Model of the exofacial substrate-binding site and helical folding of the human Glut1 glucose transporter based on scanning mutagenesis

Biochemistry

Volumn 48, Issue 25, 2009, Pages 5934-5942

  Mueckler, Mike ^a   Makepeace, Carol ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RESIDUES; AMINO ACID SUBSTITUTION; CYSTEINE RESIDUES; CYSTEINE-SCANNING MUTAGENESIS; GLUT1 GLUCOSE TRANSPORTER; HELICAL BUNDLE; HELICAL FOLDING; MUTANT PROTEINS; RELATIVE ORIENTATION; SIDE CHAINS; SINGLE MUTANT; SUBSTRATE BINDING; SUBSTRATE-BINDING SITES; SULFHYDRYL-SPECIFIC REAGENT; TRANSMEMBRANE HELICES; TRANSMEMBRANE SEGMENTS; TRANSPORT ACTIVITY; TRANSPORT FUNCTION; UPDATED MODEL; XENOPUS OOCYTE;

AMINATION; AMINES; AMINO ACIDS; BINDING ENERGY; BIOLOGICAL MEMBRANES; CELL MEMBRANES; GLUCOSE; MUTAGENESIS; ORGANIC ACIDS; SCANNING; SUBSTRATES;

BINDING SITES;

CYSTEINE; GLUCOSE TRANSPORTER 1; MUTANT PROTEIN;

ARTICLE; BINDING SITE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STABILITY; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; FEMALE; GLUCOSE TRANSPORTER TYPE 1; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PREDICTIVE VALUE OF TESTS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY; XENOPUS LAEVIS;

EID: 67649616342     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900521n     Document Type: Article

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