Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain

Journal of Pharmacology and Experimental Therapeutics

Volumn 345, Issue 3, 2013, Pages 502-511

  Hopkins, Seth C ^a   Zhao, Fei Yue ^b   Bowen, Carrie A ^a   Fang, Xin ^b   Wei, Haifeng ^b   Heffernan, Michele L R ^a   Spear, Kerry L ^a   Spanswick, David C ^b,c,d   Varney, Mark A ^a   Large, Thomas H ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b NEUROSOLUTIONS LTD   (United Kingdom)

^c MONASH UNIVERSITY   (Australia)

^d UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4H FURO[3,2 B]PYRROLE 5 CARBOXYLIC ACID; ANALGESIC AGENT; DEXTRO AMINO ACID OXIDASE; DEXTRO SERINE; GABAPENTIN; IBUPROFEN; UNCLASSIFIED DRUG;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; BRAIN FUNCTION; CELL ACTIVITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; EVOKED CORTICAL RESPONSE; INFLAMMATORY PAIN; LOW DRUG DOSE; MALE; NERVE CONDUCTION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; SPINAL CORD DORSAL HORN; SPINAL GANGLION; TIME TO MAXIMUM PLASMA CONCENTRATION;

AMINES; ANALGESICS; ANESTHESIA; ANIMALS; BEHAVIOR, ANIMAL; CONSTRICTION, PATHOLOGIC; CYCLOHEXANECARBOXYLIC ACIDS; D-AMINO-ACID OXIDASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EXCITATORY AMINO ACID ANTAGONISTS; FREUND'S ADJUVANT; FURANS; GAMMA-AMINOBUTYRIC ACID; HOT TEMPERATURE; HYPERALGESIA; LIGATION; MALE; NEURALGIA; PHYSICAL STIMULATION; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; SERINE; SPINAL CORD; SPINAL NERVES;

EID: 84877689416     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.113.204016     Document Type: Article

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