Vitamin D3 modulates T lymphocyte responses in hepatitis C virus-infected liver transplant recipients

Digestive and Liver Disease

Volumn 44, Issue 1, 2012, Pages 67-73

  Almerighi, Cristiana ^a   Bergamini, Alberto ^a   Lionetti, Raffaella ^b   Sinistro, Anna ^a   Lenci, Ilaria ^a   Tariciotti, Laura ^a   Tisone, Giuseppe ^a   Angelico, Mario ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

Author keywords

HCV; Immunosuppression; Liver transplant; T lymphocytes; Vitamin D3

Indexed keywords

25 HYDROXYVITAMIN D; CD3 ANTIGEN; COLECALCIFEROL; CYCLOSPORIN; TACROLIMUS; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL VIABILITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GRAFT RECIPIENT; HEPATITIS C; HEPATITIS C VIRUS RELATED CIRRHOSIS; HUMAN; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; LIVER CIRRHOSIS; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VITAMIN BLOOD LEVEL;

ADULT; AGED; CHOLECALCIFEROL; END STAGE LIVER DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; T-LYMPHOCYTES;

EID: 83855164112     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2011.08.010     Document Type: Article

References (33)

1. Adam R., McMaster P., O'Grady J.G., et al. Evolution of liver transplantation in Europe: report of the European Liver Transplant Registry. Liver Transpl 2003, 9:1231-1243.
2. Schirren C.A., Jung M., Worzfeld T., et al. Cytokine profile of liver- and blood-derived nonspecific T cells after liver transplantation: T helper cells type 1/0 lymphokines dominate in recurrent hepatitis C virus infection and rejection. Liver Transpl 2000, 6:222-228.
3. Martinez O.M., Krams S.M., Sterneck M., et al. Intragraft cytokine profile during human liver allograft rejection. Transplantation 1992, 53:449-456.
4. Gorczynski R.M., Adams R.B., Levy G.A., et al. Correlation of peripheral blood lymphocyte and intragraft cytokine mRNA expression with rejection in orthotopic liver transplantation. Surgery 1996, 120:496-502.
5. Mosmann T.R., Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996, 17:138-146.
6. Luscinskas F.W., Cybulsky M.I., Kiely J.M., et al. Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1. J Immunol 1991, 146:1617-1625.
7. Chollet-Martin S., Depoix J.P., Hvass U., et al. Raised plasma levels of tumor necrosis factor in heart allograft rejection. Transplant Proc 1990, 22:283-286.
8. Golshayan D., Buhler L., Lechler R.I., et al. From current immunosuppressive strategies to clinical tolerance of allografts. Transpl Int 2007, 20:12-24.
9. Rigby W.F., Noelle R.J., Krause K., et al. The effects of 1,25-dihydroxyvitamin D3 on human T lymphocyte activation and proliferation: a cell cycle analysis. J Immunol 1985, 135:2279-2286.
10. Rigby W.F., Denome S., Fanger M.W. Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA. J Clin Invest 1987, 79:1659-1664.
11. Lemire J.M. Immunomodulatory actions of 1,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol 1995, 53:599-602.
12. Thomasset M. Vitamin D and the immune system. Pathol Biol (Paris) 1994, 42:163-172.
13. Lemire J.M., Adams J.S., Sakai R., et al. 1Alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells. J Clin Invest 1984, 74:657-661.
14. Lemire J.M. Immunomodulatory role of 1,25-dihydroxyvitamin D3. J Cell Biochem 1992, 49:26-31.
15. Vanham G., Ceuppens J.L., Bouillon R. T lymphocytes and their CD4 subset are direct targets for the inhibitory effect of calcitriol. Cell Immunol 1989, 124:320-333.
16. Staeva-Vieira T.P., Freedman L.P. 1,25-Dihydroxyvitamin D3 inhibits IFN-gamma and IL-4 levels during in vitro polarization of primary murine CD4+ T cells. J Immunol 2002, 168:1181-1189.
17. Cantorna M.T., Hayes C.E., DeLuca H.F. 1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc Natl Acad Sci U S A 1996, 93:7861-7864.
18. Fournier C., Gepner P., Sadouk M., et al. In vivo beneficial effects of cyclosporin A and 1,25-dihydroxyvitamin D3 on the induction of experimental autoimmune thyroiditis. Clin Immunol Immunopathol 1990, 54:53-63.
19. Gregori S., Giarratana N., Smiroldo S., et al. A 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes 2002, 51:1367-1374.
20. Branisteanu D.D., Leenaerts P., van Damme B., et al. Partial prevention of active Heymann nephritis by 1alpha,25-dihydroxyvitamin D3. Clin Exp Immunol 1993, 94:412-417.
21. Hullett D.A., Cantorna M.T., Redaelli C., et al. Prolongation of allograft survival by 1,25-dihydroxyvitamin D3. Transplantation 1998, 66:824-828.
22. Redaelli C.A., Wagner M., Gunter-Duwe D., et al. 1Alpha,25-dihydroxyvitamin D3 shows strong and additive immunomodulatory effects with cyclosporine A in rat renal allotransplants. Kidney Int 2002, 61:288-296.
23. Gregori S., Casorati M., Amuchastegui S., et al. Regulatory T cells induced by 1alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol 2001, 167:1945-1953.
24. Redaelli C.A., Wagner M., Tien Y.H., et al. 1Alpha,25-Dihydroxycholecalciferol reduces rejection and improves survival in rat liver allografts. Hepatology 2001, 34:926-934.
25. Veyron P., Pamphile R., Binderup L., et al. Two novel vitamin D analogues, KH 1060 and CB 966, prolong skin allograft survival in mice. Transpl Immunol 1993, 1:72-76.
26. Platz K.P., Mueller A.R., Rossaint R., et al. Cytokine pattern during rejection and infection after liver transplantation-improvements in postoperative monitoring?. Transplantation 1996, 62:1441-1450.
27. Imagawa D.K., Millis J.M., Olthoff K.M., et al. The role of tumor necrosis factor in allograft rejection. I. Evidence that elevated levels of tumor necrosis factor-alpha predict rejection following orthotopic liver transplantation. Transplantation 1990, 50:219-225.
28. Vieth R. Vitamin D supplementation, 25 hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999, 69:842-856.
29. Monegal A., Navasa M., Guañabens N., et al. Osteoporosis and bone mineral metabolism disorders in cirrhotic patients referred for orthotopic liver transplantation. Calcif Tissue Int 1997, 60:148-154.
30. Masuda S., Okano T., Osawa K., et al. Concentrations of vitamin D-binding protein and vitamin D metabolites in plasma of patients with liver cirrhosis. J Nutr Sci Vitaminol (Tokyo) 1989, 35:225-234.
31. Bitetto D., Fabris C., Fornasiere E., et al. Vitamin D supplementation improves response to antiviral treatment for recurrent hepatitis C. Transpl Int 2011, 24:43-50.
32. Hypponen E., Laara E., Reunanen A., et al. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 2001, 358:1500-1503.
33. Stio M., Treves C., Celli A., et al. Synergistic inhibitory effect of cyclosporin A and vitamin D derivatives on T-lymphocyte proliferation in active ulcerative colitis. Am J Gastroenterol 2002, 97:679-689.