GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia

Leukemia

Volumn 28, Issue 6, 2014, Pages 1259-1270

  Maroz, A ^a   Stachorski, L ^a   Emmrich, S ^a   Reinhardt, K ^a   Xu, J ^b,c,d   Shao, Z ^b,c,d   Kabler S ^a   Dertmann, T ^a   Hitzler, J ^e   Roberts, I ^f   Vyas, P ^g,h   Juban, G ^g,h   Hennig, C ^a   Hansen, G ^a   Li, Z ⁱ   Orkin, S ^b,c,d   Reinhardt, D ^a   Klusmann, J H ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g UNIVERSITY OF OXFORD   (United Kingdom)

^h OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

ⁱ BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Down syndrome; E2F; eosinophilia; GATA1s; MYC

Indexed keywords

CD123 ANTIGEN; CD15 ANTIGEN; CD16 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; GATA1S PROTEIN; MYC PROTEIN; THY 1 ANTIGEN; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR GATA 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CLONE; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN SYNDROME; EOSINOPHIL; EOSINOPHIL COUNT; EOSINOPHILIA; GENE MUTATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA; LEUKEMIA CELL; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROMYELOCYTE; STEM CELL; TRANSIENT LEUKEMIA; DISEASE ASSOCIATION; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; DOWN SYNDROME; EOSINOPHILIA; GATA1 TRANSCRIPTION FACTOR; HEMATOPOIETIC STEM CELLS; HUMANS; INFANT; INFANT, NEWBORN; LEUKEMIA, MYELOID, ACUTE; MICE; MUTATION; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 84902119138     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.373     Document Type: Article

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