Total alkaloids of Rubus aleaefolius Poir inhibit hepatocellular carcinoma growth in vivo and in vitro via activation of mitochondrial-dependent apoptosis

International Journal of Oncology

Volumn 42, Issue 3, 2013, Pages 971-978

  Zhao, Jinyan ^a   Chen, Xuzheng ^a   Lin, Wei ^a   Wu, Guangwen ^a   Zhuang, Qunchuan ^a   Zhong, Xiaoyong ^a   Hong, Zhenfeng ^a   Peng, Jun ^a  

^a FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Apoptosis; Hepatocellular carcinoma; Mitochondrion; Total alkaloids of Rubus aleaefolius Poir

Indexed keywords

ALKALOID; CASPASE 3; LIPOCORTIN 5; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CANCER GROWTH; CANCER INHIBITION; CANCER SIZE; CANCER TISSUE; CELL STRUCTURE; COLORIMETRY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NICK END LABELING; NONHUMAN; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RUBUS; RUBUS ALEAEFOLIUS POIR; TREATMENT DURATION; TUMOR XENOGRAFT; WEIGHT GAIN;

ALKALOIDS; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; ENZYME ACTIVATION; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOCHONDRIA; NEOPLASM TRANSPLANTATION; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; ROSACEAE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84873692581     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.1779     Document Type: Article

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