Whey protein/polysaccharide-stabilized emulsions: Effect of polymer type and pH on release and topical delivery of salicylic acid

AAPS PharmSciTech

Volumn 15, Issue 3, 2014, Pages 588-600

  Combrinck, Johann ^a   Otto, Anja ^a   Du Plessis, Jeanetta ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

Author keywords

emulsion; release; salicylic acid; topical; transdermal

Indexed keywords

CARRAGEENAN; CHITOSAN; POLYMER; POLYSACCHARIDE; SALICYLIC ACID; EMULSION; EXCIPIENT; MILK PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; WHEY PROTEIN;

ARTICLE; CHEMICAL COMPOSITION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; EMULSION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; PARTICLE SIZE; PH; PRIORITY JOURNAL; SKIN ABSORPTION; TURBIDITY; VISCOSITY; WHEY; ZETA POTENTIAL; CHEMICAL MODEL; CHEMISTRY; INTRADERMAL DRUG ADMINISTRATION; KINETICS; MEDICINAL CHEMISTRY; METABOLISM; PHARMACEUTICS; PROCEDURES; SKIN; SOLUBILITY; STATIC ELECTRICITY; SURFACE PROPERTY;

ADMINISTRATION, CUTANEOUS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; EMULSIONS; EXCIPIENTS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MILK PROTEINS; MODELS, CHEMICAL; PARTICLE SIZE; SALICYLIC ACID; SKIN; SKIN ABSORPTION; SOLUBILITY; STATIC ELECTRICITY; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; WHEY PROTEINS;

EID: 84902013379     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-014-0081-3     Document Type: Article

References (23)

1. Förster T, Von Rybinski W. Applications of emulsions. In: Binks BP, editor. Modern aspects of emulsion science. Cambridge: Royal Society of Chemistry; 1998. p. 395-426.
2. Youenang Piemi MP, Korner D, Benita S, Marty JP. Positively and negatively charged submicron emulsions for enhanced topical delivery of antifungal drugs. J Control Release. 1999;58:177-87. (Pubitemid 29112888)
3. Frelichowska J, Bolzinger MA, Valour JP, Mouaziz H, Pelletier J, Chevalier Y. Pickering w/o emulsions: drug release and topical delivery. Int J Pharm. 2009;368:7-15.
4. Förster M, Bolzinger MA, Ach D, Montagnac G, Briancon S. Ingredients tracking of cosmetic formulations in the skin: a confocal Raman microscopy investigation. Pharm Res. 2011;28:858-72.
5. Oborska A, Arct J, Mojski M, Jaremko E. Influence of polyalcohols and surfactants on skin penetration of flavonoids from the emulsion. J Appl Cosmetol. 2004;22:35-42. (Pubitemid 38679298)
6. Dalvi UG, Zatz JL. Effect of nonionic surfactants on penetration of dissolved benzocaine through hairless mouse skin. J Soc Cosmet Chem. 1981;32:87-94. (Pubitemid 11009556)
7. McClements DJ. Structural design principles for improved food performance: nanolaminated biopolymer structures in foods. In: Huang Q, Given P, Qian M, editors. Micro/nanoencapsulation of active food ingredients. ACS Symposium Series 1007. Washington, DC: American Chemical Society; 2009. p. 3-34.
8. Cho YH, Decker EA, McClements DJ. Competitive adsorption of mixed anionic polysaccharides at the surfaces of protein-coated lipid droplets. Langmuir. 2009;25:2654-60.
9. Livney YD. Milk proteins as vehicles for bioactives. Curr Opin Colloid Interface Sci. 2010;15:73-83.
10. Bouyer E, Mekhloufia G, Rosilio V, Grossiord JL, Agnely F. Proteins, polysaccharides and their complexes used as stabilizers for emulsions: alternatives to synthetic surfactants in the pharmaceutical field? Int J Pharm. 2012;436:359-78.
11. He W, Tan Y, Tian Z, Chen L, Hu F, Wu W. Food protein-stabilized nanoemulsions as potential delivery systems for poorly water-soluble drugs: preparation, in vitro characterization and pharmacokinetics in rats. Int J Nanomedicine. 2011;6:521-33.
12. Ru Q, Cho Y, Huang Q. Biopolymer-stabilized emulsions on the basis of interactions between β-lactoglobulin and ι-carrageenan. Front Chem Eng China. 2009;3:399-406.
13. Rodríguez MS, Albertengo LA, Agulló E. Emulsification capacity of chitosan. Carbohydr Polym. 2002;48:271-6. (Pubitemid 34141165)
14. Lima EL, Muñoz LC, Harris RE, Caballero AMH. Potential applications of chitosan as a marine cosmeceutical. In: Kim SK, editor. Marine cosmeceuticals: trends and prospects. Boca Raton: CRC; 2012. p. 319-33.
15. Guzey D, McClements DJ. Characterization of β-lactoglobulin-chitosan interactions in aqueous solutions: a calorimetry, light scattering, electrophoretic mobility and solubility study. Food Hydrocoll. 2006;20:124-31. (Pubitemid 41116843)
16. Li Y, Hu M, Xiao H, Du Y, Decker EA, McClements DJ. Controlling the functional performance of emulsion-based delivery systems using multi-component biopolymer coatings. Eur J Pharm Biopharm. 2010;76:38-47.
17. Gu YS, Decker EA, McClements DJ. Influence of pH and ι-carrageenan concentration on physicochemical properties and stability of β-lactoglobulin-stabilized oil-in-water emulsions. J Agric Food Chem. 2004;52:3626-32.
18. Fasano WJ,Manning LA, Green JW. Rapid integrity assessment of rat and human epidermal membranes for in vitro dermal regulatory testing: correlation of electrical resistance with tritiated water permeability. Toxicol In Vitro. 2002;16:731-40. (Pubitemid 35356281)
19. Shchukina EM, Shchukin DG. Layer-by-layer coated emulsion microparticles as storage and delivery tool. Curr Opin Colloid Interface Sci. 2012;17:281-9.
20. Serajuddin ATM, Jarowski CI. Effect of diffusion layer pH and solubility on the dissolution rate of pharmaceutical acids and their sodium salts. II: Salicylic acid, theophylline, and benzoic acid. J Pharm Sci. 1985;74:148-54. (Pubitemid 15135800)
21. Smith JC, Irwin WJ. Ionization and the effect of absorption enhancers on transport of salicylic acid through silastic rubber and human skin. Int J Pharm. 2000;210:69-82. (Pubitemid 32332643)
22. Abdel-Mottaleb MMA, Moulari B, Beduneau A, Pellequer Y, Lamprecht A. Surface-charge-dependent nanoparticles accumulation in inflamed skin. J Pharm Sci. 2012;101:4231-9.
23. Ghouchi Eskandar N, Simovic S, Prestidge CA. Nanoparticle coated submicron emulsions: sustained in-vitro release and improved dermal delivery of all-trans-retinol. Pharm Res. 2009;26:1764-75.