Vitamin D levels in adults with Crohn's disease are responsive to disease activity and treatment

Inflammatory Bowel Diseases

Volumn 20, Issue 5, 2014, Pages 856-860

  Ham, Maggie ^a   Longhi, Maria S ^a   Lahiff, Conor ^a   Cheifetz, Adam ^a   Robson, Simon ^a   Moss, Alan C ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Crohn's disease; Infliximab; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; C REACTIVE PROTEIN; CD4 ANTIGEN; COLECALCIFEROL; INFLIXIMAB; VITAMIN D; VITAMIN D RECEPTOR; MONOCLONAL ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CROHN DISEASE; DISEASE ACTIVITY; DISEASE ACTIVITY SCORE; DISEASE DURATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOREACTIVITY; LYMPHOCYTE PROLIFERATION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REMISSION; SMOKING; T LYMPHOCYTE; TREATMENT RESPONSE; VITAMIN BLOOD LEVEL; BLOOD; CELL PROLIFERATION; DIET SUPPLEMENTATION; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; FOLLOW UP; METABOLISM; PATHOLOGY; PROGNOSIS; PROSPECTIVE STUDY; RISK FACTOR; VITAMIN D DEFICIENCY;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIBODIES, MONOCLONAL; C-REACTIVE PROTEIN; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CROHN DISEASE; DIETARY SUPPLEMENTS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FOLLOW-UP STUDIES; HUMANS; MALE; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84902151713     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0000000000000016     Document Type: Article

References (37)

1. Sentongo TA, Semaeo EJ, Stettler N, et al. Vitamin D status in children, adolescents, and young adults with Crohn disease. Am J Clin Nutr. 2002; 76:1077-1081.
2. Palmer MT, Weaver CT. Linking vitamin D deficiency to inflammatory bowel disease. In flamm Bowel Dis. 2013;19:2245-2256.
3. Sonnenberg A, McCarty DJ, Jacobsen SJ. Geographic variation of inflammatory bowel disease within the United States. Gastroenterology. 1991; 100:143-149.
4. Sonnenberg A, Jacobsen SJ, Wasserman IH. Periodicity of hospital admissions for inflammatory bowel disease. Am J Gastroenterol. 1994;89: 847-851.
5. Ananthakrishnan AN, Khalili H, Higuchi LM, et al. Higher predicted vitamin D status is associated with reduced risk of Crohn's disease. Gastroenterology. 2012;142:482-489.
6. Ulitsky A, Ananthakrishnan AN, Naik A, et al. Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life. JPEN J Parenter Enteral Nutr. 2011;35:308-316.
7. Ahuja V, Tandon RK. Inflammatory bowel disease in the Asia-Pacific area: a comparison with developed countries and regional differences. J Dig Dis. 2010;11:134-147.
8. Levin AD, Wadhera V, Leach ST, et al. Vitamin D deficiency in children with inflammatory bowel disease. Dig Dis Sci. 2011;56:830-836.
9. Yang L, Weaver V, Smith JP, et al. Therapeutic effect of vitamin d supplementation in a pilot study of Crohn's patients. Clin Transl Gastroenterol. 2013;4:e33.
10. Gottfried E, Rehli M, Hahn J, et al. Monocyte-derived cells express CYP27A1 and convert vitamin D3 into its active metabolite. Biochem Biophys Res Commun. 2006;349:209-213.
11. Moran-Auth Y, Penna-Martinez M, Shoghi F, et al. Vitamin D status and gene transcription in immune cells. J Steroid Biochem Mol Biol. 2013; 136:83-85.
12. Hewison M, Burke F, Evans KN, et al. Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease. J Steroid Biochem Mol Biol. 2007;103:316-321.
13. Yang CY, Leung PS, Adamopoulos IE, et al. The implication of vitamin D and autoimmunity: a comprehensive review. Clin Rev Allergy Immunol. 2013;45: 217-226.
14. Bartels LE, Jorgensen SP, Agnholt J, et al. 1,25-dihydroxyvitamin D3 and dexamethasone increase interleukin-10 production in CD4+ T cells from patients with Crohn's disease. Int Immunopharmacol. 2007;7:1755-1764.
15. Ramagopalan SV, Heger A, Berlanga AJ, et al. A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Res. 2010;20:1352-1360.
16. Penna G, Roncari A, Amuchastegui S, et al. Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4 +Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3. Blood. 2005; 106:3490-3497.
17. Bendix-Struve M, Bartels LE, Agnholt J, et al. Vitamin D3 treatment of Crohn's disease patients increases stimulated T cell IL-6 production and proliferation. Aliment Pharmacol Ther. 2010;32:1364-1372.
18. Stio M, Treves C, Martinesi M, et al. Effect of anti-TNF therapy and vitamin D derivatives on the proliferation of peripheral blood mononuclear cells in Crohn's disease. Dig Dis Sci. 2004;49:328-335.
19. von Essen MR, Kongsbak M, Schjerling P, et al. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol. 2010;11:344-349.
20. Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin Dmediated human antimicrobial response. Science. 2006;311:1770-1773.
21. Strisciuglio C, Miele E, Wildenberg ME, et al. T300A variant of autophagy ATG16L1 gene is associated with decreased antigen sampling and processing by dendritic cells in pediatric Crohn's disease. In flamm Bowel Dis. 2013;19:2339-2348.
22. Liu W, Chen Y, Golan MA, et al. Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis. J Clin Invest. 2013;123: 3983-3996.
23. Hassan V, Hassan S, Seyed-Javad P, et al. Association between serum 25 (OH) vitamin D concentrations and inflammatory bowel diseases (IBDs) activity. Med J Malaysia. 2013;68:34-38.
24. Harvey RF, Bradshaw MJ. Measuring Crohn's disease activity. Lancet. 1980;1:1134-1135.
25. Pandian R, Pandian J, Elias A. Clinical importance of bioavailable vitamin D: development and analytical validation of bioavailable 25 hydroxy vitamin D assay. Amer Assoc Clin Chem. 2013. Ref Type: Abstract.
26. Kunzli BM, Berberat PO, Dwyer K, et al. Variable impact of CD39 in experimental murine colitis. Dig Dis Sci. 2011;56:1393-1403.
27. Jorgensen SP, Hvas CL, Agnholt J, et al. Active Crohn's disease is associated with low vitamin D levels. J Crohns Colitis. 2013;7:e407-e413.
28. Tajika M, Matsuura A, Nakamura T, et al. Risk factors for vitamin D deficiency in patients with Crohn's disease. J Gastroenterol. 2004;39:527-533.
29. Nishida N, Sasaki M, Kurihara M, et al. Changes of energy metabolism, nutritional status and serum cytokine levels in patients with Crohn's disease after anti-tumor necrosis factor-alpha therapy. J Clin Biochem Nutr. 2013;53:122-127.
30. Wiese D, Lashner B, Seidner D. Measurement of nutrition status in Crohn's disease patients receiving infliximab therapy. Nutr Clin Pract. 2008;23:551-556.
31. Goswami R, Mondal AM, Tomar N, et al. Presence of 25(OH)D deficiency and its effect on vitamin D receptor mRNA expression. Eur J Clin Nutr. 2009;63:446-449.
32. Tuller T, Atar S, Ruppin E, et al. Common and specific signatures of gene expression and protein-protein interactions in autoimmune diseases. Genes Immun. 2013;14:67-82.
33. Edfeldt K, Liu PT, Chun R, et al. T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism. Proc Natl Acad Sci U S A. 2010;107:22593-22598.
34. Spanier JA, Nashold FE, Olson JK, et al. The Ifng gene is essential for Vdr gene expression and vitamin D(3)-mediated reduction of the pathogenic T cell burden in the central nervous system in experimental autoimmune encephalomyelitis, a multiple sclerosis model. J Immunol. 2012; 189:3188-3197.
35. Gyetko MR, Hsu CH, Wilkinson CC, et al. Monocyte 1 alphahydroxylase regulation: induction by inflammatory cytokines and suppression by dexamethasone and uremia toxin. J Leukoc Biol. 1993;54:17-22.
36. Almerighi C, Bergamini A, Lionetti R, et al. Vitamin D3 modulates T lymphocyte responses in hepatitis C virus-infected liver transplant recipients. Dig Liver Dis. 2012;44:67-73.
37. Correale J, Ysrraelit MC, Gaitan MI. Vitamin D-mediated immune regulation in multiple sclerosis. J Neurol Sci. 2011;311:23-31.