The influence of hydroxypropyl methylcellulose (HPMC) molecular weight, concentration and effect of food on in vivo erosion behavior of HPMC matrix tablets

Journal of Controlled Release

Volumn 187, Issue , 2014, Pages 50-58

  Jain, Arun Kumar ^a   Söderlind, Erik ^b   Viridén, Anna ^b   Schug, Barbara ^c   Abrahamsson, Bertil ^b   Knopke, Christian ^c   Tajarobi, Farhad ^b   Blume, Henning ^c   Anschütz, Maria ^c   Welinder, Anette ^b   Richardson, Sara ^b   Nagel, Stefan ^a   Abrahmsén Alami, Susanna ^b   Weitschies, Werner ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b ASTRAZENECA R AND D   (Sweden)

^c SocraTec R and D GmbH   (Germany)

Author keywords

Hydrophilic matrix; Hydroxypropyl methylcellulose (HPMC); In vivo erosion; Magnetic marker monitoring (MMM)

Indexed keywords

DISINTEGRATION; HYDROPHILICITY; MAGNETIC DEVICES; MOLECULAR WEIGHT;

EROSION BEHAVIOR; EROSION PROPERTIES; HIGH MOLECULAR WEIGHT; HYDROPHILIC MATRIX; HYDROXYPROPYL METHYLCELLULOSE; IN-VIVO; MAGNETIC MARKER MONITORING; STATE ADMINISTRATION;

EROSION;

HYDROXYPROPYLMETHYLCELLULOSE; METHYLCELLULOSE; FERRIC ION; FERRIC OXIDE; TABLET;

ADULT; ARTICLE; CHEMICAL COMPOSITION; CLINICAL ARTICLE; COLON ARRIVAL TIME; DIET RESTRICTION; DISSOLUTION; DRUG RELEASE; FOOD; GASTRIC EMPTYING TIME; GASTROINTESTINAL TRACT FUNCTION; GASTROINTESTINAL TRANSIT; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MAGNETIC MARKER MONITORING; MATRIX TABLET; MOLECULAR WEIGHT; MONITORING; NORMAL HUMAN; PH; POSTPRANDIAL STATE; PRIORITY JOURNAL; PRODUCT DEVELOPMENT; TABLET DISINTEGRATION; TABLET FORMULATION; CHEMISTRY; CLINICAL TRIAL; FOOD DRUG INTERACTION; LARGE INTESTINE; LIPID DIET; MAGNETISM; MALE; METABOLISM; SMALL INTESTINE; SOLUBILITY; STOMACH; TABLET;

ADULT; DIET, HIGH-FAT; FASTING; FERRIC COMPOUNDS; FOOD-DRUG INTERACTIONS; GASTROINTESTINAL TRANSIT; HUMANS; HYPROMELLOSE DERIVATIVES; INTESTINE, LARGE; INTESTINE, SMALL; MAGNETIC PHENOMENA; MALE; MOLECULAR WEIGHT; POSTPRANDIAL PERIOD; SOLUBILITY; STOMACH; TABLETS;

EID: 84901999670     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.04.058     Document Type: Article

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