Suppression of heat shock protein 27 using OGX-427 induces endoplasmic reticulum stress and potentiates heat shock protein 90 inhibitors to delay castrate-resistant prostate cancer

European Urology

Volumn 66, Issue 1, 2014, Pages 145-155

  Lamoureux, François ^a   Thomas, Christian ^a   Yin, Min Jean ^b   Fazli, Ladan ^a   Zoubeidi, Amina ^a   Gleave, Martin E ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b PFIZER INC   (United States)

Author keywords

Androgen receptor; Castration resistant prostate cancer; Hsp27; Hsp90 inhibition; OGX 427

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ANDROGEN RECEPTOR; APATORSEN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PF 04929113; PROSTATE SPECIFIC ANTIGEN; PROTEIN KINASE B; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BENZOQUINONE DERIVATIVE; FUSED HETEROCYCLIC RINGS; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; MACROCYCLIC LACTAM; MOLECULAR CHAPERONE GRP78; OGX-427; OLIGONUCLEOTIDE; RNA; SNX 2112; TANESPIMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER SIZE; CANCER SURVIVAL; CASTRATION RESISTANT PROSTATE CANCER; CELL DEATH; CELL GROWTH; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG POTENTIATION; DRUG TARGETING; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LNCAP CELL LINE; MALE; MOUSE; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; DRUG EFFECTS; ENDOPLASMIC RETICULUM; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGICAL STRESS; PHYSIOLOGY; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; SURVIVAL RATE; TUMOR CELL LINE; UNFOLDED PROTEIN RESPONSE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOQUINONES; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HSP27 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MALE; MICE; OLIGONUCLEOTIDES; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; RNA; STRESS, PHYSIOLOGICAL; SURVIVAL RATE; TRANSCRIPTION FACTOR CHOP; UNFOLDED PROTEIN RESPONSE;

EID: 84902083706     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2013.12.019     Document Type: Article

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