Inhibition of Enterococcus faecalis biofilm formation by highly active lactones and lactams analogues of rubrolides

European Journal of Medicinal Chemistry

Volumn 82, Issue , 2014, Pages 127-138

  Pereira, Ulisses A ^a   Barbosa, Luiz C A ^a,b   Maltha, Célia R A ^a   Demuner, Antônio J ^a   Masood, Mohammed A ^c   Pimenta, Andréa L ^d,e  

^a FEDERAL UNIVERSITY OF VIÇOSA   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c RheoGene LLC   (United States)

^d FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^e UNIVERSITÉ DE CERGY PONTOISE   (France)

Author keywords

Anti biofilm activity; Quorum sensing antagonist; Rubrolides; Alkylidene lactams; Alkylidene lactones; Hydroxy lactams

Indexed keywords

3 BROMO 4 (2 METHOXYPHENYL) 5 (4 TRIFLUOROMETHYLBENZYLIDENE)FURAN 2(5H) ONE; 3 BROMO 4 (5 BROMO 2 METHOXYPHENYL ) 5 (3 CHLOROBENZYL) 5 HYDROXY 1 ISOBUTYLPYRROL 2(5H) ONE; 3 BROMO 4 (5 BROMO 2 METHOXYPHENYL) 5 (3 CHLOROBENZYLIDENE) 1 ISOBUTYLPYRROL 2(5H) ONE; 3 BROMO 4 (5 BROMO 2 METHOXYPHENYL) 5 (3 CHLOROBENZYLIDENE)FURAN 2(5H) ONE; 3 BROMO 4 (5 BROMO 2 METHOXYPHENYL) 5 (4 BROMOBENZYL) 5 HYDROXY 1 ISOBUTYLPYRROL 2(5H) ONE; 3 BROMO 4 (5 BROMO 2 METHOXYPHENYL) 5 (4 BROMOBENZYLIDENE) 1 ISOBUTYLPYRROL 2(5H) ONE; 3 BROMO 4 (5 BROMO 2 METHOXYPHENYL) 5 (4 BROMOBENZYLIDENE)FURAN 2(5H) ONE; 3 BROMO 4 (5 CHLORO 2 METHOXYPHENYL) 1 ISOBUTYL 5 (3 METHOXYBENZYLIDENE)PYRROL 2(5H) ONE; 3 BROMO 4 (5 CHLORO 2 METHOXYPHENYL) 4 (3 METHOXYBENZYLIDENE)FURAN 2(5H) ONE; 3 BROMO 4 (5 CHLORO 2 METHOXYPHENYL) 5 HYDROXY 1 ISOBUTYL 5 (3 METHOXYBENZYL)PYRROL 2(5H) ONE; 3 BROMO 5 (2 BROMOBENZYL) 4 (5 CHLORO 2 METHOXYPHENYL) 5 HYDROXY 1 ISOBUTYLPYRROL 2(5H) ONE; 3 BROMO 5 (2 BROMOBENZYLIDENE) 4 (5 CHLORO 2 METHOXYPHENYL) 1 ISOBUTYLPYRROL 2(5H) ONE; 3 BROMO 5 (2 BROMOBENZYLIDENE) 4 (5 CHLORO 2 METHOXYPHENYL)FURAN 2(5H) ONE; 3 BROMO 5 (2 CHLOROBENZYL) 5 HYDROXY 1 ISOBUTYL 4 (5 METHYL 2 METHOXYPHENYL)PYRROL 2(5H) ONE; 3 BROMO 5 (2 CHLOROBENZYLIDENE) 1 ISOBUTYL 4 (5 METHYL 2 METHOXYPHENYL)PYRROL 2(5H) ONEL; 3 BROMO 5 (2 CHLOROBENZYLIDENE) 4 (5 METHYL 2 METHOXYPHENYL)FURAN 2(5H) ONE; 3 BROMO 5 (3 CHLOROBENZYL) 5 HYDROXY 1 ISOBUTYL 4 (5 METHYL 2 METHOXYPHENYL)PYRROL 2(5H) ONE; 3 BROMO 5 (3 CHLOROBENZYLIDENE) 1 ISOBUTYL 4 (5 METHYL 2 METHOXYPHENYL)PYRROL 2(5H) ONE; 3 BROMO 5 (3 CHLOROBENZYLIDENE) 4 (5 METHYL 2 METHOXYPHENYL)FURAN 2(5H) ONE; 3 BROMO 5 (4 TRIFLUOROMETHYLBENZYL) 5 HYDROXY 1 ISOBUTYL 4 (2 METHOXYPHENYL)PYRROL 2(5H) ONE; 3 BROMO 5 (4 TRIFLUOROMETHYLBENZYLIDENE) 1 ISOBUTYL 4 (2 METHOXYPHENYL)PYRROL 2(5H) ONE; 3 BROMO 5 (4 TRIFLUOROMETHYLBENZYLIDINE) 1 ISOBUTYL 4 (2 METHOXYPHENYL)PYRROL 2(5H) ONE; 3 BROMO 5(2 CHLOROBENZYLIDENE) 1 ISOBUTYL 4 (5 METHYL 2 METHOXYPHENYL)PYRROL 2(5H) ONE; ANTIBIOTIC AGENT; LACTAM DERIVATIVE; LACTONE DERIVATIVE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; FURAN DERIVATIVE; LACTAM; LACTONE; MUCOBROMIC ACID;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL VIABILITY; BACTERIUM ADHERENCE; BIOFILM; COST EFFECTIVENESS ANALYSIS; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; GEOMETRY; HYDROGEN BOND; IC 50; NONHUMAN; NUCLEOPHILICITY; PHYSICAL CHEMISTRY; QUORUM SENSING; STEREOCHEMISTRY; STEREOSPECIFICITY; SUZUKI REACTION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; BIOFILMS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROCOCCUS FAECALIS; FURANS; LACTAMS; LACTONES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84901926654     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.035     Document Type: Article

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