Modelling of human transplacental transport as performed in Copenhagen, Denmark

Basic and Clinical Pharmacology and Toxicology

Volumn 115, Issue 1, 2014, Pages 93-100

  Mathiesen, Line ^a   Mørck, Thit Aarøe ^a   Zuri, Giuseppina ^a   Andersen, Maria Helena ^a   Pehrson, Caroline ^b   Frederiksen, Marie ^c   Mose, Tina ^d   Rytting, Erik ^e   Poulsen, Marie S ^a   Nielsen, Jeanette Ks ^a   Knudsen, Lisbeth E ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c AALBORG UNIVERSITY   (Denmark)

^d ODENSE UNIVERSITY HOSPITAL   (Denmark)

^e University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; FLAME RETARDANT; NANOPARTICLE; POLYCHLORINATED BIPHENYL; RECEPTOR PROTEIN; RECOMBINANT ANTIBODY; POLLUTANT;

ADSORPTION; ARTICLE; DENMARK; ENVIRONMENTAL EXPOSURE; EX VIVO STUDY; HUMAN; HUMAN CELL CULTURE; PHYSICAL CHEMISTRY; PLACENTA; PLACENTA PERFUSION; PLACENTAL TRANSFER; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROTEIN METABOLISM; TROPHOBLAST; BIOLOGICAL MODEL; COMPARATIVE STUDY; DRUG EFFECTS; FEMALE; FETOMATERNAL TRANSFUSION; FETUS; METABOLISM; MOLECULAR CLONING; PERFUSION; POLLUTANT; PREGNANCY; PROCEDURES; RISK ASSESSMENT; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALIA;

BIOLOGICAL TRANSPORT; CLONING, MOLECULAR; DENMARK; ENVIRONMENTAL POLLUTANTS; FEMALE; FETUS; HUMANS; MATERNAL-FETAL EXCHANGE; MODELS, BIOLOGICAL; PERFUSION; PLACENTA; PREGNANCY; RISK ASSESSMENT;

EID: 84902075339     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/bcpt.12228     Document Type: Article

References (42)

1. Knudsen LE. Animal-free toxicology:the use of human tissue to replace the use of animals. Examples from human biomonitoring and human placental transport studies. ATLA 2013;41:443-7.
2. Leist M, Lidbury BA, Yang C, Hayden PJ, Kelm JM, Ringeissen S et al. Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods. ALTEX 2012;29:373-88.
3. Davis M, Boekelheide K, Boverhof DR, Eichenbaum G, Hartung T, Holsapple MP et al. The new revolution in toxicology: the good, the bad, and the ugly. Ann N Y Acad Sci 2013;1278:11-24.
4. Myllynen P, Pienimaki P, Vahakangas K. Human placental perfusion method in the assessment of transplacental passage of antiepileptic drugs. Toxicol Appl Pharmacol 2005;207:489-94.
5. Myren M, Mose T, Mathiesen L, Knudsen LE. The human placenta-an alternative for studying foetal exposure. Toxicol In Vitro 2007;21:1332-40.
6. Liu F, Soares MJ, Audus KL. Permeability properties of monolayers of the human trophoblast cell line BeWo. Am J Physiol 1997;273:C1596-604.
7. Bode CJ, Jin H, Rytting E, Silverstein PS, Young AM, Audus KL. In vitro models for studying trophoblast transcellular transport. Methods Mol Med 2006;122:225-39.
8. Rytting E, Bryan J, Southard M, Audus KL. Low-affinity uptake of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (4-Di-1-ASP) in BeWo cells. Biochem Pharmacol 2007;73:891-900.
9. Avery ML, Meek CE, Audus KL. The presence of inducible cytochrome P450 types 1A1 and 1A2 in the BeWo cell line. Placenta 2003;24:45-52.
10. Schneider H. Techniques: in vitro perfusion of the human placenta. In: Sastry BVR(ed.). Placental Toxicology. CRC Press, Boca Raton, 1995; 1-25.
11. Mathiesen L, Mose T, Morck TJ, Nielsen JK, Nielsen LK, Maroun LL et al. Quality assessment of a placental perfusion protocol. Reprod Toxicol 2010;30:138-46.
12. Morgan DJ. Drug disposition in mother and foetus. Clin Exp Pharmacol Physiol 1997;24:869-73.
13. Wier PJ, Miller RK. Oxygen transfer as an indicator of perfusion variability in the isolated human placental lobule. Contrib Gynecol Obstet 1985;13:127-31.
14. Schneider H. Tolerance of human placental tissue to severe hypoxia and its relevance for dual ex vivo perfusion. Placenta 2009;30(Suppl A):S71-6.
15. Schneider H. Placental oxygen consumption. Part II: in vitro studies-a review. Placenta 2000;21(Suppl A):S38-44.
16. Di Santo S, Malek A, Sager R, Andres AC, Schneider H. Trophoblast viability in perfused term placental tissue and explant cultures limited to 7-24 hr. Placenta 2003;24:882-94.
17. Dunn WB, Brown M, Worton SA, Crocker IP, Broadhurst D, Horgan R et al. Changes in the metabolic footprint of placental explant-conditioned culture medium identifies metabolic disturbances related to hypoxia and pre-eclampsia. Placenta 2009;30:974-80.
18. Horgan RP, Broadhurst DI, Dunn WB, Brown M, Heazell AE, Kell DB et al. Changes in the metabolic footprint of placental explant-conditioned medium cultured in different oxygen tensions from placentas of small for gestational age and normal pregnancies. Placenta 2010;31:893-901.
19. Lind U, Mose T, Knudsen LE. Participation in environmental health research by placenta donation - a perception study. Environ Health 2007;6:36.
20. Poulsen M, Rytting E, Mose T, Knudsen L. Modeling placental transport: correlation of in vitro BeWo cell permeability and ex vivo human placental perfusion. Toxicol In Vitro 2009;23:1380-6.
21. Mose T, Kjaerstad MB, Mathiesen L, Nielsen JB, Edelfors S, Knudsen LE. Placental passage of benzoic acid, caffeine, and glyphosate in an ex vivo human perfusion system. J Toxicol Environ Health A 2008;71:984-91.
22. Li H, van RB, Rietjens IM, Louisse J. Assessment of an in vitro transport model using BeWo b30 cells to predict placental transfer of compounds. Arch Toxicol 2013;87:1661-9.
23. Myllynen P, Mathiesen L, Weimer M, Annola K, Immonen E, Karttunen V et al. Preliminary interlaboratory comparison of the ex vivo dual human placental perfusion system. Reprod Toxicol 2010;30:94-102.
24. Merlo DF, Wild CP, Kogevinas M, Kyrtopoulos S, Kleinjans J. NewGeneris: a European study on maternal diet during pregnancy and child health. Cancer Epidemiol Biomarkers Prev 2009;18:5-10.
25. Mose T, Mathiesen L, Karttunen V, Nielsen JKS, Sieppi E, Kummu M et al. Meta-analysis of data from human ex-vivo placental perfusion studies on genotoxic and immunotoxic agents within the integrated European project NewGeneris. Placenta 2012;33:433-9.
26. Syme MR, Paxton JW, Keelan JA. Drug transfer and metabolism by the human placenta. Clin Pharmacokinet 2004;43:487-514.
27. Tropper PJ, Goland RS, Wardlaw SL, Fox HE, Frantz AG. Effects of betamethasone on maternal plasma corticotropin releasing factor, ACTH and cortisol during pregnancy. J Perinat Med 1987;15:221-5.
28. Mathiesen L, Rytting E, Mose T, Knudsen LE. Transport of benzo[alpha]pyrene in the dually perfused human placenta perfusion model: effect of albumin in the perfusion medium. Basic Clin Pharmacol Toxicol 2009;105:181-7.
29. Morck TJ, Sorda G, Bechi N, Rasmussen BS, Nielsen JB, Ietta F et al. Placental transport and in vitro effects of Bisphenol A. Reprod Toxicol 2010;30:131-7.
30. Myllynen P, Kummu M, Kangas T, Ilves M, Immonen E, Rysa J et al. ABCG2/BCRP decreases the transfer of a food-born chemical carcinogen, 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP) in perfused term human placenta. Toxicol Appl Pharmacol 2008;232:210-7.
31. Immonen E, Kummu M, Petsalo A, Pihlaja T, Mathiesen L, Nielsen JK et al. Toxicokinetics of the food-toxin IQ in human placental perfusion is not affected by ABCG2 or xenobiotic metabolism. Placenta 2010;31:641-8.
32. Mathiesen L, Nielsen LK, Andersen JT, Grevys A, Sandlie I, Michaelsen TE et al. Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functions. Blood 2013;122:1174-81.
33. Kelman BJ, Springer DL. Movements of benzo[a]pyrene across the hemochorial placenta of the guinea pig. Proc Soc Exp Biol Med 1982;169:58-62.
34. Kihlström I. Placental transfer of benzo(a)pyrene and its hydrophilic metabolites in the guinea pig. Acta Pharmacol Toxicol (Copenh) 1986;58:272-6.
35. Autrup H, Vestergaard AB, Okkels H. Transplacental transfer of environmental genotoxins: polycyclic aromatic hydrocarbon-albumin in non-smoking women, and the effect of maternal GSTM1 genotype. Carcinogenesis 1995;16:1305-9.
36. Hansen C, Sorensen LD, Asmussen I, Autrup H. Transplacental exposure to tobacco smoke in human-adduct formation in placenta and umbilical cord blood vessels. Teratog Carcinog Mutagen 1992;12:51-60.
37. Lambot N, Lybaert P, Boom A, ogne-Desnoeck J, Vanbellinghen AM, Graff G et al. Evidence for a clathrin-mediated recycling of albumin in human term placenta. Biol Reprod 2006;75:90-7.
38. Frederiksen M, Vorkamp K, Mathiesen L, Mose T, Knudsen LE. Placental transfer of the polybrominated diphenyl ethers BDE-47, BDE-99 and BDE-209 in a human placenta perfusion system: an experimental study. Environ Health 2010;9:32-41.
39. Correia Carreira S, Cartwright L, Mathiesen L, Knudsen LE, Saunders M. Studying placental transfer of highly purified non-dioxin-like PCBs in two models of the placental barrier. Placenta 2011;32:283-91.
40. Cartwright L, Poulsen MS, Nielsen HM, Pojana G, Knudsen LE, Saunders M et al. In vitro placental model optimization for nanoparticle transport studies. Int J Nanomedicine 2012;7:497-510.
41. Wick P, Malek A, Manser P, Meili D, Maeder-Althaus X, Diener L et al. Barrier capacity of human placenta for nanosized materials. Environ Health Perspect 2010;118:432-6.
42. Poulsen MS, Mose T, Maroun LL, Mathiesen L, Knudsen LE, Rytting E. Kinetics of silica nanoparticles in the human placenta. Nanotoxicology 2014;doi:10.3109/17435390.2013.812259 [Epub ahead of print].