How the microenvironment shapes chronic lymphocytic leukemia: The cytoskeleton connection

Leukemia and Lymphoma

Volumn 51, Issue 8, 2010, Pages 1371-1374

  Scielzo, Cristina ^a,c   Ten Hacken, Elisa ^a   Bertilaccio, Maria T S ^a   Muzio, Marta ^a   Calissano, Carlo ^a   Ghia, Paolo ^a,b   Caligaris Cappio, Federico ^a,b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

CLL; Cytoskeleton; Microenviroment

Indexed keywords

B LYMPHOCYTE RECEPTOR; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; GUANOSINE TRIPHOSPHATASE; HEMATOPOIETIC CELL SPECIFIC LYN SUBSTRATE 1; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN CDC42; PROTEIN KINASE ZAP 70; RAC1 PROTEIN; SECONDARY LYMPHOID TISSUE CHEMOKINE; TUMOR MARKER; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4;

ANTIGEN RECOGNITION; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL ADHESION; CELL MOTILITY; CELL SHAPE; CELLULAR IMMUNITY; CHRONIC LYMPHATIC LEUKEMIA; CYTOSKELETON; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE HOMING; LYMPHOCYTE MIGRATION; MICROENVIRONMENT; MOLECULAR INTERACTION; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

BLOOD PROTEINS; CELL MOVEMENT; CELL SHAPE; CYTOSKELETON; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION;

EID: 77955444557     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2010.505061     Document Type: Article

References (34)

1. Burger JA, Ghia P, Rosenwald A, Caligaris-Cappio F. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood 2009;114:3367-3375.
2. Caligaris-Cappio F. Role of the microenvironment in chronic lymphocytic leukaemia. Br J Haematol 2003;123: 380-388.
3. Messmer BT, Albesiano E, Efremov DG, et al. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med 2004;200:519-525.
4. Burger JA, Tsukada N, Burger M, Zvaifler NJ, Dell'Aquila M, Kipps TJ. Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1. Blood 2000;96:2655-2663.
5. Kurtova AV, Balakrishnan K, Chen R, et al. Diverse marrow stromal cells protect CLL cells from spontaneous and druginduced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance. Blood 2009;114:4441-4450.
6. Deaglio S, Capobianco A, Bergui L, et al. CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells. Blood 2003;102:2146-2155.
7. Calissano C, Damle RN, Hayes G, et al. In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia. Blood 2009;114:4832-4842.
8. Chiorazzi N, Hatzi K, Albesiano E. B-cell chronic lymphocytic leukemia, a clonal disease of B lymphocytes with receptors that vary in specificity for (auto)antigens. Ann NY Acad Sci 2005;1062:1-12.
9. Burger JA, Kipps TJ. Chemokine receptors and stromal cells in the homing and homeostasis of chronic lymphocytic leukemia B cells. Leuk Lymphoma 2002;43:461-466.
10. Richardson SJ, Matthews C, Catherwood MA, et al. ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL). Blood 2006;107:3584-3592.
11. Stark RS, Liebes LF, Shelanski ML, Silber R. Anomalous function of vimentin in chronic lymphocytic leukemia lymphocytes. Blood 1984;63:415-420.
12. Caligaris-Cappio F, Bergui L, Tesio L, Corbascio G, Tousco F, Marchisio PC. Cytoskeleton organization is aberrantly rearranged in the cells of B chronic lymphocytic leukemia and hairy cell leukemia. Blood 1986;67:233-239.
13. Nowakowski GS, Hoyer JD, Shanafelt TD, et al. Percentage of smudge cells on routine blood smear predicts survival in chronic lymphocytic leukemia. J Clin Oncol 2009;27:1844-1849.
14. Deaglio S, Vaisitti T, Aydin S, et al. CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential. Blood 2007;110:4012-4021.
15. Hartmann TN, Grabovsky V, Wang W, et al. Circulating Bcell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow. Cancer Res 2009;69:3121-3130.
16. Montresor A, Bolomini-Vittori M, Simon SI, Rigo A, Vinante F, Laudanna C. Comparative analysis of normal versus CLL B-lymphocytes reveals patient-specific variability in signaling mechanisms controlling LFA-1 activation by chemokines. Cancer Res 2009;69:9281-9290.
17. Tybulewicz VL, Henderson RB. Rho family GTPases and their regulators in lymphocytes. Nat Rev Immunol 2009;9:630-644.
18. Till KJ, Harris RJ, Linford A, Spiller DG, Zuzel M, Cawley JC. Cell motility in chronic lymphocytic leukemia: defective Rap1 and alphaLbeta2 activation by chemokine. Cancer Res 2008;68:8429-8436.
19. Carrasco YR, Fleire SJ, Cameron T, Dustin ML, Batista FD. LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. Immunity 2004;20:589-599.
20. Fleire SJ, Goldman JP, Carrasco YR, Weber M, Bray D, Batista FD. B cell ligand discrimination through a spreading and contraction response. Science 2006;312:738-741.
21. Ramsay AG, Johnson AJ, Lee AM, et al. Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J Clin Invest 2008;118:2427-2437.
22. Vicente-Manzanares M, Sanchez-Madrid F. Role of the cytoskeleton during leukocyte responses. Nat Rev Immunol 2004;4:110-122.
23. Hao JJ, Zhu J, Zhou K, Smith N, Zhan X. The coiled-coil domain is required for HS1 to bind to F-actin and activate Arp2/3 complex. J Biol Chem 2005;280:37988-37994.
24. Mateo V, Brown EJ, Biron G, et al. Mechanisms of CD47- induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization. Blood 2002;100:2882-2890.
25. Sanchez-Aguilera A, Rattmann I, Drew DZ, et al. Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia. Leukemia 2010;24:97-104.
26. Scielzo C, Ghia P, Conti A, et al. HS1 protein is differentially expressed in chronic lymphocytic leukemia patient subsets with good or poor prognoses. J Clin Invest 2005;115:1644-1650.
27. Kitamura D, Kaneko H, Miyagoe Y, Ariyasu T, Watanabe T. Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage. Nucleic Acids Res 1989;17:9367-9379.
28. Fischer U, Michel A, Meese EU. Expression of the gene for hematopoietic cell specific protein is not restricted to cells of hematopoietic origin. Int J Mol Med 2005;15:611-615.
29. Takemoto Y, Sato M, Furuta M, Hashimoto Y. Distinct binding patterns of HS1 to the Src SH2 and SH3 domains reflect possible mechanisms of recruitment and activation of downstream molecules. Int Immunol 1996;8:1699-1705.
30. Gomez TS, McCarney SD, Carrizosa E, et al. HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse. Immunity 2006;24:741-752.
31. Carrizosa E, Gomez TS, Labno CM, et al. Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 microcluster dynamics during T cell spreading. J Immunol 2009;183:7352-7361.
32. Butler B, Kastendieck DH, Cooper JA. Differently phosphorylated forms of the cortactin homolog HS1 mediate distinct functions in natural killer cells. Nat Immunol 2008; 9:887-897.
33. Muzio M, Scielzo C, Frenquelli M, et al. HS1 complexes with cytoskeleton adapters in normal and malignant chronic lymphocytic leukemia B cells. Leukemia 2007;21:2067-2070.
34. Bertilaccio MT, Scielzo C, Simonetti G, et al. A novel Rag27/7{gamma}c-/-xenograft model of human CLL. Blood 2010;115:1605-1609.