Vitamin E, oxidative stress, and inflammation

Annual Review of Nutrition

Volumn 25, Issue , 2005, Pages 151-174

  Singh, U ^a   Devaraj, S ^a   Jialal, I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

tocopherol; Antioxidant; Atherosclerosis; CRP; Oxidation

Indexed keywords

ALPHA TOCOPHEROL; ARACHIDONATE 5 LIPOXYGENASE; AUTOANTIBODY; C REACTIVE PROTEIN; CYCLOOXYGENASE 2; CYTOKINE; DNA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; ISOPROSTANE; LOW DENSITY LIPOPROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROSTAGLANDIN E2; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ATHEROGENESIS; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; DIET SUPPLEMENTATION; DNA SYNTHESIS; ENDOTHELIUM CELL; HUMAN; INFLAMMATION; LEUKOCYTE ADHERENCE; LIPID OXIDATION; MACROPHAGE; MONOCYTE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; REVIEW; THROMBOCYTE; THROMBOCYTE AGGREGATION; VASCULAR SMOOTH MUSCLE;

ALPHA-TOCOPHEROL; ANIMALS; ARTERIOSCLEROSIS; BLOOD PLATELETS; DIETARY SUPPLEMENTS; ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; MACROPHAGES; MONOCYTES; MUSCLE, SMOOTH; OXIDATIVE STRESS; VITAMIN E;

ANIMALIA;

EID: 23944493587     PISSN: 01999885     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.nutr.24.012003.132446     Document Type: Review

References (135)

1. Akeson AL, Woods CW, Mosher LB, Thomas CE, Jackson RL. 1991. Inhibition of IL-1 beta expression in THP-1 cells by probucol and tocopherol. Atherosclerosis 86:261-70
2. Arrol S, Mackness MI, Durrington PN. 2000. Vitamin E supplementation increases the resistance of both LDL and HDL to oxidation and increases cholesteryl ester transfer activity. Atherosclerosis 150:129-34
3. Azzi A. 2004. The role of alpha-tocopherol in preventing disease. Eur. J. Nutr. 43(Suppl. 1):118-25
4. Azzi A, Breyer I, Feher M, Ricciarelli R, Stocker A, et al. 2001. Nonantioxidant functions of alpha-tocopherol in smooth muscle cells. J. Nutr. 131:3788-818
5. Azzi A, Ricciarelli R, Zingg JM. 2002. Non-antioxidant molecular functions of alpha-tocopherol (vitamin E). FEBS Lett. 519:8-10
6. Beckman JA, Goldfine AB, Gordon MB, Garrett LA, Keaney JF Jr, Creager MA. 2003. Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus. Am. J. Physiol. Heart Circ. Physiol. 285:H2392-98
7. Blatt DH, Pryor WA, Mata JE, Rodriguez-Proteau R. 2004. Re-evaluation of the relative potency of synthetic and natural alpha-tocopherol: experimental and clinical observations. J. Nutr. Biochem. 15:380-95
8. Boscoboinik D, Szewczyk A, Hensey C, Azzi A. 1991. Inhibition of cell proliferation by α-tocopherol, role of PKC. J. Biol. Chem. 266:6188-94
9. Bufano G, Usberti M, Mandolfo S, Malberti F, Piroddi M, Galli F. 2004. Von Willebrand factor and autoantibodies against oxidized LDL in hemodialysis patients treated with vitamin E-modified dialyzers. Int. J. Artif. Organs 27:214-21
10. Cachia O, Benna JE, Pedruzzi E, Descomps B, Gougerot-Pocidalo MA, Leger CL. 1998. α-Tocopherol inhibits the respiratory burst in human monocytes: attenuation of p47 (phox) membrane translocation and phosphorylation. J. Biol. Chem. 273:32801-5
11. Calzada C, Bruckdorfer K, Rice Evans C. 1997. The influence of antioxidant nutrients on platelet function in healthy volunteers. Atherosclerosis 128:97-105
12. Carroll MF, Schade DS. 2003. Timing of antioxidant vitamin ingestion alters postprandial proatherogenic serum markers. Circulation 108:24-31
13. Chatelain E, Boscoboinik DO, Bartoli GM, Kagan VE, Gey FK, et al. 1993. Inhibition of smooth muscle cell proliferation and protein kinase C activity by tocopherols and tocotrienols. Biochim. Biophys. Acta 1176:83-89
14. Cominacini L, Garbin U, Pasini AF, Davoli A, Campagnola M, et al. 1997. Antioxidants inhibit the expression of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 induced by oxidized LDL on human umbilical vein endothelial cells. Free Radic. Biol. Med. 22:117-27
15. Danenberg HD, Szalai AJ, Swaminathan RV, Peng L, Chen Z, et al. 2003. Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice. Circulation 108:512-15
16. 2 is increased in hypercholesterolemia. Arterioscler. Thromb. Vasc. Biol. 17:3230-35
17. 2- and platelet activation in diabetes mellitus: effect of improved metabolic control and vitamin E supplementation. Circulation 99:224-29
18. Davi G, Falco A, Patrono C. 2004. Determinants of F2-isoprostane biosynthesis and inhibition in man. Chem. Phys. Lipids 128:149-63
19. Davi G, Romano M, Mezzetti A, Procopio A, Iacobelli S, et al. 1998. Increased levels of soluble P-selectin in hypercholesterolemic patients. Circulation 97:953-57
20. DeMaio SJ, King SB III, Lembo NJ, Roubin GS, Hearn JA, et al. 1992. Vitamin E supplementation, plasma lipids, and incidence of restenosis after percutaneous transluminal coronary angioplasty (TCA). J. Am. Coll. Nutr. 11:68-73
21. Devaraj S, Adams-Huet B, Fuller CJ, Jialal I. 1997. Dose-response comparison of RRR-AT and all-rac-tocopherol on LDL oxidation. Arterioscler. Thromb. Vasc. Biol. 17:2273-79
22. Devaraj S, Chan AV Jr, Jialal I. 2002. Alpha-tocopherol supplementation decreases plasminogen activator inhibitor-1 and P-selectin levels in type 2 diabetic patients. Diabetes Care 25:524-29
23. Devaraj S, Jialal I. 1998. The effects of α-tocopherol on critical cells in atherogenesis. Curr. Opin. Lipidol. 9:1115-17
24. Devaraj S, Jialal I. 1999. Alpha-tocopherol decreases interleukin-1 beta release from activated human monocytes by inhibition of 5-lipoxygenase. Arterioscler. Thromb. Vasc. Biol. 19:1125-33
25. Devaraj S, Jialal I. 2000. Alpha-tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients. Free Radic. Biol. Med. 29:790-92
26. Devaraj S, Jialal I. 2000. Low-density lipoprotein postsecretory modification, monocyte function, and circulating adhesion molecules in type 2 diabetic patients with and without macrovascular complications: the effect of alpha-tocopherol supplementation. Circulation 102:191-96
27. Devaraj S, Li D, Jialal I. 1996. The effects of alpha-tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium. J. Clin. Invest. 98:756-63
28. Devaraj S, Venugopal SK, Singh U, Jialal I. 2005. Hyperglycemia induces monocytic IL-6 via induction of PK-C alpha and beta. Diabetes 54:85-91
29. Dhanasekaran A, Kotamraju S, Kalivendi SV, Matsunaga T, Shang T, et al. 2004. Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage and apoptosis. J. Biol. Chem. 279:37575-87
30. Elliott TG, Barth JD, Mancini GB. 1995. Effects of vitamin E on endothelial function in men after myocardial infarction. Am. J. Cardiol. 76:1188-90
31. Engler MM, Engler MB, Malloy MJ, Chiu EY, Schloetter MC, et al. 2003. Antioxidant vitamins C and E improve endothelial function in children with hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial. Circulation 108:1059-63
32. Esterbauer H, Dieber-Rotheneder M, Striegl G, Waeg G. 1991. Role of vitamin E in preventing the oxidation of low-density lipoprotein. Am. J. Clin. Nutr. 53(Suppl. 1):314S-21S
33. Fan Y, Liu ML, Qi YY, Ren ZW. 2004. Effect of different isoforms of tocopherols on expression of intercellular adhesion molecule-1 in human umbilical vein endothelial cells. Beijing Da Xue Xue Bao 36:70-74
34. Faruqui R, De La Motte C, Dicorleto P. 1994. α-Tocopherol inhibits agonist-induced monocyte cell adherence to cultured human endothelial cells. J. Clin. Invest. 94:592-600
35. Freedman JE, Farhat JH, Loscalzo J, Keaney JF Jr. 1996. α-Tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation 94:2434-40
36. Friedrich MJ. 2004. To "E" or not to "E," vitamin E's role in health and disease is the question. JAMA 292:671-73
37. Gazis A, White DJ, Page SR, Cockcroft JR. 1999. Effect of oral vitamin E (alpha-tocopherol) supplementation on vascular endothelial function in type 2 diabetes mellitus. Diabet. Med. 16:304-11
38. 2 isoprostanes, are present in increased amounts in human atherosclerotic lesions. Arterioscler. Thromb. Vasc. Biol. 17:3236-41
39. Green D, O'Driscoll G, Rankin JM, Maiorana AJ, Taylor RR. 1998. Beneficial effect of vitamin E administration on nitric oxide function in subjects with hypercholesterolaemia. Clin. Sci. (Lond.) 95:361-67
40. Heitzer T, Yla Herttuala S, Wild E, Luoma J, Drexler H. 1999. Effect of vitamin E on endothelial vasodilator function in patients with hypercholesterolemia, chronic smoking or both. J. Am. Coll. Cardiol. 33:499-505
41. Higashi O, Kikuchi Y. 1974. Effects of vitamin E on the aggregation and lipid peroxidation of platelets exposed to hydrogen peroxide. Tohoku J. Exp. Med. 112:271-78
42. Himmelfarb J, Kane J, McMonagle E, Zaltas E, Bobzin S, et al. 2003. Alpha and gamma tocopherol metabolism in healthy subjects and patients with end-stage renal disease. Kidney Int. 64:978-91
43. Hodis HN, Mack WJ, LaBree L, Mahrer PR, Sevanian A, et al. 2002. Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis. Circulation 106:1453-59
44. Inoue M, Itoh H, Tanaka T, Chun TH, Doi K, et al. 2001. Oxidized LDL regulates vascular endothelial growth factor expression in human macrophages and endothelial cells through activation of peroxisome proliferator-activated receptor-gamma. Arterioscler. Thromb. Vasc. Biol. 21:560-66
45. Islam KN, O'Byrne D, Devaraj S, Palmer B, Grundy SM, Jialal I. 2000. Alpha-tocopherol supplementation decreases the oxidative susceptibility of LDL in renal failure patients on dialysis therapy. Atherosclerosis 150:217-24
46. Jessup W, Kritharides L, Stocker R. 2004. Lipid oxidation in atherogenesis: an overview. Biochem. Soc. Trans. 32:134-38
47. Jialal I. 1998. Evolving lipoprotein risk factors: lipoprotein(a) and oxidized low-density lipoprotein. Clin. Chem. 44:1827-32
48. Jialal I, Devaraj S. 2001. Inflammation and atherosclerosis: the value of the high-sensitivity C-reactive protein assay as a risk marker. Am. J. Clin. Pathol. 116(Suppl.):S108-15
49. Jialal I, Devaraj S. 2003. Antioxidants and atherosclerosis: Don't throw out the baby with the bath water. Circulation 107:926-28
50. Jialal I, Devaraj S, Venugopal. 2004. C-reactive protein: risk marker or mediator in atherothrombosis? Hypertension 44:1-6
51. Jialal I, Fuller C, Huet B. 1995. The effect of AT supplementation on LDL oxidation: a dose-response study. Arterioscler. Thromb. Vasc. Biol. 15:190-98
52. Jialal I, Grundy SM. 1992. Effect of dietary supplementation with α-tocopherol on the oxidative modification of low-density lipoprotein. J. Lipid Res. 33:899-906
53. Jialal I, Grundy SM. 1992. Influence of antioxidant vitamins on LDL oxidation. Ann. N.Y. Acad. Sci. 669:237-48
54. Jones SA, O'Donnell VB, Wood JD, Broughton JP, Hughes EJ, et al. 1996. Expression of phagocytic NADPH oxidase components in human endothelial cells. Am. J. Phys. 271:H1626-34
55. Kaul N, Devaraj S, Grundy SM, Jialal I. 2001. Failure to demonstrate a major anti-inflammatory effect with alpha tocopherol supplementation (400 IU/day) in normal subjects. Am. J. Cardiol. 87:1320-23
56. Kaul N, Devaraj S, Jialal I. 2001. Alpha-tocopherol and atherosclerosis. Exp. Biol. Med. (Maywood) 226:5-12
57. Keaney JF Jr, Gaziano JM, Xu A, Frei B, Curran-Celentano J, et al. 1994. Low-dose α-tocopherol improves and high-dose α-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits. Clin. Invest. 93:844-51
58. Keaney JF Jr, Guo Y, Cunningham D, Shwaery GT, Xu A, Vita JA. 1996. Vascular incorporation of α-tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase C stimulation. J. Clin. Invest. 98:386-94
59. Kinlay S, Fang JC, Hikita H, Ho I, Delagrange DM, et al. 1999. Plasma alpha-tocopherol and coronary endothelium-dependent vasodilator function. Circulation 100:219-21
60. Kirii H, Niwa T, Yamada Y, Wada H, Saito K, et al. 2003. Lack of interleukin-1β decreases the severity of atherosclerosis in apoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 23:656-60
61. Kobayashi S, Inoue N, Ohashi Y, Terashima M, Matsui K, et al. 2003. Interaction of oxidative stress and inflammatory response in coronary plaque instability: important role of C-reactive protein. Arterioscler. Thromb. Vasc. Biol. 23:1398-404
62. Kontush A, Chapman MJ, Stocker R. 2004. Vitamin E is not deficient in human atherosclerotic plaques. Arterioscler. Thromb. Vasc. Biol. 24:e139-40
63. Koya D, Haneda M, Kikkawa R, King GL. 1998. α- and δ-Tocopherol treatment prevents glomerular dysfunctions in diabetic rats through inhibition of protein-kinase C-diacylglycerol pathway. Biofactors 7:69-76
64. Kris-Etherton PM, Lichtenstein AH, Howard BV, Steinberg D, Witztum JL. 2004. Nutrition Committee of the American Heart Association Council on Nutrition, Physical Activity, and Metabolism. Antioxidant vitamin supplements and cardiovascular disease. Circulation 110:637-40
65. Kunisaki M, Bursell SE, Umeda F, Nawata H, King GL. 1994. Normalization of DAG-PKC activation by vitamin E in aorta of diabetic rats and cultured rat SMC exposed to elevated glucose levels. Diabetes 42:1372-77
66. Lafont AM, Chai YC, Cornhill JF, Whitlow PL, Howe PH, et al. 1995. Effect of α-tocopherol on restenosis after angioplasty in a model of experimental atherosclerosis. J. Clin. Invest. 95:1018-25
67. Laursen JB, Boesgaard S, Trautner S, Rubin I, Poulsen HE, Aldershvile J. 2001. Endothelium-dependent vasorelaxation in inhibited by in vivo depletion of vascular thiol levels: role of endothelial nitric oxide synthase. Free Radic. Res. 35:387-94
68. Libby P. 2002. Inflammation in atherosclerosis. Nature 420:868-74
69. Mabile L, Bruckdorfer K, Rice Evans C. 1999. Moderate supplementation with natural alpha-tocopherol decreases platelet aggregation and low-density lipoprotein oxidation. Atherosclerosis 147:177-85
70. Marangon K, Devaraj S, Jialal I. 1999. The effect of α-lipoate and α-tocopherol on plasma, whole body, and LDL oxidation. Free Radic. Biol. Med. 27:1114-21
71. Martin A, Foxall T, Blumberg JB, Meydani M. 1997. AT inhibits LDL-induced adhesion of monocytes to human aortic endothelial cells in vitro. Arterioscler. Thromb. Vasc. Biol. 17:429-36
72. Micheletta F, Natoli S, Misuraca M, Sbarigia E, Diczfalusy U, Iuliano L. 2004. Vitamin E supplementation in patients with carotid atherosclerosis: reversal of altered oxidative stress status in plasma but not in plaque. Arterioscler. Thromb. Vasc. Biol. 24:136-40
73. Miller FJ Jr, Gutterman DD, Rios CD, Heistad DD, Davidson BL. 1998. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ. Res. 82:1298-305
74. Miyamoto S, Kawano H, Takazoe K, Soejima H, Sakamoto T, et al. 2004. Vitamin E improves fibrinolytic activity in patients with coronary spastic angina. Thromb. Res. 113:345-51
75. Mol MJ, de Rijke YB, Demacker PN, Stalenhoef AF. 1997. Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: effects of vitamin E treatment. Atherosclerosis 129:169-76
76. Motoyama T, Kawano H, Kugiyama K, Hirashima O, Ohgushi M, et al. 1998. Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronary spastic angina. J. Am. Coll. Cardiol. 32:1672-79
77. Mottrram P, Shige H, Nestel P. 1999. Vitamin E improves arterial compliance in middle-aged men and women. Atherosclerosis 145:399-404
78. Mugge A, Elwell JH, Peterson TE, Hofmeyer TG, Heistad DD, Harrison DG. 1991. Chronic treatment with PEG-SOD partially restores endothelial-dependent vascular relaxation in cholesterol-fed rabbits. Circ. Res. 69:1293-300
79. Munteanu A, Zingg JM, Azzi A. 2004. Anti-atherosclerotic effects of vitamin E-myth or reality? J. Cell. Mol. Med. 8:59-76
80. Munteanu A, Zingg JM, Ogru E, Libinaki R, Gianello R, et al. 2004. Modulation of cell proliferation and gene expression by alpha-tocopheryl phosphates: relevance to atherosclerosis and inflammation. Biochem. Biophys. Res. Commun. 318:311-16
81. Murphy RT, Foley JB, Tome MT, Mulvihill NT, Murphy A, et al. 2004. Vitamin E modulation of C-reactive protein in smokers with acute coronary syndromes. Free Radic. Biol. Med. 36:959-65
82. Paolisso G, Tagliamonte MR, Barbieri M, Zito GA, Gambardella A, et al. 2000. Chronic vitamin E administration improves brachial reactivity and increases intracellular magnesium concentration in type II diabetic patients. J. Clin. Endocrinol. Metab. 85:109-15
83. Paul A, Ko KW, Li L, Yechoor V, McCrory MA, et al. 2004. C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Circulation 109:647-55
84. Patrano C, Fitzgerald G. 1997. Isoprostanes: potential markers of oxidant stress in atherothrombotic disease. Arterioscler. Thromb. Vasc. Biol. 17:2309-15
85. Peluzio MC, Homem AP, Cesar GC, Azevedo GS, Amorim R, et al. 2001. Influences of alpha-tocopherol on cholesterol metabolism and fatty streak development in apolipoprotein E-deficient mice fed an atherogenic diet. Braz. J. Med. Biol. Res. 34:1539-45
86. Peluzio MC, Miguel E Jr, Drumond TC, Cesar GC, Santiago HC, et al. 2003. Monocyte chemoattractant protein-1 involvement in the alpha-tocopherol-induced reduction of atherosclerotic lesions in apolipoprotein E knockout mice. Br. J. Nutr. 90:3-11
87. Pickup JC. 2004. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 27:813-23
88. 2-isoprostanes in human atherosclerotic lesions. J. Clin. Invest. 100:915-24
89. Ramsey MW, Goodfellow J, Jones CJ, Luddington LA, Lewis MJ, Henderson AH. 1995. Endothelial control of arterial distensibility is impaired in chronic heart failure. Circulation 92:3212-19
90. Reaven P, Witztum J. 1993. Comparison of supplementation with RRR-α-tocopherol and all-rac-tocopherol in humans. Arterioscler. Thromb. Vasc. Biol. 13:601-8
91. Ridker PM. 2003. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 168:363-69
92. Roberts LJ 2nd; Morrow JD. 2002. Products of the isoprostane pathway: unique bioactive compounds and markers of lipid peroxidation. Cell. Mol. Life Sci. 59:808-20
93. Ross R. 1999. Atherosclerosis: an inflammatory disease. N. Engl. J. Med. 340:115-26
94. Saldeen T, Li D, Mehta JL. 1999. Differential effects of alpha- and gamma-tocopherol on low-density lipoprotein oxidation, superoxide activity, platelet aggregation and arterial thrombogenesis. J. Am. Coll. Cardiol. 34:1208-15
95. Saran R, Novak JE, Desai A, Abdulhayoglu E, Warren JS, et al. 2003. Impact of vitamin E on plasma asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD): a pilot study. Nephrol. Dial. Transplant. 18:2415-20
96. Schnell JW, Anderson RA, Stegner JE, Schindler SP, Weinberg RB. 2001. Effects of a high polyunsaturated fat diet and vitamin E supplementation on high-density lipoprotein oxidation in humans. Atherosclerosis 159:459-66
97. Schock BC, Van der Vliet A, Corbacho AM, Leonard SW, Finkelstein E, et al. 2004. Enhanced inflammatory responses in alpha-tocopherol transfer protein null mice. Arch. Biochem. Biophys. 423:162-69
98. Schwenke DC, Rudel LL, Sorci-Thomas MG, Thomas MJ. 2002. Alpha-tocopherol protects against diet-induced atherosclerosis in New Zealand white rabbits. J. Lipid Res. 43:1927-38
99. Simons LA, von Konigsmark M, Simons J, Stocker R, Celermajer DS. 1999. Vitamin E ingestion does not improve arterial endothelial dysfunction in older adults. Atherosclerosis 143:193-99
100. Singh U, Jialal I. 2004. Anti-inflammatory effects of alpha-tocopherol. Ann. N.Y. Acad. Sci. 1031:195-203
101. Smith KS, Lee CL, Ridlington JW, Leonard SW, Devaraj S, Traber MG. 2003. Vitamin E supplementation increases circulating vitamin E metabolites tenfold in end-stage renal disease patients. Lipids 38:813-19
102. Smith T, Kummerow F. 1989. Effect of dietary vitamin E on plasma lipids and atherogenesis in restricted ovulator chicken. Atherosclerosis 75:105-9
103. Steinbrecher U. 1984. Modification of low-density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low-density lipoprotein phospholipids. Proc. Natl. Acad. Sci. USA 81:3883-87
104. Steiner M. 1983. Effect of alpha-tocopherol administration on platelet function in man. Thromb. Haemost. 49:73-77
105. Steiner M. 1991. Influence of vitamin E on platelet function in humans. J. Am. Coll. Nutr. 10:466-73
106. Stewart-Lee AL, Forster LA, Nourooz-Zadeh J, Ferns GA, Anggard EE. 1994. Vitamin E protects against impairment of endothelium-mediated relaxations in cholesterol-fed rabbits. Arterioscler. Thromb. Vasc. Biol. 14:494-99
107. Stocker R, Keaney JF Jr. 2004. Role of oxidative modifications in atherosclerosis. Physiol. Rev. 84:1381-478
108. Suarna C, Dean RT, May J, Stocker R. 1995. Human atherosclerotic plaque contains both oxidized lipids and relatively large amounts of alpha-tocopherol and ascorbate. Arterioscler. Thromb. Vasc. Biol. 15:1616-24
109. Suzuki YJ, Packer L. 1993. Inhibition of NF-κB DNA binding activity by AT succinate. Biochem. Mol. Biol. Int. 31:693-700
110. Suzuki YJ, Tsuchiya M, Wassail SR, Choo YM, Govil G, et al. 1993. Structural and dynamic properties of AT and T3: implication to the molecular mechanism of their antioxidant potency. Biochemistry 32:10692-99
111. Takamatsu S, Takamatsu M, Satoh K. 1995. Effects on health of dietary supplementation with 100 mg α- and δ-tocopheryl acetate, daily for 6 years. J. Int. Med. Res. 23:342-57
112. Tasinato A, Boscoboinik D, Bartoli GM, Maroni P, Azzi A. 1995. d-α-Tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties. Proc. Natl. Acad. Sci. USA 92:12190-94
113. Terasawa Y, Ladha Z, Leonard SW, Morrow JD, Newland D, et al. 2000. Increased atherosclerosis in hyperlipidemic mice deficient in alpha-tocopherol transfer protein and vitamin E. Proc. Natl. Acad. Sci. USA 97:13830-34
114. Teupser D, Thiery J, Seidel D. 1999. AT downregulates SR activity in macrophages. Atherosclerosis 144:109-15
115. Thomas SR, Stocker R. 2000. Molecular action of vitamin E in lipoprotein oxidation: implications for atherosclerosis. Free Radic. Biol. Med. 28(12):1795-805
116. Traber MG, Arai H. 1999. Molecular mechanism of vitamin E transport. Annu. Rev. Nutr. 19:343-55
117. Ulker S, McKeown PP, Bayraktutan U. 2003. Vitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities. Hypertension 41:534-39
118. Upritchard JE, Sutherland WHE, Mann JI. 2000. Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care 23:733-38
119. Upston JM, Terentis AC, Morris K, Keaney Jr JF, Stocker R. 2002. Oxidized lipid accumulates in the presence of alpha-tocopherol in atherosclerosis. Biochem. J. 363:753-60
120. van Aalst JA, Burmeister W, Fox PL, Graham LM. 2004. α-Tocopherol preserves endothelial cell migration in the presence of cell-oxidized low-density lipoprotein by inhibiting changes in cell membrane fluidity. J. Vasc. Surg. 39:229-37
121. Van Tits LJ, Demacker PN, de Graaf J, Hak-Lemmers HL, Stalenhoef AF. 2000. α-Tocopherol supplementation decreases production of superoxide and cytokines by leukocytes ex vivo in both normolipidemic and hypertriglyceridemic individuals. Am. J. Clin. Nutr. 71:458-64
122. Vega-Lopez S, Kaul N, Devaraj S, Cai RY, German B, Jialal I. 2004. Supplementation with ω3 polyunsaturated fatty acids and all-rac AT alone and in combination failed to exert an anti-inflammatory effect in human volunteers. Metabolism 53:236-40
123. Venugopal SK, Devaraj S, Jialal I. 2003. CRP decreases prostacyclin release from human aortic endothelial cells. Circulation 108:1676-78
124. Venugopal SK, Devaraj S, Jialal I. 2004. RRR-AT decreases the expression of the major SR, CD36, in human macrophages via inhibition of tyrosine kinase (Tyk2). Atherosclerosis 175:213-20
125. Venugopal SK, Devaraj S, Jialal I. 2005. Macrophage conditioned medium induces the expression of CRP in human aortic endothelial cells: potential for paracrine/autocrine effects. Am J. Pathol. 166:1265-71
126. Venugopal SK, Devaraj S, Yang T, Jialal I. 2002. AT decreases superoxide anion release in human monocytes under hyperglycemic conditions via inhibition of PKC-α. Diabetes 51:3049-54
127. Verlangieri A, Buxh M. 1992. Effects of AT supplementation on experimentally induced primate atherosclerosis. J. Am. Coll. Nutr. 11:131-38
128. Wang CH, Li SH, Weisel RD, Fedak PW, Dumont AS, et al. 2003. C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle. Circulation 107:1783-90
129. Weinberg RB, VanderWerken BS, Anderson RA, Stegner JE, Thomas MJ. 2001. Pro-oxidant effect of vitamin E in cigarette smokers consuming a high polyunsaturated fat diet. Arterioscler. Thromb. Vasc. Biol. 21:1029-33
130. Williams RJ, Motteram JM, Sharp CH, Gallagher PJ. 1992. Dietary vitamin E and attenuation of early lesion development in modified Watanabe rabbits. Atherosclerosis 94:153-59
131. Witzum J, Steinberg D. 1991. Role of oxidized low-density lipoprotein in atherogenesis. J. Clin. Invest. 88:1785-92
132. Wu D, Koga T, Martin KR, Meydani M. 1999. Effect of vitamin E on human aortic endothelial cell production of chemokines and adhesion to monocytes. Atherosclerosis 147:297-307
133. Wu D, Mura C, Beharka AA, Han SN, Paulson KE, et al. 1998. Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E. Am. J. Physiol. 275:C661-68
134. Yang T, Devaraj S, Jialal I. 2001. Oxidative stress and atherosclerosis. J. Clin. Ligand Assay 24:13-24
135. Yasojima K, Schwab C, McGeer EG, McGeer PL. 2001. Generation of CRP and complement components in atherosclerotic plaques. Am. J. Pathol. 158:1039-51