In vivo imaging of drug delivery systems in the gastrointestinal tract

International Journal of Pharmaceutics

Volumn 417, Issue 1-2, 2011, Pages 216-226

  Weitschies, Werner ^a   Wilson, Clive G ^b  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

AC biosusceptometry; Drug delivery systems; Gamma scintigraphy; In vivo imaging; Magnetic marker monitoring; Magnetic moment imaging; Magnetic pill tracking; Magnetic resonance imaging

Indexed keywords

ACTIFAST; BARIUM SULFATE; BICARBONATE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CONTRAST MEDIUM; GEFITINIB; INDIUM 111; MAGNETITE; PARACETAMOL; PENTETATE INDIUM IN 111; PENTETATE TECHNETIUM TC 99M; RADIOISOTOPE; SUPERPARAMAGNETIC IRON OXIDE; TECHNETIUM 99M; UNCLASSIFIED DRUG;

ABDOMINAL WALL; ACCURACY; ALTERNATE CURRENT BIOSUSCEPTOMETRY; ANGIOGRAPHY; ARTICLE; B SCAN; CAPSULE ENDOSCOPE; CAPSULE ENDOSCOPY; COLLIMATOR; COLOR ULTRASOUND FLOWMETRY; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG LABELING; DUODENUM ULCER; ECHOGRAPHY; ELECTRIC ACTIVITY; ELECTROCARDIOGRAPHY; ELECTROENCEPHALOGRAPHY; ELECTROGASTROGRAPHY; ENTERIC COATED TABLET; FLUOROSCOPY; GAMMA SCINTIGRAPHY; GASTROINTESTINAL MANOMETRY; GASTROINTESTINAL TRACT; GASTROINTESTINAL TRACT SCINTISCANNING; GASTROINTESTINAL TRANSIT; GOLD STANDARD; HUMAN; IN VIVO STUDY; IONIZING RADIATION; LIPOSOMAL DELIVERY; LYMPHATIC SYSTEM; MAGNETIC MARKER MONITORING; MAGNETIC MOMENT IMAGING; MAGNETOCARDIOGRAPHY; MAGNETOENCEPHALOGRAPHY; MANOMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIATION DOSE; SCINTILLATION CAMERA; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STOMACH EMPTYING; STOMACH ULCER;

EID: 80052261518     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.07.031     Document Type: Review

References (72)

1. G.L. Amidon, H. Lennernäs, V. Shah, and J.R. Crison A Theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability Pharm. Res. 12 1995 413 420
2. Y. Amitai, B. Silver, J.B. Leikin, and H. Frischer Visualization of ingested medications in the stomach by ultrasound Am. J. Emerg. Med. 10 1992 18 23
3. W. Andrä, H. Danan, K. Eitner, M. Hocke, H.H. Kramer, H. Parusel, P. Saupe, C. Werner, and M.E. Bellemann A novel magnetic method for examination of bowel motility Med. Phys. 32 2005 2942 2944 (Pubitemid 41384091)
4. W. Andrä, H. Danan, W. Kirmsse, H.H. Kramer, P. Saupe, R. Schmieg, and M.E. Bellemann A novel method for real-time magnetic marker monitoring in the gastrointestinal tract Phys. Med. Biol. 45 2000 3081 3093
5. M. Anschütz, G. Garbacz, O. Kosch, F. Donath, J. Wiedmann, W. Hoeckh, L. Trahms, B. Schug, W. Weitschies, and H. Blume Characterization of the behavior of alginate-based microcapsules in vitro and in vivo Int. J. Clin. Pharmacol. Ther. 47 2009 556 563
6. H.L. Ashworth, C.G. Wilson, E.E. Sims, P. Wotton, and J.G. Hardy Delivery of propellant soluble drug from a metered dose inhaler Thorax 46 1991 245 247
7. O. Baffa, R.B. Oliveira, J.R.A. Miranda, and L.E.A. Troncon Analysis and development of an AC Biosusceptometer for orocaecal transit time measurements Med. Biol. Eng. Comput. 33 1995 353 357
8. R.H. Bayford Bioimpedance tomography (electrical impedance tomography) Annu. Rev. Biomed. Eng. 8 2006 63 91 (Pubitemid 44314813)
9. J. Bork, H.D. Hahlbohm, R. Klein, and A. Schnabel The 8-layered magnetically shielded room of the PTB: Design and construction J. Nenonen, R.J. Ilmoniemi, T. Katila, In Biomag 2000, Proc. 12th Int. Conf. on Biomagnetism Helsinki Univ. of Technology, Espoo, Finland 2001 970 973
10. F.S. Bukey, and P. Rhodes A comparative study of enteric coatings J. Pharm. Sci. 24 1935 567 570
11. D.L. Casey, R.M. Beihn, G.A. Digenis, and M.B. Shabhu Method for monitoring hard gelatin capsule disintegration times in humans using external scintigraphy J. Pharm. Sci. 65 1976 1412 1413
12. L.A. Corá, M.F. Américo, R.B. Oliveira, O. Baffa, R. Moraes, F.G. Romeiro, and J.R. Miranda Disintegration of magnetic tablets in human stomach evaluated by alternate current biosusceptometry Eur. J. Pharm. Biopharm. 56 2003 413 420 (Pubitemid 37346516)
13. Corá, L.A., Américo, M.F., Oliveira, R.B., Serra, C.H., Baffa, O., Evangelista, R.C., Oliveira, G.F., Miranda, J.R. Biomagnetic methods: technologies applied to pharmaceutical research. Pharm. Res., in press.
14. L.A. Corá, U. Andreis, F.G. Romeiro, M.F. Américo, R.B. Oliveira, O. Baffa, and J.R. Miranda Magnetic images of the disintegration process of tablets in the human stomach by ac biosusceptometry Phys. Med. Biol. 50 2005 5523 5534 (Pubitemid 41750438)
15. L.A. Corá, F.G. Romeiro, F.C. Paixão, M.F. Américo, R.B. Oliveira, O. Baffa, and J.R. Miranda Enteric coated magnetic HPMC capsules evaluated in human gastrointestinal tract by AC biosusceptometry Pharm. Res. 23 2006 1809 1816 (Pubitemid 44200544)
16. S.S. Davis, J.G. Hardy, M.J. Taylor, D.R. Whalley, and C.G. Wilson A comparative study of gastrointestinal transit of a pellet and tablet formulation Int. J. Pharm. 21 1984 117 167
17. G.A. Digenis, E. Sandefer, R.M. Beihn, and A.F. Parr Dual-isotope imaging of neutron-activated Erbium-171 and Samarium-153 and the in vivo evaluation of a dual-labeled bilayer tablet by gamma scintigraphy Pharm. Res. 8 1991 1335 1340
18. D. Drung The PTB 83-SQUID System for biomagnetic applications in a clinic IEEE Trans. Appl. Supercond. 5 1995 2112 2117
19. L. Ehrhardt, V. Hartmann, and L. Patt Vergleichende Untersuchung der Enzymaktivität einiger Pankreatinpräparate Dtsch. Apoth. Ztg. 112 1972 2005 2009
20. H. Faas, W. Schwizer, C. Feinle, H. Lengsfeld, C. de Smidt, P. Boesiger, M. Fried, and T. Rades Monitoring the intragastric distribution of a colloidal drug carrier model by magnetic resonance imaging Pharm. Res. 18 2001 460 466 (Pubitemid 32592577)
21. H. Faas, A. Steingoetter, C. Feinle, T. Rades, H. Lengsfeld, P. Boesiger, M. Fried, and W. Schwizer Effects of meal consistency and ingested fluid volume on the intragastric distribution of a drug model in humans - a magnetic resonance imaging study Aliment. Pharmacol. Ther. 16 2002 217 224 (Pubitemid 34146362)
22. M. Galeone, L. Nizzola, D. Cacioli, and G. Moise In-vivo demonstration of delivery mechanisms from sustained release pellets Curr. Ther. Res. 29 1981 217 234 (Pubitemid 11134060)
23. M. Galeone, L. Nizzola, D. Cacioli, and G. Moise In-vivo demonstration of delivery mechanisms from diversified controlled-release preparations Curr. Ther. Res. 31 1982 456 466 (Pubitemid 12107601)
24. K. Goodman, L.A. Hodges, H.N.E. Stevens, W. Weitschies, and C.G. Wilson Assessing gastrointestinal motility and disintegration profiles of magnetic tablets by a novel magnetic imaging device and gamma scintigraphy Eur. J. Pharm. Biopharm. 74 2010 84 92
25. R. Gröning, and G. Heun Oral dosage forms with controlled gastrointestinal transit Drug Dev. Ind. Pharm. 10 1984 527 539 (Pubitemid 14122735)
26. J.G. Hardy, and C.G. Wilson Radionuclide imaging in pharmaceutical, physiological and pharmacological research Clin. Phys. Physiol. Meas. 2 1981 71 121 (Pubitemid 11062114)
27. K.J. Harnor, A.C. Perkins, M.L. Wastie, C.G. Wilson, E.E. Sims, L.C. Feely, and S.J. Farr Effect of vapour pressure on the deposition pattern from solution phase metered dose inhalers Int. J. Pharm. 95 1993 111 116 (Pubitemid 23203143)
28. P. Hiroz, V. Schlageter, J.C. Givel, and P. Kucera Colonic movements in healthy subjects as monitored by a magnet tracking system Neurogastroenterol. Motil. 21 2009 838 857
29. C.L. Hoad, L. Marciani, S. Foley, J.J. Totman, J. Wright, D. Bush, E.F. Cox, E. Campbell, R.C. Spiller, and P.A. Gowland Non-invasive quantification of small bowel water content by MRI: a validation study Phys. Med. Biol. 52 2005 6909 6922
30. M. Hocke, U. Schöne, H. Richert, P. Görnert, J. Keller, P. Layer, and A. Stallmach Every slow wave impulse is associated with motor activity of the human stomach Am. J. Physiol. Gastrointest. Liver Physiol. 296 2009 G709 G716
31. Z. Hu, S. Mawatari, N. Shibata, K. Takada, H. Yoshikawa, A. Arakawa, and Y. Yosida Application of a biomagnetic measurement system (BMS) to the evaluation of gastrointestinal transit of intestinal pressure-controlled colon delivery capsules (PCDCs) in human subjects Pharm. Res. 17 2000 160 167 (Pubitemid 30158364)
32. International Transporter Consortium, K.M. Giacomini, S.M. Huang, D.J. Tweedie, L.Z. Benet, K.L. Brouwer, X. Chu, A. Dahlin, R. Evers, V. Fischer, K.M. Hillgren, K.A. Hoffmaster, T. Ishikawa, D. Keppler, R.B. Kim, C.A. Lee, M. Niemi, J.W. Polli, Y. Sugiyama, P.W. Swaan, J.A. Ware, S.H. Wright, S.W. Yee, M.J. Zamek-Gliszczynski, and L. Zhang Membrane transporters in drug development Nat. Rev. Drug Discov. 9 2010 215 236
33. L. Kagan, N. Lapidot, M. Afargan, D. Kirmayer, E. Moor, Y. Mardor, M. Friedman, and A. Hoffman Gastroretentive accordion pill: enhancement of riboflavin bioavailability in humans J. Control. Release 113 2006 208 215 (Pubitemid 43963188)
34. K. Kelly, B. O'Mahony, B. Lindsay, T. Jones, T.J. Grattan, A. Rostami-Hodjegan, H.N.E. Stevens, and C.G. Wilson Comparison of the rates of disintegration, gastric emptying and drug absorption, following administration of a new and a conventional paracetamol formulation, using gamma scintigraphy Pharm. Res. 20 2003 1668 1673 (Pubitemid 37268285)
35. J. Klohs, A. Wunder, and K. Licha Near-infrared fluorescent probes for imaging vascular pathophysiology Basic Res. Cardiol. 103 2008 144 151 (Pubitemid 351356756)
36. M. Knörgen, R.P. Spielmann, A. Abdalla, H. Metz, and K. Mäder Non-invasive MRI detection of individual pellets in the human stomach Eur. J. Pharm. Biopharm. 74 2010 120 125
37. B. Kuo, R.W. McCallum, K.L. Koch, M.D. Sitrin, J.M. Wo, W.D. Chey, W.L. Hasler, J.M. Lackner, L.A. Katz, J.R. Semler, G.E. Wilding, and H.P. Parkman Comparison of gastric emptying of a nondigestible capsule to a radio-labelled meal in healthy and gastroparetic subjects Aliment. Pharmacol. Ther. 27 2008 186 196 (Pubitemid 350256610)
38. B. Laulicht, A. Tripathi, V. Schlageter, P. Kucera, and E. Mathiowitz Understanding gastric forces calculated from high-resolution pill tracking Proc. Natl. Acad. Sci. U.S.A. 107 2010 8201 8206
39. J.R. Malagelada, J.S. Robertson, M.L. Brown, M. Remington, J.A. Duenes, G.M. Thomforde, and P.W. Carryer Intestinal transit of solid and liquid components of a meal in health Gastroenterology 87 1984 1255 1263 (Pubitemid 15201422)
40. L. Marciani, E.F. Cox, C.L. Hoad, S. Pritchard, J.J. Totman, S. Foley, A. Mistry, S. Evans, P.A. Gowland, and R.C. Spiller Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome Gastroenterology 138 2010 469 477
41. J.C. Maublant, H. Hassine, M. Sournac, M. Dapogny, A. Veyre, J.M. Aiache, and E. Goutay Ultrasonic visualization of tablets in the gastrointestinal tract J. Nucl. Med. 29 1988 129
42. E. McConnell, H.M. Fadda, and A.W. Basit Gut instincts: explorations in intestinal physiology and drug delivery Int. J. Pharm. 364 2008 213 226
43. J.R. Miranda, L.A. Corá, M.F. Américo, and F.G. Romeiro AC biosusceptometry technique to evaluate the gastrointestinal transit of pellets under influence of prandial state J. Pharm. Sci. 99 2010 317 324
44. H.G. Noeller The endoradio sound for electrical pH measurement in the stomach and its clinical significance Dtsch. Med. Wochenschr. 85 1960 1707 1713
45. F.O. Ogundare, C.Z. Uche, and F.A. Balogun Radiological parameters and radiation doses of patients undergoing abdomen, pelvis and lumbar spine X-ray examinations in three Nigerian hospitals Br. J. Radiol. 77 2004 934 940 (Pubitemid 39600236)
46. E. Osmanoglou, I.R. van der Voort, K. Fach, O. Kosch, D. Bach, V. Hartmann, A. Strenzke, W. Weitschies, B. Wiedenmann, L. Trahms, and H. Mönnikes Oesophageal transport of solid dosage forms depends on body position, swallowing volume, and pharyngeal propulsion velocity Neurogastroenterol. Motil. 16 2004 547 556 (Pubitemid 39472188)
47. Palmer H., Wilson C.G., Clarke C P., Starkey Y L., Clarke G D. Comparison of a novel fast dissolving acetaminophen tablet formulation (FD-APAP) and standard acetaminophen tablets using gamma scintigraphy and pharmacokinetic studies. Drug Dev. Ind. Pharm., in press.
48. N.W. Read, M.N. Al-Janabi, A.M. Holgate, D.C. Barber, and C.A. Edwards Simultaneous measurement of gastric emptying Small bowel residence and colonic filling of a solid meal by the use of the gamma camera Gut 27 1986 300 308 (Pubitemid 16101902)
49. J.A. Romijn, E.P. Corssmit, L.M. Havekes, and H. Pijl Gut-brain axis Curr. Opin. Clin. Nutr. Metab. Care 11 2008 518 521
50. C. Schiller, C.P. Fröhlich, T. Giessmann, W. Siegmund, H. Mönnikes, N. Hosten, and W. Weitschies Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging Aliment. Pharmacol. Ther. 22 2005 971 979 (Pubitemid 41634879)
51. R. Schittenhelm Biomagnetic imaging Digitale Bilddiagn. 10 1990 76 85
52. R. Sidhu, D.S. Danders, and M.E. McAlindon Gastrointestinal capsule endoscopy: from tertiary centres to primary care BMJ 332 2006 528 531 (Pubitemid 44364371)
53. R. Singh, Chen, S.L. Yi Mei, W. Tam, D. Raju, and A. Ruszkiewicz Real-time histology with the endocytoscope World J. Gastroenterol. 16 2010 5016 5019
54. T. Sousa, R. Paterson, V. Moore, A. Carlsson, B. Abrahamsson, and A.W. Basit The gastrointestinal microbiota as a site for the biotransformation of drugs Int. J. Pharm. 363 2008 1 25
55. E. Stathopoulos, V. Schlageter, B. Meyrat, Y. Ribaupierre, and P. Kucera Magnetic pill tracking: a novel non-invasive tool for investigation of human digestive motility Neurogastroenterol. Motil. 17 2005 148 154 (Pubitemid 40204022)
56. W.H. Steinberg, G.H. Grey, J.M. Masci, and H.H. Hutchins Method for determining in vivo tablet disintegration J. Pharm. Sci. 54 1965 747 752
57. A. Steingoetter, P. Kunz, D. Weishaupt, K. Mäder, H. Lengsfeld, M. Thumshirn, P. Boesiger, M. Fried, and W. Schwizer Analysis of the meal-dependent intragastric performance of a gastric-retentive tablet assessed by magnetic resonance imaging Aliment. Pharmacol. Ther. 18 2003 713 720 (Pubitemid 37271837)
58. A. Steingoetter, D. Weishaupt, P. Kunz, K. Mäder, H. Lengsfeld, M. Thumshirn, P. Boesiger, M. Fried, and W. Schwizer Magnetic resonance imaging for the in vivo evaluation of gastric-retentive tablets 20 2003 2001 2007
59. E.J. Van Liere, and C.K. Sleeth Some normal variations in gastric emptying-time of the human stomach (using a carbohydrate meal) Am. J. Dig. Dis. 2 1935 671 672
60. N. Washington, J.L. Greaves, and C.G. Wilson Effect of time of dosing relative to a meal on the raft formation of an anti-reflux agent J. Pharm. Pharmacol. 42 1990 50 53 (Pubitemid 20124197)
61. P.J. Watts, L. Barrow, K.P. Steed, C.G. Wilson, R.C. Spiller, C.D. Melia, and M.C. Davies The transit rate of different-sized model dosage forms through the human colon and the effects of a lactulose-induced catharsis Int. J. Pharm. 87 1992 215 221
62. P.J. Watts, C.G. Wilson, M.C. Davies, and C.D. Melia Radiolabelling of polymer microspheres for scintigraphic investigations by neutron activation 4. The biopharmaceutical performance of colon-targeted Eudragit RS: sulphapyridine microspheres in human volunteers Int. J. Pharm. 102 1994 101 108
63. W. Weitschies, H. Blume, and H. Mönnikes Magnetic marker monitoring: high resolution real-time tracking of oral solid dosage forms in the gastrointestinal tract Eur. J. Pharm. Biopharm. 74 2010 93 101
64. W. Weitschies, D. Cordini, M. Karaus, L. Trahms, and W. Semmler Magnetic marker monitoring of esophageal, gastric, and duodenal transit of non-disintegrating capsules Pharmazie 54 1999 426 430 (Pubitemid 29277443)
65. W. Weitschies, R. Grützmann, V. Hartmann, and J. Breitkreutz Investigation of the disintegration behavior of magnetically marked tablets Eur. J. Pharm. Biopharm. 52 2001 221 226 (Pubitemid 32755901)
66. W. Weitschies, M. Karaus, D. Cordini, L. Trahms, J. Breitkreutz, and W. Semmler Magnetic marker monitoring of disintegrating capsules Eur. J. Pharm. Sci. 13 2001 411 416 (Pubitemid 32611599)
67. W. Weitschies, O. Kosch, H. Mönnikes, and L. Trahms Magnetic marker monitoring: an application of biomagnetic measurement instrumentation and principles for the determination of the gastrointestinal behavior of magnetically marked solid dosage forms Adv. Drug Deliv. Rev. 57 2005 1210 1222 (Pubitemid 40797575)
68. W. Weitschies, J. Wedemeyer, R. Stehr, and L. Trahms Magnetic markers as a noninvasive tool to monitor gastrointestinal transit IEEE Trans. Biomed. Eng. 41 1994 192 195 (Pubitemid 24152759)
69. W. Weitschies, R.S. Wedemeyer, O. Kosch, K. Fach, S. Nagel, E. Söderlind, B. Abrahamsson, L. Trahms, and H. Mönnikes Impact of the intragastric location of extended release tablets on food interactions J. Control. Release 108 2005 375 385 (Pubitemid 41608669)
70. C.G. Wilson The transit of dosage forms through the colon Int. J. Pharm. 395 2010 17 25
71. C.G. Wilson, M. McJury, B. O'Mahony, M. Frier, and A.C. Perkins Imaging oily formulations in the gastrointestinal tract Adv. Drug Deliv. Rev. 25 1997 91 101 (Pubitemid 27107793)
72. C.G. Wilson, B. O'Mahony, S.M. Connolly, M.V. Cantarini, M.R. Farmer, P.A. Dickinson, R.P. Smith, and H.C. Swaisland Do gastrointestinal transit parameters influence the pharmacokinetics of gefitinib? Int. J. Pharm. 376 2009 7 12