Copper-catalyzed synthesis of indoles and related heterocycles in renewable solvents

ACS Sustainable Chemistry and Engineering

Volumn 2, Issue 6, 2014, Pages 1359-1363

  Koenig, Stefan G ^a   Dankwardt, John W ^a   Liu, Yanbing ^a   Zhao, Hang ^a   Singh, Surendra P ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Cascade; Catalysis; Dipolar aprotic solvent; Green chemistry; Heterocycle; Indole; One pot; Pharmaceutical; Renewable; Sustainability

Indexed keywords

CASCADES (FLUID MECHANICS); COPPER; DRUG PRODUCTS; SUSTAINABLE DEVELOPMENT;

DIPOLAR APROTIC SOLVENT; GREEN CHEMISTRY; HETEROCYCLES; INDOLE; ONE POT; RENEWABLE;

CATALYSIS;

EID: 84901943552     PISSN: None     EISSN: 21680485     Source Type: Journal    
DOI: 10.1021/sc5002098     Document Type: Article

References (57)

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55. We compared the solvents DMSO, 2-MeTHF, and EtOAc in the ACS Green Chemistry Institute Pharmaceutical Roundtable (GCIPR) Solvent Selection Guide. The biggest differences between DMSO and the greener options are (1) a very poor score for DMSO on "environmental waste" compared to the other two (8 vs 4 vs 4) with (2) a slightly better score for DMSO in the category of "safety" (3 vs 5 vs 5). To access the GCIPR solvent guide, visit http://www.acs.org/content/dam/acsorg/greenchemistry/industriainnovation/ roundtable/acs-gci-pr-solvent-selection-guide.pdf.
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