Janus kinase mutations in the development of acute megakaryoblastic leukemia in children with and without Down's syndrome [12]

Leukemia

Volumn 21, Issue 7, 2007, Pages 1584-1587

  Klusmann, J H ^a,b   Reinhardt, D ^b   Hasle, H ^c   Kaspers, G J ^d   Creutzig, U ^e   Hahlen, K ^f   van den Heuvel Eibrink, M M ^a   Zwaan, C M ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^e UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^f DUTCH CHILDHOOD ONCOLOGY GROUP   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; JANUS KINASE 2; JANUS KINASE 3;

ACUTE MEGAKARYOCYTIC LEUKEMIA; AMINO ACID SUBSTITUTION; AUTOLOGOUS STEM CELL TRANSPLANTATION; BONE MARROW CELL; CARCINOGENESIS; CHILD; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CYTOGENETICS; DOWN SYNDROME; GENE MUTATION; HUMAN; HUMAN CELL; INFANT; LETTER; LEUKEMIA CELL; LEUKEMIA RELAPSE; LEUKOCYTE COUNT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 34250733916     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404694     Document Type: Letter

References (8)

1. Hasle H. Pattern of malignant disorders in individuals with Down's syndrome. Lancet Oncol 2001; 2: 429-436.
2. Creutzig U, Reinhardt D, Diekamp S, Dworzak M, Stary J, Zimmermann M. AML patients with Down syndrome have a high cure rate with AML-BFM therapy with reduced dose intensity. Leukemia 2005; 19: 1355-1360.
3. Hollanda LM, Lima CS, Cunha AF, Albuquerque DM, Vassallo J, Ozelo MC et al. An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis. Nat Genet 2006; 38: 807-812.
4. Li Z, Godinho FJ, Klusmann JH, Garriga-Canut M, Yu C, Orkin SH. Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet 2005; 37: 613-619.
5. Goemans BF, Zwaan CM, Miller M, Zimmermann M, Harlow A, Meshinchi S et al. Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia. Leukemia 2005; 19 1536-1542.
6. Walters DK, Mercher T, Gu TL, O'Hare T, Tyner JW, Loriaux M et al. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell 2006; 10: 65-75.
7. Mercher T, Wernig G, Moore SA, Levine RL, Gu TL, Frohling S et al. JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model. Blood 2006; 108: 2770-2779.
8. Kiyoi H, Yamaji S, Kojima S, Naoe T. JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults. Leukemia 2007; 21: 574-576.