. Thomson, and P. U. Cameron. 2002. Heterogeneity of freshly isolated human tonsil dendritic cells demonstrated by intracellular markers, phagocytosis, and membrane dye transfer. Cytometry 48: 167-176. (Pubitemid 34753631)
18. Dalgaard, J., K. J. Beckstrøm, F. L. Jahnsen, and J. E. Brinchmann. 2005. Differential capability for phagocytosis of apoptotic and necrotic leukemia cells by human peripheral blood dendritic cell subsets. J. Leukoc. Biol. 77: 689-698.
19. Grouard, G., M. C. Rissoan, L. Filgueira, I. Durand, J. Banchereau, and Y. J. Liu. 1997. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J. Exp. Med. 185: 1101-1111.
20. Waeckerle-Men, Y., E. Scandella, E. Uetz-Von Allmen, B. Ludewig, S. Gillessen, H. P. Merkle, B. Gander, and M. Groettrup. 2004. Phenotype and functional analysis of human monocyte-derived dendritic cells loaded with biodegradable poly(lactide-co-glycolide) microspheres for immunotherapy. J. Immunol. Methods 287: 109-124. (Pubitemid 38510213)
21. Waeckerle-Men, Y., and M. Groettrup. 2005. PLGA microspheres for improved antigen delivery to dendritic cells as cellular vaccines. Adv. Drug Deliv. Rev. 57: 475-482.
22. Wischke, C., J. Zimmermann, B. Wessinger, A. Schendler, H. H. Borchert, J. H. Peters, T. Nesselhut, and D. R. Lorenzen. 2009. Poly(I:C) coated PLGA microparticles induce dendritic cell maturation. Int. J. Pharm. 365: 61-68.
23. Xiang, S. D., K. Scalzo-Inguanti, G. Minigo, A. Park, C. L. Hardy, and M. Plebanski. 2008. Promising particle-based vaccines in cancer therapy. Expert Rev. Vaccines 7: 1103-1119.
24. Houghten, R. A., J. R. Appel, S. E. Blondelle, J. H. Cuervo, C. T. Dooley, and C. Pinilla. 1992. The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides. Biotechniques 13: 412-421.
25. Cruz, L. J., E. Iglesias, J. C. Aguilar, L. J. González, O. Reyes, F. Albericio, and D. Andreu. 2004. A comparative study of different presentation strategies for an HIV peptide immunogen. Bioconjug. Chem. 15: 112-120.
26. Jain, R. A. 2000. The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials 21: 2475-2490.
27. Benitez-Ribas, D., P. Tacken, C. J. Punt, I. J. de Vries, and C. G. Figdor. 2008. Activation of human plasmacytoid dendritic cells by TLR9 impairs Fc gammaRII-mediated uptake of immune complexes and presentation by MHC class II. J. Immunol. 181: 5219-5224.
28. Kumagai, Y., H. Kumar, S. Koyama, T. Kawai, O. Takeuchi, and S. Akira. 2009. Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-alpha production in plasmacytoid dendritic cells. J. Immunol. 182: 3960-3964.
29. Guiducci, C., G. Ott, J. H. Chan, E. Damon, C. Calacsan, T. Matray, K. D. Lee, R. L. Coffman, and F. J. Barrat. 2006. Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J. Exp. Med. 203: 1999-2008.
30. Meyer-Wentrup, F., D. Benitez-Ribas, P. J. Tacken, C. J. Punt, C. G. Figdor, I. J. de Vries, and G. J. Adema. 2008. Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production. Blood 111: 4245-4253.
31. Cella, M., F. Facchetti, A. Lanzavecchia, and M. Colonna. 2000. Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization. Nat. Immunol. 1: 305-310.
32. Moseman, E. A., X. Liang, A. J. Dawson, A. Panoskaltsis-Mortari, A. M. Krieg, Y. J. Liu, B. R. Blazar, and W. Chen. 2004. Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. J. Immunol. 173: 4433-4442.
33. Wei, S., I. Kryczek, L. Zou, B. Daniel, P. Cheng, P. Mottram, T. Curiel, A. Lange, and W. Zou. 2005. Plasmacytoid dendritic cells induce CD8+ regulatory T cells in human ovarian carcinoma. Cancer Res. 65: 5020-5026. (Pubitemid 40827308)
34. Yoshida, M., and J. E. Babensee. 2006. Molecular aspects of microparticle phagocytosis by dendritic cells. J. Biomater. Sci. Polym. Ed. 17: 893-907.
35. Cruz, L. J., P. J. Tacken, R. Fokkink, B. Joosten, M. Cohen Stuart, F. Albericio, R. Torensma, and C. G. Figdor. 2010. Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro. J. Control. Release. In press.
36. Schlosser, E., M. Mueller, S. Fischer, S. Basta, D. H. Busch, B. Gander, and M. Groettrup. 2008. TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses. Vaccine 26: 1626-1637.
37. Waeckerle-Men, Y., E. U. Allmen, B. Gander, E. Scandella, E. Schlosser, G. Schmidtke, H. P. Merkle, and M. Groettrup. 2006. Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells. Vaccine 24: 1847-1857. (Pubitemid 43238266)
38. Tacken, P. J., I. de Vries, K. Gijzen, B. Joosten, D. Wu, R. P. Rother, S. J. Faas, C. J. Punt, R. Torensma, G. J. Adema, and C. G. Figdor. 2005. Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody. Blood 106: 1278-1285.
39. Tacken, P. J., I. J. de Vries, R. Torensma, and C. G. Figdor. 2007. Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting. Nat. Rev. Immunol. 7: 790-802.
40. Zhang, J., A. Raper, N. Sugita, R. Hingorani, M. Salio, M. J. Palmowski, V. Cerundolo, and P. R. Crocker. 2006. Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors. Blood 107: 3600-3608.
41. Tacken, P. J., R. Torensma, and C. G. Figdor. 2006. Targeting antigens to dendritic cells in vivo. Immunobiology 211: 599-608. (Pubitemid 44241649)
42. Haining, W. N., J. Davies, H. Kanzler, L. Drury, T. Brenn, J. Evans, J. Angelosanto, S. Rivoli, K. Russell, S. George, et al. 2008. CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans. Clin. Cancer Res. 14: 5626-5634.
43. Molenkamp, B. G., P. A. van Leeuwen, S. Meijer, B. J. Sluijter, P. G. Wijnands, A. Baars, A. J. van den Eertwegh, R. J. Scheper, and T. D. de Gruijl. 2007. Intradermal CpG-B activates both plasmacytoid and myeloid dendritic cells in the sentinel lymph node of melanoma patients. Clin. Cancer Res. 13: 2961-2969.
44. Pashenkov, M., G. Goëss, C. Wagner, M. Hörmann, T. Jandl, A. Moser, C. M. Britten, J. Smolle, S. Koller, C. Mauch, et al. 2006. Phase II trial of a toll-like receptor 9-activating oligonucleotide in patients with metastatic melanoma. J. Clin. Oncol. 24: 5716-5724.
45. Salio, M., M. Cella, W. Vermi, F. Facchetti, M. J. Palmowski, C. L. Smith, D. Shepherd, M. Colonna, and V. Cerundolo. 2003. Plasmacytoid dendritic cells prime IFN-gamma-secreting melanoma-specific CD8 lymphocytes and are found in primary melanoma lesions. Eur. J. Immunol. 33: 1052-1062.
46. Chianese-Bullock, K. A., W. P. Irvin, Jr., G. R. Petroni, C. Murphy, M. Smolkin, W. C. Olson, E. Coleman, S. A. Boerner, C. J. Nail, P. Y. Neese, et al. 2008. A multipeptide vaccine is safe and elicits T-cell responses in participants with advanced stage ovarian cancer. J. Immunother. 31: 420-430.
47. Ito, T., R. Amakawa, M. Inaba, T. Hori, M. Ota, K. Nakamura, M. Takebayashi, M. Miyaji, T. Yoshimura, K. Inaba, and S. Fukuhara. 2004. Plasmacytoid dendritic cells regulate Th cell responses through OX40 ligand and type I IFNs. J. Immunol. 172: 4253-4259. (Pubitemid 38375238)
48. Salio, M., M. J. Palmowski, A. Atzberger, I. F. Hermans, and V. Cerundolo. 2004. CpG-matured murine plasmacytoid dendritic cells are capable of in vivo priming of functional CD8 T cell responses to endogenous but not exogenous antigens. J. Exp. Med. 199: 567-579.
49. Fonteneau, J. F., M. Gilliet, M. Larsson, I. Dasilva, C. Münz, Y. J. Liu, and N. Bhardwaj. 2003. Activation of influenza virus-specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity. Blood 101: 3520-3526.
50. Arpinati, M., G. Chirumbolo, B. Urbini, G. Perrone, D. Rondelli, and C. Anasetti. 2003. Role of plasmacytoid dendritic cells in immunity and tolerance after allogeneic hematopoietic stem cell transplantation. Transpl. Immunol. 11: 345-356.
51. Schnurr, M., Q. Chen, A. Shin, W. Chen, T. Toy, C. Jenderek, S. Green, L. Miloradovic, D. Drane, I. D. Davis, et al. 2005. Tumor antigen processing and presentation depend critically on dendritic cell type and the mode of antigen delivery. Blood 105: 2465-2472. (Pubitemid 40387047)