Isoform-selective inhibition of facilitative glucose transporters: Elucidation of the molecular mechanism of HIV protease inhibitor binding

Journal of Biological Chemistry

Volumn 289, Issue 23, 2014, Pages 16100-16113

  Hresko, Richard C ^a   Kraft, Thomas E ^a   Tzekov, Anatoly ^a   Wildman, Scott A ^a   Hruz, Paul W ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; GLUCOSE; PROTEINS;

AMINO ACID RESIDUES; FUNCTIONAL INTEGRITIES; GLUCOSE TRANSPORTER 4; GLUCOSE TRANSPORTERS; HIV-PROTEASE INHIBITORS; MOLECULAR MECHANISM; TARGETED TREATMENT; TRANSMEMBRANE HELICES;

ENZYME INHIBITION;

DEOXYGLUCOSE; FLUORESCENT DYE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 4; HISTIDINE; INDINAVIR; ISOPROTEIN; N [2 [2 [2 [(N BIOTINYLCAPROYLAMINO)ETHOXY]ETHOXYL]]] 4 [[2 (TRIFLUOROMETHYL) 3H DIAZIRIN 3 YL]BENZOYL] 1,3 BIS(MANNOPYRANOSYL 4 YLOXY) 2 PROPYLAMINE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CHIMERA; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; FLUORESCENCE; INHIBITION KINETICS; MICROSOME; PHOTOAFFINITY LABELING; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN;

GLUCOSE TRANSPORT; HIV; HIV PROTEASE INHIBITOR; HOMOLOGY MODELING; INSULIN RESISTANCE; MONOSACCHARIDE TRANSPORT PROTEIN; PHOTOAFFINITY LABELING; PROTEIN CHIMERAS;

AMINO ACID SEQUENCE; CELL LINE; CLONING, MOLECULAR; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HIV PROTEASE INHIBITORS; HUMANS; INDINAVIR; PROTEIN ISOFORMS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84902193703     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.528430     Document Type: Article

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