Animal-free toxicology: The use of human tissue to replace the use of animals - Examples from human biomonitoring and human placental transport studies

Alternatives to Laboratory Animals

Volumn 41, Issue 6, 2013, Pages 443-447

  Knudsen, Lisbeth E ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Human biomonitoring; Placental transport; Risk assessment in children

Indexed keywords

AFLATOXIN;

AIR POLLUTION; ANIMAL EXPERIMENT; ANIMAL USE; ARTICLE; BIOLOGICAL MONITORING; CANCER RISK; CELL CULTURE; CHEMICAL STRUCTURE; CHILDHOOD DISEASE; CHLORINATION; CHROMOSOME ABERRATION; DENMARK; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; FETUS CIRCULATION; FOLLOW UP; FOOD CONTAMINATION; FOOD INTAKE; FOOD SAFETY; HORMONE SYNTHESIS; HUMAN; HUMAN TISSUE; MATERNAL BLOOD; MORBIDITY; NERVE CELL DIFFERENTIATION; NONHUMAN; PLACENTA; PLACENTA PERFUSION; PLACENTAL TRANSFER; POPULATION; PREGNANCY OUTCOME; PRENATAL EXPOSURE; PRIORITY JOURNAL; QUESTIONNAIRE; RISK ASSESSMENT; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; TOXICOLOGY; ANIMAL; ANIMAL TESTING ALTERNATIVE; ENVIRONMENTAL MONITORING; FEMALE; FETOMATERNAL TRANSFUSION; METABOLISM; METHODOLOGY; PREGNANCY;

ANIMAL TESTING ALTERNATIVES; ANIMALS; ENVIRONMENTAL MONITORING; FEMALE; HUMANS; MATERNAL-FETAL EXCHANGE; PLACENTA; PREGNANCY;

EID: 84898421574     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119291304100606     Document Type: Article

References (28)

1. Leist, M., Lidbury, B.A., Yang, C., Hayden, P.J., Kelm, J.M., Ringeissen, S., Detroyer, A., Meunie, J.R., Rathman, J.F., Jackson, G.R., Jr, Stolper, G. & Hasiwa, N. (2013). Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods. ALTEX 29, 373-388.
2. Davis, M., Boekelheide, K., Boverhof, D.R., Eichenbaum, G., Hartung, T., Holsapple, M.P., Jones, T.W., Richard, A.M. & Watkins, P.B. (2013). The new revolution in toxicology: The good, the bad, and the ugly. Annals of the New York Academy of Sciences 1278, 11-24.
3. Knudsen, L.E., Boisen, T., Christensen, J.M., Jelnes, J.E., Jensen, G.E., Jensen, J.C., Lundgren, K., Lundsteen, C., Pedersen, B., Wassermann, K., Wilhardt, P., Wulf, H.C. & Zebitz, U. (1992). Biomonitoring of genotoxic exposure among stainless steel welders. Mutation Research 279, 129-143.
4. Autrup, H., Daneshvar, B., Dragsted, L.O., Gamborg, M., Hansen, A.M., Loft, S., Okkels, H., Nielsen, F., Nielsen, P.S., Raffn, E., Wallin, H. & Knudsen, L.E. (1999). Biomarkers for exposure to ambient air pollution - comparison of carcinogen-DNA adduct levels with other exposure markers and markers for oxidative stress. Environmental Health Perspectives 107, 233-238. (Pubitemid 29176843)
5. Knudsen, L.E., Norppa, H., Gamborg, M.O., Nielsen, P.S., Okkels, H., Soll-Johanning, H., Raffn, E., Järventaus, H. & Autrup, H. (1999). Chromosomal aberrations in humans induced by urban air pollution: Influence of DNA repair and polymorphisms of glutathione S-transferase M1 and N-acetyltransferase 2. Cancer Epidemiology & Biomarkers 8, 303-310.
6. Loft, S., Poulsen, H.E., Vistisen, K. & Knudsen, L.E. (1999). Increased urinary excretion of 8-oxo7,8-dihydro-2′-deoxyguanosine, a biomarker of oxidative DNA damage, in urban bus drivers. Mutation Research 441, 11-19. (Pubitemid 29192850)
7. Pedersen, M., Wichmann, J., Autrup, H., Dang, D.A., Decordier, I., Hvidberg, M., Bossi, R., Jakobsen, J., Loft, S. & Knudsen, L.E. (2009). Increased micronuclei and bulky DNA adducts in cord blood after maternal exposures to traffic-related air pollution. Environmental Research 109, 1012-1020.
8. Pedersen, M., Halldorsson, T.I., Mathiesen, L., Mose, T., Brouwer, A., Hedegaard, M., Loft, S., Kleinjans, J.C., Besselink, H. & Knudsen, L.E. (2010). Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother-newborn pairs. Environment International 36, 344-351.
9. Pedersen, M., von Stedingk, H., Botsivali, M., Agramunt, S., Alexander, J., Brunborg, G., Chatzi, L., Fleming, S., Fthenou, E., Granum, B., Gutzkow, K.B., Hardie, L.J., Knudsen, L.E., Kyrtopoulos, S.A., Mendez, M.A., Merlo, D.F., Nielsen, J.K., Rydberg, P., Segerbäck, D., Sunyer, J., Wright, J., Törnqvist, M., Kleinjans, J.C., Kogevinas, M. & the NewGeneris Consortium. (2012). Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: The European Prospective Mother-Child Study (NewGeneris). Environmental Health Perspectives 120, 1739-1745.
10. Bonassi, S., Norppa, H., Ceppi, M., Stromberg, U., Vermeulen, R., Znaor, A., Cebulska-Wasilewska, A., Fabianova, E., Fucic, A., Gundy, S., Hansteen, I.L., Knudsen, L.E., Lazutka, J., Rossner, P., Sram, R.J. & Boffetta, P. (2008). Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: Results from a pooled cohort study of 22,358 subjects in 11 countries. Carcinogenesis 29, 1178-1183. (Pubitemid 351958697)
11. Bonassi, S., El-Zein, R., Bolognesi, C. & Fenech, M. (2011). Micronuclei frequency in peripheral blood lymphocytes and cancer risk: Evidence from human studies. Mutagenesis 26, 93-100.
12. Neri, M., Bonassi, S., Knudsen, L.E., Sram, R., Holland, N., Ugolini D. & Merlo, D.F. (2005). Children's exposure to environmental pollutants and biomarkers of genetic damage. I: Overview and critical issues. Mutation Research 612, 1-13. (Pubitemid 43038814)
13. Neri, M., Ugolini, D., Bonassi, S., Fucic, A., Holland, N., Knudsen, L.E., Sram, R., Ceppi, M., Borrchini, V. & Merlo, D.F. (2006). Children's exposure to environmental pollutants and biomarkers of genetic damage. II: Results of a comprehensive literature search and meta-analysis. Mutation Research 612, 14-39. (Pubitemid 43038815)
14. Mathiesen, L., Mose, T., Mørck, T.J., Nielsen, J.K., Nielsen, L.K., Maroun, L.L., Dziegiel, M.H., Larsen, L.G. & Knudsen, L.E. (2010). Quality assessment of a placental perfusion protocol. Reproductive Toxicology 30, 138-146.
15. Myllynen, P., Mathiesen, L., Weimer, M., Annola, K., Immonen, E., Karttunen, V., Kummu, M., Morck, T.J., Nielsen, J.K., Knudsen, L.E. & Vähäkangas, K. (2010). Preliminary interlaboratory comparison of the ex vivo dual human placental perfusion system. Reproductive Toxicology 30, 94-102.
16. Mose, T., Mathiesen, L., Karttunen, V., Nielsen, J.K.S., Sieppi, E., Kummu, M., Mørck, T.A., Myöhanen, K., Partanen, H., Vähäkangas, K., Knudsen, L.E. & Myllynen, P. (2012). Meta-analysis of data from human ex vivo placental perfusion studies on genotoxic and immunotoxic agents within the Integrated European Project NewGeneris. Placenta 33, 433-439.
17. Lind, U., Knudsen, L.E. & Mose, T. (2007). Participation in environmental health research by placenta donation - a perception study. Environmental Health 6, 36.
18. Cartwright, L., Poulsen, M.S., Nielsen, H.M., Pojana, G., Knudsen, L.E., Saunders, M. & Rytting, E. (2012). In vitro placental model optimization for nanoparticle transport studies. International Journal of Nanomedicine 7, 497-510.
19. Poulsen, M.S., Mose, T., Maroun, L., Mathiesen, L., Knudsen, L.E. & Rytting, E. (2013). Kinetics of silica nanoparticles in the human placenta. Nano-toxicology [In press.]
20. Mose, T., Knudsen, L.E., Hedegaard, M. & Mortensen, G.K. (2007). Transplacental transfer of monomethyl phthalate and mono (2-ethylhexyl) phthalate in a human placenta perfusion system. International Journal of Toxicology 26, 221-229. (Pubitemid 46918924)
21. Mose, T., Kjærstad, M.B., Mathiesen, L., Nielsen, J.B., Edelfors, S. & Knudsen, L.E. (2008). Placental passage of benzoic acid, caffeine, and glyphosate in an ex vivo human placental system. Journal of Toxicology & Environmental Health, Part A 71, 984-991. (Pubitemid 352000685)
22. Poulsen, M.S., Rytting, E., Mose, T. & Knudsen, L.E. (2009). Modeling placental transport: Correlation of in vitro BeWo cell permeability and ex vivo human placental perfusion. Toxicology in Vitro 23, 1380-1386.
23. Mørck, T.J., Sorda, G., Bechi, N., Rasmussen, B.S., Nielsen, J.B., Ietta, F., Rytting, E., Mathiesen, L., Paulesu, L. & Knudsen, L.E. (2010). Placental transport and in vitro effects of Bisphenol A. Reproductive Toxicology 30, 131-137.
24. Pedersen, M., Halldorsson, T.I., Mathiesen, L., Mose, T., Brouwer, A., Hedegaard, M., Loft, S., Kleinjans, J.C., Besselink, H. & Knudsen, L.E. (2010). Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother-newborn pairs. Environment International 36, 344-351.
25. Frederiksen, M., Thomsen, C., Frøshaug, M., Vorkamp, K., Thomsen, M., Becher, G. & Knudsen, L.E. (2010). Polybrominated diphenyl ethers in paired samples of maternal and fetal blood plasma and associations with house dust in a Danish cohort. International Journal of Hygiene & Environmental Health 213, 233-242.
26. Frederiksen, M., Vorkamp, K., Mathiesen, L., Mose, T. & Knudsen, L.E. (2010). Placental transfer of the polybrominated diphenyl ethers BDE-47, BDE-99 and BDE-209 in a human placenta perfusion system: An experimental study. Environmental Health 9, 32.
27. Carreira, S.C., Cartwright, L., Mathiesen, L., Knudsen, L.E. & Saunders, M. (2011). Placental transfer of highly purified NDL-PCBs ex vivo and in a refined in vitro model of the placental barrier. Placenta 3, 283-291.
28. Mathiesen, L., Nielsen, L.K., Andersen, J.T., Grevys, A., Sandlie, I., Michaelsen, T.E., Hedegaard, M., Knudsen, L.E. & Dziegiel, M.H. (2013). Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functions. Blood 122, 1174-1181.