Dietary triglycerides, up to 40 g/meal, do not affect preformed vitamin A bioavailability in humans

European Journal of Clinical Nutrition

Volumn 51, Issue 11, 1997, Pages 717-722

  Borel, P ^a,c   Dubois, C ^b   Mekki, N ^b   Grolier, P ^a   Partier, A ^a   Alexandre Gouabau, M C ^a   Lairon, D ^b   Azais Braesco, V ^a  

^a CEMAGREF   (France)

^b INSERM   (France)

^c CRNH AUVERGNE   (France)

Author keywords

Bioaviailability; Chylomicrons; Dietary triglycerides; Retinyl palmitate; Vitamin A

Indexed keywords

CHYLOMICRON; LINOLEIC ACID; PALMITIC ACID; RETINOID; RETINOL; RETINOL ESTER; RETINOL STEARATE; TRIACYLGLYCEROL;

ADULT; ARTICLE; BIOAVAILABILITY; BLOOD SAMPLING; CENTRIFUGATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ESTERIFICATION; FAT INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMEOSTASIS; HUMAN; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SERUM;

EID: 0030717162     PISSN: 09543007     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1600466     Document Type: Article

References (39)

1. Ahmed F, Ellis J, Murphy J, Wootton S & Jackson AA (1990): Excessive faecal losses of vitamin A (retinol) in cystic fibrosis. Arch. Dis. Child. 65, 589-593.
2. Armand M, Borel P, Cara L, Senft M, Chautan M, Lafont H & Lairon D (1990): Adaptation of lingual lipase to dietary fat in rats. J. Nutr. 120, 1148-1156.
3. Azaïs-Braesco V, Forget A, Mercier M & Grolier P (1992): Rapid synthesis and purification of vitamin A esters. J. Am. Oil Chem. Soc. 69, 1272-1273.
4. Berr F & Kern F (1984): Plasma clearance of chylomicrons labeled with retinyl palmitate in healthy human subjects. J. Lipid Res. 25, 805-812.
5. Blaner S & Olson JA (1994): Retinol and retinoic acid metabolism. In The Retinoids (2nd edn), eds. MB Sporn, AB Roberts, DS Goodman, pp 229-258. New York: Raven Press.
6. Blaner WS (1989): Retinol-binding protein: the serum transport protein for vitamin A. Endocr. Rev. 10, 308-316.
7. Blomhoff R, Green MH, Green JB, Berg T & Norum KR (1991): Vitamin A metabolism: new perspectives on absorption, transport and storage. Physiol. Rev. 71, 951-990.
8. Buccolo G & David H (1973): Quantitative determination of serum triglycerides by the use of enzymes. Clin. Chem. 19, 476-482.
9. Chait A, Lewis B, February AW & Mattock M (1973): Functional overlap between 'chylomicra' and VLDL' of human plasma during alimentary lipemia. Atherosclerosis 17, 455-462.
10. Collins MD, Eckhoff C, Slikker W, Bailey JR & Nau N (1992): Quantitative plasma disposition of retinol and retinyl esters after high-dose oral vitamin A administration in the cynomolgus monkey. Fundam. Appl. Toxicol. 19, 109-116.
11. Craft NE, Brown ED & Smith JC (1988): Effects of storage and handling conditions on concentrations of individual carotenoids, retinol, and tocopherol in plasma. Clin. Chem. 34, 44-48.
12. De Pee S, West CE, Muhilal, Karyadi D & Hautvast JGAJ (1995): Lack of improvement in vitamin A status with increased consumption of darg-green leafy vegetables. Lancet 346, 75-81.
13. Dubois C, Armand M, Azais-Braesco V, Portugal H, Pauli AM, Bernard PM, Latge C, Lafont H, Borel P & Lairon D (1994): Effects of moderate amounts of emulsified dietary fat on postprandial lipemia and lipoproteins in normolipidemic adults. Am. J. Clin. Nutr. 60, 374-382.
14. Erdman JW, Poor CL & Dietz JM (1988): Factors affecting the bioavailability of vitamin A, carotenoids, and vitamin E. Food Technol. 10, 214-221.
15. Figueira F, Mendonca S, Rocha J, Azevado M, Bunce GE & Reynolds JW (1969): Absorption of vitamin A by infants receiving fat-free or fat-containing dried skim milk formulas. Am. J. Clin. Nutr. 22, 588-593.
16. Goda T, Yasutake H & Takase S (1994): Dietary fat regulates cellular retinol-binding protein II gene expression in rat jejunum. Biochem. Biophys. Acta 1200, 34-40.
17. Helgerud P, Petersen LB & Norum KR (1983): Retinol esterification by microsomes from the mucosa of human small intestine. J. Clin. Invest. 71, 747-753.
18. 1 intestinal absorption in vivo: influence of luminal factors on transport. Am. J. Physiol. 232, E471-E477.
19. Hollander D & Ruble PE (1978): β-carotene intestinal absorption: bile, fatty acids, pH, and flow rate effects on transport. Am. J. Physiol. 235, E686-E691.
20. Jayarajan P, Reddy V & Mohansan M (1980): Effect of dietary fat on absorption of β-carotene from green leafy vegetables in children. Indian J. Med. Res. 71, 53-56.
21. Jeppesen J, Chen YDI, Zhou MY, Wang T & Reaven G (1995): Effect of variations in oral fat and carbohydrate load on postprandial lipemia. Am. J. Clin. Nutr. 62, 1201-1205.
22. Johnson EJ, Krasinski SD, Howard LJ, Alger SA, Dutta SK & Russell RM (1992): Evaluation of vitamin A absorption by using oil-soluble and water-miscible vitamin A preparations in normal adults and in patients with gastrointestinal disease. Am. J. Clin. Nutr. 55, 857-864.
23. Krasinski SD, Cohn JS, Russell RM & Schaefer EJ (1990): Postprandial plasma vitamin A metabolism in humans: a reassessment of the use of plasma retinyl esters as markers for intestinally derived chylomicrons and their remnants. Metabolism 39, 357-365.
24. Levin MS (1993): Cellular retinol-binding proteins are determinants of retinol uptake and metabolism in stably transfected Caco-2 cells. J. Biol. Chem. 268, 8267-8276.
25. Levin MS (1994): Intestinal absorption and metabolism of vitamin A. In Physiology of the Gastrointestinal Tract, ed. LR Johnson, pp 1957-1978. New York: Raven Press.
26. Lewis JM, Bodansky O, Birmingham J & Cohlan SQ (1947): Comparative absorption, excretion and storage of oily and aqueous preparations of vitamin A. A. J. Pediatr. 31, 496-508.
27. Norum KR & Blomhoff R (1992): McCollum award lecture, vitamin A absorption, transport, cellular uptake, and storage. Am. J. Clin. Nutr. 56, 735-744.
28. Olson JA (1982): New approaches to methods for the assessment of nutritional status of the individual. Am. J. Clin. Nutr. 35, 1166-1168.
29. Ong DE (1993): Retinoid metabolism during intestinal absorption. J. Nutr. 123, 351-355.
30. Quick TC & Ong DE (1990): Vitamin A metabolism in the human intestinal caco-2 cell line. Biochemistry 29, 11116-11123.
31. Rasmussen M, Petersen LB & Norum KR (1984): The activity of acyl CoA: retinol acyltransferase in the rat: variation with vitamin A status. Br. J. Nutr. 51, 245-253.
32. Reddy V & Srikantia SG (1996): Serum vitamin A in kwashiorkor. Am. J. Clin. Nutr. 18, 105-109.
33. Sprecher DL, Knauer SL, Black DM, Kaplan LA, Akeson AA, Dusing M, Lattier D, Stein EA, Rymaszewski M & Wiginton DA (1991): Chylomicron-retinyl palmitate clearance in type I hyperlipidemic families. J. Clin. Invest. 88, 985-994.
34. Ullrey DE (1972): Biological availability of fat-soluble vitamins: vitamin A and carotene. J. Animal Sci. 35, 648-657.
35. Underwood BA (1994): Hypovitaminosis A: international programmatic issues. J. Nutr. 124, 1467S-1472S.
36. Van Vliet T, Schreurs WHP & Van den Berg H (1995): Intestinal β-carotene absorption and cleavage in men: response of β-carotene and retinyl esters in the triglyceride-rich lipoprotein fraction after a single oral dose of β-carotene. Am. J. Clin. Nutr. 62, 110-116.
37. Weintraub MS, Einsenberg S & Breslow JL (1987): Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effect of treatment with cholestyramine and gemfibrozil. J. Clin. Invest. 79, 1110-1119.
38. Wilson DE & Chan IF (1983): In vitro transfer of chylomicron retinol and retinyl esters. Biochim. Biophys. Acta 115, 958-964.
39. Winner BJ (1971): Statistical Principles in Experimental Design. New York: McGraw-Hill.