Laboratory medicine best practice guideline: Vitamins A, E and the carotenoids in blood

Clinical Biochemist Reviews

Volumn 35, Issue 2, 2014, Pages 81-113

  Greaves, Ronda F ^a,b   Woollard, Gerald A ^a,c   Hoad, Kirsten E ^a,d   Walmsley, Trevor A ^a,e   Johnson, Lambro A ^a,f   Briscoe, Scott ^a,f   Koetsier, Sabrina ^a,g   Harrower, Tamantha ^a,h   Gill, Janice P ^a,g  

^a RMIT UNIVERSITY   (Australia)

^b MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^c AUCKLAND CITY HOSPITAL   (New Zealand)

^d ROYAL PERTH HOSPITAL   (Australia)

^e CANTERBURY HEALTH LABORATORIES   (New Zealand)

^f Biochemistry Department Canterbury Health Laboratories ^*  (Australia)

^g RCPAQAP Chemical Pathology   (Australia)

^h SULLIVAN NICOLAIDES PATHOLOGY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84901978944     PISSN: 01598090     EISSN: 18380212     Source Type: Journal    
DOI: None     Document Type: Article

References (119)

1. Schneider HG. Vitamins. In: Kaplan LA, Pesce AJ, editors. Clinical Chemistry: Theory, Analysis, Correlation. 5th ed. St. Louis, Missouri: Mosby; 2010. pp. 822-53.
2. World Health Organization. Global prevalence of vitamin A deficiency in populations at risk 1995-2005. WHO global database on vitamin A deficiency. Geneva: World Health Organization; 2009. http://whqlibdoc.who.int/publications/2009/9789241598019_eng.pdf (Accessed 24 June 2013).
3. Key TJ, Appleby PN, Allen NE, Travis RC, Roddam AW, Jenab M, et al. Plasma carotenoids, retinol, and tocopherols and the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition study. Am J Clin Nutr 2007; 86: 672-81.
4. Epplein M, Shvetsov YB, Wilkens LR, Franke AA, Cooney RV, Le Marchand L, et al. Plasma carotenoids, retinol, and tocopherols and postmenopausal breast cancer risk in the Multiethnic Cohort Study: a nested case-control study. Breast Cancer Res 2009; 11: R49. doi: 10.1186/bcr2338.
5. Donkena KV, Karnes RJ, Young CY. Vitamins and prostate cancer risk. Molecules 2010; 15: 1762-83.
6. RCPA Quality Assurance Programs-Chemical Pathology. http://www.rcpaqap.com.au/chempath/(Accessed 24 June 2013).
7. Armbruster D, Miller RR. The Joint Committee for Traceability in Laboratory Medicine (JCTLM): a global approach to promote the standardisation of clinical laboratory test results. Clin Biochem Rev 2007; 28: 105-13.
8. Greaves RF. A guide to harmonisation and standardisation of measurands determined by liquid chromatography-tandem mass spectrometry in routine clinical biochemistry. Clin Biochem Rev 2012; 33: 123-32.
9. Greaves R, Jolly L, Woollard G, Hoad K. Serum vitamin A and E analysis: comparison of methods between laboratories enrolled in an external quality assurance programme. Ann Clin Biochem 2010; 47: 78-80.
10. Greaves RF, Hoad KE, Woollard GA, Walmsley TA, Briscoe S, Johnson LA, et al. External quality assurance target setting with NIST SRM 968d material: performance in the 2010 Royal College of Pathologists of Australasia Quality Assurance Program with retinol, α-tocopherol and ß-carotene. Ann Clin Biochem 2011; 48: 480-2.
11. International Union of Pure and Applied Chemistry (IUPAC) Commission on the Nomenclature of Biological Chemistry. Definitive rules for the nomenclature of amino acids, steroids, vitamins, and carotenoids. J Am Chem Soc 1960; 82: 5575-84.
12. Kurlandsky SB, Xiao JH, Duell EA, Voorhees JJ, Fisher GJ. Biological activity of all-trans retinol requires metabolic conversion to all-trans retinoic acid and is mediated through activation of nuclear retinoid receptors in human keratinocytes. J Biol Chem 1994; 269: 32821-7.
13. IUPAC-IUB Joint Commission on Biological Nomenclature (JCBN). Nomenclature of retinoids-Recommendations 1981. Eur J Biochem 1982; 129: 1-5.
14. Sommer A. Vitamin A deficiency and its consequences: A field guide to detection and Control. 3rd ed. Geneva: World Health Organization; 1995.
15. Beaton GH, Martorell R, Aronson KJ, Edmonston B, McCabe G, Ross AC, et al. 1993. Effectiveness of vitamin A supplementation in the control of young child morbidity and mortality in developing countries. Nutrition Policy Discussion Paper No. 13. http://www.unscn.org/layout/modules/resources/files/Policy_ paper_No_13.pdf (Accessed 24 June 2013).
16. Penniston KL, Tanumihardjo SA. The acute and chronic toxic effects of vitamin A. Am J Clin Nutr 2006; 83: 191-201.
17. Goodman DS, Huang HS, Shiratori T. Mechanism of the biosynthesis of vitamin A from beta-carotene. J Biol Chem 1966; 241: 1929-32.
18. Lietz G, Oxley A, Leung W, Hesketh J. Single nucleotide polymorphisms upstream from the ß-carotene 15, 15'-monoxygenase gene influence provitamin A conversion efficiency in female volunteers. J Nutr 2012; 142: 161S-5S.
19. Linus Pauling Institute at Oregon State University. http://lpi.oregonstate.edu/infocenter/phytochemicals/carotenoids/#biological_activity (Accessed 24 June 2013).
20. Tang G. Techniques for measuring vitamin A activity from ß-carotene. Am J Clin Nutr 2012; 96: 1185S-8S.
21. Brigelius-Flohé R, Traber MG. Vitamin E: function and metabolism. FASEB J 1999; 13: 1145-55.
22. Traber MG, Burton GW, Hughes L, Ingold KU, Hidaka H, Malloy M, et al. Discrimination between forms of vitamin E by humans with and without genetic abnormalities of lipoprotein metabolism. J Lipid Res 1992; 33: 1171-82.
23. Traber MG, Burton GW, Ingold KU, Kayden HJ. RRR-and SRR-alphα-tocopherols are secreted without discrimination in human chylomicrons, but RRR-alphatocopherol is preferentially secreted in very low density lipoproteins. J Lipid Res 1990; 31: 675-85.
24. Singh U, Devaraj S. Vitamin E: inflammation and atherosclerosis. Vitam Horm 2007; 76: 519-49.
25. Singh U, Devaraj S, Jialal I. Vitamin E, oxidative stress, and inflammation. Annu Rev Nutr 2005; 25: 151-74.
26. Zingg JM, Azzi A. Non-antioxidant activities of vitamin E. Curr Med Chem 2004; 11: 1113-33.
27. Vasudevan DM, Sreekumari S, Kannan V. Textbook of Biochemistry for Medical Students. 6th ed. Jaypee Brothers Medical Publishers; 2010 p. 388.
28. Oski FA, Barness LA. Vitamin E deficiency: a previously unrecognized cause of hemolytic anemia in the premature infant. J Pediatr 1967; 70: 211-20.
29. Miller ER 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005; 142: 37-46.
30. Fraser CG. Quality Specifications. In: Biological Variation: From Principles to Practice. Washington, DC, USA: AACC Press; 2001. pp. 29-66.
31. Jones GR, Sikaris K, Gill J. 'Allowable limits of performance' for external quality assurance programs-an approach to application of the Stockholm Criteria by the RCPA Quality Assurance Programs. Clin Biochem Rev 2012; 33: 133-9.
32. Westgard JO. 2009. Westgard QC. http://www.westgard.com/right-quality-goal.htm (Accessed 24 June 2013).
33. Kenny D, Fraser CG, Hyltoft Petersen P, Kallner A. Strategies to set global analytical quality specifications in laboratory medicine-consensus agreement. Scand J Clin Lab Invest 1999; 59: 585.
34. Centers for Disease Control and Prevention. Laboratory Medicine Best Practices: Developing an Evidence-Based Review and Evaluation Process. Final Technical Report 2007: Phase I. Atlanta: US Department of Health and Human Services; 2008.
35. Barreto-Lins MH, Campos FA, Azevedo MC, Flores H. A re-examination of the stability of retinol in blood and serum, and effects of a standardized meal. Clin Chem 1988; 34: 2308-10.
36. Borel P, Dubois C, Mekki N, Grolier P, Partier A, Alexandre-Gouabau MC, et al. Dietary triglycerides, up to 40 g/meal, do not affect preformed vitamin A bioavailability in humans. Eur J Clin Nutr 1997; 51: 717-22.
37. Sánchez-Campillo M, Larqué E, González-Silvera D, Martínez-Tomás R, García-Fernández M, Avilés F, et al. Changes in the carotenoid concentration in human postprandial chylomicron and antioxidant effect in HepG2 caused by differently processed fruit and vegetable soups. Food Chem 2012; 133: 38-44.
38. Greaves RF. Vitamin A: Serum Vitamin A Analysis. In: Preedy VR, editor. Food and Nutritional Components in Focus: Chemistry, Analysis, Function and Effects. 1st Ed. Cambridge, UK: The Royal Society of Chemistry; 2012. pp. 162-83.
39. Young DS. Effects of Preanalytical Variables on Clinical Laboratory Tests. 3rd ed. Washington, DC: AACC Press; 2007.
40. Brouwer DA, Molin F, van Beusekom CM, van Doormaal JJ, Muskiet FA. Influence of fasting on circulating levels of α-tocopherol and ß-carotene. Effect of short-term supplementation. Clin Chim Acta 1998; 277: 127-39.
41. Traber MG, Jialal I. Measurement of lipid-soluble vitamins-further adjustment needed? Lancet 2000; 355: 2013-4.
42. Talwar DK, Azharuddin MK, Williamson C, Teoh YP, McMillan DC, St J O'Reilly D. Biological variation of vitamins in blood of healthy individuals. Clin Chem 2005; 51: 2145-50.
43. Mathews-Roth MM, Stampfer MJ. Some factors affecting determination of carotenoids in serum. Clin Chem 1984; 30: 459-61.
44. Clark S, Youngman LD, Chukwurah B, Palmer A, Parish S, Peto R, et al. Effect of temperature and light on the stability of fat-soluble vitamins in whole blood over several days: implications for epidemiological studies. Int J Epidemiol 2004; 33: 518-25.
45. Craft NE, Brown ED, Smith JC Jr. Effects of storage and handling conditions on concentrations of individual carotenoids, retinol, and tocopherol in plasma. Clin Chem 1988; 34: 44-8.
46. Su Q, Rowley KG, O'Dea K. Stability of individual carotenoids, retinol and tocopherols in human plasma during exposure to light and after extraction. J Chromatogr B Biomed Sci Appl 1999; 729: 191-8.
47. Hsing AW, Comstock GW, Polk BF. Effect of repeated freezing and thawing on vitamins and hormones in serum. Clin Chem 1989; 35: 2145.
48. Comstock GW, Alberg AJ, Helzlsouer KJ. Reported effects of long-term freezer storage on concentrations of retinol, ß-carotene, and α-tocopherol in serum or plasma summarized. Clin Chem 1993; 39: 1075-8.
49. Rodriguez-Amaya DB. A guide to carotenoid analysis in foods. 2001. http://pdf.usaid.gov/pdf_docs/PNACQ929.pdf (Accessed 31 December 2013).
50. Lehrer M. Chromatographic Techniques. In: Kaplan LA, Pesce AJ, editors Clinical Chemistry: Theory, Analysis, Correlation. 5th ed. St. Louis, Missouri: Mosby; 2010. pp. 81-117.
51. Honour JW. Development and validation of a quantitative assay based on tandem mass spectrometry. Ann Clin Biochem 2011; 48: 97-111.
52. Gueguen S, Herbeth B, Siest G, Leroy P. An isocratic liquid chromatographic method with diode-array detection for the simultaneous determination of α-tocopherol, retinol, and five carotenoids in human serum. J Chromatogr Sci 2002; 40: 69-76.
53. Talwar D, Ha TK, Cooney J, Brownlee C, O'Reilly DS. A routine method for the simultaneous measurement of retinol, α-tocopherol and five carotenoids in human plasma by reverse phase HPLC. Clin Chim Acta 1998; 270: 85-100.
54. Lee BL, New AL, Ong CN. Simultaneous determination of tocotrienols, tocopherols, retinol, and major carotenoids in human plasma. Clin Chem 2003; 49: 2056-66.
55. Woollard GA, Hammer-Plecas A. Comparison of a complete commercial kitset Clinrep® with a validated extraction method for the determination of serum vitamins A & E. Clin Biochem Rev 2008; 29: S149.
56. Steghens JP, van Kappel AL, Riboli E, Collombel C. Simultaneous measurement of seven carotenoids, retinol and α-tocopherol in serum by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 1997; 694: 71-81.
57. Thibeault D, Su H, MacNamara E, Schipper HM. Isocratic rapid liquid chromatographic method for simultaneous determination of carotenoids, retinol, and tocopherols in human serum. J Chromatogr B Analyt Technol Biomed Life Sci 2009; 877: 1077-83.
58. Bortolotti A, Lucchini G, Barzago MM, Stellari F, Bonati M. Simultaneous determination of retinol, α-tocopherol and retinyl palmitate in plasma of premature newborns by reversed-phase high-performance liquid chromatography. J Chromatogr 1993; 617: 313-7.
59. Karppi J, Nurmi T, Olmedilla-Alonso B, Granado-Lorencio F, Nyyssönen K. Simultaneous measurement of retinol, α-tocopherol and six carotenoids in human plasma by using an isocratic reversed-phase HPLC method. J Chromatogr B Analyt Technol Biomed Life Sci 2008; 867: 226-32.
60. Sharpless KE, Thomas JB, Sander LC, Wise SA. Liquid chromatographic determination of carotenoids in human serum using an engineered C30 and a C18 stationary phase. J Chromatogr B Biomed Appl 1996; 678: 187-95.
61. Nilsson LB, Eklund G. Direct quantification in bioanalytical LC-MS/MS using internal calibration via analyte/stable isotope ratio. J Pharm Biomed Anal 2007; 43: 1094-9.
62. Albahrani AA, Rotarou V, Roche PJ, Greaves RF. Comparison of three commercial calibrators for α-tocopherol using liquid chromatography-tandem mass spectrometry. Clin Biochem 2013; 46: 1884-8.
63. Albahrani AA, Rotarou V, Roche P, Greaves RF. Candidate reference method for quantitation of fat soluble vitamins using liquid chromatography-tandem mass spectrometry. Clin Biochem Rev 2013; 34: S20.
64. Chow FI, Omaye ST. Use of antioxidants in the analysis of vitamins A and E in mammalian plasma by high performance liquid chromatography. Lipids 1983; 18: 837-41.
65. Mosca F, Fattorini D, Bompadre S, Littarru GP. Assay of coenzyme Q(10) in plasma by a single dilution step. Anal Biochem 2002; 305: 49-54.
66. Lucini L, Pellizzoni M, Baffi C, Molinari GP. Rapid determination of lycopene and ß-carotene in tomato by liquid chromatography/electrospray tandem mass spectrometry. J Sci Food Agric 2012; 92: 1297-303.
67. Finckh B, Kontush A, Commentz J, Hübner C, Burdelski M, Kohlschütter A. Monitoring of ubiquinol-10, ubiquinone-10, carotenoids, and tocopherols in neonatal plasma microsamples using high-performance liquid chromatography with coulometric electrochemical detection. Anal Biochem 1995; 232: 210-6.
68. Ferruzzi MG, Sander LC, Rock CL, Schwartz SJ. Carotenoid determination in biological microsamples using liquid chromatography with a coulometric electrochemical array detector. Anal Biochem 1998; 256: 74-81.
69. Cals MJ, Succari M, Pontezière C, Desmoulins D, Morgant G, Jardel A, et al. [Usual values of serum vitamin A using a modified fluorimetric method]. Ann Biol Clin (Paris) 1982; 40: 685-9.
70. Thomas JB, Duewer DL, Mugenya IO, Phinney KW, Sander LC, Sharpless KE, et al. Preparation and value assignment of standard reference material 968e fatsoluble vitamins, carotenoids, and cholesterol in human serum. Anal Bioanal Chem 2012; 402: 749-62.
71. Joint Committee for Traceability in Laboratory Medicine. 2002. Appendix III, The JCTLM Framework: A Framework for the international recognition of available higher-order reference materials, available higher-order reference measurement procedures and reference measurement laboratories for laboratory medicine. http://www.bipm.org/utils/en/pdf/jctlm_framework.pdf (Accessed 24 June 2013).
72. Joint Committee for Traceability in Laboratory Medicine. 2011. Database of higher-order reference materials, measurement methods/procedures and services. http://www.bipm.org/jctlm/(Accessed 24 June 2013).
73. Kock R, Seitz S, Delvoux B, Greiling H. Two high performance liquid chromatographic methods for the determination of α-tocopherol in serum compared to isotope dilution-gas chromatography-mass spectrometry. Eur J Clin Chem Clin Biochem 1997; 35: 371-8.
74. National Institute of Standards and Technology. Certificate of Analysis, Standard Reference Material 968c. Fat-Soluble Vitamins, Carotenoids, and Cholesterol in Human Serum. Gaithersburg, Marylands, USA; 1999.
75. National Institute of Standards and Technology. Certificate of Analysis, Standard Reference Material 968d. Fat-Soluble Vitamins, Carotenoids, and Cholesterol in Human Serum. Gaithersburg, Marylands, USA; 2008.
76. National Institute of Standards and Technology. Certificate of Analysis, Standard Reference Material 968e. Fat-Soluble Vitamins, Carotenoids, and Cholesterol in Human Serum. Gaithersburg, Marylands, USA; 2010.
77. Woollard GA, Hammer-Plecas A, Hoad KE, Walmsley TA, Briscoe S, Johnson LA, et al. Calibrators for human serum ß carotene made from bovine serum. Clin Biochem Rev 2013; 34: S39.
78. Stöckl D, Sluss PM, Thienpont LM. Specifications for trueness and precision of a reference measurement system for serum/plasma 25-hydroxyvitamin D analysis. Clin Chim Acta 2009; 408: 8-13.
79. Bio-Rad Vitamin A and E control set. http://www.bio-rad.com/en-au/product/vitamin-ae-reversed-phase (Accessed 8 January 2014).
80. Vitamin Profiling-Chromsystems Instruments & Chemicals GmbH. Available at http://chromsystems.com/en/produkte/vitaminstatus (Accessed 8 January 2014).
81. RECIPE-HPLC Diagnostics. http://www.recipe.de/en/products.html (Accessed 8 January 2014).
82. Jolly L, Woollard G, Hoad K, Freemantle M, Greaves R. Vitamin A and E methods: does a common calibrator improve the between laboratory agreement of results? Clin Biochem Rev 2008; 29: S128.
83. Miller WG, Myers GL, Rej R. Why commutability matters. Clin Chem 2006; 52: 553-4.
84. Westgard JO. Basic Method Validation. Madison, WI, USA: Westgard Quality Corporation; 1999. pp. 250.
85. Armbruster DA, Pry T. Limit of blank, limit of detection and limit of quantitation. Clin Biochem Rev 2008; 29(Suppl 1): S49-52.
86. Ricos C, Alvarez V, Cava F, García-Lario JV, Hernández A, Jiménez CV, et al. Current databases on biological variation: pros, cons and progress. Scand J Clin Lab Invest 1999; 59: 491-500. http://www.westgard.com/biodatabase1.htm (Accessed June 24th, 2013).
87. Herbeth B, Didelot-Barthelemy L, Le Devehat C, Lemoine A. Rétinol, caroténoïdes et tocophérols plasmatiques: facteurs de variation biologique entre 18 et 45 ans. Ann Nutr Metab 1988; 32: 297-304.
88. Koerbin G, Greaves RF, Robins H, Farquhar J, Hickman PE. Total intra-individual variation in sweat sodium and chloride concentrations for the diagnosis of cystic fibrosis. Clin Chim Acta 2008; 393: 128-9.
89. Joint Committee for Guides in Metrology. International vocabulary of metrology-Basic and general concepts and associated terms (VIM). Third edition. 2012. http://www.bipm.org/utils/common/documents/jcgm/JCGM_200_2012.pdf (Accessed 24 June 2013).
90. International Standards Organization. Medical laboratories-Particular requirements for quality and competence. ISO 15189: 2012. Geneva: ISO; 2012.
91. White GH, Farrance I; AACB Uncertainty of Measurement Working Group. Uncertainty of measurement in quantitative medical testing: a laboratory implementation guide. Clin Biochem Rev 2004; 25: S1-24.
92. Burns DT, Danzer K, Townshend A. Use of the terms "recovery" and "apparent recovery" in analytical procedures (IUPAC Recommendations 2002). Pure Appl Chem 2002; 74: 2201-5.
93. Henry RJ, Segalove M. The running of standards in clinical chemistry and the use of the control chart. J Clin Pathol 1952; 5: 305-11.
94. Westgard JO, Barry PL, Hunt MR, Groth T. A multi-rule Shewhart chart for quality control in clinical chemistry. Clin Chem 1981; 27: 493-501.
95. Westgard J. Basic QC Practices. 3rd Edition. Madison, WI, USA: Westgard Quality Corporation; 2010.
96. Levey S, Jennings ER. The use of control charts in the clinical laboratory. Am J Clin Pathol 1950; 20: 1059-66.
97. Bermes EW JR, Erviti V, Forman DT. Statistics, normal values, and quality control. In: Tietz NW, ed. Fundamentals of Clinical Chemistry. Philadelphia: WB Saunders; 1976. pp. 60-102.
98. Streitberg GS, Angel L, Sikaris KA, Bwititi PT. Laboratory information systems in clinical biochemistry in Australia. Aust J Med Sci 2014 (in press).
99. The International System of Units (SI). http://www.bipm.org/en/si/si_brochure (Accessed 4 October 2013).
100. Jay Clinical Services. Clinical Analyte Unit Conversion http://dwjay.tripod.com/conversion.html (Accessed 30 September 2013).
101. Jones GR, Bryant S, Fullinfaw R, Ilett K, Miners JO, Morris RG, et al. Mass or molar? Recommendations for reporting concentrations of therapeutic drugs. Med J Aust 2013; 198: 368-9.
102. Hawkins RC, Johnson RN. The significance of significant figures. Clin Chem 1990; 36: 824.
103. Badrick T, Wilson SR, Dimeski G, Hickman PE. Objective determination of appropriate reporting intervals. Ann Clin Biochem 2004; 41: 385-90.
104. World Health Organization. Serum retinol concentrations for determining the prevalence of vitamin A deficiency in populations. 2011. WHO/NHM/NHD/MNM/11.3. http://www.who.int/vmnis/indicators/retinol.pdf (Accessed 24 June 2013).
105. Lockitch G. Handbook of Diagnostic Biochemistry and Hematology in Normal Pregnancy. Boca Raton, FL: CRC Press; 1993. pp. 537.
106. Lockitch G, Halstead AC, Wadsworth L, Quigley G, Reston L, Jacobson B. Age-and sex-specific pediatric reference intervals and correlations for zinc, copper, selenium, iron, vitamins A and E, and related proteins. Clin Chem 1988; 34: 1625-8.
107. Soldin SJ, Brugnara C, Hicks JM. Pediatric Reference Ranges. 3rd Ed. Washington, DC, USA: AACC Press; 1999.
108. Karr M, Mira M, Causer J, Earl J, Alperstein G, Wood F, et al. Age-specific reference intervals for plasma vitamins A, E and ß-carotene and for serum zinc, retinolbinding protein and prealbumin for Sydney children aged 9-62 months. Int J Vitam Nutr Res 1997; 67: 432-6.
109. Lindblad BS, Patel M, Hamadeh M, Helmy N, Ahmad I, Dawodu A, et al. Age and sex are important factors in determining normal retinol levels. J Trop Pediatr 1998; 44: 96-9.
110. Olmedilla B, Granado F, Blanco I, Rojas-Hidalgo E. Seasonal and sex-related variations in six serum carotenoids, retinol, and α-tocopherol. Am J Clin Nutr 1994; 60: 106-10.
111. Kieu NT, Yurie K, Hung NT, Yamamoto S, Chuyen NV. Simultaneous analysis of retinol, ß-carotene and tocopherol levels in serum of Vietnamese populations with different incomes. Asia Pac J Clin Nutr 2002; 11: 92-7.
112. Sklan D, Donoghue S. Vitamin E response to high dietary vitamin A in the chick. J Nutr 1982; 112: 759-65.
113. Hollander D. Intestinal absorption of vitamins A, E, D, and K. J Lab Clin Med 1981; 97: 449-62.
114. Goodman DS. Vitamin A transport and retinol-binding protein metabolism. Vitam Horm 1974; 32: 167-80.
115. Bjornson LK, Kayden HJ, Miller E, Moshell AN. The transport of α-tocopherol and ß-carotene in human blood. J Lipid Res 1976; 17: 343-52.
116. Baeten JM, Richardson BA, Bankson DD, Wener MH, Kreiss JK, Lavreys L, et al. Use of serum retinol-binding protein for prediction of vitamin A deficiency: effects of HIV-1 infection, protein malnutrition, and the acute phase response. Am J Clin Nutr 2004; 79: 218-25.
117. Weinman AR, Jorge SM, Martins AR, de Assis MD, Martinez FE, Camelo JS Jr. Assessment of vitamin A nutritional status in newborn preterm infants. Nutrition 2007; 23: 454-60.
118. Mishra A, Greaves R, Massie J. The limitations of sweat electrolyte reference intervals for the diagnosis of cystic fibrosis: a systematic review. Clin Biochem Rev 2007; 28: 60-76.
119. Clinical and Laboratory Standards Institute. Defining, Establishing and Verifying Reference Intervals in the Clinical Laboratory. Approved Guideline-Third Edition. CLSI document EP28-A3c. Wayne, PA, USA: CLSI; 2008.