Effects of barbiturates on facilitative glucose transporters are pharmacologically specific and isoform selective

Journal of Membrane Biology

Volumn 169, Issue 1, 1999, Pages 45-53

  Haspel, H C ^a   Stephenson, K N ^a   Davies Hill, T ^b   El Barbary, A ^a   Lobo, J F ^a   Croxen, R L ^a   Mougrabi, W ^a   Koehler Stec, E M ^b   Fenstermacher, J D ^a   Simpson, I A ^b  

^a Anesthesia Research   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Anesthetics; Barbiturates; Binding; Glucose transport; Isoform selectivity; Pharmacologic specificity

Indexed keywords

3 METHYLGLUCOSE; ALCOHOL; ALLOBARBITAL; AMOBARBITAL; ANESTHETIC AGENT; BARBITURIC ACID DERIVATIVE; CARBON 14; DEOXYGLUCOSE; DESFLURANE; ENFLURANE; HALOGENATED HYDROCARBON; HALOTHANE; ISOFLURANE; METHOHEXITAL; METHOXYFLURANE; PENTOBARBITAL; SECOBARBITAL; THIAMYLAL; THIOBARBITAL; THIOPENTAL; TRITIUM;

ADIPOCYTE; ANESTHESIA MECHANISM; ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; CELL STRAIN 3T3; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ERYTHROCYTE MEMBRANE; FIBROBLAST; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; NONHUMAN;

3T3 CELLS; ANESTHETICS; ANIMALS; BARBITURATES; BIOLOGICAL TRANSPORT; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; HALOTHANE; HUMANS; HYDROCARBONS, HALOGENATED; ISOFLURANE; MICE; MONOSACCHARIDE TRANSPORT PROTEINS; RATS;

ANIMALIA; MAMMALIA; MURINAE; OXY; TRITIUM;

EID: 0032951946     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005900     Document Type: Article

References (32)

1. Arbuckle, M.I., Kane, S., Porter, L.M., Seatter, M.J., Gould, G.W. 1996. Structure-function analysis of liver-type (GLUT2) and brain-type (GLUT3) glucose transporters: Expression of chimeric transporters m Xenopus oocytes suggests an important role for putative transmembrane helix 7 in determining substrate selectivity. Biochemistry 35:16519-16527
2. Asano, T., Takata, K., Katagiri, II., Tsukuda, K., Lin, J-L., Ishihara, H., Inukai, K., Hirano, H., Yazaki, Y., Oka, Y. 1992. Domains responsible for the differential targeting of glucose transporter isoforms. J. Biol. Chem. 267:19636-19641
3. Baldwin, S.A. 1993. Mammalian passive glucose transporters: Members of an ubiquitous family of active and passive transport proteins. Biochim. Biophys. Acta 1154:7-49
4. Baldwin, S.A., Lienhard, G.E. 1989. Purification and reconstitution of glucose transporter from human erythrocytes. Methods Enzymol. 174:39-50
5. Buchs, A., Wu, L., Morita, H., Whitesell, R.R., Powers, A.C. 1995. Two regions of GLUT 2 glucose transporter protein are responsible for its distinctive affinity for glucose. Endocrinology 136:4224-4230
6. Carruthers, A. 1990. Facilitated diffusion of glucose. Physiol. Rev. 70:1135-1176
7. Craik, J.D., Elliot, K.R.F. 1979. Kinetics of 3-O-methyl-D-glucose transport in isolated rat hepatocytes. Biochem. J. 182:503-508
8. Eckenhoff, R.G., Johansson, J.S. 1997. Molecular interactions between inhaled anesthetics and proteins. Pharmacol. Rev. 49:343-367
9. El-Barbary, A., Fenstermacher, J.D., Haspel, H.C. 1996. Barbiturate inhibition of GLUT-1 mediated hexose transport in human erythrocytes exhibits substrate dependence for equilibrium exchange but not unidirectional sugar flux. Biochemistry 35:15222-15227
10. Fenstermacher, J.D., Wei, L., Acuff, V., Lin, S.-Z., Chen, J.-L., Bereczki, D., Otsuka, T., Nakata, II., Tajima, A., Hans, F.-J., Haspel, H., Patlak, C. 1995. The dependency of influx across the blood-brain barrier on blood flow and the apparent flow-independence of glucose influx during stress. In: New Concepts of a Blood-Brain-Barrier. J. Greenwood, editor. pp. 89-101. Plenum Press, New York
11. Firestone, L.L., Miller, J.C., Miller, K.W. 1986. Tables of physical and pharmacological properties of anesthetics. In: Molecular and Cellular Mechanisms of Anesthetics. S.H. Roth, K.W. Miller, editors. pp. 455-470. Plenum Medical Book, New York
12. Franks, N.P., Lieb, W.R. 1994. Molecular and cellular mechanisms of general anaesthesia. Nature 367:607-614
13. Gjedde, A., Rasmussen, M. 1980. Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat. J. Neurochem. 35:1382-1387
14. Gould, G.W., Holman, G.D. 1993. The glucose transporter family: Structure, function and tissue-specific expression. Biochem. J. 295:329-341
15. Harvey, S.C. 1985. Hypnotics and sedatives. In: Goodman and Gilman's The Pharmacological Basis of Therapeutics. Seventh Edition. A.G. Gilman, L.S. Goodman, T.W. Rall and F. Murad, editors. pp. 339-371. Macmillan Publishing, New York
16. Honkanen, R.A., McBath, H., Kushmerick, C., Callender, G.E., Scarlata, S.F., Fenstermacher, J.D., Haspel, II.C. 1995. Barbiturates inhibit hexose transport in cultured mammalian cells and human erythrocytes and interact directly with purified GLUT-1. Biochemistry 34:535-544
17. Hughes, S.D., Johnson, J.H., Quaade, C., Newgard, C.B. 1992. Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells. Proc. Natl. Acad. Sci. USA 89:688-692
18. Hulme, E.C., Birdsall, N.J.M. 1993. Strategy and tactics in receptor-binding studies. In: Receptor-Ligand Interactions. A Practical Approach, E.C. Hulme, editor. pp. 63-176. IRL Press, New York
19. Krauss, S.W., Diamond, I., Gordon, A.S. 1994. Selective inhibition by ethanol of the type 1 facilitative glucose transporter (GLUT1). Mol. Pharmacol. 45:1281-1286
20. Kutchai, H., Chandler, L.H., Geddis, L.M. 1980. Effects of anesthetic alcohols on membrane transport processes in human erythrocytes. Biochim. Biophys. Acta 600:870-881
21. Lakowicz, J.R. 1983. Quenching of fluorescence. In: Principles of Fluorescence Spectroscopy. Chapter 9. pp. 258-297. Plenum Press, New York
22. Maher, F., Davies-Hill, T.M., Lysko, P.G., Henneberry, R.C., Simpson, I.A. 1991. Expression of two glucose transporters, GLUT 1 and GLUT 3, in cultured cerebellar neurons: Evidence for neuron-specific expression of GLUT 3. Mol. Cell. Neurosci. 2:351-360
23. Maher, F., Davies-Hill, T.M., Simpson, I.A. 1996. Substrate specificity and kinetic parameters of GLUT3 in rat cerebellar granule neurons. Biochem. J. 315:827-831
24. Maher, F., Vannucci, S.J., Simpson, I.A. 1994. Glucose transporter proteins in brain. FASEB J. 8:1003-1011
25. Nakashima, M.D., Todd, M.M., Warner, D.S. 1995. The relationship between cerebral metabolic rate and ischemic depolarization: A comparison of the effects of hyperthermia, pentobarbital, and isoflurane. Anesthesiology 82:1199-1208
26. Otsuka, T., Wei, L., Bereczki, D., Acuff, V., Pallak, C., Fenstermacher, J.D. 1991. Pentobarbital produces dissimilar changes in glucose influx and utilization in brain. Am. J. Physiol. 261:R265-R275
27. Pardridge, W.M., Boado, R.J. 1993. Molecular cloning and regulation of gene expression of blood-brain barrier glucose transporter. In: The Blood-Brain Barrier: Cellular and Molecular Biology. W.M. Pardridge, editor, pp. 395-440. Raven Press, New York
28. Poole, R.K., Bashford, C.L. 1987. Spectra. In: Spectrophotometry and Spectrofluorimetry. A Practical Approach. C.L. Bashford, D.A. Harris, editors, pp. 23-48. IRL Press, Oxford
29. Richter, J.A., Waller, M.B. 1977. Effects of pentobarbital on the regulation of acetylcholine content and release in different regions of rat brain. Biochem. Pharmacol. 26:609-615
30. Silverman, M.S., Mynarcik, D.C., Corin, R.E., Haspel, H.C., Sonenberg, M. 1989. Antagonism by growth hormone of insulin-sensitive hexose transport in 3T3-F442A adipocytes. Endocrinology 125:2600-2604
31. Vannucci, S.J., Maher, F., Simpson, I.A. 1997. Glucose transporter proteins in brain: Delivery of glucose to neurons and glia. Glia 21:2-21
32. Weber, T.M., Joost, H.-G., Simpson, I.A., Cushman, S.W. 1988. Methods for assessment of glucose transport activity and the number of glucose transporters in isolated rat adipose cells and membrane fractions. In: Receptor Biochemistry and Methodology. Insulin Receptors, Vol. 12, Part B: Clinical Assessment, Biological Responses, and Comparison to the IGF-I Receptor. C.R. Kahn, L.C. Harrison, editors. pp. 171-187. Alan R. Liss, Inc., New York