메뉴 건너뛰기




Volumn 32, Issue 7, 2012, Pages 2423-2437

Asparaginases: Biochemical pharmacology and modes of drug resistance

Author keywords

Acute lymphoblastic leukemia; Amino acid; Antibody; Asparaginase; Asparagine synthetase; Clinical outcomes; Crystalline structures of proteins; Drug resistance; Epitopes; Glutamine synthetase; Review

Indexed keywords

ASPARAGINASE; ASPARTATE AMMONIA LIGASE; CATHEPSIN B; CLADRIBINE; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; DOXORUBICIN; FLUDARABINE; FLUOROURACIL; GEMCITABINE; GLUTAMATE AMMONIA LIGASE; GLUTAMINE; HLA A ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; IMATINIB; LEGUMAIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; METHOTREXATE; MYC PROTEIN; ORNITHINE DECARBOXYLASE; PHOSPHATIDYLINOSITOL 3 KINASE; PREDNISONE; PROTEIN BCL 2; RECOMBINANT DNA; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN C; T LYMPHOCYTE RECEPTOR; VINCRISTINE;

EID: 84865679567     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (87)

References (87)
  • 2
    • 33644798329 scopus 로고    scopus 로고
    • Childhood acute lymphoblastic leukaemia and relapse
    • Gaynon PS: Childhood acute lymphoblastic leukaemia and relapse. Br J Haematol 131(5): 579-587, 2005.
    • (2005) Br J Haematol , vol.131 , Issue.5 , pp. 579-587
    • Gaynon, P.S.1
  • 3
    • 70449700006 scopus 로고    scopus 로고
    • Toward a total cure for acute lymphoblastic leukemia
    • Pui CH: Toward a total cure for acute lymphoblastic leukemia. J Clin Oncol 27(31): 5121 -5123, 2009.
    • (2009) J Clin Oncol , vol.27 , Issue.31 , pp. 5121-5123
    • Pui, C.H.1
  • 6
    • 0033816156 scopus 로고    scopus 로고
    • ABL protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-KIT and platelet-derived growth factor receptors
    • Buchdunger E, Cioffi CL, Law N, Stover D, Ohno-Jones S, Druker BJ and Lydon NB. ABL protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-KIT and platelet-derived growth factor receptors. J Pharmacol Exp Ther 295(1): 139-145, 2000.
    • (2000) J Pharmacol Exp Ther , vol.295 , Issue.1 , pp. 139-145
    • Buchdunger, E.1    Cioffi, C.L.2    Law, N.3    Stover, D.4    Ohno-Jones, S.5    Druker, B.J.6    Lydon, N.B.7
  • 9
    • 8544279767 scopus 로고
    • Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum. II. Studies on the nature of the active serum constituent: Histological mechanism of the regression: \Tests for effects of guinea pig serum on lymphoma cells in vitro: discussion
    • Kidd JG: Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum. II. Studies on the nature of the active serum constituent: histological mechanism of the regression: \Tests for effects of guinea pig serum on lymphoma cells in vitro: discussion. J Exp Med 98(6): 583-606, 1953.
    • (1953) J Exp Med , vol.98 , Issue.6 , pp. 583-606
    • Kidd, J.G.1
  • 10
    • 75449142384 scopus 로고
    • Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects. I. Properties of the L-asparaginase of guinea pig serum in relation to those of the antilymphoma substance
    • Broome JD: Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects. I. Properties of the L-asparaginase of guinea pig serum in relation to those of the antilymphoma substance. J Exp Med 118: 99-120, 1963.
    • (1963) J Exp Med , vol.118 , pp. 99-120
    • Broome, J.D.1
  • 11
    • 0013837631 scopus 로고
    • Antilymphoma activity of L-asparaginase in vivo: Clearance rates of enzyme preparations from guinea pig serum and yeast in relation to their effect on tumor growth
    • Broome JD: Antilymphoma activity of L-asparaginase in vivo: clearance rates of enzyme preparations from guinea pig serum and yeast in relation to their effect on tumor growth. J Natl Cancer Inst 35(6): 967-974, 1965.
    • (1965) J Natl Cancer Inst , vol.35 , Issue.6 , pp. 967-974
    • Broome, J.D.1
  • 13
    • 18644364984 scopus 로고    scopus 로고
    • Pharmacokinetic/pharmacodynamic relationships of asparaginase formulations: The past, the present and recommendations for the future
    • DOI 10.2165/00003088-200544040-00003
    • Avramis VI and Panosyan EH: Pharmacokinetic/pharmacodynamic relationships of asparaginase formulations: the past, the present and recommendations for the future. Clin Pharmacokinet 44(4): 367-393, 2005. (Pubitemid 40663683)
    • (2005) Clinical Pharmacokinetics , vol.44 , Issue.4 , pp. 367-393
    • Avramis, V.I.1    Panosyan, E.H.2
  • 14
    • 33947600985 scopus 로고    scopus 로고
    • Pharmacodynamics and safety of intravenous pegaspargase during remission induction in adults aged 55 years or younger with newly diagnosed acute lymphoblastic leukemia
    • DOI 10.1182/blood-2006-07-035006
    • Douer D, Yampolsky H, Cohen LJ, Watkins K, Levine AM, Periclou AP and Avramis VI: Pharmacodynamics and safety of intravenous pegaspargase during remission induction in adults aged 55 years or younger with newly diagnosed acute lymphoblastic leukemia. Blood 109(7): 2744-2750, 2007. (Pubitemid 46482066)
    • (2007) Blood , vol.109 , Issue.7 , pp. 2744-2750
    • Douer, D.1    Yampolsky, H.2    Cohen, L.J.3    Watkins, K.4    Levine, A.M.5    Periclou, A.P.6    Avramis, V.I.7
  • 15
    • 0031865643 scopus 로고    scopus 로고
    • The synergism of 6-mercaptopurine plus cytosine arabinoside followed by PEG-Asparaginase in human leukemia cell lines (CCRF/CEM/0 and (CCRF/CEM/ara-C/7A) is due to increased cellular apoptosis
    • Nandy P, Periclou AP and Avramis VI: The synergism of 6-mercaptopurine plus cytosine arabinoside followed by PEG-asparaginase in human leukemia cell lines (CCRF/CEM/0 and (CCRF/CEM/ara-C/7A) is due to increased cellular apoptosis. Anticancer Res 18(2A): 727-737, 1998. (Pubitemid 28239587)
    • (1998) Anticancer Research , vol.18 , Issue.2 A , pp. 727-737
    • Nandy, P.1    Periclou, A.P.2    Avramis, V.I.3
  • 16
    • 0142039654 scopus 로고    scopus 로고
    • Strategies for detection, measurement and characterization of unwanted antibodies induced by therapeutic biologicals
    • DOI 10.1016/S0022-1759(03)00206-0
    • Wadhwa W, Bird C, Dilger P, Gaines-Das R and Thorpe R: Strategies for detection, measurement, and characterization of unwanted antibodies induced by therapeutic biologicals. J Immunol Methods 278: 1-17, 2003. (Pubitemid 37281188)
    • (2003) Journal of Immunological Methods , vol.278 , Issue.1-2 , pp. 1-17
    • Wadhwa, M.1    Bird, C.2    Dilger, P.3    Gaines-Das, R.4    Thorpe, R.5
  • 18
    • 0032920099 scopus 로고    scopus 로고
    • Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response
    • DOI 10.1016/S0014-5793(99)00373-7, PII S0014579399003737
    • Jousse C, Bruhat A, Harding HP, Ferrara M, Ron D and Fafournoux P: Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response. FEBS Lett 448(2-3): 211-216, 1999. (Pubitemid 29168490)
    • (1999) FEBS Letters , vol.448 , Issue.2-3 , pp. 211-216
    • Jousse, C.1    Bruhat, A.2    Harding, H.P.3    Ferrara, M.4    Ron, D.5    Fafournoux, P.6
  • 20
    • 0032834055 scopus 로고    scopus 로고
    • eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
    • DOI 10.1146/annurev.biochem.68.1.913
    • Gingras AC, Raught B and Sonenberg N: eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 68: 913-963, 1999. (Pubitemid 29449212)
    • (1999) Annual Review of Biochemistry , vol.68 , pp. 913-963
    • Gingras, A.-C.1    Raught, B.2    Sonenberg, N.3
  • 21
    • 11244314360 scopus 로고    scopus 로고
    • A genome-wide view of the in vitro response to L-asparaginase in acute lymphoblastic leukemia
    • Fine BM, Kaspers GJ, Ho M, Loonen AH and Boxer LM: A genome-wide view of the in vitro response to asparaginase in acute lymphoblastic leukemia. Cancer Res 65(1): 291-299, 2005. (Pubitemid 40070821)
    • (2005) Cancer Research , vol.65 , Issue.1 , pp. 291-299
    • Fine, B.M.1    Kaspers, G.J.L.2    Ho, M.3    Loonen, A.H.4    Boxer, L.M.5
  • 22
    • 0036856008 scopus 로고    scopus 로고
    • Translational control in the endoplasmic reticulum stress response
    • Ron D: Translational control in the endoplasmic reticulum stress response. J Clin Invest 110(10): 1383-1388, 2002.
    • (2002) J Clin Invest , vol.110 , Issue.10 , pp. 1383-1388
    • Ron, D.1
  • 23
    • 0035060610 scopus 로고    scopus 로고
    • Development of a double-drug-resistant human leukemia model to cytosine arabinoside and L-asparaginase: Evaluation of cross-resistance to other treatment modalities
    • Majlessipour F, Kwock R, Martin-Aragon S, Weinberg KI and Avramis VI: Development of a double-drug-resistant human leukemia model to cytosine arabinoside and L-asparaginase: evaluation of cross-resistance to other treatment modalities. Anticancer Res 21(1A): 11-22, 2001. (Pubitemid 32267619)
    • (2001) Anticancer Research , vol.21 , Issue.1 A , pp. 11-22
    • Majlessipour, F.1    Kwock, R.2    Martin-Aragon, S.3    Weinberg, K.I.4    Avramis, V.I.5
  • 24
    • 0036324014 scopus 로고    scopus 로고
    • The combination regimen of Idarubicin and Taxotere is effective against human drug-resistant leukemic cell lines
    • Majlessipour F, Avramis IA, Kwock R, Weinberg KI and Avramis VI: The combination regimen of idarubicin and taxotere is effective against human drug-resistant leukemic cell lines. Anticancer Res 22(3): 1361-1368, 2002. (Pubitemid 34839139)
    • (2002) Anticancer Research , vol.22 , Issue.3 , pp. 1361-1368
    • Majlessipour, F.1    Avramis, I.A.2    Kwock, R.3    Weinberg, K.I.4    Avramis, V.I.5
  • 25
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis RJ, Lum JJ, Hatzivassiliou G and Thompson CB: The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7(1): 11-20, 2008.
    • (2008) Cell Metab , vol.7 , Issue.1 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 26
    • 12944265179 scopus 로고    scopus 로고
    • Rapid induction of the intrinsic apoptotic pathway by L-glutamine starvation
    • DOI 10.1002/jcp.20194
    • Paquette, JC, Guérin, PJ, and Gauthier ER: Rapid Induction of the Intrinsic Apoptotic Pathway by L-Glutamine Starvation. J Cell Physiol 202: 912-921, 2005. (Pubitemid 40175869)
    • (2005) Journal of Cellular Physiology , vol.202 , Issue.3 , pp. 912-921
    • Paquette, J.C.1    Guerin, P.J.2    Gauthier, E.R.3
  • 27
    • 66149164593 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies
    • Teachey DT, Grupp SA and Brown VI.: Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies. Br J Haematol 145(5): 569-580, 2009.
    • (2009) Br J Haematol , vol.145 , Issue.5 , pp. 569-580
    • Teachey, D.T.1    Grupp, S.A.2    Brown, V.I.3
  • 29
    • 30444446961 scopus 로고    scopus 로고
    • The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia
    • DOI 10.1182/blood-2005-07-2930
    • Holleman A, den Boer ML, de Menezes RX, Cheok MH, Cheng C, Kazemier KM, Janka-Schaub GE, Göbel U, Graubner UB, Evans WE and Pieters R: The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia. Blood 107(2): 769-776, 2006. (Pubitemid 43076404)
    • (2006) Blood , vol.107 , Issue.2 , pp. 769-776
    • Holleman, A.1    Den, B.M.L.2    De Menezes, R.X.3    Cheok, M.H.4    Cheng, C.5    Kazemier, K.M.6    Janka-Schaub, G.E.7    Gobel, U.8    Graubner, U.B.9    Evans, W.E.10    Pieters, R.11
  • 30
    • 34147153377 scopus 로고    scopus 로고
    • Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase
    • DOI 10.1172/JCI30235
    • Iwamoto S, Mihara K, Downing JR, Pui CH and Campana D: Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase. J Clin Invest 117(4): 1049-1057, 2007. (Pubitemid 46556761)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.4 , pp. 1049-1057
    • Iwamoto, S.1    Mihara, K.2    Downing, J.R.3    Pui, C.-H.4    Campana, D.5
  • 32
    • 80052854761 scopus 로고    scopus 로고
    • L-Asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of β-catenin-mutated human hepatocellular carcinoma cells
    • Tardito S, Chiu M, Uggeri J, Zerbini A, Da Ros F, Dall'Asta V, Missale G and Bussolati O: L-Asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of β-catenin-mutated human hepatocellular carcinoma cells. Curr Cancer Drug Targets 11(8): 929-943, 2011.
    • (2011) Curr Cancer Drug Targets , vol.11 , Issue.8 , pp. 929-943
    • Tardito, S.1    Chiu, M.2    Uggeri, J.3    Zerbini, A.4    Da Ros, F.5    Dall'Asta, V.6    Missale, G.7    Bussolati, O.8
  • 33
    • 0017090511 scopus 로고
    • Physical properties of antitumor glutaminase-asparaginase from Pseudomonas 7A
    • Holcenberg JS and Teller DC: Physical properties of antitumor glutaminase-asparaginase from Pseudomonas 7A. J Biol Chem 251(17): 5375-5380, 1976.
    • (1976) J Biol Chem , vol.251 , Issue.17 , pp. 5375-5380
    • Holcenberg, J.S.1    Teller, D.C.2
  • 34
    • 15044340295 scopus 로고    scopus 로고
    • Epigenetic changes in the repression and induction of asparagine synthetase in human leukemic cell lines
    • DOI 10.1038/sj.leu.2403639
    • Ding Y, Li Z and Broome JD: Epigenetic changes in the repression and induction of asparagine synthetase in human leukemic cell lines. Leukemia 19(3): 420-426, 2005. (Pubitemid 40403320)
    • (2005) Leukemia , vol.19 , Issue.3 , pp. 420-426
    • Ding, Y.1    Li, Z.2    Broome, J.D.3
  • 35
    • 0024341467 scopus 로고
    • DNA methylation patterns associated with asparagine synthetase expression in asparagine-overproducing and -auxotrophic cells
    • Andrulis IL and Barrett MT: DNA methylation patterns associated with asparagine synthetase expression in asparagine-overproducing and -auxotrophic cells. Mol Cell Biol 9(7): 2922-2927, 1989. (Pubitemid 19163055)
    • (1989) Molecular and Cellular Biology , vol.9 , Issue.7 , pp. 2922-2927
    • Andrulis, I.L.1    Barrett, M.T.2
  • 36
    • 0027299874 scopus 로고
    • Cis- and trans-acting elements involved in amino acid regulation of asparagine synthetase gene expression
    • Guerrini L, Gong SS, Mangasarian K and Basilico C: Cis- and trans-acting elements involved in amino acid regulation of asparagine synthetase gene expression. Mol Cell Biol 13(6): 3202-3212 & 3234-3237, 1993.
    • (1993) Mol Cell Biol , vol.13 , Issue.6
    • Guerrini, L.1    Gong, S.S.2    Mangasarian, K.3    Basilico, C.4
  • 37
    • 0034282704 scopus 로고    scopus 로고
    • Activation of the human asparagine synthetase gene by the amino acid response and the endoplasmic reticulum stress response pathways occurs by common genomic elements
    • Barbosa-Tessmann IP, Chen C, Zhong C, Siu F, Schuster SM, Nick HS and Kilberg MS: Activation of the human asparagine synthetase gene by the amino acid response and the endoplasmic reticulum stress response pathways occurs by common genomic elements. J Biol Chem 275(35): 26976-26785, 2000.
    • (2000) J Biol Chem , vol.275 , Issue.35 , pp. 26976-126785
    • Barbosa-Tessmann, I.P.1    Chen, C.2    Zhong, C.3    Siu, F.4    Schuster, S.M.5    Nick, H.S.6    Kilberg, M.S.7
  • 38
    • 0037025396 scopus 로고    scopus 로고
    • ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene
    • DOI 10.1074/jbc.M201959200
    • Siu F, Bain PJ, LeBlanc-Chaffin R, Chen H and Kilberg MS: ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. J Biol Chem 277(27): 24120-24127, 2002. (Pubitemid 34951925)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.27 , pp. 24120-24127
    • Siu, F.1    Bain, P.J.2    Leblanc-Chaffin, R.3    Chen, H.4    Kilberg, M.S.5
  • 39
    • 0026066607 scopus 로고
    • Regulation of Asparagine Synthetase Gene Expression by Amino Acid Starvation
    • Gong SS, Guerrini L and Basilico C: Regulation of asparagine synthetase gene expression by amino acid starvation. Mol Cell Biol 11(12): 6059-6066, 1991. (Pubitemid 21895377)
    • (1991) Molecular and Cellular Biology , vol.11 , Issue.12 , pp. 6059-6066
    • Gong, S.S.1    Guerrini, L.2    Basilico, C.3
  • 40
    • 0027299874 scopus 로고
    • cis- and trans-Acting elements involved in amino acid regulation of asparagine synthetase gene expression
    • Guerrini L, Gong SS, Mangasarian K and Basilico C: Cis- and trans-acting elements involved in amino acid regulation of asparagine synthetase gene expression. Mol Cell Biol 13(6): 3202-3212, 1993. (Pubitemid 23157258)
    • (1993) Molecular and Cellular Biology , vol.13 , Issue.6 , pp. 3202-3212
    • Guerrini, L.1    Gong, S.S.2    Mangasarian, K.3    Basilico, C.4
  • 41
    • 1842841753 scopus 로고    scopus 로고
    • Changes of amino acid serum levels in pediatrics patients with higher-risk acute lymphoblastic leukemia (CCG-1961)
    • Grigoryan RS, Panosyan EH, Seibel NL, Gaynon PS, Avramis IA and Avramis VI: Changes of amino acid serum levels in pediatric patients with higher-risk acute lymphoblastic leukemia (CCG-1961). In Vivo 18(2): 107-112, 2004. (Pubitemid 38488992)
    • (2004) In Vivo , vol.18 , Issue.2 , pp. 107-112
    • Grigoryan, R.S.1    Panosyan, E.H.2    Seibel, N.L.3    Gaynon, P.S.4    Avramis, I.A.5    Avramis, V.I.6
  • 42
    • 34247176698 scopus 로고    scopus 로고
    • Clinical pharmacology of asparaginases in the United States: Asparaginase population pharmacokinetic and pharmacodynamic (PK-PD) models (NONMEM) in adult and pediatric ALL patients
    • DOI 10.1097/MPH.0b013e318047b79d, PII 0004342620070400000007
    • Avramis VI and Spence SA: Clinical pharmacology of asparaginases in the United States: asparaginase population pharmacokinetic and pharmacodynamic (PK-PD) models (NONMEM) in adult and pediatric ALL patients. J Pediatr Hematol Oncol 29(4): 239-247, 2007. (Pubitemid 46597688)
    • (2007) Journal of Pediatric Hematology/Oncology , vol.29 , Issue.4 , pp. 239-247
    • Avramis, V.I.1    Spence, S.A.2
  • 43
    • 34547811078 scopus 로고    scopus 로고
    • Pharmacoanalytical assays of Erwinia asparaginase (Erwinase) and pharmacokinetic results in high-risk acute lymphoblastic leukemia (HR ALL) patients: Simulations of Erwinase population PK-PD models
    • Avramis VI, Martin-Aragon S, Avramis EV and Asselin BL: Pharmacoanalytical assays of Erwinia asparaginase (erwinase) and pharmacokinetic results in high-risk acute lymphoblastic leukemia (HR ALL) patients: simulations of erwinase population PK-PD models. Anticancer Res 27(4C): 2561-2572, 2007. (Pubitemid 47227966)
    • (2007) Anticancer Research , vol.27 , Issue.4 C , pp. 2561-2572
    • Avramis, V.I.1    Martin-Aragon, S.2    Avramis, E.V.3    Asselin, B.L.4
  • 44
    • 0031681258 scopus 로고    scopus 로고
    • Anti-asparaginase antibodies following E. coli asparaginase therapy in pediatric acute lymphoblastic leukemia
    • Woo MH, Hak LJ, Storm MC, Evans WE, Sandlund JT, Rivera GK, Wang B, Pui CH and Relling M: Anti-asparaginase antibodies following E. coli asparaginase therapy in pediatric acute lymphoblastic leukemia. Leukemia 12(10): 1527-1533, 1998. (Pubitemid 28470435)
    • (1998) Leukemia , vol.12 , Issue.10 , pp. 1527-1533
    • Woo, M.H.1    Hak, L.J.2    Storm, M.C.3    Evans, W.E.4    Sandlund, J.T.5    Rivera, G.K.6    Wang, B.7    Pui, C.-H.8    Relling, M.V.9
  • 46
    • 0041520550 scopus 로고    scopus 로고
    • Evaluation of immunologic crossreaction of antiasparaginase antibodies in acute lymphoblastic leukemia (ALL) and lymphoma patients
    • DOI 10.1038/sj.leu.2403011
    • Wang B, Relling MV, Storm MC, Woo MH, Ribeiro R, Pui CH and Hak LJ: Evaluation of immunologic cross-reaction of antiasparaginase antibodies in acute lymphoblastic leukemia (ALL) and lymphoma patients. Leukemia 17(8): 1583-1588, 2003. (Pubitemid 36992159)
    • (2003) Leukemia , vol.17 , Issue.8 , pp. 1583-1588
    • Wang, B.1    Relling, M.V.2    Storm, M.C.3    Woo, M.H.4    Ribeiro, R.5    Pui, C.-H.6    Hak, L.J.7
  • 49
    • 84987500362 scopus 로고
    • 2nd edn. Academic Press, New York
    • Meiser A (Ed.).: Biochemistry of Amino Acids, 2nd edn. Vol. 1. Academic Press, New York, pp. 457-460 1965.
    • (1965) Biochemistry of Amino Acids , vol.1 , pp. 457-460
    • Meiser, A.1
  • 51
    • 0015523863 scopus 로고
    • Glutamine-dependent asparagine synthetase from leukemia cells. Chloride dependence, mechanism of action, and inhibition
    • Horowitz B and Meister A: Glutamine-dependent asparagine synthetase from leukemia cells. Chloride dependence, mechanism of action, and inhibition. J Biol Chem 247(20): 6708-6719, 1972.
    • (1972) J Biol Chem , vol.247 , Issue.20 , pp. 6708-6719
    • Horowitz, B.1    Meister, A.2
  • 52
    • 0035873421 scopus 로고    scopus 로고
    • Structural basis for the activity and substrate specificity of Erwinia chrysanthemi L-asparaginase
    • DOI 10.1021/bi0029595
    • Aghaiypour K, Wlodawer A and Lubkowski J: Structural basis for the activity and substrate specificity of Erwinia chrysanthemi L-asparaginase. Biochemistry 40(19): 5655-5664, 2001. (Pubitemid 32440869)
    • (2001) Biochemistry , vol.40 , Issue.19 , pp. 5655-5664
    • Aghaiypour, K.1    Wlodawer, A.2    Lubkowski, J.3
  • 53
    • 33845649780 scopus 로고    scopus 로고
    • l-Asparaginase from Erwinia Chrysanthemi 3937: Cloning, expression and characterization
    • DOI 10.1016/j.jbiotec.2006.07.037, PII S0168165606006912
    • Kotzia GA and Labrou NE: L-Asparaginase from Erwinia chrysanthemi 3937: cloning, expression and characterization. J Biotechnol 127(4): 657-669, 2007. (Pubitemid 44959113)
    • (2007) Journal of Biotechnology , vol.127 , Issue.4 , pp. 657-669
    • Kotzia, G.A.1    Labrou, N.E.2
  • 56
    • 4143063669 scopus 로고    scopus 로고
    • Asparaginase pharmacokinetics after intensive polyethylene glycol-conjugated L-asparaginase therapy for children with relapsed acute lymphoblastic leukemia
    • DOI 10.1158/1078-0432.CCR-04-0222
    • Hawkins DS, Park JR, Thomson BG, Felgenhauer JL, Holcenberg JS, Panosyan EH and Avramis VI: Asparaginase pharmacokinetics after intensive polyethylene glycol-conjugated L-asparaginase therapy for children with relapsed acute lymphoblastic leukemia. Clin Cancer Res 10(16): 5335-5341, 2004. (Pubitemid 39100468)
    • (2004) Clinical Cancer Research , vol.10 , Issue.16 , pp. 5335-5341
    • Hawkins, D.S.1    Park, J.R.2    Thomson, B.G.3    Felgenhauer, J.L.4    Holcenberg, J.S.5    Panosyan, E.H.6    Avramis, Y.I.7
  • 57
    • 33745765204 scopus 로고    scopus 로고
    • Asparagine depletion after pegylated E. coli asparaginase treatment and induction outcome in children with acute lymphoblastic leukemia in first bone marrow relapse: A Children's Oncology Group Study (CCG-1941)
    • DOI 10.1002/pbc.20713
    • Jarrar M, Gaynon PS, Periclou AP, Fu C, Harris RE, Stram D, Altman A, Bostrom B, Breneman J, Steele D, Trigg M, Zipf T and Avramis VI: Asparagine depletion after pegylated E. coli asparaginase treatment and induction outcome in children with acute lymphoblastic leukemia in first bone marrow relapse: a Children's Oncology Group study (CCG-1941). Pediatr Blood Cancer 47(2): 141-146, 2006. (Pubitemid 44025245)
    • (2006) Pediatric Blood and Cancer , vol.47 , Issue.2 , pp. 141-146
    • Jarrar, M.1    Gaynon, P.S.2    Periclou, A.P.3    Fu, C.4    Harris, R.E.5    Stram, D.6    Altman, A.7    Bostrom, B.8    Breneman, J.9    Steele, D.10    Trigg, M.11    Zipf, T.12    Avramis, V.I.13
  • 58
    • 43049143059 scopus 로고    scopus 로고
    • HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway
    • DOI 10.1152/physiolgenomics.00263.2007
    • Lee JI, Dominy JE Jr., Sikalidis AK, Hirschberger LL, Wang W and Stipanuk MH: HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway. Physiol Genomics 33(2): 218-229, 2008. (Pubitemid 351629530)
    • (2008) Physiological Genomics , vol.33 , Issue.2 , pp. 218-229
    • Lee, J.-I.1    Dominy Jr., J.E.2    Sikalidis, A.K.3    Hirschberger, L.L.4    Wang, W.5    Stipanuk, M.H.6
  • 59
    • 34548550698 scopus 로고    scopus 로고
    • Genetic alterations determine chemotherapy resistance in childhood T-ALL: Modelling in stage-specific cell lines and correlation with diagnostic patient samples
    • DOI 10.1111/j.1365-2141.2007.06763.x
    • Estes DA, Lovato DM, Khawaja HM, Winter SS and Larson RS: Genetic alterations determine chemotherapy resistance in childhood T-ALL: modelling in stage-specific cell lines and correlation with diagnostic patient samples. Br J Haematol 139(1): 20-30, 2007. (Pubitemid 47389934)
    • (2007) British Journal of Haematology , vol.139 , Issue.1 , pp. 20-30
    • Estes, D.A.1    Lovato, D.M.2    Khawaja, H.M.3    Winter, S.S.4    Larson, R.S.5
  • 60
    • 13544256602 scopus 로고    scopus 로고
    • Up-regulation of asparagine synthetase and cell cycle arrest in t(12;21)-positive ALL
    • author reply: 319-321, 2005
    • Stams WA, den Boer ML, Beverloo HB, van Wering ER and Pieters R: Up-regulation of asparagine synthetase and cell cycle arrest in t(12;21)-positive ALL. Leukemia 19(2): 318-319, 2005; author reply: 319-321, 2005.
    • (2005) Leukemia , vol.19 , Issue.2 , pp. 318-319
    • Stams, W.A.1    Den Boer, M.L.2    Beverloo, H.B.3    Van Wering, E.R.4    Pieters, R.5
  • 61
    • 33744497255 scopus 로고    scopus 로고
    • Up-regulation of asparagine synthetase expression is not linked to the clinical response to L-asparaginase in pediatric acute lymphoblastic leukemia
    • DOI 10.1182/blood-2005-06-2597
    • Appel IM, den Boer ML, Meijerink JP, Veerman AJ, Reniers NC and Pieters R: Up-regulation of asparagine synthetase expression is not linked to the clinical response L-asparaginase in pediatric acute lymphoblastic leukemia. Blood 107(11): 4244-4249, 2006. (Pubitemid 43801347)
    • (2006) Blood , vol.107 , Issue.11 , pp. 4244-4249
    • Appel, I.M.1    Den, B.M.L.2    Meijerink, J.P.P.3    Veerman, A.J.P.4    Reniers, N.C.M.5    Pieters, R.6
  • 63
    • 0027414441 scopus 로고
    • Asparaginase revisited
    • Capizzi RL: Asparaginase revisited. Leuk Lymphoma 10 Suppl: 147-150, 1993.
    • (1993) Leuk Lymphoma , vol.10 , Issue.SUPPL. , pp. 147-150
    • Capizzi, R.L.1
  • 64
    • 0035672697 scopus 로고    scopus 로고
    • Comparison of intramuscular therapy with Erwinia asparaginase and asparaginase Medac: Pharmacokinetics, pharmacodynamics, formation of antibodies and influence on the coagulation system
    • DOI 10.1046/j.1365-2141.2001.03148.x
    • Albertsen BK, Schrøder H, Ingerslev J, Jakobsen P, Avramis VI, Müller HJ, Carlsen NT and Schmiegelow K: Comparison of intramuscular therapy with Erwinia asparaginase and asparaginase Medac: pharmacokinetics, pharmacodynamics, formation of antibodies and influence on the coagulation system. Br J Haematol 115(4): 983-990, 2001. (Pubitemid 34042920)
    • (2001) British Journal of Haematology , vol.115 , Issue.4 , pp. 983-990
    • Albertsen, B.K.1    Schroder, H.2    Ingerslev, J.3    Jakobsen, P.4    Avramis, V.I.5    Muller, H.-J.6    Carlsen, N.T.7    Schmiegelow, K.8
  • 66
    • 61449179384 scopus 로고    scopus 로고
    • Immunogenicity of native or pegylated E. coli and Erwinia asparaginases assessed by ELISA and surface plasmon resonance (SPR-biacore) assays of IgG antibodies (Ab) in sera from patients with acute lymphoblastic leukemia (ALL)
    • Avramis VI, Avramis EV, Hunter W and Long MC: Immunogenicity of native or pegylated E. coli and Erwinia asparaginases assessed by ELISA and surface plasmon resonance (SPR-biacore) assays of IgG antibodies (Ab) in sera from patients with acute lymphoblastic leukemia (ALL). Anticancer Res 29(1): 299-302, 2009.
    • (2009) Anticancer Res , vol.29 , Issue.1 , pp. 299-302
    • Avramis, V.I.1    Avramis, E.V.2    Hunter, W.3    Long, M.C.4
  • 67
    • 34548776939 scopus 로고    scopus 로고
    • Asparaginase (native ASNase or pegylated ASNase) in the treatment of acute lymphoblastic leukemia
    • Avramis VI and Tiwari PN: Asparaginase (native ASNase or pegylated ASNase) in the treatment of acute lymphoblastic leukemia. Int J Nanomedicine 1(3): 241-254, 2006.
    • (2006) Int J Nanomedicine , vol.1 , Issue.3 , pp. 241-254
    • Avramis, V.I.1    Tiwari, P.N.2
  • 68
    • 0028136892 scopus 로고
    • Erwinia chrysanthemi L-asparaginase: Epitope mapping and production of antigenically modified enzymes
    • Moola ZB, Scawen MD, Atkinson T and Nicholls DJ: Erwinia chrysanthemi L-asparaginase: epitope mapping and production of antigenically modified enzymes. Biochem J 302 (Pt 3): 921-927, 1994. (Pubitemid 24289334)
    • (1994) Biochemical Journal , vol.302 , Issue.3 , pp. 921-927
    • Moola, Z.B.1    Scawen, M.D.2    Atkinson, T.3    Nicholls, D.J.4
  • 69
    • 26844525474 scopus 로고    scopus 로고
    • Mapping of B-cell epitopes in E. coli asparaginase II, an enzyme used in leukemia treatment
    • DOI 10.1515/BC.2005.063
    • Werner A, Röhm KH and Müller HJ: Mapping of B-cell epitopes in E. coli asparaginase II, an enzyme used in leukemia treatment. Biol Chem 386(6): 535-540, 2005. (Pubitemid 41460232)
    • (2005) Biological Chemistry , vol.386 , Issue.6 , pp. 535-540
    • Werner, A.1    Rohm, K.-H.2    Muller, H.-J.3
  • 70
    • 0026684162 scopus 로고
    • Allergic reactions to Erwinia asparaginase in children with acute lymphoblastic leukemia who had previous allergic reactions to Escherichia coli asparaginase
    • Billett AL, Carls A, Gelber RD and Sallan SE: Allergic reactions to Erwinia asparaginase in children with acute lymphoblastic leukemia who had previous allergic reactions to Escherichia coli asparaginase. Cancer 70(1): 201-206, 1992.
    • (1992) Cancer , vol.70 , Issue.1 , pp. 201-206
    • Billett, A.L.1    Carls, A.2    Gelber, R.D.3    Sallan, S.E.4
  • 72
    • 0028136892 scopus 로고
    • Erwinia chrysanthemi L-asparaginase: Epitope mapping and production of antigenically modified enzymes
    • Scawen MD, Atkinson T and Nicholls DJ: Erwinia chrysanthemi L-asparaginase: epitope mapping and production of antigenically modified enzymes. Biochem J 302(Pt 3): 921-927, 1994. (Pubitemid 24289334)
    • (1994) Biochemical Journal , vol.302 , Issue.3 , pp. 921-927
    • Moola, Z.B.1    Scawen, M.D.2    Atkinson, T.3    Nicholls, D.J.4
  • 73
    • 0018851598 scopus 로고
    • The primary structure of L-asparaginase from Escherichia coli
    • Maita T and Matsuda G: The primary structure of L-asparaginase from Escherichia coli . Hoppe Seylers Z Physiol Chem 361(2): 105-117, 1980. (Pubitemid 10122209)
    • (1980) Journal of Biological Chemistry , vol.255 , Issue.4 , pp. 105-117
    • Maita, T.1    Matsuda, G.2
  • 75
    • 80455158087 scopus 로고    scopus 로고
    • Asparaginases: A successful class of drugs against leukemias and lymphomas
    • Avramis VI: Asparaginases: a successful class of drugs against leukemias and lymphomas. J Pediatr Hematol Oncol 33(8): 573-579, 2011.
    • (2011) J Pediatr Hematol Oncol , vol.33 , Issue.8 , pp. 573-579
    • Avramis, V.I.1
  • 76
    • 0034284267 scopus 로고    scopus 로고
    • Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: A pediatric oncology group study
    • Abshire TC, Pollock BH, Billett AL, Bradley P and Buchanan GR: Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a Pediatric Oncology Group Study. Blood 96(5): 1709-1715, 2000. (Pubitemid 30661053)
    • (2000) Blood , vol.96 , Issue.5 , pp. 1709-1715
    • Abshire, T.C.1    Pollock, B.H.2    Billett, A.L.3    Bradley, P.4    Buchanan, G.R.5
  • 77
    • 77955602245 scopus 로고    scopus 로고
    • Structure-function relationships and clinical applications of L-asparaginases
    • Labrou NE, Papageorgiou AC and Avramis VI: Structure-function relationships and clinical applications of L-asparaginases. Curr Med Chem 17(20): 2183-2195, 2010.
    • (2010) Curr Med Chem , vol.17 , Issue.20 , pp. 2183-2195
    • Labrou, N.E.1    Papageorgiou, A.C.2    Avramis, V.I.3
  • 78
    • 79551625096 scopus 로고    scopus 로고
    • Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity
    • Offman MN, Krol M, Patel N, Krishnan S, Liu J, Saha V and Bates PA: Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity. Blood 117(5): 1614-1621, 2011.
    • (2011) Blood , vol.117 , Issue.5 , pp. 1614-1621
    • Offman, M.N.1    Krol, M.2    Patel, N.3    Krishnan, S.4    Liu, J.5    Saha, V.6    Bates, P.A.7
  • 79
    • 79953267172 scopus 로고    scopus 로고
    • Site-saturation mutagenesis: A powerful tool for structure-based design of combinatorial mutation libraries
    • Chapter 26:Unit 26.6 Feb
    • Chronopoulou EG and Labrou NE: Site-saturation mutagenesis: a powerful tool for structure-based design of combinatorial mutation libraries. Curr Protoc Protein Sci. Chapter 26:Unit 26.6 Feb; 2011.
    • (2011) Curr Protoc Protein Sci
    • Chronopoulou, E.G.1    Labrou, N.E.2
  • 81
    • 80455131078 scopus 로고    scopus 로고
    • In silico Engineering of L-Asparaginase to Have Reduced Glutaminase Side Activity for Effective Treatment of Acute Lymphoblastic Leukemia
    • Ramya LN, Mukesh D, Rekha PB and Pulicherla KK: In silico Engineering of L-Asparaginase to Have Reduced Glutaminase Side Activity for Effective Treatment of Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol 33(8): 617-621, 2011.
    • (2011) J Pediatr Hematol Oncol , vol.33 , Issue.8 , pp. 617-621
    • Ramya, L.N.1    Mukesh, D.2    Rekha, P.B.3    Pulicherla, K.K.4
  • 83
    • 80455158077 scopus 로고    scopus 로고
    • Polyethylene glycol-conjugated L-asparaginase versus native L-asparaginase in combination with standard agents for children with acute lymphoblastic leukemia in second bone marrow relapse: A Children's Oncology Group Study (POG 8866)
    • Kurtzberg J, Asselin B, Bernstein M, Buchanan GR, Pollock BH and Camitta BM: Polyethylene glycol-conjugated L-asparaginase versus native L-asparaginase in combination with standard agents for children with acute lymphoblastic leukemia in second bone marrow relapse: a Children's Oncology Group Study (POG 8866). J Pediatr Hematol Oncol 33(8): 610-616, 2011.
    • (2011) J Pediatr Hematol Oncol , vol.33 , Issue.8 , pp. 610-616
    • Kurtzberg, J.1    Asselin, B.2    Bernstein, M.3    Buchanan, G.R.4    Pollock, B.H.5    Camitta, B.M.6
  • 84
    • 84865681125 scopus 로고    scopus 로고
    • Administration of Erwinia asparaginase (Erwinase®) following allergy to PEG-asparaginase in children and young adults with acute lymphoblastic leukemia treated on AALL07P2 achieves therapeutic Nadir serum asparaginase activity: A report from the children's oncology group (COG)
    • Abstr# 2134, presented in December at ASH-2010, Orlando, FL, Blood, November 19
    • Salzer W, Asselin B, Supko J, Devidas M, Kaiser N, Plourde PV, Winick N, Reaman G, Raetz E, Carroll W and Hunger S: Administration of Erwinia asparaginase (Erwinase®) following allergy to PEG-asparaginase in children and young adults with acute lymphoblastic leukemia treated on AALL07P2 achieves therapeutic Nadir serum asparaginase activity: A report from the children's oncology group (COG). In: Proceedings of 52nd ASH Annual Meeting and Exposition, Abstr# 2134, presented in December at ASH-2010, Orlando, FL, Blood, November 19, 116, p. 882, 2010.
    • (2010) Proceedings of 52nd ASH Annual Meeting and Exposition , vol.116 , pp. 882
    • Salzer, W.1    Asselin, B.2    Supko, J.3    Devidas, M.4    Kaiser, N.5    Plourde, P.V.6    Winick, N.7    Reaman, G.8    Raetz, E.9    Carroll, W.10    Hunger, S.11
  • 85
    • 33846219021 scopus 로고    scopus 로고
    • Mathematical modeling as accounting: Predicting the fate of serum proteins and therapeutic monoclonal antibodies
    • Gurbaxani B: Mathematical modeling as accounting: Predicting the fate of serum proteins and therapeutic monoclonal antibodies. Clin Immunol 122(2): 121-124, 2007.
    • (2007) Clin Immunol , vol.122 , Issue.2 , pp. 121-124
    • Gurbaxani, B.1
  • 86
    • 4043152040 scopus 로고    scopus 로고
    • Isolation of high-affinity human IgE and IgG antibodies recognising Bet v 1 and Humicola lanuginosa lipase from combinatorial phage libraries
    • DOI 10.1016/j.molimm.2004.05.009, PII S0161589004001993
    • Jakobsen CG, Bodtger U, Kristensen P, Poulsen LK and Roggen EL: Isolation of high-affinity human IgE and IgG antibodies recognising Bet v 1 and Humicola lanuginosa lipase from combinatorial phage libraries. Mol Immunol 41(10): 941-953, 2004. (Pubitemid 39070323)
    • (2004) Molecular Immunology , vol.41 , Issue.10 , pp. 941-953
    • Jakobsen, C.G.1    Bodtger, U.2    Kristensen, P.3    Poulsen, L.K.4    Roggen, E.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.