Is glutamine depletion needed in ALL disease?

Blood

Volumn 123, Issue 23, 2014, Pages 3532-3533

  Avramis, Vassilios I ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINASE; GLUTAMINASE; GLUTAMINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; CLONE; DNA SYNTHESIS; ENZYME ACTIVITY; ESCHERICHIA COLI; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANTINEOPLASTIC AGENTS; ASPARAGINASE; ASPARTATE-AMMONIA LIGASE; GLUTAMINASE; HUMANS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

EID: 84902140489     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-04-565523     Document Type: Review

References (10)

1. Chan WK, Lorenzi PL, Anishkin A, et al. The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells. Blood. 2014;123(23):3596-3606.
2. Avramis VI. Asparaginases: biochemical pharmacology and modes of drug resistance. Anticancer Res. 2012;32(7):2423-2437.
3. Willems L, Jacque N, Jacquel A, et al. Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia. Blood. 2013;122(20):3521-3532.
4. Gesto DS, Cerqueira NM, Fernandes PA, Ramos MJ. Unraveling the enigmatic mechanism of L-asparaginase II with QM/QM calculations. J Am Chem Soc. 2013;135(19): 7146-7158.
5. Palm GJ, Lubkowski J, Derst C, Schleper S, Röhm KH, Wlodawer A. A covalently bound catalytic intermediate in Escherichia coli asparaginase: crystalstructure of a Thr-89-Val mutant. FEBS Lett. 1996;390(2): 211-216. (Pubitemid 26281204)
6. Covini D, Tardito S, Bussolati O, et al. Expanding targets for a metabolic therapy of cancer: L-asparaginase. Recent Patents Anticancer Drug Discov. 2012;7(1):4-13.
7. Patel N, Krishnan S, Offman MN, et al. A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase. J Clin Invest. 2009; 119(7):1964-1973.
8. Fine BM, Kaspers GJ, Ho M, Loonen AH, Boxer LM. A genome-wide view of the in vitro response to l-asparaginase in acute lymphoblastic leukemia. Cancer Res. 2005;65(1):291-299. (Pubitemid 40070821)
9. Bunpo P, Cundiff JK, Reinert RB, Wek RC, Aldrich CJ, Anthony TG. The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase. J Nutr. 2010;140(11):2020-2027.
10. Ehsanipour EA, Sheng X, Behan JW, et al. Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine. Cancer Res. 2013;73(10):2998-3006.