Uptake mechanism of trientine by rat intestinal brush-border membrane vesicles

Journal of Pharmacy and Pharmacology

Volumn 48, Issue 5, 1996, Pages 517-521

  Tanabe, Ryou ^a   Kobayashi, Michiya ^a   Sugawara, Mitsuru ^a   Iseki, Ken ^a   Miyazaki, Katsumi ^a  

^a HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

POLYAMINE; SPERMIDINE; SPERMINE; TRIENTINE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG UPTAKE; INTESTINE BRUSH BORDER MEMBRANE; MALE; MEMBRANE VESICLE; NONHUMAN; PH; POTASSIUM TRANSPORT; RAT; TEMPERATURE DEPENDENCE;

EID: 0030007542     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1996.tb05965.x     Document Type: Article

References (12)

1. Iseki, K., Kobayashi, M., Miyazaki, K. (1991) Spermine uptake by rat intestinal brush-border membrane vesicles. Biochim. Biophys. Acta 1068: 105-110
2. Iseki, K., Kobayashi, M., Ohba, A., Miyazaki, K., Li, Y., Togashi, Y., Takeichi, N. (1992) Comparison of disposition behavior and decoppering effect of triethylenetetramine in an animal model for Wilson's disease (Long-Evans Cinnamon rat) with normal Wistar rat. Biopharm. Drug Dispos. 13: 273-283
3. Kobayashi, M., Iseki, K., Saitoh, H., Miyazaki, K. (1992) Uptake characteristics of polyamines into rat intestinal brush-border membrane. Biochim. Biophys. Acta 1105: 177-183
4. +-independent uptake systems for polyamines in rat intestinal brush-border membrane vesicles. Biochim. Biophys. Acta 1151: 161-167
5. Kobayashi, M., Nagahara, S., Sugawara, M., Iseki, K., Arashima, S., Takahashi, T., Hiuga, T., Okayasu, T., Matsumoto, S., Miyazaki, K. (1993b) Serum concentration and urinary excretion of trientine in patients with Wilson's disease. TDM Kenkyu 10: 166-171 (in Japanese)
6. Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J. (1951) Protein measurement with the folin phenol reagent. J. Biol. Chem. 193: 265-275
7. Miyazaki, K., Kishino, S., Kobayashi, M., Arashima, S., Matsumoto, S., Arita, T. (1990) Determination of triethylenetetramine in plasma of patients by high-performance liquid chromatography. Chem. Pharm. Bull. 38: 1035-1038
8. Osborne, D. L., Seidel, E. R. (1990) Gastrointestinal luminal polyamines: cellular accumulation and enterohepatic circulation. Am. J. Physiol. 258: G576-G584
9. Seiler, N., Dezeure, F. (1990) Polyamine transport in mammalian cells. Int. J. Biochem. 22: 211-218
10. Sugawara, M., Sasaki, M., Iseki, K., Miyazaki, K. (1992) Membrane-potential-dependent uptake of tryptamine by rat intestinal brushborder membrane vesicles. Biochim. Biophys. Acta 1111: 145-150
11. Takahashi, Y., Itoh, T., Kobayashi, M., Sugawara, M., Saitoh, H., Iseki, K., Miyazaki, K.,Miyazaki, S., Takada, M., Kawashima, Y. (1993) The transport mechanism of an organic cation, disopyramide, by brush-border membranes. Comparison between renal cortex and small intestine of the rat. J. Pharm. Pharmacol. 45: 419-424
12. Walshe, J. M. (1982) Treatment of Wilson's disease with trientine (triethylenetetramine) dihydrochloride. Lancet i: 643-647