Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton

Leukemia

Volumn 28, Issue 6, 2014, Pages 1289-1298

  Knudsen, P B ^a,b   Hanna, B ^a   Ohl, S ^a   Sellner, L ^a,c   Zenz, T ^a,c   Dohner H ^d   Stilgenbauer, S ^d   Larsen, T O ^b   Lichter, P ^a   Seiffert, M ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF ULM   (Germany)

Author keywords

chronic lymphocytic leukemia; cytochalasan; cytoskeleton; drug screening; microenvironment; migration

Indexed keywords

ANTILEUKEMIC AGENT; CD40 LIGAND; CHAETOGLOBOSIN A; FLUDARABINE; FUNGAL EXTRACT; IBRUTINIB; IDELALISIB; PLERIXAFOR; PROTEIN P53; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ACTIN POLYMERIZATION; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL ACTIVATION; CELL CYCLE ARREST; CELL DIVISION; CELL MIGRATION; CELL SURVIVAL; CELL VIABILITY; CHROMOSOME 17P; CHRONIC LYMPHATIC LEUKEMIA; COCULTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSKELETON; DNA REPLICATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; FLOW CYTOMETRY; FUNGAL STRAIN; GENE DELETION; GENE MUTATION; HUMAN; IN VITRO STUDY; LD 50; LEUKEMIA CELL LINE; LYMPHOID TISSUE; NONHUMAN; PENICILLIUM AQUAMARINIUM; PRIORITY JOURNAL; TARGET CELL; BONE MARROW CELL; CANCER PROGNOSIS; CELL CYCLE G2 PHASE; CELL PROLIFERATION; DRUG SCREENING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN CELL; LEUKEMIA CELL; MASS SPECTROMETRY; PENICILLIUM; PERIPHERAL BLOOD MONONUCLEAR CELL; STROMA CELL;

ACTINS; APOPTOSIS; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CELL ADHESION; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COCULTURE TECHNIQUES; CYTOKINESIS; CYTOSKELETON; FLOW CYTOMETRY; FUNGI; HEALTHY VOLUNTEERS; HUMANS; INDOLE ALKALOIDS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MYCOTOXINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STROMAL CELLS; TUMOR CELLS, CULTURED;

EID: 84902078299     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.360     Document Type: Article

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