A copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-β activation in the kidneys of rats used as a model of diabetes

Diabetologia

Volumn 51, Issue 9, 2008, Pages 1741-1751

  Gong, D ^a   Lu, J ^a   Chen, X ^a   Reddy, S ^a   Crossman, D J ^a   Glyn Jones, S ^a   Choong, Y S ^a   Kennedy, J ^d   Barry, B ^d   Zhang, S ^a,b   Chan, Y K ^a   Ruggiero, K ^a   Phillips, A R J ^a,b   Cooper, G J S ^a,b,c  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d GNS SCIENCE   (New Zealand)

Author keywords

Albuminuria; Diabetic nephropathy; Divalent copper; Extracellular matrix; Glomerular hypertrophy; Semicarbazide sensitive amine oxidase; SSAO; TGF ; Triethylenetetramine

Indexed keywords

AMINE OXIDASE (COPPER CONTAINING); CHELATING AGENT; COLLAGEN TYPE 3; COLLAGEN TYPE 4; CUPRIC ION; FIBRONECTIN; GLUCOSE; PLASMINOGEN ACTIVATOR INHIBITOR 1; SMAD2 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRIENTINE;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROL GROUP; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; HEART DISEASE; KIDNEY CORTEX; KIDNEY FIBROSIS; KIDNEY HYPERTROPHY; MALE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

ALBUMINURIA; ANIMALS; CHELATING AGENTS; COPPER; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DISEASE MODELS, ANIMAL; FIBROSIS; KIDNEY; KIDNEY GLOMERULUS; RATS; TRANSFORMING GROWTH FACTOR BETA; TRIETHYLENETETRAMINE;

EID: 49249098236     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-008-1088-7     Document Type: Article

References (50)

1. K Susztak AC Raff M Schiffer EP Bottinger 2006 Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy Diabetes 55 225 233
2. AB Roberts BK McCune MB Sporn 1992 TGF-beta: regulation of extracellular matrix Kidney Int 41 557 559
3. T Yamamoto T Nakamura NA Noble 1993 Expression of transforming growth factor β is elevated in human and experimental diabetic nephropathy Proc Natl Acad Sci USA 90 1814 1818
4. RA Bruijn A Roos B de Geus 1994 Transforming growth factor-beta and the glomerular extracellular matrix in renal pathology J Lab Clin Med 123 34 47
5. MA Haralson 1997 Transforming growth factor-beta, other growth factors, and the extracellular matrix J Lab Clin Med 130 455 458
6. GJS Cooper ARJ Phillips SY Choong 2004 Regeneration of the heart in diabetes by selective copper chelation Diabetes 53 2501 2508
7. GJS Cooper Y-K Chan AM Dissanayake 2005 Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: quantitative comparisons between the biology of copper and eight other nutritionally essential elements in normal and diabetic individuals Diabetes 54 1468 1476
8. D Gong J Lu X Chen 2006 Molecular changes evoked by triethylenetetramine treatment in the extracellular matrix of the heart and aorta in diabetic rats Mol Pharmacol 70 2045 2051
9. G Leblondel P Allain 1988 Altered element concentrations in tissues of spontaneously hypertensive rats Biomed Pharmacother 42 121 129
10. K Minakata K Kawai F Horio H Takeuchi O Suzuki 2004 Accumulation of copper in kidney of spontaneously hypertensive rats, a preliminary study Biofactors 22 29 31
11. S Ito H Fujita T Narita 2001 Urinary copper excretion in type 2 diabetic patients with nephropathy Nephron 88 307 312
12. F Boomsma AH van den Meiracker S Winkel AJ Man in't Veld MA Schalekamp 1999 Circulating semicarbazide-sensitive amine oxidase is raised both in type I (insulin-dependent), type II (non-insulin-dependent) diabetes mellitus and even in childhood type I diabetes at first diagnosis Diabetologia 42 233 237
13. KC Mathys SN Ponnampalam S Padival RH Nagaraj 2002 Semicarbazide- sensitive amine oxidase in aortic smooth muscle cells mediates synthesis of a methylglyoxal-AGE: implications for vascular complications in diabetes Biochem Biophys Res Commun 297 863 869
14. CM Stolen R Madanat L Marti 2004 Semicarbazide sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complications FASEB J 18 702 704
15. FK Askari R Dick M Mao GJ Brewer 2004 Tetrathiomolybdate therapy protects against concanavalin A and carbon tetrachloride hepatic damage in mice Exp Biol Med 229 857 863
16. J Geist I Werner KJ Eder CM Leutenegger 2007 Comparisons of tissue-specific transcription of stress response genes with whole animal endpoints of adverse effect in striped bass (Morone saxatilis) following treatment with copper and esfenvalerate Aquatic Toxicol 85 28 39
17. M Song I Deaciuc Z Song 2008 Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis J Pharmacol Exp Ther 325 409 416
18. D Liu MS Razzaque M Cheng 2001 The renal expression of heat shock protein 47 and collagens in acute and chronic experimental diabetes in rats Histochem J 33 621 628
19. G Wilson EH Leiter 1999 Streptozotocin interactions with pancreatic beta cells and the induction of insulin-dependent diabetes Curr Top Microbiol Immunol 156 27 54
20. M Bertrand G Weber B Schoefs 2003 Metal determination and quantification in biological materials using particle induced X-ray emission Trends Anal Chem 22 254 262
21. GK Reddy CS Enwemeka 1996 A simplified method for the analysis of hydroxyproline in biological tissues Clin Biochem 29 225 229
22. D de Zeeuw G Remuzzi H-H Parving 2004 Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL Kidney Int 65 2309 2320
23. L Chen Y Wang YC Tay DC Harris 1997 Proteinuria and tubulointerstitial injury Kidney Int 61 S60 S62
24. GK Saunders 1986 The effects of excess renal copper on kidney function in the diabetic rat Res Commun Chem Pathol Pharmacol 52 45 49
25. JM Walshe 1982 Treatment of Wilson's disease with trientine (triethylene tetramine) dihydrochloride Lancet 1 643 647
26. H Kodama Y Murata T Itsuka T Abe 1997 Metabolism of administered triethylene tetramine dihydrochloride in humans Life Sci 61 899 907
27. FN Ziyadeh 2004 Mediators of diabetic renal disease: the case for TGF-β as the major mediator J Am Soc Nephrol 15 S55 S57
28. MD O'Conner-McCourt LM Wakefield 1987 Latent transforming growth factor beta in serum J Biol Chem 262 14090 14099
29. Y Yamaguchi DM Mann E Ruoslahti 1990 Negative regulation of transforming growth factor-beta by the proteoglycan decorin Nature 346 281 284
30. J Massagué YG Chen 2000 Controlling TGF-beta signalling Genes Dev 14 627 644
31. TF Lane ML Iruela-Arispe RS Johnson EH Sage 1994 SPARC is a source of copper-binding peptides that stimulate angiogenesis J Cell Biol 125 929 943
32. TP Strandjord DK Madtes DJ Weiss EH Sage 1999 Collagen accumulation is decreased in SPARC-null mice with bleomycin-induced pulmonary fibrosis Am J Physiol 277 L628 L635
33. GJ Brewer MR Ullenbruch R Dick L Olivarez SH Phan 2003 Tetrathiomolybdate therapy protects against bleomycin-induced pulmonary fibrosis in mice J Lab Clin Med 141 210 216
34. HB Lee H Ha 2005 Plasminogen activator inhibitor-1 and diabetic nephropathy Nephrology 10 S11 S13
35. JP Rerolle C Vigneau A Hertig J Berrou E Rondeau 2001 Plasminogen activator inhibitor type 1: physiology and role in renal physiopathology Nephrology 22 5 13
36. SD Langford MB Trent PJ Boor 2002 Semicarbazide-sensitive amine oxidase and extracellular matrix deposition by smooth-muscle cells Cardiovasc Toxicol 2 141 150
37. MU Ahmed SR Thorpe JW Baynes 1996 Identification of N-(carboxymethyl) lysine as a degradation product of fructose lysine in glycated protein J Biol Chem 261 4889 4894
38. ME Williams 2006 New potential agents in treating diabetic kidney disease: the fourth act Drugs 66 2287 2298
39. N Nazratun AA Mahmood UR Kuppusamy TS Ahmad SY Tan 2006 Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients Vascular Med 11 245 250
40. M Qian M Liu JW Eaton 1998 Transition metals bind to glycated proteins forming redox active "glycochelates": implications for the pathogenesis of certain diabetic complications Biochem Biophys Res Commun 250 385 389
41. L Cai S Chen T Evans MG Cherian S Chakrabarti 2002 Endothelin-1-mediated alteration of metallothionein and trace metals in the liver and kidneys of chronically diabetic rats Int J Exp Diabetes Res 3 193 198
42. H Kodama Y Murata 1999 Molecular genetics and pathophysiology of Menkes' disease Pediatr Int 41 430 435
43. H Ozawa H Kodama H Kawaguchi T Mochizuki M Kobayashi T Igarashi 2003 Renal function in patients with Menkes' disease Eur J Pediatr 162 51 52
44. ML Leu GT Strickland RA Gutman 1970 Renal function in Wilson's disease: response to penicillamine therapy Am J Med Sci 260 381 398
45. M Hayashi K Miyane M Senou 2005 Inhibitory effects of trientine, a copper-chelating agent, on induction of DNA strand breaks in kidney cells of Long-Evans cinnamon (LEC) rats Exp Anim 54 403 412
46. K Tsujikawa N Suzuki T Shimaoka 1994 Abnormal accumulation of copper-metallothionein in the liver and kidney of Long-Evans rats with a cinnamon-like coat color (LEC rats) Biol Pharm Bull 17 591 595
47. Y Sumi S Kawahara Y Kikuchi J Sawada T Suzuki KT Suzuki 1993 Histochemical and immunohistochemical localization of copper, iron and metallothionein in the liver and kidney of LEC rats Acta Histochem Cytochem 26 5 9
48. M Suzuki-Kurasaki M Okabe M Kurasaki 1997 Copper-metallothionein in the kidney of macular mice: a model of Menkes' disease J Histochem Cytochem 45 1493 1501
49. ML Chen ML Failla 1988 Metallothionein metabolism in the liver and kidney of the streptozotocin-diabetic rat Comp Biochem Physiol B 90 439 445
50. KA Wichmann PDW Boyd T Söhnel GR Allen ARJ Phillips GJS Cooper 2007 Characterization of dicarboxylic salts of protonated triethylenetetramine useful for the treatment of copper-related pathologies Cryst Growth Des 7 1844 1850