Variable impact of CD39 in experimental murine colitis

Digestive Diseases and Sciences

Volumn 56, Issue 5, 2011, Pages 1393-1403

  Künzli, Beat M ^a,b   Berberat, Pascal O ^b,c   Dwyer, Karen ^d   Deaglio, Silvia ^e   Csizmadia, Eva ^a   Cowan, Peter ^d   D'Apice, Anthony ^d   Moore, Gregory ^d   Enjyoji, Keiichi ^a   Friess, Helmut ^b   Robson, Simon C ^a,f  

^a HARVARD UNIVERSITY   (United States)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e UNIVERSITY OF TURIN   (Italy)

^f BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

CD39; Crohn's disease; Inflammatory bowel disease (IBD); Murine colitis; NTPDase1; P2 receptors; Purinergic signaling; Ulcerative colitis

Indexed keywords

ALCOHOL; CD39 ANTIGEN; GAMMA INTERFERON; MESSENGER RNA; OXAZOLONE; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN TISSUE; INTESTINE BIOPSY; LAMINA PROPRIA; MAJOR CLINICAL STUDY; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL; ULCERATIVE COLITIS;

ANIMALS; ANTIGENS, CD; APYRASE; COLITIS; COLON; CYTOKINES; HUMANS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, KNOCKOUT; OXAZOLONE; SPECIFIC PATHOGEN-FREE ORGANISMS; TRINITROBENZENESULFONIC ACID;

EID: 79955634114     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-010-1425-9     Document Type: Article

References (34)

1. Heller F, Fuss IJ, Nieuwenhuis EE, Blumberg RS, Strober W. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity. 2002;17:629-638. (Pubitemid 35351508)
2. Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology. 1998;115:182-205. (Pubitemid 28307304)
3. Loftus EV Jr. Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology. 2004;126:1504-1517.
4. Apte MV, Haber PS, Darby SJ, et al. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut. 1999;44:534-541. (Pubitemid 29169954)
5. Buell G, Lewis C, Collo G, North RA, Surprenant A. An antagonist-insensitive P2X receptor expressed in epithelia and brain. Embo J. 1996;15:55-62.
6. Burnstock G, Knight GE. Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol. 2004;240:31-304. (Pubitemid 39539202)
7. Dranoff JA, Kruglov EA, Robson SC, Braun N, Zimmermann H, Sevigny J. The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver. Hepatology. 2002;36:1135-1144. (Pubitemid 35253429)
8. Di Virgilio F, Solini A. P2 receptors: new potential players in atherosclerosis. Br J Pharmacol. 2002;135:831-842. (Pubitemid 34214442)
9. Hou M, Harden TK, Kuhn CM, et al. UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors. Am J Physiol Heart Circ Physiol. 2002;282:H784-792.
10. Atarashi K, Nishimura J, Shima T, et al. ATP drives lamina propria T(H)17 cell differentiation. Nature. 2008;455:808-812.
11. Enjyoji K, Sevigny J, Lin Y, et al. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nat Med. 1999;5:1010-1017. (Pubitemid 29439571)
12. Robson SEK, Goepfert C, Imai M, et al. Modulation of extracellular nucleotide-mediated signaling by CD39/nucleoside triphosphate diphosphohydrolase-1. Drug Dev Res. 2001;53:193-207. (Pubitemid 32845860)
13. Kaczmarek E, Koziak K, Sevigny J, et al. Identification and characterization of CD39/vascular ATP diphosphohydrolase. J Biol Chem. 1996;271:33116-33122. (Pubitemid 27008752)
14. Sevigny J, Sundberg C, Braun N, et al. Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation. Blood. 2002;99:2801-2809. (Pubitemid 34525368)
15. Kansas GS, Tedder TF. Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway. J Immunol. 1991;147:4094-4102.
16. Vrij AA, Rijken J, van Wersch JW, Stockbrugger RW. Coagulation and fibrinolysis in inflammatory bowel disease and in giant cell arteritis. Pathophysiol Haemost Thromb. 2003;33:75-83. (Pubitemid 37451780)
17. Mizumoto N, Kumamoto T, Robson SC, et al. CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness. Nat Med. 2002;8:358-365. (Pubitemid 34407030)
18. Takashima A, Mummert M, Kitajima T, Matsue H. New technologies to prevent and treat contact hypersensitivity responses. Ann NY Acad Sci. 2000;919:205-213.
19. Deaglio S, Dwyer KM, Gao W, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007;204:1257-1265. (Pubitemid 46919862)
20. Kunzli BM, Nuhn P, Enjyoji K, et al. Disordered pancreatic inflammatory responses and inhibition of fibrosis in CD39-null mice. Gastroenterology. 2008;134:292-305. (Pubitemid 350309325)
21. Matsuura M, Okazaki K, Nishio A, et al. Therapeutic effects of rectal administration of basic fibroblast growth factor on experimental murine colitis. Gastroenterology. 2005;128:975-986. (Pubitemid 40523548)
22. Boirivant M, Fuss IJ, Chu A, Strober W. Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med. 1998;188:1929-1939. (Pubitemid 28536780)
23. Kunzli BM, Berberat PO, Giese T, et al. Upregulation of CD39/NTPDases and P2 receptors in human pancreatic disease. Am J Physiol Gastrointest Liver Physiol. 2007;292:G223-230.
24. De Jong YP, Comiskey M, Kalled SL, et al. Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administration. Gastroenterology. 2000;119:715-723.
25. Bauer P, Russell JM, Granger DN. Role of endotoxin in intestinal reperfusion-induced expression of E-selectin. Am J Physiol. 1999;276:G479-484.
26. Atkinson B, Dwyer K, Enjyoji K, Robson SC. Ecto-nucleotidases of the CD39/NTPDase family modulate platelet activation and thrombus formation: potential as therapeutic targets. Blood Cells Mol Dis. 2006;36(2):217-222.
27. Dranoff JA, Ogawa M, Kruglov EA, et al. Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2004;287:G417-424.
28. Dwyer KM, Robson SC, Nandurkar HH, et al. Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation. J Clin Invest. 2004;113:1440-1446. (Pubitemid 39071699)
29. Friedman DJ, Kunzli BM YIAR, Sevigny J, et al. From the Cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease. Proc Natl Acad Sci USA. 2009;106:16788-16793.
30. Steinbrink K, Kolde G, Sorg C, Macher E. Induction of low zone tolerance to contact allergens in mice does not require functional Langerhans cells. J Invest Dermatol. 1996;107:243-247. (Pubitemid 26254841)
31. Fuss IJ, Heller F, Boirivant M, et al. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest. 2004;113:1490-1497. (Pubitemid 39071705)
32. Naganuma M, Wiznerowicz EB, Lappas CM, Linden J, Worthington MT, Ernst PB. Cutting edge: critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis. J Immunol. 2006;177:2765-2769. (Pubitemid 44277790)
33. Kolachala VL, Vijay-Kumar M, Dalmasso G, et al. A2B adenosine receptor gene deletion attenuates murine colitis. Gastroenterology. 2008;135:861-870.
34. Frick JS, MacManus CF, Scully M, Glover LE, Eltzschig HK, Colgan SP. Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis. J Immunol. 2009;182:4957-4964.