Synergism of three-drug combinations of sanguinarine and other plant secondary metabolites with digitonin and doxorubicin in multi-drug resistant cancer cells

Phytomedicine

Volumn 19, Issue 14, 2012, Pages 1288-1297

  Eid, Safaa Yehia ^a   El Readi, Mahmoud Zaki ^a,b   Wink, Michael ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Al Azhar University   (Egypt)

Author keywords

Alkaloids; Digitonin; Doxorubicin; Reversal agent; Synergy; Terpenoids; Three drug combination

Indexed keywords

AROMADENDRENE; BETA CAROTENE; DIGITONIN; DOXORUBICIN; GLAUCINE; HARMINE; MENTHOL; PHENOL DERIVATIVE; PLANT MEDICINAL PRODUCT; SANGUINARINE; SITOSTEROL DERIVATIVE;

ARTICLE; CANCER CELL; CANCER COMBINATION CHEMOTHERAPY; CONCENTRATION RESPONSE; CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL;

ALKALOIDS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZOPHENANTHRIDINES; CACO-2 CELLS; DIGITONIN; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; HUMANS; INHIBITORY CONCENTRATION 50; ISOQUINOLINES; NEOPLASMS; PHENOLS; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS; TERPENES;

EID: 84870053873     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.08.010     Document Type: Article

References (37)

1. C. Bachran, M. Sutherland, I. Heisler, P. Hebestreit, M.F. Melzig, and H. Fuchs The saponin-mediated enhanced uptake of targeted saporin-based drugs is strongly dependent on the saponin structure Experimental Biology and Medicine (Maywood, N.J.) 231 2006 412 420
2. L.-P. Bai, Z.-Z. Zhao, Z. Cai, and Z.-H. Jiang DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine Bioorganic & Medicinal Chemistry 14 2006 5439 5445
3. Y. Baran, B. Gur, P. Kaya, A.U. Ural, F. Avcu, and U. Gunduz Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance Hematology 12 2007 511 517
4. M.C. Berenbaum What is synergy? Pharmacological Reviews 41 1989 93 141
5. H.B. Cai, F.G. Dai, Q.F. Min, M. Shi, J.X. Miao, and R.C. Luo Clinical study of the effects of radiotherapy in combination with traditional Chinese medicine on non-small cell lung cancer Di Yi Jun Yi Da Xue Xue Bao 22 2002 1112 1113
6. J. Cai, M. Liu, Z. Wang, and Y. Ju Apoptosis induced by dioscin in Hela cells Biological and Pharmaceutical Bulletin 25 2002 193 196
7. R. Cao, W. Peng, Z. Wang, and A. Xu beta-Carboline alkaloids: biochemical and pharmacological functions Current Medicinal Chemistry 14 2007 479 500
8. J.H. Chou, and T.C. Chou Computerized simulation of dose reduction index (DRI) in synergistic drug combinations Pharmacologist 30 1988 A231
9. T.C. Chou, and P. Talalay Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors Advances in Enzyme Regulation 22 1984 27 55
10. T.C. Chou Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies Pharmacological Reviews 58 2006 621 681
11. T.C. Chou Drug combination studies and their synergy quantification using the Chou-Talalay method Cancer Research 70 2010 440 446
12. T. Efferth, M. Davey, A. Olbrich, G. Rucker, E. Gebhart, and R. Davey Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells Blood Cells, Molecules & Diseases 28 2002 160 168
13. M.Z. El-Readi, D. Hamdan, N. Farrag, A. El-Shazly, and M. Wink Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines European Journal of Pharmacology 626 2010 139 145
14. F.A. Fornari, J.K. Randolph, J.C. Yalowich, M.K. Ritke, and D.A. Gewirtz Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells Molecular Pharmacology 45 1994 649 656
15. W.R. Greco, G. Bravo, and J.C. Parsons The search for synergy: a critical review from a response surface perspective Pharmacological Reviews 47 1995 331 385
16. V. Haridas, M. Higuchi, G.S. Jayatilake, D. Bailey, K. Mujoo, M.E. Blake, C.J. Arntzen, and J.U. Gutterman Avicins: triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation Proceedings of the National Academy of Sciences of the United States of America 98 2001 5821 5826
17. B.G. Katzung Basic & Clinical Pharmacology 1992 Appleton & Lange Norwalk, CT
18. J.H. Li A study on treatment of lung cancer by combined therapy of traditional Chinese medicine and chemotherapy Zhongguo Zhong Xi Yi Jie He Za Zhi 16 1996 136 138
19. S. Li, Y. Lei, Y. Jia, N. Li, M. Wink, and Y. Ma Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells Phytomedicine 19 2011 83 87
20. Y. Ma, and M. Wink Lobeline, a piperidine alkaloid from Lobelia can reverse P-gp dependent multidrug resistance in tumor cells Phytomedicine 15 2008 754 758
21. M. Möller, J. Weiss, and M. Wink Reduction of cytotoxicity of the alkaloid emetine through P-glycoprotein (MDR1/ABCB1) in human Caco-2 cells and leukemia cell lines Planta Medica 72 2006 1121 1126
22. M. Möller, K. Herzer, T. Wenger, I. Herr, and M. Wink The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells Oncology Reports 18 2007 737 744
23. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays Journal of Immunological Methods 65 1983 55 63
24. C.P. Reynolds, and B.J. Maurer Evaluating response to antineoplastic drug combinations in tissue culture models Methods in Molecular Medicine 110 2005 173 183
25. M.F. Roberts, and M. Wink Alkaloids: Biochemistry, Ecology and Medicinal Applications 1998 Plenum Press New York
26. V. Rosenkranz, and M. Wink Alkaloids induce programmed cell death in bloodstream forms of trypanosomes (Trypanosoma b. brucei) Molecules 13 2008 2462 2473
27. B.-E. Van Wyk, and M. Wink Medicinal Plants of the World: An Illustrated Scientific Guide to Important Medicinal Plants and Their Uses 2004 Timber Press Portland
28. H. Wagner Synergy research: a new approach to evaluating the efficacy of herbal mono-drug extracts and their combinations Natural Product Communications 4 2009 303 304
29. H. Wagner Synergy research: approaching a new generation of phytopharmaceuticals Fitoterapia 82 2011 34 37
30. M. Wink Modes of action of alkaloids M.F. Roberts, M. Wink, Alkaloids: Biochemistry, Ecology, and Medicinal Applications 1998 Plenum Press New York 301 326
31. M. Wink Molecular modes of action of cytotoxic alkaloids: from DNA intercalation, spindle poisoning, topoisomerase inhibition to apoptosis and multiple drug resistance G.A. Cordell, The Alkaloids: Chemistry and Biology vol. 64 2007 Academic Press San Diego, USA 1 47
32. M. Wink Evolutionary advantage and molecular modes of action of multi-component mixtures used in phytomedicine Current Drug Metabolism 9 2008 996 1009
33. M. Wink, and B.-E. Van Wyk Mind-altering and Poisonous Plants of the World 2008 Timber Press Portland, OR
34. M. Wink Molecular modes of action of drugs used in phytomedicine G. Bagetta, M. Cosentino, M.T. Corasaniti, S. Sakurada, Herbal Medicines Development and Validation of Plant-derived Medicines for Human Health, Clinical Pharmacognosy Series [1] 2012 CRC Press Boca Raton 161 172
35. M. Wink, M.L. Ashour, and M.Z. El-Readi Secondary metabolites from plants inhibiting ABC transporters and reversing resistance of cancer cells and microbes to cytotoxic and antimicrobial agents Frontiers in Microbiology 3 2012 130
36. G. You, and M.E. Morris Drug Transporters: Molecular Characterization and Role in Drug Disposition 2007 Wiley-Interscience Hoboken, NJ
37. L. Zhao, M.G. Wientjes, and J.L. Au Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses Clinical Cancer Research 10 2004 7994 8004