Structural, kinetic, and pharmacodynamic mechanisms of d-amino acid oxidase inhibition by small molecules

Journal of Medicinal Chemistry

Volumn 56, Issue 9, 2013, Pages 3710-3724

  Hopkins, Seth C ^a   Heffernan, Michele L R ^a   Saraswat, Lakshmi D ^a   Bowen, Carrie A ^a   Melnick, Laurence ^a   Hardy, Larry W ^a   Orsini, Michael A ^a   Allen, Michael S ^e   Koch, Patrick ^a   Spear, Kerry L ^a   Foglesong, Robert J ^f   Soukri, Mustapha ^f   Chytil, Milan ^a   Fang, Q Kevin ^a   Jones, Steven W ^a   Varney, Mark A ^a   Panatier, Aude ^b   Oliet, Stephane H R ^b   Pollegioni, Loredano ^c,d   Piubelli, Luciano ^c,d   Molla, Gianluca ^c,d   Nardini, Marco ^g   Large, Thomas H ^a   more..

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c UNIVERSITY OF INSUBRIA   (Italy)

^d CNR   (Italy)

^e Tandem Labs   (United States)

^f SCYNEXIS   (United States)

^g UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOIC ACID; DEXTRO AMINO ACID OXIDASE; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OXIDOREDUCTASE INHIBITOR; PYRROLE; SERINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG MECHANISM; DRUG RELEASE; DRUG STRUCTURE; ENZYME INHIBITION; MOUSE; NONHUMAN; RAT; STEADY STATE; X RAY CRYSTALLOGRAPHY;

ANIMALS; BEHAVIOR, ANIMAL; BINDING, COMPETITIVE; CATALYTIC DOMAIN; D-AMINO-ACID OXIDASE; ENZYME INHIBITORS; GLYCINE; HUMANS; KINETICS; MALE; MOLECULAR DOCKING SIMULATION; NEUROGLIA; RATS; RATS, SPRAGUE-DAWLEY; SERINE; SMALL MOLECULE LIBRARIES;

EID: 84877711069     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4002583     Document Type: Article

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