Tetrandrine and fangchinoline, bisbenzylisoquinoline alkaloids from Stephania tetrandra can reverse multidrug resistance by inhibiting P-glycoprotein activity in multidrug resistant human cancer cells

Phytomedicine

Volumn 21, Issue 8-9, 2014, Pages 1110-1119

  Sun, Yan Fang ^a,b   Wink, Michael ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b LIAONING TECHNICAL UNIVERSITY   (China)

Author keywords

ABC transporter activity; Fangchinoline; Multidrug resistance (MDR); P glycoprotein (P gp); Tetrandrine

Indexed keywords

ANTINEOPLASTIC AGENT; BISBENZYLISOQUINOLINE ALKALOID; DOXORUBICIN; FANGQUINOLINE; MULTIDRUG RESISTANCE PROTEIN; RHODAMINE 123; TETRANDRINE; ABC TRANSPORTER; ALKALOID; BENZYLISOQUINOLINE DERIVATIVE;

ARTICLE; CACO 2 CELL LINE; CANCER CELL; CANCER RESISTANCE; CANCER THERAPY; CONCENTRATION RESPONSE; CYTOTOXICITY; DRUG EFFECT; ENZYME INHIBITION; HCT116 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEPHANIA TETRANDRA; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; MEDICINAL PLANT; METABOLISM; TUMOR CELL LINE;

STEPHANIA TETRANDRA;

ALKALOIDS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ATP-BINDING CASSETTE TRANSPORTERS; BENZYLISOQUINOLINES; CELL LINE, TUMOR; CELL SURVIVAL; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; P-GLYCOPROTEIN; PLANTS, MEDICINAL; RHODAMINE 123; STEPHANIA TETRANDRA;

EID: 84902011359     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.04.029     Document Type: Article

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