Optimalisation of the clinical pharmacogenetic model to predict methotrexate treatment response: The influence of the number of haplotypes of MTHFR 1298A-677C alleles on probability to respond

Annals of the Rheumatic Diseases

Volumn 68, Issue 8, 2009, Pages 1371-

  Kooloos, W M ^a   Wessels, J A M ^a   Van Der Kooij, S M ^a   Allaart, C F ^a   Huizinga, T W J ^a   Guchelaar, H J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

METHOTREXATE; ANTIRHEUMATIC AGENT; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ALLELE; DISEASE ACTIVITY; DRUG EFFICACY; GENETIC ASSOCIATION; GENETIC MODEL; GENOTYPE; HAPLOTYPE; HETEROZYGOTE; HUMAN; LETTER; MONOTHERAPY; PHARMACOGENETICS; PREDICTION; PRIORITY JOURNAL; PROBABILITY; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; BIOLOGICAL MODEL; GENETICS; PROGNOSIS; TREATMENT OUTCOME;

ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; HAPLOTYPES; HUMANS; METHOTREXATE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MODELS, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; TREATMENT OUTCOME;

EID: 67651225612     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2008.096891     Document Type: Letter

References (4)

1. Ranganathan P, An update on methotrexate pharmacogenetics in rheumatoid arthritis. Pharmacogenomics 2008;9:439-51.
2. Wesoly J, Wessels JA, Guchelaar HJ. Huizinga TW, Genetic markers of treatment response in rheumatoid arthritis. Curr Rheumatol Rep 2006;8:369-77.
3. Wessels JA, van der Kooij SM, le Cessie S, Kievit W, Barerra P, Allaart CF, et al. A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis. Arthritis Rheum 2007;56:1765-75.
4. Wessels JA, de Vries-Bouwstra JK, Heijmans BT, Slagboom PE, Goekoop-Ruiterman YP, Allaart CF, et al. Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes. Arthritis Rheum 2006;54:1087-95.