A copper(II)-selective chelator ameliorates left-ventricular hypertrophy in type 2 diabetic patients: A randomised placebo-controlled study

Diabetologia

Volumn 52, Issue 4, 2009, Pages 715-722

  Cooper, G J S ^a,b,c   Young, A A ^d   Gamble, G D ^c   Occleshaw, C J ^e   Dissanayake, A M ^f   Cowan, B R ^c,d   Brunton, D H ^a   Baker, J R ^f   Phillips, A R J ^a,b   Frampton, C M ^g   Poppitt, S D ^a,c   Doughty, R N ^c  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d UNIVERSITY OF AUCKLAND   (New Zealand)

^e GREEN LANE HOSPITAL   (New Zealand)

^f MIDDLEMORE HOSPITAL   (New Zealand)

^g UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Cardiac magnetic resonance imaging; Copper; Diabetic cardiomyopathy; Left ventricular hypertrophy; Oral copper chelation; Triethylenetetramine

Indexed keywords

PLACEBO; TRIENTINE;

ADULT; AGED; ARTICLE; BIVARIATE ANALYSIS; BODY SURFACE; CAREGIVER; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FOLLOW UP; HEART EJECTION FRACTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HUMAN; MALE; MULTIPLE REGRESSION; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; OUTPATIENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; URINARY EXCRETION;

ADULT; AGED; BLOOD PRESSURE; BODY SURFACE AREA; CHELATING AGENTS; CREATININE; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; FEMALE; HEART VENTRICLES; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PATIENT SELECTION; PLACEBOS; TRIETHYLENETETRAMINE;

EID: 61449239980     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1265-3     Document Type: Article

References (23)

1. RB Devereux MJ Roman M Paranicas 2000 Impact of diabetes on cardiac structure and function: The Strong Heart Study Circulation 101 2271 2276
2. M Galderisi KM Anderson PF Wilson D Levy 1991 Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy (The Framingham Heart Study) Am J Cardiol 68 85 89
3. AD Struthers AD Morris 2002 Screening for and treating left-ventricular abnormalities in diabetes mellitus: a new way of reducing cardiac deaths Lancet 359 1430 1432
4. KH Mak EJ Topol 2000 Emerging concepts in the management of acute MI in patients with diabetes mellitus J Am Coll Cardiol 35 563 568
5. GJS Cooper YK Chan Dissanayake 2005 Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation. Quantitative comparisons between the biology of copper and of eight other nutritionally-essential elements in normal and diabetic individuals Diabetes 54 1468 1476
6. R Siegemund J Lößner K Günther R Siegemund HJ Kühn H Bachmann 1991 Mode of action of triethylenetetramine dihydrochloride on copper metabolism in Wilson's disease Acta Neurol Scand 83 364 366
7. GJS Cooper ARJ Phillips SY Choong 2004 Regeneration of the heart in diabetes by selective copper chelation Diabetes 53 2501 2508
8. D Gong J Lu X Chen 2006 Molecular changes evoked by triethylenetetramine (TETA) treatment in the extracellular matrix of the heart and aorta in diabetic rats Mol Pharmacol 70 2045 2051
9. D Gong J Lu X Chen 2008 A copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-β activation in the kidneys of rats used as a model of diabetes Diabetologia 51 1741 1751
10. RN Doughty GA Whalley HA Walsh 2004 Effects of carvedilol on left ventricular remodeling after acute myocardial infarction: the CAPRICORN Echo Substudy Circulation 109 201 206
11. AA Young BR Cowan SF Thrupp WJ Hedley LJ Dell'Italia 2000 Left ventricular mass and volume: fast calculation with guide-point modeling on MR images Radiol 216 597 602
12. World Medical Association Declaration of Helsinki 1997 Recommendations guiding physicians in biomedical research involving human subjects Cardiovasc Res 35 2 3
13. PG Reeves NV Ralston JP Idso HC Lukaski 2004 Contrasting and cooperative effects of copper and iron deficiencies in male rats fed different concentrations of manganese and different sources of sulfur amino acids in an AIN-93G-based diet J Nutr 134 416 425
14. D DuBois EF DuBois 1916 A formula to estimate the approximate surface area if height and weight be known Arch Intern Med 17 863 871
15. Little RJ, Rubin DB (1987) Statistical analysis with missing data. New York, Wiley
16. Panel on Micronutrients, Subcommittees on Upper Reference Levels of Nutrients and of Interpretation and Use of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Institute of Medicine (2001) Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC, National Academy of Sciences
17. L Elsherif L Wang JT Saari YJ Kang 2005 Regression of dietary copper restriction-induced cardiomyopathy by copper repletion in mice J Nutr 134 855 860
18. DR Bosman AS Winkler JT Marsden IC Macdougall PJ Watkins 2001 Anemia with erythropoietin deficiency occurs early in diabetic nephropathy Diabetes Care 24 495 499
19. D Levy RJ Garrison DD Savage WB Kannel WP Castelli 1990 Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study N Engl J Med 322 1561 1566
20. L Condamine O Hermine P Alvin M Levine C Rey V Courtecuisse 1993 Acquired sideroblastic anaemia during treatment of Wilson's disease with triethylene tetramine dihydrochloride Br J Haematol 83 166 168
21. J Morita M Yoshino H Watari 1992 Wilson's disease treatment by triethylene tetramine dihydrochloride (trientine, 2HCl): long-term observation Dev Pharmacol Therap 19 6 9
22. Linder MC (1991) Biochemistry of copper. New York, Plenum
23. E Bourdon N Loreau D Blache 1999 Glucose and free radicals impair the antioxidant properties of serum albumin FASEB J 13 233 244