Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl) nicotinamides as potential anticancer agents that inhibit tubulin polymerization

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 13, 2014, Pages 3465-3477

  Kamal, Ahmed ^a,b   Reddy, N V Subba ^a   Nayak, V Lakshma ^a   Bolla, Narasimha Rao ^b   Subba Rao, A V ^a   Prasad, B ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Cell cycle; Cytotoxicity; E7010; Triazoles; Tubulin polymerization

Indexed keywords

2 (2,4 DIMETHOXYPHENYLAMINO) N [[1 (3 PHENOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]NICOTINAMIDE; 2 (2,4 DIMETHOXYPHENYLAMINO) N [[1 (4 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]NICOTINAMIDE; 2 (2,4 DIMETHOXYPHENYLAMINO) N [[1 (4 METHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]NICOTINAMIDE; 2 (2,5 DIMETHOXYPHENYLAMINO) N [[1 (3 PHENOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]NICOTINAMIDE; 2 (3 FLUOROPHENYLAMINO) N [[1 (3 PHENOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]NICOTINAMIDE; 2 (3,5 DIMETHOXYPHENYLAMINO) N [[1 (3 PHENOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]NICOTINAMIDE; 2 (4 BROMOPHENYLAMINO) N [[1 (3 PHENOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]NICOTINAMIDE; 2 (4 CHLOROBENZYLAMINO) N [[1 (3 PHENOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]NICOTINAMIDE; 2 (4 CHLOROPHENYLAMINO) N [[1 (3 PHENOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]NICOTINAMIDE; 2 (4 FLUOROPHENYLAMINO) N [[1 (3 PHENOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]NICOTINAMIDE; 2 (4 LUOROPHENYLAMINO) N [[1 (3 PHENOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]NICOTINAMIDE; 2 (4 METHOXYPHENYLAMINO) N [[1 (3 PHENOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]NICOTINAMIDE; ANTINEOPLASTIC AGENT; N [(1 BENZYL 1H 1,2,,3 TRIAZOL 4 YL)METHYL]NICOTINAMIDE DERIVATIVE; N [2 [(4 HYDROXYPHENYL)AMINO] 3 PYRIDINYL] 4 METHOXYBENZENESULFONAMIDE; N [[1 (3 PHENOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 2 (PHENYLAMINO)NICOTINAMIDE; N [[1 (3,5 D IMETHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 2 (4 FLUOROPHENYLAMINO)NICOTINAMIDE; N [[1 (3,5 DIMETHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 2 (2,4 DIMETHOXYPHENYLAMINO)NICOTINAMIDE; N [[1 (3,5 DIMETHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 2 (4 METHOXYPHENYLAMINO)NICOTINAMIDE; N [[1 (4 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 2 (4 METHOXYPHENYLAMINO)NICOTINAMIDE; N [[1 (4 FLUOROBENZYL)1H 1,2,3 TRIAZOL 4 YL]METHYL] 2 (PHENYLAMINO)NICOTINAMIDE; N [[1 (4 METHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 2 (4 METHOXYPHENYLAMINO)NICOTINAMIDE; UNCLASSIFIED DRUG; NICOTINAMIDE; TRIAZOLE DERIVATIVE; TUBULIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; MCF 7 CELL LINE; MICROTUBULE ASSEMBLY; ANALOGS AND DERIVATIVES; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; POLYMERIZATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NIACINAMIDE; POLYMERIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; TUBULIN;

EID: 84901943672     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.04.038     Document Type: Article

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