메뉴 건너뛰기




Volumn 61, Issue 8, 2014, Pages 1497-1505

Lessons learned from adult clinical experience to inform evaluations of VEGF pathway inhibitors in children with cancer

Author keywords

Anti angiogenesis; Kinase inhibitors; Vascular endothelial growth factor

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; CEDIRANIB; PAZOPANIB; PHOSPHOTRANSFERASE INHIBITOR; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 2 KINASE INHIBITOR;

EID: 84902006835     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.25036     Document Type: Review
Times cited : (9)

References (147)
  • 1
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: Therapeutic implications. N Engl J Med 1971; 285:1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 2
    • 84901981079 scopus 로고    scopus 로고
    • Hope in the lab: A special report. A cautious awe greets drugs that eradicate tumors in mice. New York Times. May 3
    • Kolata G. Hope in the lab: A special report. A cautious awe greets drugs that eradicate tumors in mice. New York Times. May 3, 1998.
    • (1998)
    • Kolata, G.1
  • 3
    • 84901981068 scopus 로고    scopus 로고
    • Nobel Prize Winner Denies Cancer Quote. Reuters. May 7
    • Nobel Prize Winner Denies Cancer Quote. Reuters. May 7, 1998.
    • (1998)
  • 4
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350:2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 5
    • 84857915848 scopus 로고    scopus 로고
    • Dynamic contrast-enhanced MRI in clinical trials of antivascular therapies
    • O'Connor JP, Jackson A, Parker GJ, et al. Dynamic contrast-enhanced MRI in clinical trials of antivascular therapies. Nat Rev Clin Oncol 2012; 9:167-177.
    • (2012) Nat Rev Clin Oncol , vol.9 , pp. 167-177
    • O'Connor, J.P.1    Jackson, A.2    Parker, G.J.3
  • 6
    • 84878979173 scopus 로고    scopus 로고
    • Predictive biomarkers for bevacizumab: Are we there yet
    • Maru D, Venook AP, Ellis LM. Predictive biomarkers for bevacizumab: Are we there yet? Clin Cancer Res 2013; 19:2824-2827.
    • (2013) Clin Cancer Res , vol.19 , pp. 2824-2827
    • Maru, D.1    Venook, A.P.2    Ellis, L.M.3
  • 7
    • 0037709883 scopus 로고    scopus 로고
    • von Hippel-Lindau disease
    • Lonser RR, Glenn GM, Walther M, et al. von Hippel-Lindau disease. Lancet 2003; 361:2059-2067.
    • (2003) Lancet , vol.361 , pp. 2059-2067
    • Lonser, R.R.1    Glenn, G.M.2    Walther, M.3
  • 9
    • 0035394516 scopus 로고    scopus 로고
    • Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas
    • Wiesener MS, Munchenhagen PM, Berger I, et al. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas. Cancer Res 2001; 61:5215-5222.
    • (2001) Cancer Res , vol.61 , pp. 5215-5222
    • Wiesener, M.S.1    Munchenhagen, P.M.2    Berger, I.3
  • 10
    • 33846260566 scopus 로고    scopus 로고
    • Sorafenib for the treatment of advanced renal cell carcinoma
    • Kane RC, Farrell AT, Saber H, et al. Sorafenib for the treatment of advanced renal cell carcinoma. Clin Cancer Res 2006; 12:7271-7278.
    • (2006) Clin Cancer Res , vol.12 , pp. 7271-7278
    • Kane, R.C.1    Farrell, A.T.2    Saber, H.3
  • 11
    • 33846440150 scopus 로고    scopus 로고
    • Food and drug administration drug approval summary: Sunitinib malate for the treatment of gastrointestinal stromal tumor and advanced renal cell carcinoma
    • Rock EP, Goodman V, Jiang JX, et al. Food and drug administration drug approval summary: Sunitinib malate for the treatment of gastrointestinal stromal tumor and advanced renal cell carcinoma. Oncologist 2007; 12:107-113.
    • (2007) Oncologist , vol.12 , pp. 107-113
    • Rock, E.P.1    Goodman, V.2    Jiang, J.X.3
  • 12
    • 79959796486 scopus 로고    scopus 로고
    • NICE guidance on pazopanib for first-line treatment of advanced renal-cell carcinoma
    • Griffiths C, Hay N, Sutcliffe F, et al. NICE guidance on pazopanib for first-line treatment of advanced renal-cell carcinoma. Lancet Oncol 2011; 12:221-222.
    • (2011) Lancet Oncol , vol.12 , pp. 221-222
    • Griffiths, C.1    Hay, N.2    Sutcliffe, F.3
  • 14
    • 84876974877 scopus 로고    scopus 로고
    • Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: Overall survival analysis and updated results from a randomised phase 3 trial
    • Motzer RJ, Escudier B, Tomczak P, et al. Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: Overall survival analysis and updated results from a randomised phase 3 trial. Lancet Oncol 2013; 14:552-562.
    • (2013) Lancet Oncol , vol.14 , pp. 552-562
    • Motzer, R.J.1    Escudier, B.2    Tomczak, P.3
  • 15
    • 84870694248 scopus 로고    scopus 로고
    • Phase III AXIS trial of axitinib versus sorafenib in metastatic renal cell carcinoma: Updated results among cytokine-treated patients
    • abstr 4546.
    • Michaelson MD, Rini BI, Escudier BJ, et al. Phase III AXIS trial of axitinib versus sorafenib in metastatic renal cell carcinoma: Updated results among cytokine-treated patients. J Clin Oncol 2012; 30: (suppl; abstr 4546).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL
    • Michaelson, M.D.1    Rini, B.I.2    Escudier, B.J.3
  • 16
    • 75649152090 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab plus interferon for advanced renal cell carcinoma
    • Summers J, Cohen MH, Keegan P, et al. FDA drug approval summary: Bevacizumab plus interferon for advanced renal cell carcinoma. Oncologist 2010; 15:104-111.
    • (2010) Oncologist , vol.15 , pp. 104-111
    • Summers, J.1    Cohen, M.H.2    Keegan, P.3
  • 17
    • 79955845255 scopus 로고    scopus 로고
    • Targeted therapies for the treatment of metastatic renal cell carcinoma: Clinical evidence
    • Hutson TE. Targeted therapies for the treatment of metastatic renal cell carcinoma: Clinical evidence. Oncologist 2011; 16:14-22.
    • (2011) Oncologist , vol.16 , pp. 14-22
    • Hutson, T.E.1
  • 18
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007; 356:115-124.
    • (2007) N Engl J Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 19
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 2009; 27:3584-3590.
    • (2009) J Clin Oncol , vol.27 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 20
    • 84891831968 scopus 로고    scopus 로고
    • Sunitinib objective response in metastatic renal cell carcinoma: analysis of 1059 patients treated on clinical trials
    • Molina AM, Lin X, Korytowsky B, et al. Sunitinib objective response in metastatic renal cell carcinoma: analysis of 1059 patients treated on clinical trials. Eur J Cancer 2014; 50:351-358.
    • (2014) Eur J Cancer , vol.50 , pp. 351-358
    • Molina, A.M.1    Lin, X.2    Korytowsky, B.3
  • 21
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
    • Sternberg CN, Davis ID, Mardiak J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial. J Clin Oncol 2010; 28:1061-1068.
    • (2010) J Clin Oncol , vol.28 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3
  • 22
    • 56749161699 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
    • Rini BI, Halabi S, Rosenberg JE, et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol 2008; 26:5422-5428.
    • (2008) J Clin Oncol , vol.26 , pp. 5422-5428
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3
  • 23
    • 77952318310 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: Final results of CALGB90206
    • Rini BI, Halabi S, Rosenberg JE, et al. Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: Final results of CALGB90206. J Clin Oncol 2010; 28:2137-2143.
    • (2010) J Clin Oncol , vol.28 , pp. 2137-2143
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3
  • 24
    • 84880916561 scopus 로고    scopus 로고
    • A phase II study of cediranib (AZD 2171) in treatment naive patients with progressive unresectable recurrent or metastatic renal cell carcinoma. A trial of the PMH phase 2 consortium
    • Sridhar SS, Mackenzie MJ, Hotte SJ, et al. A phase II study of cediranib (AZD 2171) in treatment naive patients with progressive unresectable recurrent or metastatic renal cell carcinoma. A trial of the PMH phase 2 consortium. Invest New Drugs 2013; 31:1008-1015.
    • (2013) Invest New Drugs , vol.31 , pp. 1008-1015
    • Sridhar, S.S.1    Mackenzie, M.J.2    Hotte, S.J.3
  • 25
    • 84857052966 scopus 로고    scopus 로고
    • Cediranib monotherapy in patients with advanced renal cell carcinoma: Results of a randomised phase II study
    • Mulders P, Hawkins R, Nathan P, et al. Cediranib monotherapy in patients with advanced renal cell carcinoma: Results of a randomised phase II study. Eur J Cancer 2012; 48:527-537.
    • (2012) Eur J Cancer , vol.48 , pp. 527-537
    • Mulders, P.1    Hawkins, R.2    Nathan, P.3
  • 26
    • 84891713447 scopus 로고    scopus 로고
    • Tivozanib versus sorafenib as initial targeted therapy for patients with metastatic renal cell carcinoma: Results from a phase III trial
    • Motzer RJ, Nosov D, Eisen T, et al. Tivozanib versus sorafenib as initial targeted therapy for patients with metastatic renal cell carcinoma: Results from a phase III trial. J Clin Oncol 2013; 31:3791-3799.
    • (2013) J Clin Oncol , vol.31 , pp. 3791-3799
    • Motzer, R.J.1    Nosov, D.2    Eisen, T.3
  • 27
    • 70450175957 scopus 로고    scopus 로고
    • Targeting angiogenesis: Progress with anti-VEGF treatment with large molecules
    • Grothey A, Galanis E. Targeting angiogenesis: Progress with anti-VEGF treatment with large molecules. Nat Rev Clin Oncol 2009; 6:507-518.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 507-518
    • Grothey, A.1    Galanis, E.2
  • 28
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
    • Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study. J Clin Oncol 2008; 26:2013-2019.
    • (2008) J Clin Oncol , vol.26 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Diaz-Rubio, E.3
  • 29
    • 84884552646 scopus 로고    scopus 로고
    • Efficacy and safety of bevacizumab in metastatic colorectal cancer: Pooled analysis from seven randomized controlled trials
    • Hurwitz HI, Tebbutt NC, Kabbinavar F, et al. Efficacy and safety of bevacizumab in metastatic colorectal cancer: Pooled analysis from seven randomized controlled trials. Oncologist 2013; 18:1004-1012.
    • (2013) Oncologist , vol.18 , pp. 1004-1012
    • Hurwitz, H.I.1    Tebbutt, N.C.2    Kabbinavar, F.3
  • 30
    • 84867047384 scopus 로고    scopus 로고
    • Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
    • Van Cutsem E, Tabernero J, Lakomy R, et al. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol 2012; 30:3499-3506.
    • (2012) J Clin Oncol , vol.30 , pp. 3499-3506
    • Van Cutsem, E.1    Tabernero, J.2    Lakomy, R.3
  • 31
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007; 357:2666-2676.
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 32
    • 20044364346 scopus 로고    scopus 로고
    • Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
    • Miller KD, Chap LI, Holmes FA, et al. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 2005; 23:792-799.
    • (2005) J Clin Oncol , vol.23 , pp. 792-799
    • Miller, K.D.1    Chap, L.I.2    Holmes, F.A.3
  • 33
    • 77954700380 scopus 로고    scopus 로고
    • Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Miles DW, Chan A, Dirix LY, et al. Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol 2010; 28:3239-3247.
    • (2010) J Clin Oncol , vol.28 , pp. 3239-3247
    • Miles, D.W.1    Chan, A.2    Dirix, L.Y.3
  • 34
    • 79953874259 scopus 로고    scopus 로고
    • RIBBON-1: Randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer
    • Robert NJ, Dieras V, Glaspy J, et al. RIBBON-1: Randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J Clin Oncol 2011; 29:1252-1260.
    • (2011) J Clin Oncol , vol.29 , pp. 1252-1260
    • Robert, N.J.1    Dieras, V.2    Glaspy, J.3
  • 35
    • 81155123190 scopus 로고    scopus 로고
    • RIBBON-2: A randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Brufsky AM, Hurvitz S, Perez E, et al. RIBBON-2: A randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol 2011; 29:4286-4293.
    • (2011) J Clin Oncol , vol.29 , pp. 4286-4293
    • Brufsky, A.M.1    Hurvitz, S.2    Perez, E.3
  • 36
    • 84857179053 scopus 로고    scopus 로고
    • FDA cancels approval for bevacizumab in advanced breast cancer
    • Tanne JH. FDA cancels approval for bevacizumab in advanced breast cancer. BMJ 2011; 343:d7684.
    • (2011) BMJ , vol.343
    • Tanne, J.H.1
  • 37
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006; 355:2542-2550.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 38
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
    • Reck M, von Pawel J, Zatloukal P, et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 2009; 27:1227-1234.
    • (2009) J Clin Oncol , vol.27 , pp. 1227-1234
    • Reck, M.1    von Pawel, J.2    Zatloukal, P.3
  • 39
    • 77951473661 scopus 로고    scopus 로고
    • Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: Results from a randomised phase III trial (AVAiL)
    • Reck M, von Pawel J, Zatloukal P, et al. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: Results from a randomised phase III trial (AVAiL). Ann Oncol 2010; 21:1804-1809.
    • (2010) Ann Oncol , vol.21 , pp. 1804-1809
    • Reck, M.1    von Pawel, J.2    Zatloukal, P.3
  • 40
    • 75449088610 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme
    • Cohen MH, Shen YL, Keegan P, et al. FDA drug approval summary: Bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme. Oncologist 2009; 14:1131-1138.
    • (2009) Oncologist , vol.14 , pp. 1131-1138
    • Cohen, M.H.1    Shen, Y.L.2    Keegan, P.3
  • 41
    • 84880660554 scopus 로고    scopus 로고
    • RTOG 0825 Phase III double-blind placebo-controlled trial evaluating bevacizumab (Bev) in patients (Pts) with newly diagnosed glioblastoma (GBM)
    • abstr 1
    • Gilbert MR, Dignam J, Won M, et al. RTOG 0825 Phase III double-blind placebo-controlled trial evaluating bevacizumab (Bev) in patients (Pts) with newly diagnosed glioblastoma (GBM). J Clin Oncol 2013; 31: (suppl; abstr 1).
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL
    • Gilbert, M.R.1    Dignam, J.2    Won, M.3
  • 42
    • 84892414912 scopus 로고    scopus 로고
    • Progression-free survival (PFS) and health-related quality of life (HRQoL) in AVAglio, a phase III study of bevacizumab (Bv), temozolomide (T), and radiotherapy (RT) in newly diagnosed glioblastoma (GBM)
    • abstr 2005
    • Henriksson R, Bottomley A, Mason W, et al. Progression-free survival (PFS) and health-related quality of life (HRQoL) in AVAglio, a phase III study of bevacizumab (Bv), temozolomide (T), and radiotherapy (RT) in newly diagnosed glioblastoma (GBM). J Clin Oncol 2013; 31: (suppl; abstr 2005).
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL
    • Henriksson, R.1    Bottomley, A.2    Mason, W.3
  • 43
    • 84883258022 scopus 로고    scopus 로고
    • Angiogenesis as a target for the treatment of ovarian cancer
    • Shaw D, Clamp A, Jayson GC. Angiogenesis as a target for the treatment of ovarian cancer. Curr Opin Oncol 2013; 25:558-565.
    • (2013) Curr Opin Oncol , vol.25 , pp. 558-565
    • Shaw, D.1    Clamp, A.2    Jayson, G.C.3
  • 44
    • 84855425106 scopus 로고    scopus 로고
    • Incorporation of bevacizumab in the primary treatment of ovarian cancer
    • Burger RA, Brady MF, Bookman MA, et al. Incorporation of bevacizumab in the primary treatment of ovarian cancer. N Engl J Med 2011; 365:2473-2483.
    • (2011) N Engl J Med , vol.365 , pp. 2473-2483
    • Burger, R.A.1    Brady, M.F.2    Bookman, M.A.3
  • 45
    • 84855466019 scopus 로고    scopus 로고
    • A phase 3 trial of bevacizumab in ovarian cancer
    • Perren TJ, Swart AM, Pfisterer J, et al. A phase 3 trial of bevacizumab in ovarian cancer. N Engl J Med 2011; 365:2484-2496.
    • (2011) N Engl J Med , vol.365 , pp. 2484-2496
    • Perren, T.J.1    Swart, A.M.2    Pfisterer, J.3
  • 46
    • 79551521053 scopus 로고    scopus 로고
    • Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: Results of NSABP protocol C-08
    • Allegra CJ, Yothers G, O'Connell MJ, et al. Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: Results of NSABP protocol C-08. J Clin Oncol 2011; 29:11-16.
    • (2011) J Clin Oncol , vol.29 , pp. 11-16
    • Allegra, C.J.1    Yothers, G.2    O'Connell, M.J.3
  • 47
    • 84873328631 scopus 로고    scopus 로고
    • Bevacizumab in stage II-III colon cancer: 5-year update of the National Surgical Adjuvant Breast and Bowel Project C-08 trial
    • Allegra CJ, Yothers G, O'Connell MJ, et al. Bevacizumab in stage II-III colon cancer: 5-year update of the National Surgical Adjuvant Breast and Bowel Project C-08 trial. J Clin Oncol 2013; 31:359-364.
    • (2013) J Clin Oncol , vol.31 , pp. 359-364
    • Allegra, C.J.1    Yothers, G.2    O'Connell, M.J.3
  • 48
    • 84870244259 scopus 로고    scopus 로고
    • Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): A phase 3 randomised controlled trial
    • de Gramont A, Van Cutsem E, Schmoll HJ, et al. Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): A phase 3 randomised controlled trial. Lancet Oncol 2012; 13:1225-1233.
    • (2012) Lancet Oncol , vol.13 , pp. 1225-1233
    • de Gramont, A.1    Van Cutsem, E.2    Schmoll, H.J.3
  • 49
    • 84883050174 scopus 로고    scopus 로고
    • Adjuvant bevacizumab-containing therapy in triple-negative breast cancer (BEATRICE): Primary results of a randomised, phase 3 trial
    • Cameron D, Brown J, Dent R, et al. Adjuvant bevacizumab-containing therapy in triple-negative breast cancer (BEATRICE): Primary results of a randomised, phase 3 trial. Lancet Oncol 2013; 14:933-942.
    • (2013) Lancet Oncol , vol.14 , pp. 933-942
    • Cameron, D.1    Brown, J.2    Dent, R.3
  • 50
    • 77955887676 scopus 로고    scopus 로고
    • Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: Phase III trial of the Cancer and Leukemia Group B (CALGB 80303)
    • Kindler HL, Niedzwiecki D, Hollis D, et al. Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: Phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J Clin Oncol 2010; 28:3617-3622.
    • (2010) J Clin Oncol , vol.28 , pp. 3617-3622
    • Kindler, H.L.1    Niedzwiecki, D.2    Hollis, D.3
  • 51
    • 65549150854 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer
    • Van Cutsem E, Vervenne WL, Bennouna J, et al. Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. J Clin Oncol 2009; 27:2231-2237.
    • (2009) J Clin Oncol , vol.27 , pp. 2231-2237
    • Van Cutsem, E.1    Vervenne, W.L.2    Bennouna, J.3
  • 52
    • 84861690508 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled phase III trial comparing docetaxel and prednisone with or without bevacizumab in men with metastatic castration-resistant prostate cancer: CALGB 90401
    • Kelly WK, Halabi S, Carducci M, et al. Randomized, double-blind, placebo-controlled phase III trial comparing docetaxel and prednisone with or without bevacizumab in men with metastatic castration-resistant prostate cancer: CALGB 90401. J Clin Oncol 2012; 30:1534-1540.
    • (2012) J Clin Oncol , vol.30 , pp. 1534-1540
    • Kelly, W.K.1    Halabi, S.2    Carducci, M.3
  • 53
    • 80053573446 scopus 로고    scopus 로고
    • Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A randomized, double-blind, placebo-controlled phase III study
    • Ohtsu A, Shah MA, Van Cutsem E, et al. Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A randomized, double-blind, placebo-controlled phase III study. J Clin Oncol 2011; 29:3968-3976.
    • (2011) J Clin Oncol , vol.29 , pp. 3968-3976
    • Ohtsu, A.1    Shah, M.A.2    Van Cutsem, E.3
  • 54
    • 84879952361 scopus 로고    scopus 로고
    • Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer
    • Rougier P, Riess H, Manges R, et al. Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer. Eur J Cancer 2013; 49:2633-2642.
    • (2013) Eur J Cancer , vol.49 , pp. 2633-2642
    • Rougier, P.1    Riess, H.2    Manges, R.3
  • 55
    • 84879786803 scopus 로고    scopus 로고
    • Aflibercept versus placebo in combination with docetaxel and prednisone for treatment of men with metastatic castration-resistant prostate cancer (VENICE): A phase 3, double-blind randomised trial
    • Tannock IF, Fizazi K, Ivanov S, et al. Aflibercept versus placebo in combination with docetaxel and prednisone for treatment of men with metastatic castration-resistant prostate cancer (VENICE): A phase 3, double-blind randomised trial. Lancet Oncol 2013; 14:760-768.
    • (2013) Lancet Oncol , vol.14 , pp. 760-768
    • Tannock, I.F.1    Fizazi, K.2    Ivanov, S.3
  • 56
    • 69249221392 scopus 로고    scopus 로고
    • Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: Sustained regression before and after allogeneic stem cell transplantation
    • Metzelder S, Wang Y, Wollmer E, et al. Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: Sustained regression before and after allogeneic stem cell transplantation. Blood 2009; 113:6567-6571.
    • (2009) Blood , vol.113 , pp. 6567-6571
    • Metzelder, S.1    Wang, Y.2    Wollmer, E.3
  • 57
    • 33846930383 scopus 로고    scopus 로고
    • The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors
    • Lierman E, Lahortiga I, Van Miegroet H, et al. The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors. Haematologica 2007; 92:27-34.
    • (2007) Haematologica , vol.92 , pp. 27-34
    • Lierman, E.1    Lahortiga, I.2    Van Miegroet, H.3
  • 58
    • 33847195060 scopus 로고    scopus 로고
    • Antitumor activity of sorafenib in FLT3-driven leukemic cells
    • Auclair D, Miller D, Yatsula V, et al. Antitumor activity of sorafenib in FLT3-driven leukemic cells. Leukemia 2007; 21:439-445.
    • (2007) Leukemia , vol.21 , pp. 439-445
    • Auclair, D.1    Miller, D.2    Yatsula, V.3
  • 59
    • 34548691437 scopus 로고    scopus 로고
    • Sensitivity toward sorafenib and sunitinib varies between different activating and drug-resistant FLT3-ITD mutations
    • Kancha RK, Grundler R, Peschel C, et al. Sensitivity toward sorafenib and sunitinib varies between different activating and drug-resistant FLT3-ITD mutations. Exp Hematol 2007; 35:1522-1526.
    • (2007) Exp Hematol , vol.35 , pp. 1522-1526
    • Kancha, R.K.1    Grundler, R.2    Peschel, C.3
  • 60
    • 84872892692 scopus 로고    scopus 로고
    • Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): An international, multicentre, randomised, placebo-controlled, phase 3 trial
    • Demetri GD, Reichardt P, Kang YK, et al. Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): An international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 2013; 381:295-302.
    • (2013) Lancet , vol.381 , pp. 295-302
    • Demetri, G.D.1    Reichardt, P.2    Kang, Y.K.3
  • 61
    • 33749505836 scopus 로고    scopus 로고
    • Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
    • Demetri GD, van Oosterom AT, Garrett CR, et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial. Lancet 2006; 368:1329-1338.
    • (2006) Lancet , vol.368 , pp. 1329-1338
    • Demetri, G.D.1    van Oosterom, A.T.2    Garrett, C.R.3
  • 62
    • 84882955940 scopus 로고    scopus 로고
    • Cediranib for metastatic alveolar soft part sarcoma
    • Kummar S, Allen D, Monks A, et al. Cediranib for metastatic alveolar soft part sarcoma. J Clin Oncol 2013; 31:2296-2302.
    • (2013) J Clin Oncol , vol.31 , pp. 2296-2302
    • Kummar, S.1    Allen, D.2    Monks, A.3
  • 63
    • 61549104154 scopus 로고    scopus 로고
    • Response to sunitinib malate in advanced alveolar soft part sarcoma
    • Stacchiotti S, Tamborini E, Marrari A, et al. Response to sunitinib malate in advanced alveolar soft part sarcoma. Clin Cancer Res 2009; 15:1096-1104.
    • (2009) Clin Cancer Res , vol.15 , pp. 1096-1104
    • Stacchiotti, S.1    Tamborini, E.2    Marrari, A.3
  • 64
    • 79958717044 scopus 로고    scopus 로고
    • Sunitinib in advanced alveolar soft part sarcoma: Evidence of a direct antitumor effect
    • Stacchiotti S, Negri T, Zaffaroni N, et al. Sunitinib in advanced alveolar soft part sarcoma: Evidence of a direct antitumor effect. Ann Oncol 2011; 22:1682-1690.
    • (2011) Ann Oncol , vol.22 , pp. 1682-1690
    • Stacchiotti, S.1    Negri, T.2    Zaffaroni, N.3
  • 65
    • 84890560584 scopus 로고    scopus 로고
    • An update on clinical trials of targeted therapies in thyroid cancer
    • Haraldsdottir S, Shah MH. An update on clinical trials of targeted therapies in thyroid cancer. Curr Opin Oncol 2014; 26:36-44.
    • (2014) Curr Opin Oncol , vol.26 , pp. 36-44
    • Haraldsdottir, S.1    Shah, M.H.2
  • 66
    • 84887111477 scopus 로고    scopus 로고
    • Sorafenib in locally advanced or metastatic patients with radioactive iodine-refractory differentiated thyroid cancer: The phase III DECISION trial
    • abstr 4
    • Brose MS, Nutting CM, Jarzab B, et al. Sorafenib in locally advanced or metastatic patients with radioactive iodine-refractory differentiated thyroid cancer: The phase III DECISION trial. J Clin Oncol 2013; 31: (suppl; abstr 4).
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL
    • Brose, M.S.1    Nutting, C.M.2    Jarzab, B.3
  • 67
    • 84863890768 scopus 로고    scopus 로고
    • Vandetanib for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease: U.S. Food and drug administration drug approval summary
    • Thornton K, Kim G, Maher VE, et al. Vandetanib for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease: U.S. Food and drug administration drug approval summary. Clin Cancer Res 2012; 18:3722-3730.
    • (2012) Clin Cancer Res , vol.18 , pp. 3722-3730
    • Thornton, K.1    Kim, G.2    Maher, V.E.3
  • 68
    • 84890571003 scopus 로고    scopus 로고
    • Cabozantinib in progressive medullary thyroid cancer
    • Elisei R, Schlumberger MJ, Muller SP, et al. Cabozantinib in progressive medullary thyroid cancer. J Clin Oncol 2013; 31:3639-3646.
    • (2013) J Clin Oncol , vol.31 , pp. 3639-3646
    • Elisei, R.1    Schlumberger, M.J.2    Muller, S.P.3
  • 69
    • 61449175950 scopus 로고    scopus 로고
    • Sorafenib for the treatment of unresectable hepatocellular carcinoma
    • Kane RC, Farrell AT, Madabushi R, et al. Sorafenib for the treatment of unresectable hepatocellular carcinoma. Oncologist 2009; 14:95-100.
    • (2009) Oncologist , vol.14 , pp. 95-100
    • Kane, R.C.1    Farrell, A.T.2    Madabushi, R.3
  • 70
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359:378-390.
    • (2008) N Engl J Med , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 71
    • 84891915708 scopus 로고    scopus 로고
    • Sunitinib versus sorafenib in advanced hepatocellular cancer: Results of a randomized phase III trial
    • Cheng AL, Kang YK, Lin DY, et al. Sunitinib versus sorafenib in advanced hepatocellular cancer: Results of a randomized phase III trial. J Clin Oncol 2013; 31:4067-4075.
    • (2013) J Clin Oncol , vol.31 , pp. 4067-4075
    • Cheng, A.L.1    Kang, Y.K.2    Lin, D.Y.3
  • 72
    • 84890274647 scopus 로고    scopus 로고
    • Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: Results from the randomized phase III BRISK-FL study
    • Johnson PJ, Qin S, Park JW, et al. Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: Results from the randomized phase III BRISK-FL study. J Clin Oncol 2013; 31:3517-3524.
    • (2013) J Clin Oncol , vol.31 , pp. 3517-3524
    • Johnson, P.J.1    Qin, S.2    Park, J.W.3
  • 73
    • 84861098484 scopus 로고    scopus 로고
    • Pazopanib for metastatic soft-tissue sarcoma (PALETTE): A randomised, double-blind, placebo-controlled phase 3 trial
    • van der Graaf WT, Blay JY, Chawla SP, et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): A randomised, double-blind, placebo-controlled phase 3 trial. Lancet 2012; 379:1879-1886.
    • (2012) Lancet , vol.379 , pp. 1879-1886
    • van der Graaf, W.T.1    Blay, J.Y.2    Chawla, S.P.3
  • 74
    • 84872921660 scopus 로고    scopus 로고
    • Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): An international, multicentre, randomised, placebo-controlled, phase 3 trial
    • Grothey A, Van Cutsem E, Sobrero A, et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): An international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 2013; 381:303-312.
    • (2013) Lancet , vol.381 , pp. 303-312
    • Grothey, A.1    Van Cutsem, E.2    Sobrero, A.3
  • 75
    • 84865183629 scopus 로고    scopus 로고
    • Multitargeted tyrosine kinase inhibitors in unselected patients with advanced non-small-cell lung cancer (NSCLC): Impressions from MONET (the motesanib NSCLC efficacy and tolerability study)
    • Morgensztern D, Herbst RS. Multitargeted tyrosine kinase inhibitors in unselected patients with advanced non-small-cell lung cancer (NSCLC): Impressions from MONET (the motesanib NSCLC efficacy and tolerability study). J Clin Oncol 2012; 30:2805-2808.
    • (2012) J Clin Oncol , vol.30 , pp. 2805-2808
    • Morgensztern, D.1    Herbst, R.S.2
  • 76
    • 84867115561 scopus 로고    scopus 로고
    • Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: A double-blind, randomized phase III study (HORIZON III)
    • Schmoll HJ, Cunningham D, Sobrero A, et al. Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: A double-blind, randomized phase III study (HORIZON III). J Clin Oncol 2012; 30:3588-3595.
    • (2012) J Clin Oncol , vol.30 , pp. 3588-3595
    • Schmoll, H.J.1    Cunningham, D.2    Sobrero, A.3
  • 77
    • 84867602281 scopus 로고    scopus 로고
    • Cediranib plus FOLFOX/CAPOX versus placebo plus FOLFOX/CAPOX in patients with previously untreated metastatic colorectal cancer: A randomized, double-blind, phase III study (HORIZON II)
    • Hoff PM, Hochhaus A, Pestalozzi BC, et al. Cediranib plus FOLFOX/CAPOX versus placebo plus FOLFOX/CAPOX in patients with previously untreated metastatic colorectal cancer: A randomized, double-blind, phase III study (HORIZON II). J Clin Oncol 2012; 30:3596-3603.
    • (2012) J Clin Oncol , vol.30 , pp. 3596-3603
    • Hoff, P.M.1    Hochhaus, A.2    Pestalozzi, B.C.3
  • 78
    • 79956297102 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, phase III study of oxaliplatin, fluorouracil, and leucovorin with or without PTK787/ZK 222584 in patients with previously treated metastatic colorectal adenocarcinoma
    • Van Cutsem E, Bajetta E, Valle J, et al. Randomized, placebo-controlled, phase III study of oxaliplatin, fluorouracil, and leucovorin with or without PTK787/ZK 222584 in patients with previously treated metastatic colorectal adenocarcinoma. J Clin Oncol 2011; 29:2004-2010.
    • (2011) J Clin Oncol , vol.29 , pp. 2004-2010
    • Van Cutsem, E.1    Bajetta, E.2    Valle, J.3
  • 79
    • 79956334386 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma
    • Hecht JR, Trarbach T, Hainsworth JD, et al. Randomized, placebo-controlled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma. J Clin Oncol 2011; 29:1997-2003.
    • (2011) J Clin Oncol , vol.29 , pp. 1997-2003
    • Hecht, J.R.1    Trarbach, T.2    Hainsworth, J.D.3
  • 80
    • 84876089340 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and irinotecan plus either sunitinib or placebo in metastatic colorectal cancer: A randomized, phase III trial
    • Carrato A, Swieboda-Sadlej A, Staszewska-Skurczynska M, et al. Fluorouracil, leucovorin, and irinotecan plus either sunitinib or placebo in metastatic colorectal cancer: A randomized, phase III trial. J Clin Oncol 2013; 31:1341-1347.
    • (2013) J Clin Oncol , vol.31 , pp. 1341-1347
    • Carrato, A.1    Swieboda-Sadlej, A.2    Staszewska-Skurczynska, M.3
  • 81
    • 80051713290 scopus 로고    scopus 로고
    • Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: A phase III, randomized, open-label trial
    • Robert NJ, Saleh MN, Paul D, et al. Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: A phase III, randomized, open-label trial. Clin Breast Cancer 2011; 11:82-92.
    • (2011) Clin Breast Cancer , vol.11 , pp. 82-92
    • Robert, N.J.1    Saleh, M.N.2    Paul, D.3
  • 82
    • 84895480028 scopus 로고    scopus 로고
    • Randomised phase II study of axitinib or bevacizumab combined with paclitaxel/carboplatin as first-line therapy for patients with advanced non-small-cell lung cancer
    • Twelves C, Chmielowska E, Havel L, et al. Randomised phase II study of axitinib or bevacizumab combined with paclitaxel/carboplatin as first-line therapy for patients with advanced non-small-cell lung cancer. Ann Oncol 2014; 25:132-138.
    • (2014) Ann Oncol , vol.25 , pp. 132-138
    • Twelves, C.1    Chmielowska, E.2    Havel, L.3
  • 83
    • 84887291388 scopus 로고    scopus 로고
    • Axitinib or bevacizumab plus FOLFIRI or modified FOLFOX-6 after failure of first-line therapy for metastatic colorectal cancer: A randomized phase II study
    • Bendell JC, Tournigand C, Swieboda-Sadlej A, et al. Axitinib or bevacizumab plus FOLFIRI or modified FOLFOX-6 after failure of first-line therapy for metastatic colorectal cancer: A randomized phase II study. Clin Colorectal Cancer 2013; 12:239-247.
    • (2013) Clin Colorectal Cancer , vol.12 , pp. 239-247
    • Bendell, J.C.1    Tournigand, C.2    Swieboda-Sadlej, A.3
  • 84
    • 84894050019 scopus 로고    scopus 로고
    • Randomised double-blind phase III trial of cediranib (AZD 2171) in relapsed platinum sensitive ovarian cancer: Results of the ICON6 trial
    • LBA10
    • Ledermann JA, Perren TJ, Raja FA, et al. Randomised double-blind phase III trial of cediranib (AZD 2171) in relapsed platinum sensitive ovarian cancer: Results of the ICON6 trial. Eur Cancer Cong 2013; 2013:LBA10.
    • (2013) Eur Cancer Cong , vol.2013
    • Ledermann, J.A.1    Perren, T.J.2    Raja, F.A.3
  • 85
    • 73949092851 scopus 로고    scopus 로고
    • Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC clinical trials group BR24 study
    • Goss GD, Arnold A, Shepherd FA, et al. Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC clinical trials group BR24 study. J Clin Oncol 2010; 28:49-55.
    • (2010) J Clin Oncol , vol.28 , pp. 49-55
    • Goss, G.D.1    Arnold, A.2    Shepherd, F.A.3
  • 86
    • 84875222627 scopus 로고    scopus 로고
    • Cediranib with mFOLFOX6 vs bevacizumab with mFOLFOX6 in previously treated metastatic colorectal cancer
    • Cunningham D, Wong RP, D'Haens G, et al. Cediranib with mFOLFOX6 vs bevacizumab with mFOLFOX6 in previously treated metastatic colorectal cancer. Br J Cancer 2013; 108:493-502.
    • (2013) Br J Cancer , vol.108 , pp. 493-502
    • Cunningham, D.1    Wong, R.P.2    D'Haens, G.3
  • 87
    • 84865095318 scopus 로고    scopus 로고
    • International, randomized, placebo-controlled, double-blind phase III study of motesanib plus carboplatin/paclitaxel in patients with advanced nonsquamous non-small-cell lung cancer: MONET1
    • Scagliotti GV, Vynnychenko I, Park K, et al. International, randomized, placebo-controlled, double-blind phase III study of motesanib plus carboplatin/paclitaxel in patients with advanced nonsquamous non-small-cell lung cancer: MONET1. J Clin Oncol 2012; 30:2829-2836.
    • (2012) J Clin Oncol , vol.30 , pp. 2829-2836
    • Scagliotti, G.V.1    Vynnychenko, I.2    Park, K.3
  • 88
    • 84901981070 scopus 로고    scopus 로고
    • Primary results from BETH, a phase 3 controlled study of adjuvant chemotherapy and trastuzumab±bevacizumab in patients with HER2-positive, node-positive or high risk nodenegative breast cancer. 36th Annual San Antonio Breast Cancer Symposium (SABCS) 2013 Abstr # S1-03.
    • Slamon DJ, Swain SM, Buyse M, et al. Primary results from BETH, a phase 3 controlled study of adjuvant chemotherapy and trastuzumab±bevacizumab in patients with HER2-positive, node-positive or high risk nodenegative breast cancer. 36th Annual San Antonio Breast Cancer Symposium (SABCS) 2013 Abstr # S1-03.
    • Slamon, D.J.1    Swain, S.M.2    Buyse, M.3
  • 89
    • 84883177229 scopus 로고    scopus 로고
    • Adjuvant therapy in renal cell carcinoma-past, present, and future
    • Janowitz T, Welsh SJ, Zaki K, et al. Adjuvant therapy in renal cell carcinoma-past, present, and future. Semin Oncol 2013; 40:482-491.
    • (2013) Semin Oncol , vol.40 , pp. 482-491
    • Janowitz, T.1    Welsh, S.J.2    Zaki, K.3
  • 90
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent
    • Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990; 82:4-6.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 4-6
    • Folkman, J.1
  • 91
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • Ebos JM, Lee CR, Cruz-Munoz W, et al. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009; 15:232-239.
    • (2009) Cancer Cell , vol.15 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3
  • 92
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009; 15:220-231.
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 93
    • 84863715967 scopus 로고    scopus 로고
    • Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models
    • Singh M, Couto SS, Forrest WF, et al. Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models. J Pathol 2012; 227:417-430.
    • (2012) J Pathol , vol.227 , pp. 417-430
    • Singh, M.1    Couto, S.S.2    Forrest, W.F.3
  • 94
    • 77953362501 scopus 로고    scopus 로고
    • Molecular mechanisms underlying tumor dormancy
    • Almog N. Molecular mechanisms underlying tumor dormancy. Cancer Lett 2010; 294:139-146.
    • (2010) Cancer Lett , vol.294 , pp. 139-146
    • Almog, N.1
  • 95
    • 0347504928 scopus 로고    scopus 로고
    • Ineffectiveness of doxorubicin treatment on solitary dormant mammary carcinoma cells or late-developing metastases
    • Naumov GN, Townson JL, MacDonald IC, et al. Ineffectiveness of doxorubicin treatment on solitary dormant mammary carcinoma cells or late-developing metastases. Breast Cancer Res Treat 2003; 82:199-206.
    • (2003) Breast Cancer Res Treat , vol.82 , pp. 199-206
    • Naumov, G.N.1    Townson, J.L.2    MacDonald, I.C.3
  • 96
    • 82355187871 scopus 로고    scopus 로고
    • Clinical development of VEGF signaling pathway inhibitors in childhood solid tumors
    • Glade Bender J, Yamashiro DJ, Fox E. Clinical development of VEGF signaling pathway inhibitors in childhood solid tumors. Oncologist 2011; 16:1614-1625.
    • (2011) Oncologist , vol.16 , pp. 1614-1625
    • Glade Bender, J.1    Yamashiro, D.J.2    Fox, E.3
  • 97
    • 70350002279 scopus 로고    scopus 로고
    • Adverse effects of anticancer agents that target the VEGF pathway
    • Chen HX, Cleck JN. Adverse effects of anticancer agents that target the VEGF pathway. Nat Rev Clin Oncol 2009; 6:465-477.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 465-477
    • Chen, H.X.1    Cleck, J.N.2
  • 99
    • 33645014406 scopus 로고    scopus 로고
    • Review of the effects of anti-angiogenic compounds on the epiphyseal growth plate
    • Hall AP, Westwood FR, Wadsworth PF. Review of the effects of anti-angiogenic compounds on the epiphyseal growth plate. Toxicol Pathol 2006; 34:131-147.
    • (2006) Toxicol Pathol , vol.34 , pp. 131-147
    • Hall, A.P.1    Westwood, F.R.2    Wadsworth, P.F.3
  • 100
    • 0033027858 scopus 로고    scopus 로고
    • VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
    • Gerber HP, Vu TH, Ryan AM, et al. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 1999; 5:623-628.
    • (1999) Nat Med , vol.5 , pp. 623-628
    • Gerber, H.P.1    Vu, T.H.2    Ryan, A.M.3
  • 101
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9:669-676.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 102
    • 0032979775 scopus 로고    scopus 로고
    • Preclinical safety evaluation of rhuMAbVEGF, an antiangiogenic humanized monoclonal antibody
    • Ryan AM, Eppler DB, Hagler KE, et al. Preclinical safety evaluation of rhuMAbVEGF, an antiangiogenic humanized monoclonal antibody. Toxicol Pathol 1999; 27:78-86.
    • (1999) Toxicol Pathol , vol.27 , pp. 78-86
    • Ryan, A.M.1    Eppler, D.B.2    Hagler, K.E.3
  • 103
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171 a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge SR, Kendrew J, Hennequin LF, et al. AZD2171 a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 2005; 65:4389-4400.
    • (2005) Cancer Res , vol.65 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3
  • 104
    • 67649246190 scopus 로고    scopus 로고
    • Nonclinical safety evaluation of sunitinib: A potent inhibitor of VEGF, PDGF, KIT, FLT3, and RET receptors
    • Patyna S, Arrigoni C, Terron A, et al. Nonclinical safety evaluation of sunitinib: A potent inhibitor of VEGF, PDGF, KIT, FLT3, and RET receptors. Toxicol Pathol 2008; 36:905-916.
    • (2008) Toxicol Pathol , vol.36 , pp. 905-916
    • Patyna, S.1    Arrigoni, C.2    Terron, A.3
  • 105
    • 84887241696 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of pazopanib in children with soft tissue sarcoma and other refractory solid tumors: A Children's Oncology Group phase I consortium report
    • Glade Bender JL, Lee A, Reid JM, et al. Phase I pharmacokinetic and pharmacodynamic study of pazopanib in children with soft tissue sarcoma and other refractory solid tumors: A Children's Oncology Group phase I consortium report. J Clin Oncol 2013; 31:3034-3043.
    • (2013) J Clin Oncol , vol.31 , pp. 3034-3043
    • Glade Bender, J.L.1    Lee, A.2    Reid, J.M.3
  • 106
    • 38649105118 scopus 로고    scopus 로고
    • Phase I trial and pharmacokinetic study of bevacizumab in pediatric patients with refractory solid tumors: A Children's Oncology Group Study
    • Glade Bender JL, Adamson PC, Reid JM, et al. Phase I trial and pharmacokinetic study of bevacizumab in pediatric patients with refractory solid tumors: A Children's Oncology Group Study. J Clin Oncol 2008; 26:399-405.
    • (2008) J Clin Oncol , vol.26 , pp. 399-405
    • Glade Bender, J.L.1    Adamson, P.C.2    Reid, J.M.3
  • 107
    • 59449086433 scopus 로고    scopus 로고
    • Lack of early bevacizumab-related skeletal radiographic changes in children with neuroblastoma
    • author reply 306.
    • Modak S, Cheung NK, Abramson SJ, et al. Lack of early bevacizumab-related skeletal radiographic changes in children with neuroblastoma. Pediatr Blood Cancer 2009; 52:304-305, author reply 306.
    • (2009) Pediatr Blood Cancer , vol.52 , pp. 304-305
    • Modak, S.1    Cheung, N.K.2    Abramson, S.J.3
  • 108
    • 84872512715 scopus 로고    scopus 로고
    • Bevacizumab-associated osteonecrosis of the wrist and knee in three pediatric patients with recurrent CNS tumors
    • Fangusaro J, Gururangan S, Jakacki RI, et al. Bevacizumab-associated osteonecrosis of the wrist and knee in three pediatric patients with recurrent CNS tumors. J Clin Oncol 2013; 31:e24-e27.
    • (2013) J Clin Oncol , vol.31
    • Fangusaro, J.1    Gururangan, S.2    Jakacki, R.I.3
  • 109
    • 84901981071 scopus 로고    scopus 로고
    • European Medicines Agency Committee for Medicinal Products for Human Use (CHMP). Assessment report-Votrient (Procedure No.: EMEA/H/C/001141/II/0007). May 24
    • European Medicines Agency Committee for Medicinal Products for Human Use (CHMP). Assessment report-Votrient (Procedure No.: EMEA/H/C/001141/II/0007). May 24, 2012. p 55.
    • (2012) , pp. 55
  • 110
    • 79952083872 scopus 로고    scopus 로고
    • Congestive heart failure risk in patients with breast cancer treated with bevacizumab
    • Choueiri TK, Mayer EL, Je Y, et al. Congestive heart failure risk in patients with breast cancer treated with bevacizumab. J Clin Oncol 2011; 29:632-638.
    • (2011) J Clin Oncol , vol.29 , pp. 632-638
    • Choueiri, T.K.1    Mayer, E.L.2    Je, Y.3
  • 111
    • 84855161152 scopus 로고    scopus 로고
    • Adverse events risk associated with bevacizumab addition to breast cancer chemotherapy: A meta-analysis
    • Cortes J, Calvo V, Ramirez-Merino N, et al. Adverse events risk associated with bevacizumab addition to breast cancer chemotherapy: A meta-analysis. Ann Oncol 2012; 23:1130-1137.
    • (2012) Ann Oncol , vol.23 , pp. 1130-1137
    • Cortes, J.1    Calvo, V.2    Ramirez-Merino, N.3
  • 112
    • 80052709825 scopus 로고    scopus 로고
    • Incidence and risk of congestive heart failure in patients with renal and nonrenal cell carcinoma treated with sunitinib
    • Richards CJ, Je Y, Schutz FA, et al. Incidence and risk of congestive heart failure in patients with renal and nonrenal cell carcinoma treated with sunitinib. J Clin Oncol 2011; 29:3450-3456.
    • (2011) J Clin Oncol , vol.29 , pp. 3450-3456
    • Richards, C.J.1    Je, Y.2    Schutz, F.A.3
  • 113
    • 84901981061 scopus 로고    scopus 로고
    • Association between takotsubo cardiomyopathy and axitinib: Case report and review of the literature
    • Ovadia D, Esquenazi Y, Bucay M, et al. Association between takotsubo cardiomyopathy and axitinib: Case report and review of the literature. J Clin Oncol 2014. http://www.ncbi.nlm.nih.gov/pubmed/24567431
    • (2014) J Clin Oncol
    • Ovadia, D.1    Esquenazi, Y.2    Bucay, M.3
  • 114
    • 58149195205 scopus 로고    scopus 로고
    • Apical ballooning syndrome during treatment with a vascular endothelial growth factor receptor antagonist
    • White AJ, LaGerche A, Toner GC, et al. Apical ballooning syndrome during treatment with a vascular endothelial growth factor receptor antagonist. Int J Cardiol 2009; 131:e92-e94.
    • (2009) Int J Cardiol , vol.131
    • White, A.J.1    LaGerche, A.2    Toner, G.C.3
  • 115
    • 84865229668 scopus 로고    scopus 로고
    • Takotsubo syndrome in a patient treated with sunitinib for renal cancer
    • Numico G, Sicuro M, Silvestris N, et al. Takotsubo syndrome in a patient treated with sunitinib for renal cancer. J Clin Oncol 2012; 30:e218-e220.
    • (2012) J Clin Oncol , vol.30
    • Numico, G.1    Sicuro, M.2    Silvestris, N.3
  • 116
    • 61549120823 scopus 로고    scopus 로고
    • Takotsubo cardiomyopathy in two men receiving bevacizumab for metastatic cancer
    • Franco TH, Khan A, Joshi V, et al. Takotsubo cardiomyopathy in two men receiving bevacizumab for metastatic cancer. Ther Clin Risk Manage 2008; 4:1367-1370.
    • (2008) Ther Clin Risk Manage , vol.4 , pp. 1367-1370
    • Franco, T.H.1    Khan, A.2    Joshi, V.3
  • 117
    • 84880566944 scopus 로고    scopus 로고
    • Coronary microvascular pericytes are the cellular target of sunitinib malate-induced cardiotoxicity
    • 187ra169
    • Chintalgattu V, Rees ML, Culver JC, et al. Coronary microvascular pericytes are the cellular target of sunitinib malate-induced cardiotoxicity. Sci Transl Med 2013; 5:187ra169.
    • (2013) Sci Transl Med , vol.5
    • Chintalgattu, V.1    Rees, M.L.2    Culver, J.C.3
  • 118
    • 38349138807 scopus 로고    scopus 로고
    • Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation
    • May D, Gilon D, Djonov V, et al. Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation. Proc Natl Acad Sci USA 2008; 105:282-287.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 282-287
    • May, D.1    Gilon, D.2    Djonov, V.3
  • 119
    • 0037143739 scopus 로고    scopus 로고
    • Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma
    • Kim ES, Serur A, Huang J, et al. Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. Proc Natl Acad Sci USA 2002; 99:11399-11404.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11399-11404
    • Kim, E.S.1    Serur, A.2    Huang, J.3
  • 120
    • 0036191974 scopus 로고    scopus 로고
    • Distinct response of experimental neuroblastoma to combination antiangiogenic strategies
    • Kim ES, Soffer SZ, Huang J, et al. Distinct response of experimental neuroblastoma to combination antiangiogenic strategies. J Pediatr Surg 2002; 37:518-522.
    • (2002) J Pediatr Surg , vol.37 , pp. 518-522
    • Kim, E.S.1    Soffer, S.Z.2    Huang, J.3
  • 121
    • 0037370294 scopus 로고    scopus 로고
    • Anti-VEGF antibody in experimental hepatoblastoma: Suppression of tumor growth and altered angiogenesis
    • discussion 308-314.
    • McCrudden KW, Hopkins B, Frischer J, et al. Anti-VEGF antibody in experimental hepatoblastoma: Suppression of tumor growth and altered angiogenesis. J Pediatr Surg 2003; 38:308-314, discussion 308-314.
    • (2003) J Pediatr Surg , vol.38 , pp. 308-314
    • McCrudden, K.W.1    Hopkins, B.2    Frischer, J.3
  • 122
    • 7944230804 scopus 로고    scopus 로고
    • Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature
    • Frischer JS, Huang J, Serur A, et al. Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature. Int J Oncol 2004; 25:549-553.
    • (2004) Int J Oncol , vol.25 , pp. 549-553
    • Frischer, J.S.1    Huang, J.2    Serur, A.3
  • 123
    • 80052495441 scopus 로고    scopus 로고
    • Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor
    • Kumar S, Mokhtari RB, Sheikh R, et al. Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clin Cancer Res 2011; 17:5656-5667.
    • (2011) Clin Cancer Res , vol.17 , pp. 5656-5667
    • Kumar, S.1    Mokhtari, R.B.2    Sheikh, R.3
  • 124
    • 38549164180 scopus 로고    scopus 로고
    • Initial testing of the VEGFR inhibitor AZD 2171 by the pediatric preclinical testing program
    • Maris JM, Courtright J, Houghton PJ, et al. Initial testing of the VEGFR inhibitor AZD 2171 by the pediatric preclinical testing program. Pediatr Blood Cancer 2008; 50:581-587.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 581-587
    • Maris, J.M.1    Courtright, J.2    Houghton, P.J.3
  • 125
    • 77958598570 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the multi-targeted kinase inhibitor sorafenib by the pediatric preclinical testing program
    • Keir ST, Maris JM, Lock R, et al. Initial testing (stage 1) of the multi-targeted kinase inhibitor sorafenib by the pediatric preclinical testing program. Pediatr Blood Cancer 2010; 55:1126-1133.
    • (2010) Pediatr Blood Cancer , vol.55 , pp. 1126-1133
    • Keir, S.T.1    Maris, J.M.2    Lock, R.3
  • 126
    • 44149115014 scopus 로고    scopus 로고
    • Initial testing (stage 1) of sunitinib by the Pediatric Preclinical Testing Program
    • Maris JM, Courtright J, Houghton PJ, et al. Initial testing (stage 1) of sunitinib by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer 2008; 51:42-48.
    • (2008) Pediatr Blood Cancer , vol.51 , pp. 42-48
    • Maris, J.M.1    Courtright, J.2    Houghton, P.J.3
  • 127
    • 84901981062 scopus 로고    scopus 로고
    • Pediatric Preclinical Testing Program (PPTP) stage 1 evaluation of cabozantinib. Proceedings of the 104th Annual Meeting of the American Association for Cancer Research 2013: LB-353.
    • Smith MA, Kang M, Reynolds P, et al. Pediatric Preclinical Testing Program (PPTP) stage 1 evaluation of cabozantinib. Proceedings of the 104th Annual Meeting of the American Association for Cancer Research 2013: LB-353.
    • Smith, M.A.1    Kang, M.2    Reynolds, P.3
  • 128
    • 84863861217 scopus 로고    scopus 로고
    • Initial testing of the multitargeted kinase inhibitor pazopanib by the pediatric preclinical testing program
    • Keir ST, Morton CL, Wu J, et al. Initial testing of the multitargeted kinase inhibitor pazopanib by the pediatric preclinical testing program. Pediatr Blood Cancer 2012; 59:586-588.
    • (2012) Pediatr Blood Cancer , vol.59 , pp. 586-588
    • Keir, S.T.1    Morton, C.L.2    Wu, J.3
  • 129
    • 84863116086 scopus 로고    scopus 로고
    • Combination testing of cediranib (AZD 2171) against childhood cancer models by the pediatric preclinical testing program
    • Morton CL, Maris JM, Keir ST, et al. Combination testing of cediranib (AZD 2171) against childhood cancer models by the pediatric preclinical testing program. Pediatr Blood Cancer 2012; 58:566-571.
    • (2012) Pediatr Blood Cancer , vol.58 , pp. 566-571
    • Morton, C.L.1    Maris, J.M.2    Keir, S.T.3
  • 130
    • 79951865371 scopus 로고    scopus 로고
    • A phase 1 trial and pharmacokinetic study of cediranib, an orally bioavailable pan-vascular endothelial growth factor receptor inhibitor, in children and adolescents with refractory solid tumors
    • Fox E, Aplenc R, Bagatell R, et al. A phase 1 trial and pharmacokinetic study of cediranib, an orally bioavailable pan-vascular endothelial growth factor receptor inhibitor, in children and adolescents with refractory solid tumors. J Clin Oncol 2010; 28:5174-5181.
    • (2010) J Clin Oncol , vol.28 , pp. 5174-5181
    • Fox, E.1    Aplenc, R.2    Bagatell, R.3
  • 131
    • 77954578108 scopus 로고    scopus 로고
    • Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: A Pediatric Brain Tumor Consortium study
    • Gururangan S, Chi SN, Young Poussaint T, et al. Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: A Pediatric Brain Tumor Consortium study. J Clin Oncol 2010; 28:3069-3075.
    • (2010) J Clin Oncol , vol.28 , pp. 3069-3075
    • Gururangan, S.1    Chi, S.N.2    Young Poussaint, T.3
  • 132
    • 84868029000 scopus 로고    scopus 로고
    • Lack of efficacy of bevacizumab+irinotecan in cases of pediatric recurrent ependymoma-A Pediatric Brain Tumor Consortium study
    • Gururangan S, Fangusaro J, Young Poussaint T, et al. Lack of efficacy of bevacizumab+irinotecan in cases of pediatric recurrent ependymoma-A Pediatric Brain Tumor Consortium study. Neuro Oncol 2012; 14:1404-1412.
    • (2012) Neuro Oncol , vol.14 , pp. 1404-1412
    • Gururangan, S.1    Fangusaro, J.2    Young Poussaint, T.3
  • 133
    • 84901986006 scopus 로고    scopus 로고
    • Efficacy of bevacizumab+CPT-11 in children with recurrent low grade glioma (LGG)-A Pediatric Brain Tumor Consortium study
    • Abstr PC-02).
    • Gururangan S, Fangusaro J, Poussaint TY, et al. Efficacy of bevacizumab+CPT-11 in children with recurrent low grade glioma (LGG)-A Pediatric Brain Tumor Consortium study. Neuro Oncol 2011; 13:95 (Abstr PC-02).
    • (2011) Neuro Oncol , vol.13 , pp. 95
    • Gururangan, S.1    Fangusaro, J.2    Poussaint, T.Y.3
  • 134
    • 66749085796 scopus 로고    scopus 로고
    • Objective response of multiply recurrent low-grade gliomas to bevacizumab and irinotecan
    • Packer RJ, Jakacki R, Horn M, et al. Objective response of multiply recurrent low-grade gliomas to bevacizumab and irinotecan. Pediatr Blood Cancer 2009; 52:791-795.
    • (2009) Pediatr Blood Cancer , vol.52 , pp. 791-795
    • Packer, R.J.1    Jakacki, R.2    Horn, M.3
  • 135
    • 84874957098 scopus 로고    scopus 로고
    • Long-term efficacy and toxicity of bevacizumab-based therapy in children with recurrent low-grade gliomas
    • Hwang EI, Jakacki RI, Fisher MJ, et al. Long-term efficacy and toxicity of bevacizumab-based therapy in children with recurrent low-grade gliomas. Pediatr Blood Cancer 2013; 60:776-782.
    • (2013) Pediatr Blood Cancer , vol.60 , pp. 776-782
    • Hwang, E.I.1    Jakacki, R.I.2    Fisher, M.J.3
  • 136
    • 84892733049 scopus 로고    scopus 로고
    • Marked recovery of vision in children with optic pathway gliomas treated with bevacizumab
    • Avery RA, Hwang EI, Jakacki RI, et al. Marked recovery of vision in children with optic pathway gliomas treated with bevacizumab. JAMA Ophthalmol 2014; 132:111-114.
    • (2014) JAMA Ophthalmol , vol.132 , pp. 111-114
    • Avery, R.A.1    Hwang, E.I.2    Jakacki, R.I.3
  • 137
    • 84855813808 scopus 로고    scopus 로고
    • Alveolar soft part sarcoma in childhood: Is Sunitinib-Sutent(R) treatment an effective approach
    • Hilbert M, Mary P, Larroquet M, et al. Alveolar soft part sarcoma in childhood: Is Sunitinib-Sutent(R) treatment an effective approach? Pediatr Blood Cancer 2012; 58:475-476.
    • (2012) Pediatr Blood Cancer , vol.58 , pp. 475-476
    • Hilbert, M.1    Mary, P.2    Larroquet, M.3
  • 138
    • 77953778637 scopus 로고    scopus 로고
    • Targeted agents in metastatic Xp11 translocation/TFE3 gene fusion renal cell carcinoma (RCC): A report from the Juvenile RCC Network
    • Malouf GG, Camparo P, Oudard S, et al. Targeted agents in metastatic Xp11 translocation/TFE3 gene fusion renal cell carcinoma (RCC): A report from the Juvenile RCC Network. Ann Oncol 2010; 21:1834-1838.
    • (2010) Ann Oncol , vol.21 , pp. 1834-1838
    • Malouf, G.G.1    Camparo, P.2    Oudard, S.3
  • 139
    • 84871764740 scopus 로고    scopus 로고
    • Persistent complete response after single-agent sunitinib treatment in a case of TFE translocation positive relapsed metastatic pediatric renal cell carcinoma
    • Chowdhury T, Prichard-Jones K, Sebire NJ, et al. Persistent complete response after single-agent sunitinib treatment in a case of TFE translocation positive relapsed metastatic pediatric renal cell carcinoma. J Pediatr Hematol Oncol 2013; 35:E1-E3.
    • (2013) J Pediatr Hematol Oncol , vol.35
    • Chowdhury, T.1    Prichard-Jones, K.2    Sebire, N.J.3
  • 140
    • 77951639655 scopus 로고    scopus 로고
    • Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer
    • Scagliotti G, Novello S, von Pawel J, et al. Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer. J Clin Oncol 2010; 28:1835-1842.
    • (2010) J Clin Oncol , vol.28 , pp. 1835-1842
    • Scagliotti, G.1    Novello, S.2    von Pawel, J.3
  • 141
    • 84865721505 scopus 로고    scopus 로고
    • Phase III, randomized, double-blind, placebo-controlled trial of gemcitabine/cisplatin alone or with sorafenib for the first-line treatment of advanced, nonsquamous non-small-cell lung cancer
    • Paz-Ares LG, Biesma B, Heigener D, et al. Phase III, randomized, double-blind, placebo-controlled trial of gemcitabine/cisplatin alone or with sorafenib for the first-line treatment of advanced, nonsquamous non-small-cell lung cancer. J Clin Oncol 2012; 30:3084-3092.
    • (2012) J Clin Oncol , vol.30 , pp. 3084-3092
    • Paz-Ares, L.G.1    Biesma, B.2    Heigener, D.3
  • 142
    • 79952742483 scopus 로고    scopus 로고
    • Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: A randomized, double-blind phase III trial
    • de Boer RH, Arrieta O, Yang CH, et al. Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: A randomized, double-blind phase III trial. J Clin Oncol 2011; 29:1067-1074.
    • (2011) J Clin Oncol , vol.29 , pp. 1067-1074
    • de Boer, R.H.1    Arrieta, O.2    Yang, C.H.3
  • 143
    • 77954035012 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): A double-blind, randomised, phase 3 trial
    • Herbst RS, Sun Y, Eberhardt WE, et al. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): A double-blind, randomised, phase 3 trial. Lancet Oncol 2010; 11:619-626.
    • (2010) Lancet Oncol , vol.11 , pp. 619-626
    • Herbst, R.S.1    Sun, Y.2    Eberhardt, W.E.3
  • 144
    • 84866371169 scopus 로고    scopus 로고
    • A phase I trial and pharmacokinetic study of aflibercept (VEGF Trap) in children with refractory solid tumors: A children's oncology group phase I consortium report
    • Bender JG, Blaney SM, Borinstein S, et al. A phase I trial and pharmacokinetic study of aflibercept (VEGF Trap) in children with refractory solid tumors: A children's oncology group phase I consortium report. Clin Cancer Res 2012; 18:5081-5089.
    • (2012) Clin Cancer Res , vol.18 , pp. 5081-5089
    • Bender, J.G.1    Blaney, S.M.2    Borinstein, S.3
  • 145
    • 84868543745 scopus 로고    scopus 로고
    • A phase I trial and pharmacokinetic study of sorafenib in children with refractory solid tumors or leukemias: A Children's Oncology Group phase I consortium report
    • Widemann BC, Kim A, Fox E, et al. A phase I trial and pharmacokinetic study of sorafenib in children with refractory solid tumors or leukemias: A Children's Oncology Group phase I consortium report. Clin Cancer Res 2012; 18:6011-6022.
    • (2012) Clin Cancer Res , vol.18 , pp. 6011-6022
    • Widemann, B.C.1    Kim, A.2    Fox, E.3
  • 146
    • 79960983264 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: A children's oncology group study
    • Dubois SG, Shusterman S, Ingle AM, et al. Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: A children's oncology group study. Clin Cancer Res 2011; 17:5113-5122.
    • (2011) Clin Cancer Res , vol.17 , pp. 5113-5122
    • Dubois, S.G.1    Shusterman, S.2    Ingle, A.M.3
  • 147
    • 84866728199 scopus 로고    scopus 로고
    • A phase I pharmacokinetic and safety evaluation of oral pazopanib dosing administered as crushed tablet or oral suspension in patients with advanced solid tumors
    • Heath EI, Forman K, Malburg L, et al. A phase I pharmacokinetic and safety evaluation of oral pazopanib dosing administered as crushed tablet or oral suspension in patients with advanced solid tumors. Invest New Drugs 2012; 30:1566-1574.
    • (2012) Invest New Drugs , vol.30 , pp. 1566-1574
    • Heath, E.I.1    Forman, K.2    Malburg, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.