Transient leukemia with extreme basophilia in a phenotypically normal infant with blast cells containing a pseudodiploid clone, 46,XY i(21)(q10)

Journal of Pediatric Hematology/Oncology

Volumn 21, Issue 1, 1999, Pages 63-66

  Worth, Laura L ^a   Zipursky, Alvin ^b   Christensen, Hilary ^b   Tubergen, David ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Basophilia; Isochromosome (21)(q10); Megakaryoblastic leukemia; Transient leukemia

Indexed keywords

ACUTE MEGAKARYOCYTIC LEUKEMIA; ARTICLE; BASOPHILIA; BONE MARROW BIOPSY; CASE REPORT; CHROMOSOME 21Q; CHROMOSOME ANALYSIS; CLINICAL FEATURE; DIAGNOSTIC APPROACH ROUTE; ELECTRON MICROSCOPY; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE LOCATION; GENE LOCUS; HUMAN; ISOCHROMOSOME; LABORATORY TEST; MALE; MEGAKARYOBLAST; NEWBORN; PRIORITY JOURNAL; RISK FACTOR; SERODIAGNOSIS; TRISOMY 21;

EID: 0033036383     PISSN: 10774114     EISSN: None     Source Type: Journal    
DOI: 10.1097/00043426-199901000-00014     Document Type: Article

References (13)

1. Jones GR, Weaver M, Laug WE. Transient blastemia in phenotypically normal newborn. Am J Pediatr Hematol Oncol 1987;9:153-7.
2. Heaton DC, Fitzgerald PH, Fraser GJ, et al. Transient leukemoid proliferation of the cytogenetically unbalanced +21 cell line of a constitutional mosaic boy. Blood 1981;57:883-7.
3. Van Dan Berghe H, Vermaelen K, Broeckaert-Van Orshoven A, et al. Pentasomy 21 characterizing spontaneously regressing congenital acute leukemia. Cancer Genet Cytogenet 1983;9:19-24.
4. Hanna MD, Melvin SL, Dow LW, et al. Transient myeloproliferative syndrome in a phenotypically normal infant. Am J Pediatr Hematol Oncol 1985;7:79-81.
5. Doyle J, Thorner P, Poon A. Transient leukemia followed by megakaryoblastic leukemia in a child with mosaic Down syndrome. Leuk Lymphoma 1995;17:345-50.
6. Kalousek DK, Chan CW. Transient myeloproliferative disorder in chromosomally normal newborn infant. Med Pediatr Oncol 1987;15:38-41.
7. Ridgway T, Benda GI, Magenis E, et al. Transient myeloproliferative disorder of the Down type in the normal newborn. Am J Dis Child 1990;144:1117-9.
8. Faed MJW, Robertson J, Todd AS et al. Trisomy 21 in transient myeloproliferative disorder. Cancer Genet Cytogenet 1990;48: 259-64.
9. Zipursky A, Doyle J, Christensen H, et al. Leukemic cells in the transient leukemia of Down syndrome [abstract]. Blood 1992;80:32a.
10. Suda T, Suda J, Miura Y, et al. Clonal analysis of basophil differentiation in bone marrow cultures froma a Down's syndrome patient with megakaryoblastic leukemia. Blood 1985;66:1278-83.
11. Zipursky A, Brown E, Christensen H, et al. Leukemia and/or myeloproliferative syndrome in neonates with Down syndrome. Semin Perinatol 1997;21:97-101.
12. Lazarus KH, Heerema NA, Palmer CG, et al. The myeloproliferative reaction in a child with Down syndrome: cytological and chromosomal evidence for a transient leukemia. Am J Hematol 1981;11:417-23.
13. Zipursky A, Poon A, Doyle J. Leukemia in Down syndrome: a review. Pediatr Hematol Oncol 1992;9:139-49.