The glutaminase activity of L- Asparaginase is not required for anticancer activity against ASNS-negative cells

Blood

Volumn 123, Issue 23, 2014, Pages 3596-3606

  Chan, Wai Kin ^a   Lorenzi, Philip L ^a   Anishkin, Andriy ^b   Purwaha, Preeti ^a   Rogers, David M ^c   Sukharev, Sergei ^d   Rempe, Susan B ^c   Weinstein, John N ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c SANDIA NATIONAL LABORATORIES   (United States)

^d Bldg 142   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINASE; ASPARAGINE; ASPARTATE AMMONIA LIGASE; ASPARTIC ACID; GLUTAMIC ACID; GLUTAMINE; Q59 ASPARAGINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; COLORIMETRY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; EXPRESSION VECTOR; FUNCTIONAL GENOMICS; GENE SILENCING; LEUKEMIA CELL LINE; LIQUID CHROMATOGRAPHY; MOLECULAR DYNAMICS; MUTAGENESIS; NONHUMAN; OVARIAN CANCER CELL LINE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; TANDEM MASS SPECTROMETRY; UPREGULATION; WESTERN BLOTTING; WILD TYPE; WOLINELLA SUCCINOGENES;

ANTINEOPLASTIC AGENTS; ASPARAGINASE; ASPARTATE-AMMONIA LIGASE; DRUG RESISTANCE, NEOPLASM; ESCHERICHIA COLI; GLUTAMINASE; HUMANS; K562 CELLS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RECOMBINANT PROTEINS; TUMOR CELLS, CULTURED;

EID: 84902196856     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-10-535112     Document Type: Article

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