Bio-activity and dereplication-based discovery of ophiobolins and other fungal secondary metabolites targeting leukemia cells

Molecules

Volumn 18, Issue 12, 2013, Pages 14629-14650

  Bladt, Tanja Thorskov ^a   Durr, Claudia ^b   Knudsen, Peter Boldsen ^a   Kildgaard, Sara ^a   Frisvad, Jens Christian ^a   Gotfredsen, Charlotte Held ^a   Seiffert, Martina ^b   Larsen, Thomas Ostenfeld ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Cancer; Cytotoxic; Dereplication; Explorative solid phase extraction (E SPE); Filamentous fungi; Leukemia; Natural products; Ophiobolin U

Indexed keywords

BIOLOGICAL PRODUCT; OPHIOBOLINS; SESTERTERPENE;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; FRACTIONATION; FUNGUS; HUMAN; LEUKEMIA; METABOLISM; SOLID PHASE EXTRACTION; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

APOPTOSIS; BIOLOGICAL PRODUCTS; CELL LINE, TUMOR; CELL SURVIVAL; CHEMICAL FRACTIONATION; DRUG SCREENING ASSAYS, ANTITUMOR; FUNGI; HUMANS; LEUKEMIA; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SESTERTERPENES; SOLID PHASE EXTRACTION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84890946411     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules181214629     Document Type: Article

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