Placental passage of benzoic acid, caffeine, and glyphosate in an ex vivo human perfusion system

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 71, Issue 15, 2008, Pages 984-991

  Mose, Tina ^a   Kjaerstad, Mia Birkhoej ^b   Mathiesen, Line ^a   Nielsen, Jesper Bo ^b   Edelfors, Sven ^c   Knudsen, Lisbeth E ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOIC ACID; CAFFEINE; GLYPHOSATE; PHENAZONE; DRUG DERIVATIVE; GLYCINE;

ARTICLE; CONTROLLED STUDY; DIFFUSION; EX VIVO STUDY; FETUS CIRCULATION; HUMAN; HUMAN TISSUE; PHYSICAL CHEMISTRY; PLACENTA PERFUSION; PLACENTAL TRANSFER; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STEADY STATE; ADULT; BIOLOGICAL MODEL; CHEMISTRY; FEMALE; FETOMATERNAL TRANSFUSION; IN VITRO STUDY; METABOLISM; PERFUSION; PHYSIOLOGY; PLACENTA; PREGNANCY;

ANIMALIA;

ADULT; BENZOIC ACID; CAFFEINE; FEMALE; GLYCINE; HUMANS; MATERNAL-FETAL EXCHANGE; MODELS, BIOLOGICAL; PERFUSION; PLACENTA; PREGNANCY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 46449086189     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/01932690801934513     Document Type: Article

References (32)

1. Abdi, F., Pollard, I., and Wilkinson, J. 1993. Placental transfer and foetal disposition of caffeine and its immediate metabolites in the 20-day pregnant rat: Function of dose. Xenobiotica 4:449-456.
2. Aldridge, A., Bailey, J., and Neims, A. H. 1981. The disposition of caffeine during and after pregnancy. Semin. Perinatol. 5:310-314.
3. Arnaud, M. J. 1987. The pharmacology of caffeine. Prog. Drug. Res. 31:273-313.
4. Audus, K. L. 1999. Controlling drug delivery across the placenta. Eur. J. Pharm. Sci. 8:161-165.
5. Brewster, D. W., Warren, J., and Hopkins, W. E. 1991. Metabolism of glyphosate in Sprague-Dawley rats: Tissue distribution, identification, and quantitation of glyphosate-derived materials following a single oral dose. Fundam. Appl. Toxicol. 17:43-51.
6. 14C]caffeine after oral administration. Drug Metab. Dispos. 10:417-423.
7. Carstensen, M. H., Leichtweiss, H.-P., and Schröder, H. 1983. Lactate carriers in the artificially perfused human term placenta. Placenta 4:165-174.
8. Danish Environmental Protection Agency. 2000a. Environmental related evaluation, glyphosate, Information and the Danish Environmental Protection Agency's evaluation of the case. [Bilag 1.a, Miljoemaessig vurdering, Glyphosat, Sagens oplysninger og Miljoestyrelsens vurdering]. J.nr. M 7042-0243.
9. Danish Environmental Protection Agency. 2000b. Health related evaluation, glyphosate, Information and the Danish Environmental Protection Agency's evaluation of the case. [Bilag 1.b, Sundhedsmæssig vurdering, Glyphosate, Sagens oplysninger og Miljoestyrelsens vurdering]. J.nr: M7042-0165.
10. Grosso, L. M., Triche, E. W., Belanger, K., Benowitz, N. L., Holford, T. R., and Bracken, M.B. 2006. Caffeine metabolites in umbilical cord blood, cytochrome P-450 1A2 activity, and intrauterine growth restriction. Am. J. Epidemiol. 163:1035-1041.
11. Hewitt, M., Madden, J. C., Rowe, P. H., and Cronen, M. T. D. 2007. Structure-based modelling in reproductive toxicology: (Q)SARs for the placental barrier. SAR QSAR Environ. Res. 18:57-76.
12. Illsley, N. P., Hall, S., Penfold, P., and Stacey, T. E. 1985. Diffusional permeability of the human placenta. Contr. Gynecol. Obstet. 13:92-97.
13. Kubota, K., and Ishizaki, T. 1991. Dose-dependent pharmacokinetics of benzoic acid following oral administration of sodium benzoate to humans. Eur. J. Clin. Pharmacol. 41:363-368.
14. Láznícek, M., and Láznícková, A.1995. The effect of lipofilicity on the protein binding and blood cell uptake of some acidic drugs. J. Pharm. Biomed. Anal. 13:823-828.
15. Leviton, A., and Cowan, L. 2002. A review of the literature relating caffeine consumption by women to their risk of reproductive hazards. Food Chem. Toxicol. 40:1271-1310.
16. Lind, U., Mose, T., Knudsen, L. E. 2007. Participation in environmental health research by placenta donation - A perception study. Environ. Health 6:36-54.
17. Mose, T., and Knudsen, L. E. 2005. Placenta perfusion-A human alternative. Altern. Anim. Exp. 22:58-363.
18. Mose, T., Mortensen, G. K., Hedegaard, M., and Knudsen, L. E. 2007. Phthalate monoesters in perfusate from a dual placenta perfusion system, the placenta and umbilical cord blood. Reprod. Toxicol. 23:83-91.
19. Musteata, F. M., Pawliszyn, J., Qian, M. G., Wu, J. T., and Miwa, G. T. 2006. Determination of drug plasma protein binding by solid phase microextraction. J. Pharm. Sci. 95:1712-1722.
20. Nielsen, J. B., Nielsen, F., and Soerensen, J. A. 2007. Defense against dermal exposures is only skin deep: Significantly increased penetration through slightly damaged skin. Arch. Dermatol. Res. 299:423-431.
21. Pacifici, G. M., Nottoli, R. 1995. Placental transfer of drugs administered to the mother. Clin. Pharmacokinet. 28:235-269.
22. Parsons, W. D., and Neims, A. H. 1978. Effect of smoking on caffeine clearance. Clin. Pharmacol. Ther. 24:40-45.
23. Pollard, I. 1989. Increases in plasma concentrations of steroids in the rat after the administration of caffeine: Comparison with plasma disposition of caffeine. Erratum. J. Endocrinol. 122:606.
24. Quick, A. J. 1931. The conjugation of benzoic acid. J. Biol. Chem. 92:65-85.
25. Schneider, H., Sodha, R. J., Prögler, M., and Young, M. P. A. 1985. Permeability of the human placenta for hydrophilic substances studied in the isolated dually in vitro perfused lobe. Contr. Gynecol. Obstet. 13:98-103.
26. Scott, W. J. 1983. Caffeine-induced limb malformations: Description of malformations and quantitation of placental transfer. Teratology 28:427-435.
27. Sesardic, D., Pasanen, M., Pelkonen, O., and Boobis, A. R. 1990. Differential expression and regulation of members of the cytochrome P4501A gene subfamily in human tissues. Carcinogenesis 11:1183-1188.
28. Tsutsumi, K., Kotegawa, T., Matsuki, S., Tanaka, Y., Ishii, Y., Kodama, Y., Kuranari, M., Miyakawa, I., and Nakano, S. 2001. The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activities in humans. Clin. Pharmacol. Ther. 70:121.125.
29. Utoguchi, N., Magnusson, M., and Audus, K. L. 1999. Carrier-mediated transport of monocarboxylic acids in BeWo cell monolayers as a model of the human trophoblast. J. Pharm. Sci. 88:1288-1292.
30. Wester, R.C., Melendres, J., Sarason, R, McMaster, J., and Maibach, H. I.1991. Glyphosate skin binding, absorption, residual tissue distribution, and skin decontamination. Fundam. Appl. Toxicol. 16:725-732.
31. Williams, G. M., Kroes, R., and Munro, I. C. 2000. Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans. Regul. Toxicol. Pharmacol. 31 :117-165.
32. World Health Organization. 2005. Benzoic acid and sodium benzoate. Concise International Chemical Assessment Document 26. http://www.who.int/ipcs/ publications/cicad/cicad26_rev_1.pdf