Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-κB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1

Phytomedicine

Volumn 21, Issue 8-9, 2014, Pages 1053-1061

  Choi, Jae Ho ^a   Jin, Sun Woo ^a   Han, Eun Hee ^a   Park, Bong Hwan ^a   Kim, Hyung Gyun ^a   Khanal, Tilak ^a   Hwang, Yong Pil ^a,b   Do, Minh Truong ^a   Lee, Hyun Sun ^c   Chung, Young Chul ^b   Kim, Hee Suk ^b   Jeong, Tae Cheon ^d   Jeong, Hye Gwang ^a  

^a Chungnam National University   (South Korea)

^b International University of Korea   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d Yeungnam University   (South Korea)

Author keywords

Atopic dermatitis; HO 1; NF B; Platycodon grandiflorum; Saponins; STAT1

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; ANTIINFLAMMATORY AGENT; CHANGKIL SAPONIN; DERMATOLOGICAL AGENT; GAMMA INTERFERON; HEME OXYGENASE 1; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; PLATYCODIN; SAPONIN DERIVATIVE; STAT1 PROTEIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSCRIPTION FACTOR NRF2; TRITERPENOID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIALLERGIC AGENT; CHANGKIL; CYTOKINE; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN; PLANT EXTRACT; PLATYCODIN D; SAPONIN; STAT1 PROTEIN, MOUSE; TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMIS; DRUG CYTOTOXICITY; EPIDERMIS; ETHNOPHARMACOLOGY; EXPERIMENTAL DERMATITIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; MAST CELL; MOUSE; NONHUMAN; PLANT ROOT; PLATYCODON; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SKIN MANIFESTATION; SKIN SENSITIZATION; SKINFOLD THICKNESS; TRANSCRIPTION INITIATION; ANIMAL; BLOOD; CELL LINE; CELL SURVIVAL; CHEMICALLY INDUCED; CHEMISTRY; DERMATITIS, ATOPIC; DRUG EFFECTS; GENE EXPRESSION REGULATION; ISOLATION AND PURIFICATION; METABOLISM; REPORTER GENE;

MUS; PLATYCODON GRANDIFLORUM;

ANIMALS; ANTI-ALLERGIC AGENTS; CELL LINE; CELL SURVIVAL; CYTOKINES; DERMATITIS, ATOPIC; DINITROCHLOROBENZENE; GENE EXPRESSION REGULATION; GENES, REPORTER; HEME OXYGENASE-1; HUMANS; IMMUNOGLOBULIN E; MEMBRANE PROTEINS; MICE; NF-KAPPA B; PLANT EXTRACTS; PLANT ROOTS; PLATYCODON; SAPONINS; STAT1 TRANSCRIPTION FACTOR; TRITERPENES;

EID: 84901984401     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.04.011     Document Type: Article

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